The Renin-Angiotensin-Aldosterone System, RAAS, Animation
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- Опубликовано: 14 окт 2024
- (USMLE topics) Renal control of blood pressure via RAAS.
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The renin-angiotensin-aldosterone system, RAAS, is a hormonal system that controls blood pressure. While baroreflex is a short-term response to sudden changes in blood pressure, RAAS is responsible for long-term regulation.
In the kidneys, within the walls of afferent arterioles, there are specialized cells producing prorenin called juxtaglomerular cells. Upon activation by a drop in blood pressure, prorenin is cleaved to form renin, which is released into the blood. Renin converts a plasma protein called angiotensinogen, produced by the liver, into angiotensin I, a peptide of 10 amino acids. Angiotensin I is further converted into angiotensin II, an 8-amino acid peptide, by the angiotensin-converting enzyme, ACE, predominantly present in the lungs and kidneys.
Angiotensin II is a hormone. It binds to angiotensin II receptors in tissues to exert various effects:
It promotes sodium reabsorption in proximal convoluted tubules of the kidneys.
It stimulates vasoconstriction in systemic arterioles.
It induces the release of aldosterone from the adrenal cortex. Aldosterone promotes sodium and water retention in the kidneys.
In the central nervous system, angiotensin II has several effects:
It acts on the hypothalamus to stimulate thirst and encourage water intake.
It induces the posterior pituitary to release antidiuretic hormone, which promotes water retention by the kidneys.
It reduces the sensitivity of the baroreceptor response to increased blood pressure, so that this response would not counteract the effect of RAAS.
All these actions lead to an increase in blood volume and blood pressure.
Angiotensin II is short-lived with a half-life of 1 to 2 minutes. It is degraded into angiotensin III and IV, which have lesser effects.
Overactive or inappropriately activated RAAS is a cause for hypertension.
RAAS is a frequent target of anti-hypertensive drugs. ACE inhibitors and angiotensin receptor blockers are common treatment for hypertension.
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I learned this at university as a pharmacy student more than 15 years ago and I am ashamed to admit I totally forgot how the RAAS works, after these 2.5 min everything came back!
Didn’t ask
Save this video because you’ll forget again in like 2 weeks.
@@Hoodinator17 😂
@@wyattkarin basic hooman nature
Now you are in which position after pharmacy
This video is by far the best to explain RAAS I've seen.
As a medical student learning about hypertension this video proved extremely helpful. Concise and easy to understand. Thanks!
Wow this video was so interesting! Its amazing how different organs of the body really does work as a team and what renin is capable of.
absolutely magnificent presentation-gives the whole picture of RAAS
Its very helpful to students for a better and clear understanding of concept on watching these videos Thank you so much @Alila Medical sciences
I think audio and video learning are the best form of learning
It helps to stick better
simple and straight forward by far the best video on RAAS
very straightforward with exactly the sort of explanation I wanted to better understand the "why" behind each step, thank you!
Short, to the point, clear, and informative.
Really help me to understand the pathophisiology of hipertension, thanks!
Great explanation! The online cardiology course I'm taking makes it very complicated but now I understand everything - thank you!
You should take our Alila Academy course instead 😀
Thank you so much! I wish I could convert all of my studies into 2.5 minute videos!
at least youre no dirty nig...
This video was really helpful. I need to know this for an exam and I didn’t understand how this worked. Thanks!
Alila Medical Media never dissapoints🎉
I now understand why aldosterone is produced when renin is high.
At first i thought that this didnt make sense, because production of aldosterone is triggered in low blood pressure. I thought we already have high pressure and aldosterone is triggered by that.
Now it is clear that the initial trigger is actually low blood pressure.
My teacher thought i was dumb for asking about this, but i now understand it in less than 3 minutes. She just didnt know how to explain it properly and had to call me out for it!
Thank you lots for this!
This is great. On the website the videos are INSANELY EXPENSIVE!!!
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I got in in less than 2 minutes while a lecture lecturing me spent the whole day.
Thanks
Great explanation, thanks!
Thank you so much It's so exclusive and short video although complex topic.
this was really helpful for me during my prep for pharm exams
Excellent presentation
This video was very helpful to me, thank you for taking your time to make such a video with coherent flow of facts.
All med students should review this video before exams!
this made everything so much easier to understand! thank you
great and fast thank you❤
Wonderful explanation thanks😀
Beautifully explained ❤
Nice presentation
Thank you very much, this helps me a lot in my lecture.
Made concepts concrete strong..thnku
Amazing video thank you so much
Thank you so much really helpful ❤️
Best explanation
thank you, finally I could understand it!
Excellent video.
Great explanation and really helpful for me❤️
reallly helpfull! thank you so much
So good!
Thank you!
Thank you ♥️🙌
Thank you
very good for neet revision
Eassy to understand , thanks a lot
Well explained mam
Very well explained 🤩
THANK YOUUU
Thank you very useful
Really helpful, thank you ❤️
Perfect
Nice work
Helpful
Nice👍
Nice amazing
Great video.
I have the AGT gene variation of genotype GG.
I am told this often results in holding on to more salt.
I want to find a way to not urinate so often and not have a thick layer of soft jiggly skin on top of an above average musculature. My jiggly spare tire is odd looking compared to the rest of me.
I'm pretty sure it's my bladder that doesn't let me sleep past 6 hours no matter what I do or don't do/eat/drink.
Anybody have any ideas?
good video!
Any specific treatment for this type of hypertension
Tnx a lot ❤️
Nice❤
Great
This is a good video,kudos 🙂
But I really didn't understand how aldosterone retains water in the kidney, I thought it reabsorbs water and salt from the tubules into the blood stream.
Yes, that's exactly how it retains water - reabsorbs water back into the blood so more water stays in the body and less water excreted in urine. That process occurs in the nephrons of the kidney - this doesn't mean water stays in the kidney.
🙏🏻🙏
Literally a cherry on a cup of desert 🍵✌️
Renin is a hormone and rennin is an enzyme
I'm here because Today our mam asked about this but I failed to answer, i forgot this I felt very bad 😔
that's ok! what matters is that you're willing to learn
Failing isn't bad instead not willing to learn is somewhat bad
Is Beta blocker system available?
Worthy In covid pandemic
I don't understand..the eqy you made this video..I don't understand anything
I wanted to ask if RAAS also works in reverse, for example if blood pressure is too high, then does the Juxtaglomerular aparatus sense that and decrease the cleavage of prorening and therefore secretion of renin? then as a result decreases the reabsorption of sodium and water? I know this is correct. I just want a confirmation that I am not crazy.
In other words, does renin get secreted less in cases of hypertension? does the RAAS act as a modulator to keep blood pressure within normal limits?
There is another system call ANF (Atrial Natriuretic Factor) Mechanism for that which acts like a check on RAAS
adrenal gland
please go ahead
I have no idea why students are bothered with all this since they will not be able to using it once they say their fake oath.
Omce they are doctors, they dont even know what an aminoacid is! 😅
If there are any private doctors who use what they have bwen taught and what they have learned on their own, it would be good to know who they are.
Thanks alot, may god bless you, and may my doctor go to hell
Unison pharmaceuticals❤️
Neet aspirant
Class 11 indian students 🐴
awesome.. but you English is not clear to the listeners.. speak clearly
Rap song RAAS pr jarur dekhna 👍
ruclips.net/video/L7RBQXrchx8/видео.html🎶