I read your book and in May I went on a vegetarian diet to aid in lowering my uric acid. I followed your instructions and purchased all the supplements you recommend in the book, taking them every day for two months. Stopped taking Allopurinol (100 mg 1 tablet daily) in March (before I started your supplements). Gave a copy of your book to my so called doctor, he wasn't impressed (of course). I have now dealt with uric acid for years (I monitor my blood daily, uric acid, ketones, glucose, blood pressure and body fat) for years. I decreased my weight from 255 to 220 (my goal is 180 or 15% body fat) I had the worst gout attack in my life in lasting June, July and August 2022 ( attacked my left toe, my right knee, ankle and foot and lower back and my right wrist) I still have pain in my right foot and am on my forth dose of Colchicine (20 tablets in ten days) to rid my foot of the crystals. My uric acid stayed between 8 - 10 mg /dl while I was taking the supplements you recommended. I realize being on a keto diet and fasting can increase uric acid (plus exercise) but not to this extent. I had a full blood analysis to see if my liver or kidneys are operating correctly and they are (did this myself through Quest Labs). I am hoping this last dose of Colchicine will eliminate the crystals left in my foot. Don't eat any foods with purines (no meat, fish). Stopped eating sugar in any form ten years ago, never eat junk food or fast food. Just letting people know one person battle.
I've had kidney stones for a decade - followed all the typical medical advice to cut out meat, coffee, chocolate, green veg, etc.. never helped a bit. Went ketovore and haven't had a stone in 6 months (previously it was at least a couple per month). Go figure
Unfortunately colchicine will not eliminate urate crystals from your body, it is intended to suppress the immune system, which is the one who "attacks" the crystals trying to get rid of them, thus proking our painful flare ups. Crystals will be flushed out of your joints as long as your serum Uric Acid/sUA stays consistently below around ≈ 7 mg/dL, doesn't matter if it is through medication, diet, etc... Colchicine is a way to treat flare ups, but the crystals will stay, and sooner or later the gout flares will eventually be triggered. I myself have gout and have to research this condition thoroughly, doctors at least for me only give you a standard template with foods high in purines, It doesn't matter if I tell them I am a teetotaler, so I don't drink beer, or that I only consume seafood at Christmas. They also tell me to lose weight and to not drink protein shakes, and they don't listen when I tell them, when I try very hard to lose weight and suceed then I have a gout flare up thus entering a vicious cycle. And I don't take excessive amounts of protein, I'm just a fat muscular man. Of course they have never heard about HFCS and other fructose issues that trigger gout. They couldn't care less, the one who is left disabled for a week with feet pain that is unbearable is you, not them. So if I have to suffer the consequences of their mistakes, for me then they may be my mistakes or my successes. What worked for me is allopurinol 300 mg three times a day every day, a zero carb/keto diet with no hidden fructose (very carefully reading food labels), then weight training 3 times per week, no fasting as it triggers my gout, and right now I can reduce my allopurinol intake to only 300 mg/day, as my sUA is consistently under 5 mg/dL. You will have to do trial and error, but if you do it right you'll never need to use colchicine again and like myself your feet won't feel like you've walked from the East to the West Coast after a hard day's work. Cheers
@@beoz658 As far as I know, Dr Perlmutter doesn't say anything about stopping allopurinol or other lowering uric acid treatments althogether. He talks about the importance of keep a sUA (serum/ blood uric acid level) equal or lower than 5mg dL, whilst the current mainstream medical advice is to keep it just under 7 or 8, which is the point when the crystals begin to accumulate. He also speaks about taking natural supplements like berberine and others, which have a similar effect to allopurinol but are less potent, thus requiring a higher dose to receive the same effect, and having less side effects because they are not drugs. At the end of the day, you are the one who suffers gout and the one who will be miserable and unable to walk and bearing an unbearable pain. So it is your duty to choose who you want to listen and have a critical mind, because most doctors coudn't care less. You could follow their guidelines to the letter of the law, not work, or even be counterproductive. And tell that to the doctor, who will not realize his/her mistake and double down, insisting that your must keep doing it. Take care
I wish my grandmother was still Alive, she was the best doctor without ever going to school for it. Her huge garden was amazing and we never got sick. She liked to see 103 yrs old and I should have paid more attention. I’m happy I found this channel.
You make some good points. Around 15 years ago when I got pre diabetes, I started doing some research. I looked at all the health problems that my great grandparents, grandparents, great aunts and uncles, and mother have or had, and they all seemed to start at around middle age. The elevated uric acid, insulin resistance, high BP etc. along with Alzheimer's and Parkinson's in old age. I figured out we have an ATP7B copper binding gene defect. There are over 400 mutations that have been discovered so far, and most of them are only partial gene defects where only part of the 6 binding exons are defective, which causes a gradual buildup over time. I had my free copper tested and it was 4 times normal and my Mother's free copper was even higher since she is 30 years older. I found a study on chickens where they fed half of them copper, and the ones given copper all had higher uric acid. When you mentioned those vegetables high in purines don't elevate uric acid, it makes me wonder if it's not the purines, but copper that is raising the uric acid, since those veggies mentioned are all low in copper? In my mother's case asparagus which as you know is high in purines, will raise her uric acid, and it's also high in copper. Organ meats, lobster, shrimp, and mushrooms are also high in copper and will also cause her gout flares. Back when the genome was mapped and free copper was discovered, 2 scientists tested the blood of people with T2 diabetics, Alzheimer's, Parkinson's, Schizophrenics, and ALS, and found they all had elevated free copper levels. They applied for a usage patent to treat these conditions with ammonium tetrathiomolybdate, but the fda never approved it. Their theory was that the free copper gradually built up over a lifetime, and their brain was protected from Alzheimer's, Parkinson's and ALS, but as they got older their BBB deteriorated and became permeable allowing the toxic free copper to enter their brain. In Schizophrenics they hypothesized that the person was born with a defective BBB and this ATP7B gene defect. It doesn't seem like there is an awareness of this free copper. It was only recently that lab corp in Oklahoma started offering the direct measurement of free copper test, after I requested it. Before that I was doing an indirect measurement of free copper which wasn't as accurate. An interesting thing I found out during my research was that allopurinol also lowers copper. After learning about this, and also reading the study where the chickens fed copper had elevated uric acid, it led me to believe copper is causing elevated uric acid in some people. Then I ran onto another study which showed elevated copper was an activator of the oxidation of xanthine to uric acid. That high fructose corn syrup thing you discovered is definitely another thing causing high uric acid and metabolic syndrome. I never thought of that until seeing your research. Thanks for sharing this great information.
This is interesting about copper and the genetic defect you mentioned. There is a research scientist/geneticist with CHOP (Children’s Hospital of Philadelphia) that shows the migration of peoples based on mitochondria DNA, since this is a maternal inheritance and can trace all population’s based on this.
I just finished your book, DROP ACID! I will encourage everyone I know to read this book! I will leave it in my kitchen, reading it over and over like my health bible. I hope everyone buys a copy and shares it with loved ones! Have a book club party, or offer potluck with friends! This one is a keeper!
I had to stop all fruit except just 1/2 cup of berries [[ switch it up every day ]] and 1/2 cup of dark or tart cherries daily. Now I love this ambrosia as daily routine and never miss any of the other fruits at all.
It is interesting to reflect that it is often combinations of constituents that make the difference. I was always puzzled why meat was always targeted for uric acid due to purines, when I knew that all living things have DNA. On my low carb journey I've stopped 3 different medications but have not yet grasped the nettle of dropping Allopurinol, but Richard Johnson's work has given me hope that I no longer need this med, because I no longer consume sugar, flour or other concentrated carbs.
I saw no mention of asparagus, which would often set my gout off like crazy. Also my favorite vegetable (frustrating). Since I have cut way down on sugar and done intermittent fasting (lost 25 pounds over about 2 months), I have no issues with gout any longer. If I eat a bunch of stuff now that used to set off my gout, I sometimes get the feeling in my big toe that gout is starting to happen, but it never goes past 'that initial feeling' anymore. That feeling used to be scary...
Well this is just great , and getting stranger all the time. I’m told sardines and anchovies are good for you because of their omega-3 benefits. Now they’re rich in purines which will not only give me gout but also Alzheimer’s. Beautiful, f#@king beautiful.
rda for purines is under 400. one tin of sardines is 385 purines. i was up to 2 or 3 a day. first ever flare and was told im at 11 ua. strict keto lots of fasting etc, ketones in the body compete with u.a in a linear fashion. the more ketones, the more uric acid in the blood.
I’m so frustrated!! Trying to eat gluten free, low oxalate, low purine...lower oxalate veggies are higher in purine? Eating carnivore is difficult trying to keep purine levels low...what do we eat? 😢
You need to increase your insulin sensitivity and also your nitric oxide production and consume lots of nitrate rich foods and stop using any kind of mouthwash or fluoride toothpaste or chlorinated tap water.
When I was under dialysis, I had gout in the ankles and knees, one side, for about one month, than it was gone for some time, and than it was the other side :-( with spinach, tomatoes, mushrooms, gerkins, as I didn’t eat much, it was easy to find out, I also found out that I was cow lactose intolerant, by suppressing foods one by one, I found out every food making me sick. Milk and cheese were the last I suppressed, at the end all I had was pure steak, 1/4 pound or 100gram per day. That was in 2016, 2 years where needed to find the poisons giving me gout. Since 2018, I’m gout free. I had a new kidney in 2019, 6 month later, I had worst pain than gout, from lower back to the little toe, I was able to walk a little, I had big pain when seated, driving the car was a nightmare, laying flat was the only solution. Again, I suppressed all food, but it remaind the same. I had all sorts of tests radiography, magnetic resonance, appointments with specialists. The only solution found was to go for a hip replacement, I had that done the other side, when I had my first transplant in 1998. You can imagine that I didn’t went out much, and one day, I was out of statines, lipitor, but still had enought other medication to not reject my kidney, cellcept, advagraft, medrol, those are mandatory if I want to live. After a few days, I couldn’t believe it, the pain was less, more time past, little by little I felt better, so I didn’t swallow statins anymore. I told the doc that I stoped statins, he said I can’t stop, statins can not have that effect, so, I obeyed, 2 days later, the pain was back. The next month, visit to doc, the pain was not completely gone, again, he tells me I need lipitor. I ask for something else with the same effect, the doc says ok, he prescribe another medication, I forgot the name. 2 days later the pain came back, when reading the notice, I see it’s statins again. Now 2023 I take meds based on walnut leaves wich don’t lower my cholesterol, but statins didn’t either. I’m almost pain free, my legs are still weak, everyday I fight to get better. What can we do? Hope, resist, fight About lactose intolerance. The smallest quantity of anything containing cow milk begun to make me sick when I did dialysis, my digestion stoped, a few minutes after exposition, I had heart burns, and nothing else would go passed my stomach, all food stayed there rotting. I didn’t know it was because of lactose, I tought it was because of dialysis, I had to puke to feel better, sometimes 3 x a day, sometimes, no problem. 🤔 My teeth where melting with the vomit. 🤢 it’s disgusting, sorry. Since I learned lactase exist, but if my body doesn’t want cow lactose, I prefer not to have it, but sometimes there is some lactose contamination on the food, I take some lactase, and I’m fine. I insisted on cow lactose, because, goat or sheep lactose doesn’t cause me any trouble. All that to say everyone is different, the doctors can guide, but you must find what is best for yourself. It’s not easy, for example, I’m sure one of my anti reject medication is giving me high cholesterol, but I can’t stop to take it, or my body will reject the kidney, and dialysis is very bad, barely enough to stay alive. If you know someone needing dialysis, go help, it’s hard. Even if it’s not visible from the outside everything is hard for those patients, even transplanted it’s still hard.
Lactose in cows, sheep and goats is all the same stuff. Where these milks differ is in the protein profile. I wonder if what you take to be lactose intolerance might be a protein intolerance. Many people find it hard to digest bovine Casein, and can often mistake negative symptoms for a lactose intolererance.
According to Dr. Royal Lee, foods high in potassium are protective against gout, such as raw leafy vegetables, raw vegetables, juices, potatoes and beans. And Quercetin is good for gout, and is found in Elderflower, green tea, red grapes, onions, yogurt, lima beans, mushrooms (all very high in potassium), kale, avocado, salmon, bananas, cantaloupe, tomatoes and sweet potatoes.
I'm taking all the supplements recommended in your book and following all the eating advice in your book. How long should it take to lower UA to, say, 6, if I started at 8? Roughly. I'd like to see a video showing average results of this protocol you are recommending.
David Perlmutter used exactly the right term: associated. Maybe he should have remind us what does "associated" really means. So high in purines vegetables consumption is associated with lower levels of uric acid in blood. Fine. But from this study we can't say if these vegetables tend to reduce uric acid levels when they are regularly eaten. That's just an hypothesis we need to verify with an interventional study. We can't say either if having low levels of acid uric in our blood makes us eat more broccoli. Looks ridiculous? No, it is an hypothesis as valid and as uncertain as the first alternative considering only the results of the study. Observational studies in nutrition can't prove much especially when they are based on such unreliable data than those coming from food frequency questionnaires. They can only show associations. They can't show cause and effect relationships nor a way to relationships. What's sure is that, generally, people eating a lot of vegetables (rich or not in purines) tend to drink less alcohol and less sugary drinks. They also tend to eat less sugary foods. So it is quite possible that the reduced levels of uric acid for people eating vegetables should be more the consequence of lesser sugar/fructose intakes rather than the result of the activity of some polyphenol present in these vegetables.
Please can you confirm the best fruits, vegetables and supplemnts. I'm at Eurovision Malmo right now and I am in agony because of gout affecting mainly my knees. Any low side effect medication ? Travelling with gout is very hard.
Would xanthine oxidase inhibitors cause higher or lower ammonia levels in the blood? I tried to figure it out but I can't! You likely know the answer being a neurologist. Please help!!
I stopped eating cauliflower, broccoli, asparagus, pumpkin, eggplant, mushrooms, 😢 also chick pea, all theother legumes, red meats even honey, only 2 cups of tea with 2 tsp honey. Coconut water, prawns, crab, squid etc.
I must be the odd person out. If I eat any high purine vegetables I have a gout attack within hours. Asparagus, mushrooms and cauliflower affect me the worst, cruciferous vegetables make me feel achy. I love those vegetables but they don't love me. I have been eating low carb for a few years so no fructose in my diet, I don't drink, I don't eat a lot of red meat or organ meats, it is the vegetables that cause my pain.
are you low carb or keto? Just learned the deeper you are into ketosis, the higher the u.a level in the blood. 1600 person study, 95 percent confidence interval.. I stopped keto because i just learned my ua is at an 11. ketones compete with ua during excretion. Looking at this study, i should be able to drop it by 3 points by eating some carbs and not fasting so much..
Who said no meat ? Been on carnivore 💯 for two months. Just red meat. My uric acid has gone down since. I have no inflammation and I've lost 10 kilos. Don't follow this guy. There are other Dr's who are practising carnivore like Dr Ken Berry. Dr Anthony Chafee who is also a neurologist. Dr Westman. Dr Eric Berg
That's what we get with epidemiological studies and correlations, interesting paradoxes at best... like the so-called French paradox. French consumed a lot saturated fat but didn't die from heart disease as much as "predicted" by Ancel Keys' seven countries study: rather than considering that France is a country large enough to invalidate the results of the study, let's call that a paradox and try to explain it with red wine (as alcohol is not healthy we will have an even greater paradox). We better not pay too much attention to epidemiological studies in nutrition. They are based on unreliable data, often contradictory and very often biased like the seven countries study: at the time of the study data were available for 22 countries including France but only seven countries that were confirming the diet-heart hypothesis were cherry-picked. When you consider the 22 countries there is simply no relation between saturated fat and heart disease. There is no French paradox either.
actually purines are composed of 4 different types of amino acids They all produce different levels of uric acid. one of the purine tables in a study has it all broken down, it was a japanese study,, 1 of the 4 is the worst by a large margin but i dont recall its name, the rest are comparatively benign.. google japanese purine table or something similar
Hmmmmmm. I limit my carbs to 25 grams per day. I eat fish twice a week. Some meat. Well?. High uric acid. No gout puzzled. Please help? P.s eat alllll above veggies
I had to stop all fruit except just 1/2 cup of berries [[ switch it up every day ]] and 1/2 cup of dark or tart cherries daily. Now I love this ambrosia as daily routine and never miss the other fruits at all.
Maybe you are just genetically inclined and may need Querticin and or Febuxostat 80mgs..I suffer it too, am 65 yrs am Diabetic T2 and Gluten issues.. Gut inflammation Diverticulitis.
Hi , same boat here for a few months, strict keto, lots of fasting Im at an 11 u.A.. I just learned that ketones compete with uric acid for excretion in a linear fashion. more ketones, more uric acid in blood, less ketones less uric acid in the blood. It was a 1600 person study with a 95 % confidence rate. If I go off what I learned, I can deop it 3 points by limiting ketosis and fasting I hoe..
I read your book and in May I went on a vegetarian diet to aid in lowering my uric acid. I followed your instructions and purchased all the supplements you recommend in the book, taking them every day for two months. Stopped taking Allopurinol (100 mg 1 tablet daily) in March (before I started your supplements). Gave a copy of your book to my so called doctor, he wasn't impressed (of course). I have now dealt with uric acid for years (I monitor my blood daily, uric acid, ketones, glucose, blood pressure and body fat) for years. I decreased my weight from 255 to 220 (my goal is 180 or 15% body fat) I had the worst gout attack in my life in lasting June, July and August 2022 ( attacked my left toe, my right knee, ankle and foot and lower back and my right wrist) I still have pain in my right foot and am on my forth dose of Colchicine (20 tablets in ten days) to rid my foot of the crystals. My uric acid stayed between 8 - 10 mg /dl while I was taking the supplements you recommended. I realize being on a keto diet and fasting can increase uric acid (plus exercise) but not to this extent. I had a full blood analysis to see if my liver or kidneys are operating correctly and they are (did this myself through Quest Labs). I am hoping this last dose of Colchicine will eliminate the crystals left in my foot. Don't eat any foods with purines (no meat, fish). Stopped eating sugar in any form ten years ago, never eat junk food or fast food. Just letting people know one person battle.
I've had kidney stones for a decade - followed all the typical medical advice to cut out meat, coffee, chocolate, green veg, etc.. never helped a bit. Went ketovore and haven't had a stone in 6 months (previously it was at least a couple per month). Go figure
Unfortunately colchicine will not eliminate urate crystals from your body, it is intended to suppress the immune system, which is the one who "attacks" the crystals trying to get rid of them, thus proking our painful flare ups. Crystals will be flushed out of your joints as long as your serum Uric Acid/sUA stays consistently below around ≈ 7 mg/dL, doesn't matter if it is through medication, diet, etc... Colchicine is a way to treat flare ups, but the crystals will stay, and sooner or later the gout flares will eventually be triggered. I myself have gout and have to research this condition thoroughly, doctors at least for me only give you a standard template with foods high in purines, It doesn't matter if I tell them I am a teetotaler, so I don't drink beer, or that I only consume seafood at Christmas. They also tell me to lose weight and to not drink protein shakes, and they don't listen when I tell them, when I try very hard to lose weight and suceed then I have a gout flare up thus entering a vicious cycle. And I don't take excessive amounts of protein, I'm just a fat muscular man. Of course they have never heard about HFCS and other fructose issues that trigger gout. They couldn't care less, the one who is left disabled for a week with feet pain that is unbearable is you, not them. So if I have to suffer the consequences of their mistakes, for me then they may be my mistakes or my successes. What worked for me is allopurinol 300 mg three times a day every day, a zero carb/keto diet with no hidden fructose (very carefully reading food labels), then weight training 3 times per week, no fasting as it triggers my gout, and right now I can reduce my allopurinol intake to only 300 mg/day, as my sUA is consistently under 5 mg/dL. You will have to do trial and error, but if you do it right you'll never need to use colchicine again and like myself your feet won't feel like you've walked from the East to the West Coast after a hard day's work. Cheers
Help
So did you follow this doctors advice and get gout.
@@beoz658 As far as I know, Dr Perlmutter doesn't say anything about stopping allopurinol or other lowering uric acid treatments althogether. He talks about the importance of keep a sUA (serum/ blood uric acid level) equal or lower than 5mg dL, whilst the current mainstream medical advice is to keep it just under 7 or 8, which is the point when the crystals begin to accumulate. He also speaks about taking natural supplements like berberine and others, which have a similar effect to allopurinol but are less potent, thus requiring a higher dose to receive the same effect, and having less side effects because they are not drugs. At the end of the day, you are the one who suffers gout and the one who will be miserable and unable to walk and bearing an unbearable pain. So it is your duty to choose who you want to listen and have a critical mind, because most doctors coudn't care less. You could follow their guidelines to the letter of the law, not work, or even be counterproductive. And tell that to the doctor, who will not realize his/her mistake and double down, insisting that your must keep doing it. Take care
@@beoz658 that's what I was wondering too!! Sounds like it.
I wish my grandmother was still Alive, she was the best doctor without ever going to school for it. Her huge garden was amazing and we never got sick. She liked to see 103 yrs old and I should have paid more attention. I’m happy I found this channel.
You make some good points. Around 15 years ago when I got pre diabetes, I started doing some research. I looked at all the health problems that my great grandparents, grandparents, great aunts and uncles, and mother have or had, and they all seemed to start at around middle age. The elevated uric acid, insulin resistance, high BP etc. along with Alzheimer's and Parkinson's in old age. I figured out we have an ATP7B copper binding gene defect. There are over 400 mutations that have been discovered so far, and most of them are only partial gene defects where only part of the 6 binding exons are defective, which causes a gradual buildup over time. I had my free copper tested and it was 4 times normal and my Mother's free copper was even higher since she is 30 years older. I found a study on chickens where they fed half of them copper, and the ones given copper all had higher uric acid. When you mentioned those vegetables high in purines don't elevate uric acid, it makes me wonder if it's not the purines, but copper that is raising the uric acid, since those veggies mentioned are all low in copper? In my mother's case asparagus which as you know is high in purines, will raise her uric acid, and it's also high in copper. Organ meats, lobster, shrimp, and mushrooms are also high in copper and will also cause her gout flares. Back when the genome was mapped and free copper was discovered, 2 scientists tested the blood of people with T2 diabetics, Alzheimer's, Parkinson's, Schizophrenics, and ALS, and found they all had elevated free copper levels. They applied for a usage patent to treat these conditions with ammonium tetrathiomolybdate, but the fda never approved it. Their theory was that the free copper gradually built up over a lifetime, and their brain was protected from Alzheimer's, Parkinson's and ALS, but as they got older their BBB deteriorated and became permeable allowing the toxic free copper to enter their brain. In Schizophrenics they hypothesized that the person was born with a defective BBB and this ATP7B gene defect. It doesn't seem like there is an awareness of this free copper. It was only recently that lab corp in Oklahoma started offering the direct measurement of free copper test, after I requested it. Before that I was doing an indirect measurement of free copper which wasn't as accurate. An interesting thing I found out during my research was that allopurinol also lowers copper. After learning about this, and also reading the study where the chickens fed copper had elevated uric acid, it led me to believe copper is causing elevated uric acid in some people. Then I ran onto another study which showed elevated copper was an activator of the oxidation of xanthine to uric acid. That high fructose corn syrup thing you discovered is definitely another thing causing high uric acid and metabolic syndrome. I never thought of that until seeing your research. Thanks for sharing this great information.
Where could I get that copper test done?
Interesting!!
This is interesting about copper and the genetic defect you mentioned. There is a research scientist/geneticist with CHOP (Children’s Hospital of Philadelphia) that shows the migration of peoples based on mitochondria DNA, since this is a maternal inheritance and can trace all population’s based on this.
Thanks. That is very interesting, Im aware that zinc balances copper, I also read how high copper levels can cause anxiety too
To lower copper that's all you need to do is increase intake of zinc
Your book [ Acid Drop ] rescued me. Everyone should discover it regardless of whether they any maladies or not.
I just finished your book, DROP ACID!
I will encourage everyone I know to read this book!
I will leave it in my kitchen, reading it over and over like my health bible.
I hope everyone buys a copy and shares it with loved ones!
Have a book club party, or offer potluck with friends!
This one is a keeper!
I had to stop all fruit except just 1/2 cup of berries [[ switch it up every day ]] and 1/2 cup of dark or tart cherries daily. Now I love this ambrosia as daily routine and never miss any of the other fruits at all.
It is interesting to reflect that it is often combinations of constituents that make the difference. I was always puzzled why meat was always targeted for uric acid due to purines, when I knew that all living things have DNA. On my low carb journey I've stopped 3 different medications but have not yet grasped the nettle of dropping Allopurinol, but Richard Johnson's work has given me hope that I no longer need this med, because I no longer consume sugar, flour or other concentrated carbs.
I saw no mention of asparagus, which would often set my gout off like crazy. Also my favorite vegetable (frustrating). Since I have cut way down on sugar and done intermittent fasting (lost 25 pounds over about 2 months), I have no issues with gout any longer. If I eat a bunch of stuff now that used to set off my gout, I sometimes get the feeling in my big toe that gout is starting to happen, but it never goes past 'that initial feeling' anymore. That feeling used to be scary...
You have to know that asparagus is loaded with toxin, as you must have noticed how rank your urine smells after eating it.
Well this is just great , and getting stranger all the time.
I’m told sardines and anchovies are good for you because of their omega-3 benefits.
Now they’re rich in purines which will not only give me gout but also Alzheimer’s.
Beautiful, f#@king beautiful.
rda for purines is under 400. one tin of sardines is 385 purines. i was up to 2 or 3 a day. first ever flare and was told im at 11 ua. strict keto lots of fasting etc, ketones in the body compete with u.a in a linear fashion. the more ketones, the more uric acid in the blood.
I feel good eating vegetables along with my low carb meals. When I took them out for 30 days...my body felt awful.
I’m so frustrated!! Trying to eat gluten free, low oxalate, low purine...lower oxalate veggies are higher in purine? Eating carnivore is difficult trying to keep purine levels low...what do we eat? 😢
You need to increase your insulin sensitivity and also your nitric oxide production and consume lots of nitrate rich foods and stop using any kind of mouthwash or fluoride toothpaste or chlorinated tap water.
When I was under dialysis, I had gout in the ankles and knees, one side, for about one month, than it was gone for some time, and than it was the other side :-( with spinach, tomatoes, mushrooms, gerkins, as I didn’t eat much, it was easy to find out, I also found out that I was cow lactose intolerant, by suppressing foods one by one, I found out every food making me sick.
Milk and cheese were the last I suppressed, at the end all I had was pure steak, 1/4 pound or 100gram per day.
That was in 2016, 2 years where needed to find the poisons giving me gout. Since 2018, I’m gout free.
I had a new kidney in 2019, 6 month later, I had worst pain than gout, from lower back to the little toe, I was able to walk a little, I had big pain when seated, driving the car was a nightmare, laying flat was the only solution. Again, I suppressed all food, but it remaind the same. I had all sorts of tests radiography, magnetic resonance, appointments with specialists. The only solution found was to go for a hip replacement, I had that done the other side, when I had my first transplant in 1998.
You can imagine that I didn’t went out much, and one day, I was out of statines, lipitor, but still had enought other medication to not reject my kidney, cellcept, advagraft, medrol, those are mandatory if I want to live.
After a few days, I couldn’t believe it, the pain was less, more time past, little by little I felt better, so I didn’t swallow statins anymore.
I told the doc that I stoped statins, he said I can’t stop, statins can not have that effect, so, I obeyed, 2 days later, the pain was back.
The next month, visit to doc, the pain was not completely gone, again, he tells me I need lipitor. I ask for something else with the same effect, the doc says ok, he prescribe another medication, I forgot the name. 2 days later the pain came back, when reading the notice, I see it’s statins again. Now 2023 I take meds based on walnut leaves wich don’t lower my cholesterol, but statins didn’t either.
I’m almost pain free, my legs are still weak, everyday I fight to get better.
What can we do? Hope, resist, fight
About lactose intolerance.
The smallest quantity of anything containing cow milk begun to make me sick when I did dialysis, my digestion stoped, a few minutes after exposition, I had heart burns, and nothing else would go passed my stomach, all food stayed there rotting.
I didn’t know it was because of lactose, I tought it was because of dialysis, I had to puke to feel better, sometimes 3 x a day, sometimes, no problem. 🤔
My teeth where melting with the vomit. 🤢 it’s disgusting, sorry.
Since I learned lactase exist, but if my body doesn’t want cow lactose, I prefer not to have it, but sometimes there is some lactose contamination on the food, I take some lactase, and I’m fine.
I insisted on cow lactose, because, goat or sheep lactose doesn’t cause me any trouble.
All that to say everyone is different, the doctors can guide, but you must find what is best for yourself.
It’s not easy, for example, I’m sure one of my anti reject medication is giving me high cholesterol, but I can’t stop to take it, or my body will reject the kidney, and dialysis is very bad, barely enough to stay alive.
If you know someone needing dialysis, go help, it’s hard. Even if it’s not visible from the outside everything is hard for those patients, even transplanted it’s still hard.
Lactose in cows, sheep and goats is all the same stuff. Where these milks differ is in the protein profile. I wonder if what you take to be lactose intolerance might be a protein intolerance. Many people find it hard to digest bovine Casein, and can often mistake negative symptoms for a lactose intolererance.
I recently ordered this book from Amazon.
Great update! Are there any similar studies recently, where organ meat is looked at? Thanks Dr P!
Thank you for clearing up confusion. We need good information not bad.
According to Dr. Royal Lee, foods high in potassium are protective against gout, such as raw leafy vegetables, raw vegetables, juices, potatoes and beans. And Quercetin is good for gout, and is found in Elderflower, green tea, red grapes, onions, yogurt, lima beans, mushrooms (all very high in potassium), kale, avocado, salmon, bananas, cantaloupe, tomatoes and sweet potatoes.
Thank you very much, Doctor
Given what we now know about fructose and the Uric acid metabolic switch, is the purine hypothesis still viable?
I'm taking all the supplements recommended in your book and following all the eating advice in your book. How long should it take to lower UA to, say, 6, if I started at 8? Roughly. I'd like to see a video showing average results of this protocol you are recommending.
David Perlmutter used exactly the right term: associated. Maybe he should have remind us what does "associated" really means.
So high in purines vegetables consumption is associated with lower levels of uric acid in blood. Fine.
But from this study we can't say if these vegetables tend to reduce uric acid levels when they are regularly eaten. That's just an hypothesis we need to verify with an interventional study.
We can't say either if having low levels of acid uric in our blood makes us eat more broccoli. Looks ridiculous? No, it is an hypothesis as valid and as uncertain as the first alternative considering only the results of the study.
Observational studies in nutrition can't prove much especially when they are based on such unreliable data than those coming from food frequency questionnaires.
They can only show associations. They can't show cause and effect relationships nor a way to relationships.
What's sure is that, generally, people eating a lot of vegetables (rich or not in purines) tend to drink less alcohol and less sugary drinks. They also tend to eat less sugary foods.
So it is quite possible that the reduced levels of uric acid for people eating vegetables should be more the consequence of lesser sugar/fructose intakes rather than the result of the activity of some polyphenol present in these vegetables.
Your video is very meaningful. I really like this your video.
Is there a cook book that we can purchase?….
Cauliflower has high purine, but broccoli is okay. Their must be something about the green color of broccoli that is better than broccoli.
Please can you confirm the best fruits, vegetables and supplemnts. I'm at Eurovision Malmo right now and I am in agony because of gout affecting mainly my knees. Any low side effect medication ? Travelling with gout is very hard.
Would xanthine oxidase inhibitors cause higher or lower ammonia levels in the blood? I tried to figure it out but I can't! You likely know the answer being a neurologist. Please help!!
I stopped eating cauliflower, broccoli, asparagus, pumpkin, eggplant, mushrooms, 😢 also chick pea, all theother legumes, red meats even honey, only 2 cups of tea with 2 tsp honey. Coconut water, prawns, crab, squid etc.
What must we eat maybe the air
Fellow
Registered
Medical professor
Broccoli
AU
Olá Dr! Seu livro já está disponível no Brasil?
Thank you.
Good info. Thanks!
High fiber in vegetable and fruit acts like swipper in your body removing all waste in your body
Is that the just of the book???
Okay, how come those who dwell in the Arctic like Eskimos, that ate only fish and meat did not get gout?
My mum gets gout when she eats too many strawberries.
It's the sugar.
I must be the odd person out. If I eat any high purine vegetables I have a gout attack within hours. Asparagus, mushrooms and cauliflower affect me the worst, cruciferous vegetables make me feel achy. I love those vegetables but they don't love me. I have been eating low carb for a few years so no fructose in my diet, I don't drink, I don't eat a lot of red meat or organ meats, it is the vegetables that cause my pain.
are you low carb or keto? Just learned the deeper you are into ketosis, the higher the u.a level in the blood. 1600 person study, 95 percent confidence interval.. I stopped keto because i just learned my ua is at an 11. ketones compete with ua during excretion. Looking at this study, i should be able to drop it by 3 points by eating some carbs and not fasting so much..
great news.
This is ridiculous! What are you supposed to eat? No dairy, no meat, no sugar, no carbs, no gluten, no soy. Good grief now vegetables?
Research is the Key
This is science, if you want to complain and contribute no value go to the therapist for that. You are ridiculous
Who said no meat ? Been on carnivore 💯 for two months. Just red meat. My uric acid has gone down since. I have no inflammation and I've lost 10 kilos. Don't follow this guy. There are other Dr's who are practising carnivore like Dr Ken Berry. Dr Anthony Chafee who is also a neurologist. Dr Westman. Dr Eric Berg
Did you watch the video? Sounds like you didn’t..
The air we breathe is pretty cr*p too. Don't start on the water subject.
Vegetables have fibre.
Same reason fruit consumption is safe.
So you are saying that purines in meat products can be dangerous, but vegetable purine are good?
This is a very interesting paradox at best.
That's what we get with epidemiological studies and correlations, interesting paradoxes at best... like the so-called French paradox.
French consumed a lot saturated fat but didn't die from heart disease as much as "predicted" by Ancel Keys' seven countries study: rather than considering that France is a country large enough to invalidate the results of the study, let's call that a paradox and try to explain it with red wine (as alcohol is not healthy we will have an even greater paradox).
We better not pay too much attention to epidemiological studies in nutrition.
They are based on unreliable data, often contradictory and very often biased like the seven countries study: at the time of the study data were available for 22 countries including France but only seven countries that were confirming the diet-heart hypothesis were cherry-picked. When you consider the 22 countries there is simply no relation between saturated fat and heart disease. There is no French paradox either.
actually purines are composed of 4 different types of amino acids They all produce different levels of uric acid. one of the purine tables in a study has it all broken down, it was a japanese study,, 1 of the 4 is the worst by a large margin but i dont recall its name, the rest are comparatively benign.. google japanese purine table or something similar
9
Hmmmmmm. I limit my carbs to 25 grams per day. I eat fish twice a week. Some meat. Well?. High uric acid. No gout puzzled. Please help? P.s eat alllll above veggies
I had to stop all fruit except just 1/2 cup of berries [[ switch it up every day ]] and 1/2 cup of dark or tart cherries daily. Now I love this ambrosia as daily routine and never miss the other fruits at all.
Maybe you are just genetically inclined and may need Querticin and or Febuxostat 80mgs..I suffer it too, am 65 yrs am Diabetic T2 and Gluten issues.. Gut inflammation Diverticulitis.
Hi , same boat here for a few months, strict keto, lots of fasting Im at an 11 u.A.. I just learned that ketones compete with uric acid for excretion in a linear fashion. more ketones, more uric acid in blood, less ketones less uric acid in the blood. It was a 1600 person study with a 95 % confidence rate. If I go off what I learned, I can deop it 3 points by limiting ketosis and fasting I hoe..
Everything in moderation
So the standard American diet then😂
Oh, then arsenic is ok "in moderation"?
🐗
Thank you.