Ensuring the truthfulness of primary research: overcoming challenges

This plenary was presented by Isabelle Boutron, Professor of Epidemiology at the Université Paris Cité and head of the Methods Research Team (INSERM- Centre of Epidemiology and Statistics-CRESS), at the Global Evidence Summit 2024.
Evidence synthesis can adequately inform guideline developers and public health decisions only if the results of primary research are trustworthy. The current scientific ecosystem mainly relies on the peer-review process to determine whether the results of clinical research deserve publication. This talk will highlight the limitations of the peer-review process, along with the new challenges arising from preprints and the development of generative AI, which is transforming research practices. We will discuss possible solutions, such as new automated tools to track untrustworthy research, and the potential role of evidence synthesis in improving the overall system.
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