The BEST Synergies!? the binding of isaac

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  • Опубликовано: 20 сен 2024
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    The BEST Synergies!? the binding of isaac
    Mods: (f word) you donation machine jams,Visible lost health,Cat Coin | Reskin for coins,Labels for coop,Pov: 50 Thousand Dollars,Tainted lost's existential dread,Chaos but it's a bit sussy,Blindfold item,Character Personalities!,Da Rules,Whats My DPS?,Too Many D6s! [REP],Vine Boom Bombs II,Vine boom over bad pill,Angel Resprite (MgTexture),Pou Cube Baby,Whatsapp black powder,Shut Up Mom and Dad,Better Coop Item Pedestals,Regret Pedestals,Antibirth Music+++,Boss Rush Wave Counter [Rep | AB+],Planetarium Chance,Visible Challenge Unlocks,[Rep] Enemy Bullet Trails,ReactionAPI,Reaction Port Pack,Mod Config Menu Pure,!!(REP)Music Mod Callback,[Rep] Enhanced Boss Bars,No mom's bra & pad active image,TimeMachine[Repentance],[AB+|Rep] External Item Descriptions,Mod Config Menu - Continued [Discontinued],Garry's Mod Death Animation,Better Milk,Better Explosions,Better minimap,Animated Items,Swaggy Mushrooms.
    #bindingofisaac #thebindingofisaac #tboi #isaac #bindingofisaacrebirth #twitch #gaming #bindingofisaacafterbirth #indiegame #twitchstreamer #games #thebindingofisaacafterbirth #thebindingofisaacrepentance #traditionalart #roguelike

Комментарии • 225

  • @Concentrated_Insomnia
    @Concentrated_Insomnia 4 месяца назад +1900

    Tainted Cain and glitched crown !!!🗣🗣🗣🗣

    • @DANIK-CORPORATION
      @DANIK-CORPORATION 4 месяца назад +42

      Tained cain REALY tained

    • @Angelpower07
      @Angelpower07 4 месяца назад +14

      Actually that could be good

    • @coltenfalzarano3433
      @coltenfalzarano3433 4 месяца назад +41

      @@Angelpower07why would that be good💀

    • @Angelpower07
      @Angelpower07 4 месяца назад

      @@coltenfalzarano3433 more items means more quality 3s and 4s. Meaning more pick ups to craft, plus potential to get a quality 4 special room item that will give massive craft potential.

    • @dany-chips
      @dany-chips 4 месяца назад +61

      ​@@Angelpower07BRO IS ONTO NOTHING 🔥🔥🔥🔥🔥

  • @elpooper8296
    @elpooper8296 4 месяца назад +991

    Ipecac and My Reflection is a great sinergy too...

    • @amistake9264
      @amistake9264 4 месяца назад +24

      I personally prefer my Ipecac with Trisagion

    • @elpooper8296
      @elpooper8296 4 месяца назад +7

      @@amistake9264 Nah, that sinergy is pretty bad since the patch that solved the self dmg bug

    • @EithanPereira-bb9cw
      @EithanPereira-bb9cw 4 месяца назад +1

      it is big dmg tho

    • @amistake9264
      @amistake9264 4 месяца назад

      @@elpooper8296 damn :(

    • @elpooper8296
      @elpooper8296 4 месяца назад +1

      @@EithanPereira-bb9cw but its boring without the non-dogeable self dmg

  • @0_SLAPS
    @0_SLAPS 4 месяца назад +878

    Plan c + panic button to the victory 🗣🔥🔥🔥

    • @phantaplasm6052
      @phantaplasm6052 4 месяца назад +58

      If I die, I'm taking you with me

    • @throg4657
      @throg4657 4 месяца назад +81

      Isaac kills himself at the slightest inconvenience

    • @Andrew9908
      @Andrew9908 4 месяца назад

      @@throg4657with this sacred button I summon

    • @0_SLAPS
      @0_SLAPS 4 месяца назад +25

      No skill issus allowed 💯

    • @neo-tap676
      @neo-tap676 4 месяца назад +9

      Basically t. Lost

  • @yukiwinters2885
    @yukiwinters2885 4 месяца назад +261

    Second one is actually crazy on the lost

    • @lumiurin2016
      @lumiurin2016 4 месяца назад +16

      Until it teleports you to the cursed room lol

    • @schizopenguin
      @schizopenguin 4 месяца назад +42

      ​@@lumiurin2016thats skill issue if you take damage in it

    • @JoMasterPlayer
      @JoMasterPlayer 4 месяца назад +5

      *Holy Mantle*

    • @chevyrodriguez4028
      @chevyrodriguez4028 4 месяца назад

      Well no you still need to take damage, which for The Lost means death

    • @a4th0r34
      @a4th0r34 4 месяца назад +14

      ​@@chevyrodriguez4028Not exactly, panic button activates when you're close to take damage. That's why taking it with book of shadows or dull razor essentially means that you'll be nearly invulnerable

  • @kristophergiovannyvilcheza5678
    @kristophergiovannyvilcheza5678 4 месяца назад +92

    the lost+cursed tower 🗣🗣🔥🗣🔥🗣

    • @maximcostiuc9740
      @maximcostiuc9740 3 месяца назад +5

      Wouldn’t do anything because of mantle

    • @Original_Flesh_Panopticon
      @Original_Flesh_Panopticon 3 месяца назад

      ​@@maximcostiuc9740that's why its a good synergy, the only character you can pick this item up no matter what

    • @destroything
      @destroything 2 месяца назад

      ​@@maximcostiuc9740(That's the point)

  • @dorito3347
    @dorito3347 4 месяца назад +96

    i once had dr. fetus with evil eye and Cain's other eye. dodging this was the funniest shit ever

    • @schizopenguin
      @schizopenguin 4 месяца назад +3

      never take epic fetus with cain other eye and lokis horns

    • @gionino459
      @gionino459 4 месяца назад +3

      @@schizopenguin I once got dr fetus with loki's horns and tractor beam worst mistake of my life

    • @gaster5569
      @gaster5569 2 месяца назад +1

      ​@@schizopenguinwhat Cain other eye does? Doesn't it just shoot normal tears?

    • @Lutwickballs
      @Lutwickballs 2 месяца назад

      Basically incubus but shots random directions

  • @ianpresa2785
    @ianpresa2785 4 месяца назад +11

    that teleport with panic button and then fricking exploding killed me fr

  • @Taynolyon
    @Taynolyon 4 месяца назад +20

    Wh..Wh..What about ipecac,continuim and my reflection....bros finna have flashbacks from the past

  • @UnluckyCharacter821
    @UnluckyCharacter821 4 месяца назад +5

    I love how popular Isaac is becoming all of a sudden!

  • @bigf9604
    @bigf9604 3 месяца назад +10

    Stand proud. You cooked.

  • @chonkimus2325
    @chonkimus2325 3 месяца назад +3

    The fact that you can predict some of the stuff matpat will comment on right before he does shows that you’ve really dedicated time into listening to reactions and feedback from players and streamers

  • @jacktheproslegend
    @jacktheproslegend 3 месяца назад +1

    Got tiny planet and dr fetus once on a run when I gladly had pyromaniac, was a walking unstoppable bomb

  • @КРЫСА_В_КАНИСТРЕ
    @КРЫСА_В_КАНИСТРЕ 4 месяца назад +7

    Even worse cursed eye. TAKE MY MONEY!

    • @xendra1724
      @xendra1724 4 месяца назад +1

      Ipecac+tech+mom knife

    • @EithanPereira-bb9cw
      @EithanPereira-bb9cw 4 месяца назад +1

      cursed eye is tier 2 change my mind (you cant and if you dont like cursed eye its probably because of the teleport which happens WHEN U GET HIT so skill issue)

    • @Anaklusmos42
      @Anaklusmos42 4 месяца назад

      ​@@EithanPereira-bb9cwcursed eye on the lost is actually good

    • @gentozik
      @gentozik 3 месяца назад

      ​@Anaklusmos42 bc you won't even feel a drawback

  • @ninjatubes9219
    @ninjatubes9219 3 месяца назад

    This song fits anything so perfectly

  • @sharinn__
    @sharinn__ 4 месяца назад +6

    dr fetus + my reflection is crazy frfr

  • @AtomicGolem
    @AtomicGolem 3 месяца назад

    1: *kocchi wo miro*
    2: Nigurendayo, Smokey!
    3: Bites Za Dusto!

  • @normalaveragename
    @normalaveragename 3 месяца назад +1

    gulped panic button + inf r key☠️
    Ipecac + my reflection ☠️
    Ipecac + trisagion ☠️
    Number one + eraser ☠️
    T lost + blood oath ☠️

  • @rubenvanderark4960
    @rubenvanderark4960 3 месяца назад +2

    Remember when trisagion ipecac would be unavoidable damage?

    • @gentozik
      @gentozik 3 месяца назад

      It was a S Tier synergy

  • @ogl273
    @ogl273 3 месяца назад +6

    edmund you little...

  • @nyororomeowelas1225
    @nyororomeowelas1225 4 месяца назад

    highkey range downs and Number One are nice on most Ipecac runs, having too much range sucks.

  • @enderslime2090
    @enderslime2090 3 месяца назад

    The explosion always gets me, all the body parts goes everywhere

  • @Плачущий_5-летний_мальчик

    Alt Lilith+epic fetus 💀💀💀

  • @daniexgamer5865
    @daniexgamer5865 4 месяца назад +12

    3 best synergies if you want to quit the game 😀👍

  • @Your_favorite_Scotsman
    @Your_favorite_Scotsman 4 месяца назад +2

    I was actually able to use the tiny planet and Dr. Fetus synergy as soon as I got ipecac and soy milk

  • @bcefkm
    @bcefkm 3 месяца назад

    Almond milk + torn card is the ultimate suicide synergy.

  • @foot2273
    @foot2273 3 месяца назад

    Gonna use the first one in my no damage run! Wish me luck guys!

  • @richardsonelite1744
    @richardsonelite1744 4 месяца назад

    Actually the first one is good because after one range up, ipecac starts to go crazy with the tear height. For thr same reason i like number one with haemolacria. Ipecac with my reflection is worse

  • @egorpolyaev7511
    @egorpolyaev7511 3 месяца назад

    Teleport + panic button is cool i did ot and found all secret rooms on the floor

  • @DustedDustSans
    @DustedDustSans 3 месяца назад

    tiny planet + dr fetus seems like some sort of challenge run bro 😭

  • @nightgammer8139
    @nightgammer8139 4 месяца назад

    I’ve actually ended up with Dr. fetus tiny planet before. that run went

  • @OllieGrigg
    @OllieGrigg 3 месяца назад

    Brimstone, rubber cement and Ipecac is a run ended also

  • @pi_xi
    @pi_xi 4 месяца назад

    Tiny Planet + Dr. Fetus sounds like an interesting challenge run.

  • @bennie.379
    @bennie.379 3 месяца назад

    Panic Button and Book of Shadows is cracked

  • @gamer-bp6ig
    @gamer-bp6ig 2 месяца назад

    honestly the last one is sick

  • @dakakey2381
    @dakakey2381 3 месяца назад

    Little planet + dr. Fetus BEST SYNERGI EVER

  • @aidandavidson1026
    @aidandavidson1026 3 месяца назад +1

    Panic button + stitches = win

  • @bahencio
    @bahencio 3 месяца назад

    We getting out of basement with these ones 🔥🔥

  • @jolopopo6442
    @jolopopo6442 3 месяца назад

    the item that makes explosion fill your health and dr fetus

  • @Dyvenr
    @Dyvenr 3 месяца назад

    Last one would be a cool challenge

  • @lipino7777
    @lipino7777 4 месяца назад

    stitches and panic button = budget timed holy mantle

    • @pi_xi
      @pi_xi 4 месяца назад

      How to Jump + Panic Button actually works well. Dull Razor is also a good choice.

    • @lipino7777
      @lipino7777 4 месяца назад

      @@pi_xi wait wouldn't How to Jump just make you invincible? lemme test it out and I'll be right back

    • @pi_xi
      @pi_xi 4 месяца назад

      @@lipino7777 As log you move, How to jump makes you invisible from most projectiles, but not from all kinds of damage.

  • @Kasane_teto_quimera
    @Kasane_teto_quimera 4 месяца назад +8

    Bro the sync

  • @axondeaxol399
    @axondeaxol399 4 месяца назад

    lemme 1-up you
    Mom's bracelet, mom's purse, broken remote and panic button

    • @KayhosYT
      @KayhosYT  4 месяца назад

      Huh

    • @gentozik
      @gentozik 3 месяца назад

      Bracelet can be fun to actually dodge or even kill the enemy, but it's not the "best" synergy

  • @chickenbrother5515
    @chickenbrother5515 4 месяца назад +1

    The thing that i dont like about, is the fact that its reminding me how dumb i was to get that stupid moon thing.

  • @Knight_221
    @Knight_221 3 месяца назад +2

    The second one make me laugh 🤣

  • @Yrewir
    @Yrewir 4 месяца назад

    Tainted Eve + Ludovico Technique 🗣️

    • @greatorb61
      @greatorb61 4 месяца назад

      just use an active

  • @ThatPenguin
    @ThatPenguin 4 месяца назад

    Alt + f4 and grass + fresh air are underrated

  • @Pabkolingu
    @Pabkolingu 3 месяца назад

    Book of jump + ipecac + number one = ballin

  • @tres6674
    @tres6674 4 месяца назад

    Cain's other eye and Dr fetus is also a good one

  • @sumboi3964
    @sumboi3964 4 месяца назад

    i once got 8 inch nails, hemolacria, cricket's head, dr fetus AND MY REFLECTION RAAHHH

  • @dr.doofenshmirtz6922
    @dr.doofenshmirtz6922 4 месяца назад

    teleport and panic button = cursed eye but worse ( somehow )

  • @우견우-v2x
    @우견우-v2x 3 месяца назад

    We have cursed eye at home
    Cursed eye at home:

  • @Chicken_nugget_fan
    @Chicken_nugget_fan 4 месяца назад

    Ngl panic button and how to jump is still the best option

  • @vandakarabeyan899
    @vandakarabeyan899 4 месяца назад

    What about eyesore,ipecac,crickets body,parasite,soy milk,and moms eye with like 7 luck. Thats seems pretty bad to me if you dont get explosion immunity

  • @janzacharski2485
    @janzacharski2485 4 месяца назад

    I know it is supposed be a meme but just slap pyromaniac (I think it is the pyromaniac, but if not, I mean the item that makes explosions heal you) on those synergies with wacky explosions and become MR.TORGUE

  • @OZZY9669
    @OZZY9669 4 месяца назад

    Awesome showcase

  • @Mal05407
    @Mal05407 4 месяца назад

    Ipecac + Almond Milk is a top tier synergy

  • @bukisantv1392
    @bukisantv1392 4 месяца назад

    panic button + how to jump = ultrainstinct
    panic button + d6 + some way of self harm = infinite reroll

    • @pi_xi
      @pi_xi 4 месяца назад

      Panic Button gives Butter Bean, Dull Razor and How To Jump to the strength of Tier 4 items.

  • @gigio667
    @gigio667 4 месяца назад

    The panic button absolutely broke me

  • @ArtVorobyov
    @ArtVorobyov 2 месяца назад

    Panic button+ teleport is good for tainted lost😅

  • @RuenAllis
    @RuenAllis 2 месяца назад

    Add pyromaniac to the first combo and you actually have a great build

  • @azhaline565
    @azhaline565 3 месяца назад

    Best synergy was trysigon and ipecac when rep first came out. Just insta damage if you didnt have pyro or hosthat

  • @Mrhuevo1960
    @Mrhuevo1960 2 месяца назад

    The second its playing the lost without the mantle

  • @nicolthebunny8869
    @nicolthebunny8869 4 месяца назад

    I hate when I have an object that touches me and it teleports me away, what a rant. 😂

  • @Wooddchips
    @Wooddchips 4 месяца назад +1

    Dude forgot about soy milk Dr fetus

  • @vegavargasjosealfonso2135
    @vegavargasjosealfonso2135 4 месяца назад +1

    Best video ever

  • @NotRealFM
    @NotRealFM 3 месяца назад

    We need more dunks with ipecac

  • @Notamushroom-f6i
    @Notamushroom-f6i 4 месяца назад

    Okay hear me out tiny planet + dr fetus + sticky bombs

  • @pepo_sad
    @pepo_sad 4 месяца назад

    Panic button + teleport = cursed eye

  • @Burrito_Express
    @Burrito_Express 4 месяца назад

    Lacrophygy and pop!
    Mainly because it'll just crash your game

    • @KayhosYT
      @KayhosYT  4 месяца назад

      I got nasa pc💪

  • @darklogh9715
    @darklogh9715 4 месяца назад

    Monstro's lung + eye of the occult 🔥🔥🔥🔥

  • @valemontesinos5598
    @valemontesinos5598 4 месяца назад +1

    0:10 Cursed Eye made in home xd.

  • @samdrop9223
    @samdrop9223 4 месяца назад

    For the second one you just made a worse cursed eye

  • @yeahyeah5338
    @yeahyeah5338 4 месяца назад

    Blank card + suicide king + panic button

  • @BigSmoke-dp4yh
    @BigSmoke-dp4yh 4 месяца назад

    i'd take ipecac with low range rather than ipecac with regular range everyday

  • @TJBOO3
    @TJBOO3 4 месяца назад

    All of these are so good

  • @user-to7re2ek1x
    @user-to7re2ek1x 3 месяца назад

    Bro made dollar store cursed eye 😭

  • @Просто_Иван
    @Просто_Иван 4 месяца назад

    So sad that trisagion+ipecac was nerfed so much

  • @swishyb
    @swishyb 4 месяца назад

    we making it outta the basement with this one 🙏

  • @NinyaBOT
    @NinyaBOT 3 месяца назад

    the first one with pyro wouldnt be so bad actually

  • @Максим-н2ю2ц
    @Максим-н2ю2ц 3 месяца назад

    I think ipecac + soy milk + mutant spider is really good

  • @tarsis5933
    @tarsis5933 Месяц назад

    How are Ipecac and Pyromaniac not here.
    Oh. Right.

  • @JojoJojo-tv7ke
    @JojoJojo-tv7ke 3 месяца назад

    Towers+ piece of glass ( im forget how this called)

  • @julianking4618
    @julianking4618 4 месяца назад

    Is at that basically just cursed eye

  • @archweeb2213
    @archweeb2213 3 месяца назад

    Tiny planet dr fetus and soy milk go hard

  • @fendycat
    @fendycat 4 месяца назад

    soymilk and Ludovico Technique

  • @GrilledCheesumidk
    @GrilledCheesumidk 4 месяца назад

    I hereby dub the third synergy "Proton Star"

  • @ubeydekaabsivren4750
    @ubeydekaabsivren4750 4 месяца назад

    We all love these..

  • @zZBaruProZz
    @zZBaruProZz 4 месяца назад

    azazel + eye of the occult🗿🗿🗿

  • @СтреОК
    @СтреОК 4 месяца назад

    Ipecac + mirror + soy milk 💀

  • @TheCuteKyuubi
    @TheCuteKyuubi 4 месяца назад +1

    Ipecac and Almond milk 🗣️

  • @influx5821
    @influx5821 4 месяца назад

    Cursed eye+brimstone🔥🔥🔥

  • @homedepotfetus
    @homedepotfetus 4 месяца назад

    Screw ipecac + Cain's other eye.

  • @TreesLayEggs
    @TreesLayEggs 4 месяца назад

    I just had an ipecac broken mirror run, i lost with 9 lives 😭, forgot its called my reflection

    • @EithanPereira-bb9cw
      @EithanPereira-bb9cw 4 месяца назад

      skill issue

    • @schizopenguin
      @schizopenguin 4 месяца назад

      i lost with 18 lives from isaacs heart as the lost (those god damn stalactites were impossible to dodge)

    • @TreesLayEggs
      @TreesLayEggs 4 месяца назад

      @@EithanPereira-bb9cw yes, it was blind too😭😭 i would not have picked up ipecac

  • @gerardomartinez7972
    @gerardomartinez7972 3 месяца назад +5

    Ipecac , my reflexion better

  • @CospOsnofla
    @CospOsnofla 3 месяца назад

    Money=power + golden razor

  • @Mc_Navia05
    @Mc_Navia05 4 месяца назад

    the last one- do u like osu👌?
    (i was not olayed osu alot)

  • @nevermind_182
    @nevermind_182 4 месяца назад

    And don't forget the "orange yellow duct tape" that makes Isaac p!ss himself every 20 seconds

  • @bureet0
    @bureet0 4 месяца назад

    3rd actually seems fun

  • @aidenblaze075
    @aidenblaze075 3 месяца назад

    Ally oop ahh synergy💀

  • @Mr.Gorsky
    @Mr.Gorsky 3 месяца назад

    R key + panic button