Actophotometer | Evaluation of Antianxiety and Antidepressant Drug | Actophotometer Parts & Function

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Behavioral models are basically divided into two types- (1) Exteroceptive means those originating outside the body and (2) Interoceptive which originating within the body, they also known as an Unconditional model and Conditional model respectively.
(1) Exteroceptive or Unconditional or Ethological Model-
All the models come in this category exist the same principle that subjects are exposed to aversive stimuli which result in readily observed changes in the behavior of the subject. This anxious behavior can be restored by the administration of anti-anxiety drugs. In this procedure, no training is required and the collection of data is rapid. When the subject is placed in an uncomfortable situation its learning capability is suppressed and this is a central feature of human anxiety
(2) Interoceptive or Conditional Models-
In the model several stimuli in the body are used to generate the anxiety different example are available to justify this principle like an application of electrical stimulation at any point of a brain, administration o anxiogenic drugs are used to create anxiety. Interoceptive models are much important in use because they are analogs to human anxiety as it is generated inside the body. For assessment of the anti-anxiety activity of any drugs in the human body, we must use this model than the unconditional model. In human anxiety is produced by using anxiogenic drugs like amphetamine, cocaine, bemegride, pentylenetetrazole, strychnine, caffeine, benzodiazepine binding site antagonist can be used for this purpose.
It is a clear indication that the drugs, which affect the locomotor activity of the experimental animal, will surely affect its anxiety level and the same instrument can be used for validation purposes. Actophotometer is used for the measurement of locomotor activity. It is a box of square size equipped with photoelectric cells, which are connected in circuits with a counter, Its number may be different in a different instrument. Photoelectric cells are arranged in one side of the box and on the opposite side of cell same number of a light source is also installed. When the beam of the light source is allowed to travel through the box it reaches the photoelectric cell and thus circuit becomes complete and the counter doesn’t count the reading, but when there is any interruption in light beam and light will not fall on the photoelectric cell there will be interrupted circuit and counter will count the reading. Different antianxiety drugs like diazepam, clonazepam, and alprazolam are effectively evaluated by this instrument.
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your efforts are very beneficial to us!!!
THANK YOU SIR....

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