Nice presentation, I have question about the degradation of glycogen using phosphoric acid. could you please explain if phosphoric acid can degrade glycogen.
It would be nice to explain the consequences of the processes. Like glycogen sythesis is important because... Its role is... In healthy individuals it is... in diabetic/obese/pre-diabetic individuals...
PKA and GSK work in tandem to down-regulate glycogenesis. cAMP (so intense energy usage) temporarily downregulates glycogen synthase by phosphorylating it via PKA into the inactive form. cAMP and large uses of ATP (so exercise) also tend to increase GSK3. In essence, both of these enzymes work together and are released from similar processes/environments: neither "deactivates" the other, both are involved in phosphorylating active glycogen synthase, and both appear to be released from similar processes (i.e increases in cAMP, increases in epinephrine, and massive ATP/ADP usage, of which, in this case, we would connect to increases in cAMP [weightlifting exercise/intense, laborious work/running]). However, during breaks in exercise or intense energy usage (even short ones), the inactive glycogen synthase is then dephosphorylated from the presence of large amounts of glucose that are in the cells/blood (assuming a carbohydrate rich meal was consumed before exercise). This process is a feedback loop that keeps the glycogen topped off from blood sugar/circulating glucose during exercise, and therefor, this stresses the importance of having some type of glucose pre-workout for most individuals, and also shows the elegant system and feedback loop of glycogen synthase in our bodies for keeping our muscles topped off, either from dietary carbs, or from glucagon released by the liver in response to low blood sugar. Another thing that is important to note is that the amount blood plasma glucose contributes to intense exercise increases in proportion as an energy substrate as glycogen is depleted - so even if glycogen is low or intense exercise tends to inhibit glycogen reuptake, it is still stresses the vital importance of having carbs preworkout/pre-work, especially if a person is lean and/or not sedentary: to provide a blood-based, non-liver generated energy source, to provide circulating carbohydrate substrates that can be stored as glycogen during breaks in intense labor/lifting, and to make sure muscle is spared from being used in gluconeogenesis because of the presence of bioavailable carbohydrate-based energy from blood glucose when glycogen is temporarily depleted.
Insulin suppresses GSK3, laborious activity increases both PKA and GSK3 through increases of cAMP via mass usage of ATP, but the presence of insulin decreases both enzymes... so during work-out/working, it is a feedback loop of downregulating glycogen synthase, with the presence of carbs/insulin upregulating active glycogen synthase/dephosphorylating the inactive form of phosphorylated glycogen synthase B.
i'm doing a presentation on gsk beta 3 and this saved me hours of work. perfectly explained thank you!
You break these topics down so nicely, a huge thank you is mandatory!!
Perfect, thank you very much. Your show must go on!!!
thank you for the wonderful and simple explanation!
You save me every semester 💚😇
lots of thanks from the technical university of munich department of biochemistry.
this is worthy of commendation.....thumbs up
Love ur explanation 💜
Nice presentation, I have question about the degradation of glycogen using phosphoric acid. could you please explain if phosphoric acid can degrade glycogen.
god bless you ... im glad to you
Well explained 👌
It would be nice to explain the consequences of the processes. Like glycogen sythesis is important because... Its role is... In healthy individuals it is... in diabetic/obese/pre-diabetic individuals...
Lots of information about that on my website ;)
Superb. Keep it up.
very good information
thank you
we havent R state or T state for this enzyme?
White board or chalkboard can never be replaced with a PowerPoint. Plain fact.
Are the PKA and GSK related??
If I say PKA will deactivate the GSK, is this right?
PKA and GSK work in tandem to down-regulate glycogenesis. cAMP (so intense energy usage) temporarily downregulates glycogen synthase by phosphorylating it via PKA into the inactive form. cAMP and large uses of ATP (so exercise) also tend to increase GSK3. In essence, both of these enzymes work together and are released from similar processes/environments: neither "deactivates" the other, both are involved in phosphorylating active glycogen synthase, and both appear to be released from similar processes (i.e increases in cAMP, increases in epinephrine, and massive ATP/ADP usage, of which, in this case, we would connect to increases in cAMP [weightlifting exercise/intense, laborious work/running]). However, during breaks in exercise or intense energy usage (even short ones), the inactive glycogen synthase is then dephosphorylated from the presence of large amounts of glucose that are in the cells/blood (assuming a carbohydrate rich meal was consumed before exercise).
This process is a feedback loop that keeps the glycogen topped off from blood sugar/circulating glucose during exercise, and therefor, this stresses the importance of having some type of glucose pre-workout for most individuals, and also shows the elegant system and feedback loop of glycogen synthase in our bodies for keeping our muscles topped off, either from dietary carbs, or from glucagon released by the liver in response to low blood sugar.
Another thing that is important to note is that the amount blood plasma glucose contributes to intense exercise increases in proportion as an energy substrate as glycogen is depleted - so even if glycogen is low or intense exercise tends to inhibit glycogen reuptake, it is still stresses the vital importance of having carbs preworkout/pre-work, especially if a person is lean and/or not sedentary: to provide a blood-based, non-liver generated energy source, to provide circulating carbohydrate substrates that can be stored as glycogen during breaks in intense labor/lifting, and to make sure muscle is spared from being used in gluconeogenesis because of the presence of bioavailable carbohydrate-based energy from blood glucose when glycogen is temporarily depleted.
thank you so much
What about insulin? How does it affect GSK3?
Insulin suppresses GSK3, laborious activity increases both PKA and GSK3 through increases of cAMP via mass usage of ATP, but the presence of insulin decreases both enzymes... so during work-out/working, it is a feedback loop of downregulating glycogen synthase, with the presence of carbs/insulin upregulating active glycogen synthase/dephosphorylating the inactive form of phosphorylated glycogen synthase B.
Thanks so much
actually
please turkish subtitles