Extremely informative along with excellent and interesting introduction for the BCS ! Frankly , In Egypt , I'm suffering as a PharmD student with the outdated curriculum which doesn't give a SINGLE OUNCE OF INFORMATION ABOUT THE BCS ! Hope you upload more and more of biopharmaceutical content to keep up with up-to-date scientific data.
10:46 it was discussed about bcs c3. It was said that it is difficult to develop such a drug and needs to be a potent one....... But in the 2nd part of pre formulations video the graph depicts highest sales of class 3 drugs does that mean most of them are potent?
That is a good point! The BCS is only a rough guide to developability, but you are right of course - as drugs are being increasing designed on a computer to ensure very strong interaction to a biological target they are becoming very potent. Hence, if they have poor solubility/permeability (or both!) they can still be effective in the body.
In BCS system, Is there magic number for solubility? such as 2 mg/ml. >2 mg/ml is good solubility for oral drug. < 2 mg /ml is low solubility for oral drug. Thanks
Thanks for your kind comments and the Q :) It used to be the case that the magic number for solubility (for an orally delivered drug) was 10 mg/mL, but this of course heavily depends on the potency of the drug, so as potency increases, solubility can decrease.
Great video, thank you! Have you thought of adding a schematic "textbook" plot with axes and BCS1-4 areas?
Another a solid video! love it.
Extremely informative along with excellent and interesting introduction for the BCS ! Frankly , In Egypt , I'm suffering as a PharmD student with the outdated curriculum which doesn't give a SINGLE OUNCE OF INFORMATION ABOUT THE BCS ! Hope you upload more and more of biopharmaceutical content to keep up with up-to-date scientific data.
Thank you for your kind words - my aim is to keep new content coming that will be relevant to all PharmD students!
this helped me a lot with my exams! thanks
10:46 it was discussed about bcs c3. It was said that it is difficult to develop such a drug and needs to be a potent one....... But in the 2nd part of pre formulations video the graph depicts highest sales of class 3 drugs does that mean most of them are potent?
That is a good point! The BCS is only a rough guide to developability, but you are right of course - as drugs are being increasing designed on a computer to ensure very strong interaction to a biological target they are becoming very potent. Hence, if they have poor solubility/permeability (or both!) they can still be effective in the body.
Could you send me a reasearch / youtube video link discussing this dazzling assay ? I'd be grateful 😄
In BCS system, Is there magic number for solubility? such as 2 mg/ml. >2 mg/ml is good solubility for oral drug. < 2 mg /ml is low solubility for oral drug. Thanks
Thanks for your kind comments and the Q :) It used to be the case that the magic number for solubility (for an orally delivered drug) was 10 mg/mL, but this of course heavily depends on the potency of the drug, so as potency increases, solubility can decrease.