Pharma Drama
Pharma Drama
  • Видео 125
  • Просмотров 293 956
Materials Masterclass: Strong and fragile glass formers explained!
Lots of pharmaceuticals can form glasses if cooled rapidly, but some are described as strong glass formers and others as fragile glass formers. But what do these terms mean? Where do they come from? And should I worry whether my material is a strong or fragile glass former? All of these questions and more* will be answered in this video!
*Actually there's no more. That's yer lot :)
Просмотров: 138

Видео

How can the same material have different glass transition temperatures?!
Просмотров 2242 месяца назад
How can one compound appear to have different Tg values? That's crazy! Surely there should be only one, true value? Well, you'd think so but in reality the way the glass is made AND the way Tg is measured will all affect the Tg value determined. But why? What is it about formation that changes Tg? And why do different analytical techniques give different Tg values? All will become clear in this...
Materials masterclass: Plasticisers in amorphous solids (glasses)
Просмотров 2532 месяца назад
Ever wondered why amorphous pharmaceuticals are so unstable when there's water around? It's because water is an excellent plasticiser, and speeds up the rate at which amorphous materials relax, ultimately leading to crystallisation. Plasticisers are also added to all sorts of plastics and polymers, to change their mechanical properties and feel to the touch. But what are they? And how do they w...
DSC Masterclass: How to interpret Glass Transitions
Просмотров 3662 месяца назад
I can't tell you how good our students seem to be at *seeing* glass transitions in their materials when run in a DSC. But are they actually glass transitions or just desperation on the part of the students? Mmm... Here we look at how glass transitions appear in a DSC, why they should be seen as a step change in the baseline and why they are sometimes seen as an exothermic peak. By exploring why...
Understanding the science behind relaxation of amorphous solids
Просмотров 2713 месяца назад
Amorphous materials are tricky! For one thing, they are always changing. If you leave candy floss (or cotton candy) in the open air it will have shrunk to almost nothing in just a few minutes. Or if you're a racoon and you put your cotton candy in water you'll be a sad and confused racoon (ruclips.net/video/rfbb4yRBH64/видео.html). Not good! But why? What is it that amorphous glasses do that me...
Revealed: Why Amorphous Solids DON'T Melt!
Просмотров 4813 месяца назад
Amorphous solids are just that - solid. Well, below their glass transition temperature anyway. When heated they turn to liquids, so just like crystalline solids they melt, right? No! In fact an amorphous material CANNOT melt. So what do they do? Well, that's what we'll look at in this video. Related content; The science behind relaxation of amorphous materials - ruclips.net/video/TGhfxRfBcM4/ви...
Unlocking the Mystery of Glass Transition Temperatures
Просмотров 5203 месяца назад
The glass transition temperature (or Tg) is one of those mysterious concepts that seems very hard to understand - not any more! In this video we look at the glass transition in easy-to-understand terms; what it is and what happens to a material to make a glass. The concept is highlighted with diagrams, video and an indecent amount of indomethacin. There are some related videos you might also wa...
How I set up an award-winning science podcast - Dr Bahijja Raimi-Abraham
Просмотров 1156 месяцев назад
Are you thinking of setting up your own Podcast series but are not sure how to? Or why? Fear not! Pharma Drama is here to help. I went to King's College London to talk with Dr Bahijja Raimi-Abraham, Senior Lecturer in Pharmaceutics, to ask her about her own experience with science and social media. In this final part of the interview, Bahijja tells us why she set up her award-winning podcast Mo...
Why you should (or shouldn't) consider a PhD and Post-Doc
Просмотров 1456 месяцев назад
Done a degree and thinking of a PhD? Or maybe you've been considering a Post-Doc but don't know what it will be like/what value it might add. Fear not! Pharma Drama is here to help. I went to King's College London to talk with Dr Bahijja Raimi-Abraham, Senior Lecturer in Pharmaceutics, to ask her about her own career journey. In the second part of the interview, Bahijja tells us about the dos a...
Should you go to university? We ask a leading academic!
Просмотров 1636 месяцев назад
Are you thinking of going to university? Not sure whether to? Or what course to study? Or which university to attend? Fear not! Pharma Drama is here to help. I went to King's College London to talk with Dr Bahijja Raimi-Abraham, Senior Lecturer in Pharmaceutics, to ask her about her own career journey. We'll hear about her personal motivations and research experiences in a 3-part series. In Par...
Entrepreneurial Advice: Setting up a Pharma Company
Просмотров 5097 месяцев назад
Mridul Majumder set up how own pharma company 8 years ago and it's just won the King's award for Enterprise, Internation Trade! Here he gives some insights into how you can set up a successful company too!
Moles in chemistry - explained clearly!
Просмотров 4339 месяцев назад
Moles are one of those concepts that ALWAYS confuses students of chemistry, yet if you understand what they are you'll be able to do all kinds of calculations and conversions. Oh, and pass your exams! Who wouldn't want to do that? So in this video we'll look at what a mole is, why we need moles in the first place and how we use moles in calculations - in fact, we'll work through six example que...
Demystifying frequency distributions
Просмотров 2379 месяцев назад
Nearly all data in nature are distributed in some way and understanding frequency distributions is absolutely key to being able to compare data sets and perform hypothesis testing (as we'll look at in a later video). So here we look at frequency distributions - in particular the Normal distribution - using our trusty example - Nurofen tablets... We'll look at what the Normal distribution is, ho...
Upgrade Your MINI F56: 2024 Head Unit Installation Guide
Просмотров 11 тыс.9 месяцев назад
The F56 MINI is fab, but if you have an early car you're missing out on the latest infotainment system and Apple Car Play. But you don't have to! It's a 20 min job to change the head unit for a 2024 edition. That's what I did on my 2016 MINI F56 JCW. And if I can do it, you can too! In this video I give you an easy to follow, step-by-step guide to change the entire infotainment system in your F...
Understanding standard error of the mean
Просмотров 3039 месяцев назад
Data are interpreted through mean (accuracy) and standard deviation (precision) as we have seen in previous videos. But there is one more parameter that we can use to estimate precision; standard error, more commonly called standard error of the mean. It's a quick and easy value to determine and is a very useful parameter, so here we look at how it's defined and how to calculate it. Oh, and I g...
Mastering Ideal, Intrinsic, and Regular Solubilities
Просмотров 5629 месяцев назад
Mastering Ideal, Intrinsic, and Regular Solubilities
Revealing the mysteries of pharmaceutical co-crystals
Просмотров 85410 месяцев назад
Revealing the mysteries of pharmaceutical co-crystals
Pharma Drama introduction
Просмотров 132 тыс.10 месяцев назад
Pharma Drama introduction
The science of pharmaceutical suspensions explained!
Просмотров 1,8 тыс.Год назад
The science of pharmaceutical suspensions explained!
What are (pharmaceutical) hydrates and solvates?
Просмотров 1,3 тыс.Год назад
What are (pharmaceutical) hydrates and solvates?
Master the art of resume writing for career success
Просмотров 397Год назад
Master the art of resume writing for career success
Study Smarter: The Key Advantages of Attending Lectures
Просмотров 333Год назад
Study Smarter: The Key Advantages of Attending Lectures
The Ultimate Guide to Rocking Freshers' Week
Просмотров 194Год назад
The Ultimate Guide to Rocking Freshers' Week
I wish I'd known this when I started university!
Просмотров 706Год назад
I wish I'd known this when I started university!
Expert Tips: Master Good Experimental Practice for DSC
Просмотров 1 тыс.Год назад
Expert Tips: Master Good Experimental Practice for DSC
Maximizing DSC Performance with Proper Calibration
Просмотров 1,1 тыс.Год назад
Maximizing DSC Performance with Proper Calibration
Don't Ruin Your DSC Experiment: Discover the Importance of Pan Selection
Просмотров 886Год назад
Don't Ruin Your DSC Experiment: Discover the Importance of Pan Selection
DSC is cool (well, it should be!) - The Surprising Benefits of DSC Cooling Revealed!
Просмотров 809Год назад
DSC is cool (well, it should be!) - The Surprising Benefits of DSC Cooling Revealed!
Mastering DSC Analysis 2: Another surprising effect of Heating Rate!
Просмотров 1,2 тыс.Год назад
Mastering DSC Analysis 2: Another surprising effect of Heating Rate!
Mastering DSC Analysis 1: The surprising effect of Heating Rate!
Просмотров 1,7 тыс.Год назад
Mastering DSC Analysis 1: The surprising effect of Heating Rate!

Комментарии

  • @chisomeze4626
    @chisomeze4626 2 дня назад

    Please I need the slides

  • @pictsidhe6471
    @pictsidhe6471 11 дней назад

    This isn't the latest type. The latest type is a circular display. This is just the f56lci2 8.8

  • @bartosz9023
    @bartosz9023 17 дней назад

    why my DSC is set to micro volts/mg instead of mW/mg?

  • @domomitsune5920
    @domomitsune5920 18 дней назад

    Great explanation but doesn't answer the question of why I clicked on your video. What's the difference between a drug a drug dealer sells and the medication that a doctor prescribes. And what if I'm using street drugs as a medication for a health condition? Doesn't that counts medication now? Joking by the way, but serious question

  • @doronkra4304
    @doronkra4304 19 дней назад

    very good

  • @jordan9507
    @jordan9507 27 дней назад

    amazing video! thank you <3

  • @divinefavouredeh4786
    @divinefavouredeh4786 Месяц назад

    Very wonderful vid I recommend😊 I can now go and watch movie😂

  • @divinefavouredeh4786
    @divinefavouredeh4786 Месяц назад

    Thank you very much Now I understand the concept of pka At least😢 Biochemistry will not kill me oo😂😂 I'm definitely subcribing❤

  • @TheMolar777
    @TheMolar777 2 месяца назад

    Little bit sketchy, phone number county area is Spain, but on ebay same company delivery says from Lithuania

  • @هبة-ص2ز
    @هبة-ص2ز 2 месяца назад

    Think you❤

  • @vaishnavil2795
    @vaishnavil2795 2 месяца назад

    You literally clearing my all doubts on basic topics of science in a simple way sir. 🇮🇳✨

  • @marioramireza
    @marioramireza 2 месяца назад

    Very clear and useful for my thesis, thanks... Guessing that coffee is Colombian like me...

  • @carlkalko5503
    @carlkalko5503 2 месяца назад

    Brilliant, thanks

  • @shigangruan8101
    @shigangruan8101 2 месяца назад

    Melting point can not determine the Gibbs free energy directly. So sometimes, the higher melting point polymorph can be meta-stable form at certain temperature.

  • @joshuabeatty189
    @joshuabeatty189 2 месяца назад

    Great video, can you still measure the Tg using the peak with relaxation present?

  • @ConnieGustave
    @ConnieGustave 2 месяца назад

    3153 Noble Burgs

  • @saikrishnasurajbavirisetty7804
    @saikrishnasurajbavirisetty7804 2 месяца назад

    Sir, can u discuss about phase solubility curves

    • @PharmaDrama
      @PharmaDrama 2 месяца назад

      Yes, I am planning to talk about phase diagrams

  • @nitinkumarswarnakar
    @nitinkumarswarnakar 2 месяца назад

    It is worth discussing a video on limit congruency as you have described crystal and amorphous in a sample.

    • @PharmaDrama
      @PharmaDrama 2 месяца назад

      I am definitely planning that as a number of people have asked!

  • @samgetsit
    @samgetsit 2 месяца назад

    Did you use electro spinning ?

    • @PharmaDrama
      @PharmaDrama 2 месяца назад

      I didn't mention electrospinning directly, but it would certainly be a method that also leads to amorphous materials

  • @vikramjoshi3452
    @vikramjoshi3452 2 месяца назад

    As always, great video Dr. Gaisford! One question related to the video: when heating an aged glass sample just above the Tg, would the cooling rate matter in a similar way as if we were cooling directly from the melt? Also, could you make a video on modulated DSC and how it helps separate "reversing" and "nonreversing" signals? Even after watching lots of videos online, which just throw some equations at me, I feel like I don't really understand it. I love the way you teach, so thank you for taking the time out to make these videos!

    • @PharmaDrama
      @PharmaDrama 2 месяца назад

      Now you raise some very good points! Firstly, cooling rate would matter - the faster the cooling rate, the lower the Tg will appear. There's a video on that coming soon (the next video will be about plasticisers, and then cooling rate). I will indeed do a video on modulated DSC, although to be fair the maths behind that is tricky! Glad you're finding the videos helpful though :)

  • @WyldeVerna
    @WyldeVerna 3 месяца назад

    8705 Vita Springs

  • @vikramjoshi3452
    @vikramjoshi3452 3 месяца назад

    Is relaxation a pre-requisite for crystallization? I think it should be because of the increasing density, but could you please confirm/explain? Great videos, Dr. Gaisford!

    • @PharmaDrama
      @PharmaDrama 3 месяца назад

      Thank you for your question :) I think the answer is yes, only because relaxation means the movement of molecules, and crystallisation requires the movement of molecules - hence they must go together.

  • @marcellopezzuto762
    @marcellopezzuto762 3 месяца назад

    Very well explained

    • @PharmaDrama
      @PharmaDrama 3 месяца назад

      Thank you - I hope it was useful

  • @llaannyyaa
    @llaannyyaa 3 месяца назад

    This video was very helpful to me Thank you

    • @PharmaDrama
      @PharmaDrama 3 месяца назад

      Thank you - that's very good to hear

  • @alexegobi4276
    @alexegobi4276 3 месяца назад

    Great explanation. But i would like to know why nicotine and cocain are called drugs, thank you 🙏🏽

    • @PharmaDrama
      @PharmaDrama 3 месяца назад

      Thank you for your kind words. Nicotine and cocaine are both called drugs because they are the chemical species that elicit a response in the body. If formulated they would be medicines. I think the confusion is that some drugs are subject to legal restrictions; for instance, controlled drugs, such as morphine, or illegal drugs such as cocaine. But to the general public the word 'drug' is often used only for illegal substances.

  • @mohammedabdeen2826
    @mohammedabdeen2826 3 месяца назад

    Very informative, thank you

  • @بنتحديدية-م6ب
    @بنتحديدية-م6ب 3 месяца назад

    thank you sooo much can you explain eutectic mixture please my exam is so soon

  • @D_D1ver
    @D_D1ver 3 месяца назад

    Thank you Simon😀

  • @LindseySwihart-x1v
    @LindseySwihart-x1v 3 месяца назад

    Beier Underpass

  • @nidhishkhemka2957
    @nidhishkhemka2957 3 месяца назад

    I really enjoyed your delivery and the easy-to-understand approach in which you explained. Thanks.

    • @PharmaDrama
      @PharmaDrama 3 месяца назад

      Thank you - that's very nice of you to say and also good to hear!

  • @mdoran3
    @mdoran3 3 месяца назад

    Your explanations are awesome. Do you have plans for more DSC videos, or other instruments series (TGA, dilatometer, LFA)?

    • @PharmaDrama
      @PharmaDrama 3 месяца назад

      Thank you :) I do indeed, so please throw any suggestions my way. I'll probably look at TGA and DVS next, as they're in my lab!

  • @virtualpharmlab
    @virtualpharmlab 3 месяца назад

    Great video, thank you! Have you thought of adding a schematic "textbook" plot with axes and BCS1-4 areas?

  • @zippydance
    @zippydance 3 месяца назад

    Thanks! My brain was fried from overwork when my cell bio professor was explaining this in class. This summed it up very eloquently and digestibly.

    • @PharmaDrama
      @PharmaDrama 2 месяца назад

      Thank you :) I'm glad you found the video helpful

  • @parsaakbari6342
    @parsaakbari6342 3 месяца назад

    I had at least four different courses during both my undergraduate and graduate education that covered glass transition, but none explained the concept as smoothly as this. Beautifully presented. thank you!

    • @PharmaDrama
      @PharmaDrama 3 месяца назад

      Thank you for your very kind words and I'm glad you found the material understandable :)

  • @PiaWalck-r2l
    @PiaWalck-r2l 3 месяца назад

    Anjali Gardens

  • @sayanpal9491
    @sayanpal9491 3 месяца назад

    if the solubility of the stable form is below industry standard, what to choose for formulation ? if you choose a metastable form, it might transition into a stable form with time. What is the best practice ?

    • @PharmaDrama
      @PharmaDrama 3 месяца назад

      Yes, that is a tricky question. I guess the answer depends on whether you get enough bioavailability for your active. If not then a metastable form is an option but I think most companies would go with the stable form and use an alternative solubilisation strategy (eg milling, salt formation or mixing in an amorphous polymer).

    • @sayanpal9491
      @sayanpal9491 3 месяца назад

      @@PharmaDrama : Thank you for response. Your channel was very helpful in brushing up my pharmaceutical crystallization knowledge.

  • @RalphGordon-k4b
    @RalphGordon-k4b 3 месяца назад

    Jarrett Throughway

  • @DonaldRobinson-u6h
    @DonaldRobinson-u6h 3 месяца назад

    Whitney Ports

  • @StephanieParker-w4k
    @StephanieParker-w4k 3 месяца назад

    Robel Shoal

  • @carissabennett3680
    @carissabennett3680 3 месяца назад

    Great explanation. Thank you!!

  • @m.a8110
    @m.a8110 3 месяца назад

    It's aich..... baaaaaaaaaaaaaaaaaaaaaaaahhhhh

  • @Egonxresh-t5y
    @Egonxresh-t5y 3 месяца назад

    Roberts Groves

  • @fabienpanda7351
    @fabienpanda7351 3 месяца назад

    Great video! Thank you

  • @MatthewPratt-o2y
    @MatthewPratt-o2y 4 месяца назад

    Lessie Cliffs

  • @MarissaLieto-b6y
    @MarissaLieto-b6y 4 месяца назад

    Lesch Stream

  • @Simran-jd4wi
    @Simran-jd4wi 4 месяца назад

    thank you, sir !!!

  • @MarkCimorelli
    @MarkCimorelli 4 месяца назад

    ❤❤❤Thank you so much

  • @yaraalkhouli7140
    @yaraalkhouli7140 4 месяца назад

    Amazing explanation! Big thanks!

  • @jennien1861
    @jennien1861 4 месяца назад

    Thanks, well explained!

  • @StephenandSally-e4g
    @StephenandSally-e4g 4 месяца назад

    Is it really that easy, tempted to have a go myself on my 2017 Mini Clubman Cooper S, but I’m a complete novice

    • @nishareid6233
      @nishareid6233 2 месяца назад

      Same! I have the Clubman S all4. I'm obsessed with the exterior as it's such a cute quirky look. But the dash is even more dated than it should be. So I'm looking into doing it myself and I'm really too scared 😢