Collidescope Episode 3 | MN, CG, and Immune Complex Deposits within the Tubular Basement Membranes

What happens when two diseases occur at the same time? Does one influence the other? How is kidney function affected?
Join Dr. Rachelle Gietzen and Dr. River Charles as they look at colliding diseases in their series Collidescope.
In this episode, Dr. Gietzen shares a collision case with membranous glomerulopathy, collapsing glomerulopathy, and immune complex deposits within the tubular basement membranes.
#Collidescope #PathTwitter #RenalPath #KidneyDisease

[@muhammedhadedy4570]

Excellent presentation. I love this series. Please, keep up the great work.
Greetings from Egypt.
❤❤❤❤

[@beninderweltseinji]

Great case and presentation. At 2:41 is that not a cellular crescent? If not what are the cells at the Bowman capsule? Thanks

[@arkanalaboratories]

This is a good question and distinguishing collapsing glomerulopathy and crescentic glomerulonephritis can be challenging in practice and when looking at a glomerulus in isolation. The cells that you see here within the Bowman's space are visceral epithelial cell that have undergone hyperplasia and hypertrophy. In general, the features that help us favor a collapsing glomerulopathy include reabsorption droplets as seen in the previous image. In a crescentic glomerulonephritis we would expect to see glomerular basement membrane breaks, karyorrhexis, and fibrinoid necrosis, as well as red blood cell casts in the biopsy.