I'm a 54 year old APOE4/4. I appreciate Dr Yassine sharing his knowledge with such clarity and honestly but as a 54 year old, this information is incredibly depressing. I wish I hadnt listened to this podcast as good as it was.
Regarding some of the brain cell types.. neurons, glial ( neuron-supporting astrocytes , oligodendrocytes, and immune-system-like micro-glial cells ), dendrites.... and how the brain prefers to use fat for building blocks not for energy, as that's inefficient and generates oxidative stress. Instead, the brain prefers lactate, which comes when astrocytes uptake and metabolize glucose (via GLUT1) and provide lactate to the neurons. In a glucose shortage, the brain can become efficient at utilizing ketones (I've even heard it said that the brain prefers ketones over glucose), however, Does dietary lactate/ ketones also go thru GLUT1? Would supplementing with milk/lactate help with TBI? Is there a way to measure one's density of MonoCarboxylate Transporters (MCT) which determines how well you shuttle lactate from the muscle back to the liver? And can lactate from cancer cells make its way to the brain? David LeMay / Tommy Wood on the STEM talk / HumanOS podcasts, suggest that during TBI/CBE, EVERYTHING crosses the blood-brain-barrier! High amounts of Oleic acid (monounsaturated fats), 20g of Omega-3 EPA/DHA (polyunsaturated fats) , creatine, CoQ10,sulforaphane, and possibly melatonin, taken prophylactically, can reduce the severity of TBI. Once brain injury has occurred, a standard therapy appears to be hypothermia + Xenon gas ,where the goal is hypoxia by saturating with oxygen using Hyperbaric Oxygen Therapy (core body temperature is cooled down (33.5 C) for three days). They also mention how the ferret brain is similar to humans, yet it's hard to induce brain damage on ferrets! Regarding how exchangeable apolipoproteins (APOE and APOC3) regulate both APOB/ldl and APOA/hdl.. APOE4 came first (then E3 came 50000 years ago, E2 10000 years ago) and this was ideally suited for when the chance of infection was high.. it also made glut1 less sensitive, and so with age/inflammation may require those with APOE to have a diet higher in fat than in carb/glucose-based. GLUT4 expression is a factor in peripheral tissue, and does not play much a role in the glucose uptake in the brain (instead GLUT1 expression decreases when it senses excess glucose in the blood, and increases during periods of hypoglycemia)... and compared to the slower aerobic production of atp inside the mitochondria (either via pyruvate or Fatty acids ->oxidation-> acetyl-CoA), the anaerobic metabolism (fermenting glucose/glutamine into lactate and pyruvate) is not efficient, but it's fast, and it's usually only seen when exercising and exhausting a muscle. However, are *ONLY* the long endurance exercises (type 1 muscle fibers) the type of exercise that can activate AMPK (from inside the muscle cell) to direct the glut4 transporter to dispose of blood glucose (no insulin signaling involved)? Finally, would have liked to have heard Hussein's thoughts on Xiang-Dong Fu's work with Parkinsons. He suggests there are 86 billion neurons, however they cannot divide, and so Parkinson's is caused when a particular (mitochondrial?) dopamine-producing nerve cell (in the substantia nigra) is exhausted which then leads to the accumulation of α-Synuclein proteins. But unlike common stem-cell approach, his UCSD lab attempts to convert (transdifferentiation ) of the astrocyte (which are equally as plentiful as neurons, but can divide) *INTO* neurons by knocking out the rna binding protein , ptb gene! It's unclear if this will work in older humans, especially since it doesn't address the initial cause of the dysfunctional/death of the neurons. I recommend his interview on the Bio Eats World podcast, as well as Dr. Giselle Petzinger interview on Rhonda Patrick's podcast (Where I've left another long-winded comment).
Hi Ben, I think you would appreciate Dr Kharrazian's course on Neuroinflammation for additional, biochemistry, lab testing, and clinical tools for TBI, et al. ✌
I dont mean to be so offtopic but does anybody know a tool to get back into an Instagram account? I was stupid forgot the login password. I would appreciate any tricks you can give me
@Gus Lionel thanks for your reply. I got to the site thru google and Im waiting for the hacking stuff atm. Seems to take quite some time so I will get back to you later with my results.
How I think about this. 1. Biochemistry matters. 3/6 ratio matters on inflammatory markers due to downstream effects 2. All PUFA, both omega-6 and omega-3 oxidize easily, and once oxidized, are inflammatory. While required, lowering all is beneficial, but we need to find what the minimum level of both is. 3. We are getting very excessive PUFA, which is likely damaging the mitochondrial membrane from their oxidative effect. Rather than taking extra omega-3, increasing total PUFA load, eat less omega-6. 4. Omega-3 supplements are probably bad, because they are already oxidized before consumed. Just eat fresh omega-3 if you need more. Gonna have to listen to this one again in a week or two.
I listen to every podcast of Dr. Attias. I hear metformin is good then I hear it is not. He prescribes it to his patients, he used to take it. Then I hear another podcast that says it isn't good, but rapamyacin is good. Very confused, any help would be appreciated. I am debating going on metformin. I am healthy 60 year old woman, diagnosed alzheimers in mom, probably lewey body in dad - both 90/near 90 at time of death. I am fit, healthy weight work out, no diabetes- metformin?? I realize I can consult my Dr. but Attia seems to have the most up to date info. Any thoughts
I like this, but I question how herbivorous animals with brains (presumably also fat based) that never see the sea get omega 3, and if they don't, how their brains handle it?
I'm a 54 year old APOE4/4. I appreciate Dr Yassine sharing his knowledge with such clarity and honestly but as a 54 year old, this information is incredibly depressing. I wish I hadnt listened to this podcast as good as it was.
Thank you very much for this interview Peter, it was truly enlightening!
Brilliant episode.
Regarding some of the brain cell types.. neurons, glial ( neuron-supporting astrocytes , oligodendrocytes, and immune-system-like micro-glial cells ), dendrites.... and how the brain prefers to use fat for building blocks not for energy, as that's inefficient and generates oxidative stress. Instead, the brain prefers lactate, which comes when astrocytes uptake and metabolize glucose (via GLUT1) and provide lactate to the neurons. In a glucose shortage, the brain can become efficient at utilizing ketones (I've even heard it said that the brain prefers ketones over glucose), however,
Does dietary lactate/ ketones also go thru GLUT1? Would supplementing with milk/lactate help with TBI? Is there a way to measure one's density of MonoCarboxylate Transporters (MCT) which determines how well you shuttle lactate from the muscle back to the liver? And can lactate from cancer cells make its way to the brain?
David LeMay / Tommy Wood on the STEM talk / HumanOS podcasts, suggest that during TBI/CBE, EVERYTHING crosses the blood-brain-barrier! High amounts of Oleic acid (monounsaturated fats), 20g of Omega-3 EPA/DHA (polyunsaturated fats) , creatine, CoQ10,sulforaphane, and possibly melatonin, taken prophylactically, can reduce the severity of TBI. Once brain injury has occurred, a standard therapy appears to be hypothermia + Xenon gas ,where the goal is hypoxia by saturating with oxygen using Hyperbaric Oxygen Therapy (core body temperature is cooled down (33.5 C) for three days). They also mention how the ferret brain is similar to humans, yet it's hard to induce brain damage on ferrets!
Regarding how exchangeable apolipoproteins (APOE and APOC3) regulate both APOB/ldl and APOA/hdl.. APOE4 came first (then E3 came 50000 years ago, E2 10000 years ago) and this was ideally suited for when the chance of infection was high.. it also made glut1 less sensitive, and so with age/inflammation may require those with APOE to have a diet higher in fat than in carb/glucose-based. GLUT4 expression is a factor in peripheral tissue, and does not play much a role in the glucose uptake in the brain (instead GLUT1 expression decreases when it senses excess glucose in the blood, and increases during periods of hypoglycemia)...
and compared to the slower aerobic production of atp inside the mitochondria (either via pyruvate or Fatty acids ->oxidation-> acetyl-CoA), the anaerobic metabolism (fermenting glucose/glutamine into lactate and pyruvate) is not efficient, but it's fast, and it's usually only seen when exercising and exhausting a muscle. However, are *ONLY* the long endurance exercises (type 1 muscle fibers) the type of exercise that can activate AMPK (from inside the muscle cell) to direct the glut4 transporter to dispose of blood glucose (no insulin signaling involved)?
Finally, would have liked to have heard Hussein's thoughts on Xiang-Dong Fu's work with Parkinsons. He suggests there are 86 billion neurons, however they cannot divide, and so Parkinson's is caused when a particular (mitochondrial?) dopamine-producing nerve cell (in the substantia nigra) is exhausted which then leads to the accumulation of α-Synuclein proteins. But unlike common stem-cell approach, his UCSD lab attempts to convert (transdifferentiation ) of the astrocyte (which are equally as plentiful as neurons, but can divide) *INTO* neurons by knocking out the rna binding protein , ptb gene! It's unclear if this will work in older humans, especially since it doesn't address the initial cause of the dysfunctional/death of the neurons. I recommend his interview on the Bio Eats World podcast, as well as Dr. Giselle Petzinger interview on Rhonda Patrick's podcast (Where I've left another long-winded comment).
Hi Ben, I think you would appreciate Dr Kharrazian's course on Neuroinflammation for additional, biochemistry, lab testing, and clinical tools for TBI, et al. ✌
Plant based diets in Northern Europe? When people moved out of Africa into Europe they primarily were eating large game. I'm super confused.
As an APO E3/E4, this was very helpful and much appreciated.
I dont mean to be so offtopic but does anybody know a tool to get back into an Instagram account?
I was stupid forgot the login password. I would appreciate any tricks you can give me
@Kamari Terrell instablaster :)
@Gus Lionel thanks for your reply. I got to the site thru google and Im waiting for the hacking stuff atm.
Seems to take quite some time so I will get back to you later with my results.
@Gus Lionel it worked and I now got access to my account again. Im so happy:D
Thank you so much you saved my ass !
@Kamari Terrell you are welcome :)
wow this is sole quality information. I will now definitely start eating more fatty fish. Did not know that supplements alone are not enough
How I think about this.
1. Biochemistry matters.
3/6 ratio matters on inflammatory markers due to downstream effects
2. All PUFA, both omega-6 and omega-3 oxidize easily, and once oxidized, are inflammatory. While required, lowering all is beneficial, but we need to find what the minimum level of both is.
3. We are getting very excessive PUFA, which is likely damaging the mitochondrial membrane from their oxidative effect. Rather than taking extra omega-3, increasing total PUFA load, eat less omega-6.
4. Omega-3 supplements are probably bad, because they are already oxidized before consumed. Just eat fresh omega-3 if you need more.
Gonna have to listen to this one again in a week or two.
Very interesting interviewee
I listen to every podcast of Dr. Attias. I hear metformin is good then I hear it is not. He prescribes it to his patients, he used to take it. Then I hear another podcast that says it isn't good, but rapamyacin is good. Very confused, any help would be appreciated. I am debating going on metformin. I am healthy 60 year old woman, diagnosed alzheimers in mom, probably lewey body in dad - both 90/near 90 at time of death. I am fit, healthy weight work out, no diabetes- metformin?? I realize I can consult my Dr. but Attia seems to have the most up to date info. Any thoughts
-Sauna,
-Hyperbaric oxygen therapy,
-Grounding/earthing mat for bed,
-Healthy balanced, whole food, non-gmo, pesticide-free diet, (look up "Pegan Diet")
-Exercise,
-Wim-Hof breathing techniques,
-Healthy dose of Sunshine(supplement Vitamin D, if needed),
-Healthy sleep schedule,
-Pulsed Magnetic Field therapy,
ummm... oh ya,
-Black Seed Oil!
God bless!
I like this, but I question how herbivorous animals with brains (presumably also fat based) that never see the sea get omega 3, and if they don't, how their brains handle it?
Good question, I'd like to know this as well. Maybe it has to do with the water they drink?
@@HankyZetts They probably convert ALA, which they get from plants.
Hey Peter,
I’ve sent you a message on Instagram. Please review it.
Thank You
HI