Repurposed Drugs for Cancer in Dogs | Lauren Barrow, DVM

Tracie is thinking her dog’s mast cell tumor might benefit from Panacur (fenbendazole). Are there any other repurposed drugs she might consider?
It’s so exciting when a familiar drug in one area shows promise as a new treatment for another health problem. Researchers and clinicians pay attention, especially when the drug is inexpensive and easily tolerated.
Such is the case with Panacur (fenbendazole), a dewormer that has caught the attention of cancer researchers. It’s early days of studying its effects on cancer, but some people want to start using it now!
And no wonder. It’s mechanism of action is the same one used by several well-known cancer drugs! But would the high doses needed cause the same kind of severe long-term effects of other chemo drugs we’re already using?
Dr. Lauren Barrow joins us for a fascinating discussion prompted by listener Tracie’s question about her dog’s mast cell tumors. We talk about the thinking general practitioners engage in around repurposing drugs for cancer … and why a trip to the oncologist might be a good idea.
After all, oncologists (especially veterinary oncologists) are not just the keepers of insights and expertise about standard treatment methods … they are the researchers on the cutting edge of oncology. They’re the ones who research and repurpose drugs!
Links Mentioned in Today’s Show:
Podcast About Panacur (fenbendazole): www.dogcancer.com/podcast/dru...
Article about Mast Cell Tumors: www.dogcancer.com/articles/ty...
Article about Benadryl: www.dogcancer.com/articles/dr...
Article about oncologists
Related Links:
Podcast about Tagamet and Benadryl for Dogs: www.dogcancer.com/podcast/dru...
Chapters:
00:00 START
00:58 Tracie's Call
02:13 Worried About Chemotherapy; Are There Other Drugs?
02:54 Panacur for Mast Cell Tumors?
04:45 Other Drugs Kill Using Microtubules, Too: Chemotherapy Drugs
05:14 Any Drug Used to Kill Cancer May Have Side Effects, Even Repurposed Drugs
06:56 Any Other Repurposed Drugs for Mast Cell Tumors?
07:12 Mast Cells Are Immune Cells That Release Histamine
07:35 Give Benadryl to Help with Histamine Symptoms
08:56 Inflammatory Cascades Are Messy
10:46 Grade Three Mast Cell Tumors Are Serious
11:30 Find Out If There's Metastasis Already
11:54 This Is a Case for an Oncologist's Expertise
13:36 Do Oncologists Respect the Word No?
15:06 Chemotherapy in Humans Is Different
17:25 Oncologists Know More About Repurposed Drugs Because They Are the Researchers!
18:46 Cutting Edge Therapies Are at the Onc's Office
19:20 Palladia for Mast Cell Tumors
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Get to know today's guest, Dr. Lauren Barrow: www.dogcancer.com/people/laur...
For more details, articles, podcast episodes, and quality education, go to the episode page: www.dogcancer.com/podcast/

[@chinookvalley]

Just watched the video on osteosarcoma. I was wondering about this! Thanks for posting it. We must have hope in order to save our pets and ourselves from the eventual probability of getting cancer. With everyday that passes, we are all one day closer to finding ourselves living with cancer. Our progress is killing us slowly.

[@chinookvalley]

The animal oncologists I have spoken to have absolutely no interest in looking at alternative therapies. They DO want to do surgery, radiation, chemo, and lots of drugs with terrible side effects. Not happy with what we are finding while trying to help save dogs lives. It's all about the $$$$. Hope to find more info here on your channel.

[@galespressos]

😮? panacur sounded worth looking into. perhaps since worms drain the nutrients that would make it harder to stay healthy, and getting rid of the worms would help relieve a huge burden and return nutrients to the host.

[@reneegossage8609]

I commented but for some reason it got removed. There is alot of current research on panacur aka fenbendazoles ability to inhibit tumor growth.

[@DogCancer]

Here's our podcast episode on Panacur -- and our article! www.dogcancer.com/articles/drugs/fenbendazole-for-dogs/

[@galespressos]

@@reneegossage8609 thank you!

[@galespressos]

@@DogCancer thank you!

[@reneegossage8609]

Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers
by Chaoran Chen 1,†,Yueming Ding 1,†,Huiyang Liu 2,Mengyao Sun 3,Honggang Wang 2,*ORCID andDongdong Wu 2,4,*ORCID
1
Institute of Nursing and Health, School of Nursing and Health, Henan University, Jinming Avenue, Kaifeng 475004, China
2
Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China
3
School of Clinical Medicine, Henan University, Kaifeng 475004, China
4
School of Stomatology, Henan University, Kaifeng 475004, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2022, 23(1), 519; doi.org/10.3390/ijms23010519
Received: 29 November 2021 / Revised: 30 December 2021 / Accepted: 1 January 2022 / Published: 4 January 2022
(This article belongs to the Collection Feature Papers in Molecular Pathology, Diagnostics, and Therapeutics)

[@hongche1268]

Does fasting and cold showers help?

[@galespressos]

Is there a pectasol for dogs?

[@DogCancer]

Here's our article on modified citrus pectin: www.dogcancer.com/articles/supplements/modified-citrus-pectin-for-dogs/

[@galespressos]

@@DogCancer thank you!

[@williammcnamara108]

I give my dog Pectasol for humans.

[@willyjohnbee]

my Daisy had a mast cell tumor Fenbandazole and tumeric coconut oil turkey tail vit E vit C green tea ....
gone in 2 weeks

[@DogCancer]

@@willyjohnbeethat's awesome! Remain vigilant, because mast cell tumors are super tricky and appear and disappear overnight, that's really common. Here's our article: www.dogcancer.com/articles/types-of-dog-cancer/mast-cell-tumors-in-dogs/

[@hongche1268]

Is that a genetic disease?