Extracting the theobromine from cocoa powder
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- Опубликовано: 14 мар 2017
- Theobromine is an interesting molecule and is very similar to caffeine. It appears in a high concentration in cocoa (a small amount of caffeine is also in cocoa).
In this video, I am extracting theobromine from cocoa. In the future, I might prepare cocoa powder from raw cocoa pods.
Link to procedure: goo.gl/o7uvc3
Other reference (Chemplayer): • Video
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Nile talks about lab safety: • Chemistry is dangerous. 
Наука
This hot cocoa recipe tastes terrible.
Underrated
*how to make dangerous chockey milk*
Well......not for much longer.
You deserve fame for this
K
Nile I love this style of intro with you in the shot talking briefly about the subject matter. I hope you'll consider doing it much more often. Thanks for being awesome.
+mannys9130 thanks! I'll do it when I can
Omg you did it!
Nice
@@NileRedcould doing this make it safe for dogs! Or would it still be just as deadly?
"in which NileRed finds an excuse to use hot piranha"
Meoiswa What is he actually saying?
he is saying that. Piranha solution is fierce
@@thesentientneuron6550 From what I've learned, it's sulphuric acid and hydrogen peroxide.
@@therealchayd and its ***far*** worse combined than either part is on its own
@@rjwaters3 It forms something called caro's acid which is an incredibly powerful oxidizer
i was expecting him to say "everything is more or less easy to get a hold of except for the cocoa powder"
Why? Why does everyone think cocoa powder is so elusive?
... I expected him to say that too...
@@Dusterisp forbidden chocolate.
Even Sigma Aldrich don't sell it...
1:22 was slick af
I had to go back to watch that, well worth it.
How many times did he redo that lol
Phloroglucinol ('Floroglucinol') = No fluorine
Chlorogenic acid = No chlorine
Theobromine = No bromine
Phosgene = No phosphorous
Pls
Just sauce = No ketchup
Nice one
Both of you
One more thing: molybdopterin = no molybdenum
Only called that because it bind to molybdenum atoms so that your body can use most molybdenum properly
Hotel = Trivago
On a side note, chlorogenic acid is called like that for the same reason as chlorophyll (also not containing any chlorine), because of its green color.
Your video looks much more professional now that you present the topic at the beginning.
+Emil Almberg thanks!
+Emil Almberg thanks!
it's like a technical report
Yes, NileRed does all experiments we dream of, one day I will also do all that ...
@Evi1M4chine what?
After many years I've finally discovered that this specifically gives me migraines.
Me too!!!
How come?
I didn’t notice until recent years but whenever I eat chocolate I get really intense migraines that leave me temporarily blind. However since I’ve stopped eating chocolate I haven’t had a migraine since
@TheNoodle Dragon it constricts blood vessels in the brain causing a headache.
Theobromine or chemistry in general?
Great video! I like the side notes that you put up on the screen for people to read if they want to. They give more basic information that a lot of people might already know, but it's very helpful for a high school student like myself who's trying to learn more about chemistry.
*how to make dangerous chockey milk*
Choccy*
Dangus
Favorite science channel tbh. He’s the one guy that doesn’t have an annoying voice and is genuinely nice to listen too.
His voice always puts me to sleep 😴. His videos are very relaxing to me lol
really like the new format where you actually can be seen
You would like that, huh?
Wut?
Extract iron from blood
+Matsuda Industries that will happen in the summer!
If he'll extract iron from his own blood then he'll be gonna facing life threatening trouble.
He can even get it from hospitals from blood bank.
and make a chain pendant from it. or a knife over time of course.
@@ritviksharma5901 or he can get animal blood from a butcher shop
@@NileRed get to it yet?
0:43 me telling people why meth and adderall are different
@TheBlondie depends on how you use them
Not really true. Cacao can fuck you up more than coffee. Not only does it contain caffeine and theobromine but the way cacao works somehow releases anadamide in our brains, a natural cannabinoid which coffee doesn't.
I think you need some new friends. And a new you.
I think you need to kill your ego and replace it with a new you like I constantly do ya stupid hypocrite
A rare “good comment” on RUclips 👏
I have just started taking theobromine for my acquired brain injury. It is helping with cognition, focus, mood and sleep.
"to use hot piranha, which shreds apart organic material"
All shall bow before my army of sexy hot piranha fish!
I have to admit, when I watched the video and you said it's one where it takes a while, I thought about the Soxhlet extractor as well. It seems perfect, and you could run it for a VERY long time to maximise your extraction. But everyone else beat me to that, so let me just say it's a good video, and I hope you keep it up!
By the way, you should work something out and collab with NurdRage. I think they're canadian as well, at least based on something said in an old video. Let the sciency part of youtube explode!
+Psychaotix2001 they are indeed Canadian!
@@NileRed Nigel I'm just a random guy on the internet but your videos instilled an everlasting love for chemistry and I am so glad I found your channel
1:20
that was boss bro. keep up the kick ass chemistry
With labware like that at your disposal...you really can turn sh/t into gold!
Love your videos. I love coming home from work and watching some neat chemistry go down. Thanks for making your videos dude, channel is full of great stuff.
Thanks for recording and posting this video of the extraction. I know that it requires lots of time and trouble, so your efforts are appreciated.
thanks for including the cleanup details. your the most throughout youtuber i watch.
First: really fun video! :)
Second: you should consider getting a Soxhlet extractor; the solvent efficiency of your extraction step would probably have been improved considerably by using one. You probably also lost quite a bit of your yield percentage to your final filtration step since the total yield is already quite small; in your place, I probably would have redissolved the theobromine in an appropriate solvent directly from the filtration funnel and recrystallized it.
Edit: looks like some folks beat me to the punch with the Soxhlet extractor comment. You shouldn't need to mix the cocoa with anything to get the extractor to drain, though; any sufficiently fine filter paper ought to do the trick as long as you don't let it block the draining tube.
Really loving the new format!
i really prefer the way you presented this video from your previous ones. The face to face really helps me digest the information.
You rock dude! I was never good in chemistry during high school, but that being said, watching your videos makes me wish I was.
Keep on doing what you're doing!
+Z Vaper thanks!
So, basically you made dog poison Oo
basically yes
humans process it better than dogs
you can od on it but you have to try harder
Pretty much everything is dog poison lol.
Theobromine, caffeine, xylitol (an artificial sweeter used in gums, candies, toothpastes, etc.), the _allium_ genus (onions, garlic, chives, etc.,) alcohol, hops, grapes/raisins, macadamia nuts, yeast dough, corn on the cob, tea tree oil, NSAIDS, THC (Humulus lupulus [hops] and Cannabis sativa are closely related members of the hemp family,) methamphetamine, antifreeze...
But don't just assume that dogs are no fun at a party... Most dogs seem to enjoy psilocybin-containing mushrooms. Dogs who have accidentally consumed them out in the yard have been observed to preferentially seek them out in the same area of the yard again at later times, so some dogs may like to get down, but only in safe ways 😎
Nick C idk man I think meth and antifreeze aren’t great for humans either
I can't believe I'm saying this but meth isn't *that* bad for humans. It's our tendency to get carried away with it because it's a quick hitting stimulant that allows you to stay awake.
It doesn't feel unhealthy despite its rep but it puts a big strain on your heart, during the high you feel pain and pressure where your heart is but it's not that bothersome.
When people stay up all the time, get addicted to it and shit. They end up getting meth mouth, skinny cheeks, lost the way of life, fuck others and themselves over etc.
What starts off harmless quickly turns into a habit that completely degenerates you. That is why it's so harmful. It's not all that toxic compared to Adderall and caffeine if you were able to use it responsibly which I do not know anyone who does.
You are showing up now! Really cool and well done! Love your channel!!
I love the new style for the introduction. It's much more personal than just you talking over some clips of equipment or preparation or what have you. You do well on camera.
+Nothing\ thanks!
1:23 -> pure skill xD
Received my beakers about 2 weeks ago, they are of great quality and the price is hard to beat! One thing, if you order the set, do not nest them in each other! the two largest sizes can stick inside each other and I made a small scratch on the inside of the largest (500 mL I believe) extracting the other. Completely my fault for trying to make them easier to carry, but just something to be aware of.
Thanks again NileRed, I hope you get some more types of branded glassware in the future! As always, keep up the excellent work!
+Aaron S. I am glad they made it! And yeah, I had that problem too. The size is just perfect for them to get stuck...
Actually the beakers are cheap for the american market. Here in Slovenia I buy glassware for 1.32€ for a half liter beaker.
How much would a good set cost?
Love the explanation at the beginning and stuff :D
Regarding 0:28, the name Theobroma comes from Greek which means food of the gods. The Theobroma Cacao tree originated in ancient times from Pre-Columbian Central America.
Ah the cute chemist returns I like these videos with u in person Nile they are much more interesting
+miranda drake thanks!
Thank you for taking the more photogenic method even if it deals with scary piranha solution.
Also. WD40/Inox/machine oil + green scourer or stainless steel wool will clean up the cast iron/steel parts of that drill press rather well. :)
+Electra Flarefire haha thanks. The press never gets used though, so it doesn't matter too much
+Electra Flarefire haha thanks. The press never gets used though, so it doesn't matter too much
So pumped to watch this only bc I did a chemistry project on this compound
absolutely ✨BOMBED✨ chemistry in high school. completely understands all nilered videos.
"a whole bunch" I love your science talk
I want to see you make a plastic or a polymer, because that would be a neat thing to see. But another good one, would be extracting the latex from milk weed. Since that plant does produce the stuff but at i think like a 30% concentration, which isn't much. Which would also be cool to show off, since latex can be vulcanized even though i don't see you doing that.
+John J good suggestions. You'll be happy to know I'm working on bakelite right now, so I am trying to make some plastic!
Hi.
That's great news.
Also what happened to (poly) styrene video you once advertised?
dude! i love your videos!!!
looking forward to the caffiene video!
A couple of questions here: For the first step, neutralising the tannins, do you think zinc oxide would work as effectively as magnesium oxide? Then for the extraction step, if the theobromine isn't all that soluble in the DCM, wouldn't it be better to use a soxhlet extractor? The design of which means that you're constantly extracting the solids over and over again with freshly distilled solvent until all the soluble components are in solution.
The soxhlet extractor is such an elegant piece of glassware! Great suggestion 👌 definitely my favorite piece that I own
Dad it's me! I love you! Keep up the good work! 😘
+Fire 7 lol thanks
NileRed Kinky...
Wesley Merritt shut up freak
Not Pulverman Nah
Make herobrine
seriously love the videos dude!
+gaetano lacara thanks!
I love Nile Red Videos so much, specially that they help me fall asleep when i can't sleep
I understand like nothing, not even the title. Still watch tho. I dunno why
Actually lol'd
2:30
The forbidden syrup
I'm in love with the coco!!!
I like this new video format
I love organic chemistry, I always look forward to seeing your videos. By the way, I like to see you in person. Teach us how to make the synthesis of a dye with an diazocompound
+Junior Cervera Villanueva I'll make one eventually!
Thanks NileRed, I'm your fan 🤓
10/10 style score on grabbing that cocoa, was that intentional?
Congrats on one million
Dude! I would love to see a lab tour.
would a solex extraction setup be better suited for the DCM part?
What's with the red neon 500 milliliter sign you have in your workspace?
You are hella smart dude. You seem great!
Maybe you could use a Soxhlet apparatus in order to do this extraction, this should reduce the amount of used DCM, and with larger times you could have a better extraction of theobromine.
hey do you think you could extract mitragynine from the plant kratom? That sounds like a super cool experiment. Many alkaloids are water soluble but some are more alcohol soluble so it seems right up your alley!
Yes!!!
Whoa very good content I just discovered you keep up the great work it reminds me a bit to the channel periodic videos you guys should collaborate it would be amazing. Awesome Channel subscribed.
+Andrés Romero I would love to collaborate!
NileRed I'd love you to work with Martyn Poliakoff though.
Can’t get enough of these videos
I would like to take a second to acknowledge that bottle flip.
Respect B)
Why not pack the cocoa powder in a cellulose thimble packed soxhlet with DCM? Would save you using so much solvent and repeatedly extracting. Could work better.
soxhlet extractors aren´t that cheap. probably Nile doesn´t have one otherwise you´re right a soxhlet is perfect for extractions but also only for the first step. ANd remember soxlet extractions aren´t that fast either. they are meant to be used for when you need expensive solvents, so you can use a minimal amount of it. (or they can be used for better yields in ether synthesis, but there i have to take Nurdrages video as a reference. i got quite some talking from my organics prof when i asked for the soxhlet. It isn´t cheap as i said)
Metalhammer1993 Nile does own one as you can see in his capsaicionoids extraction video.
He does have a soxhlet, also they are not that expensive (I got one shipped from China complete with reflux condenser for about $20)
give me the link pls, i was scolded they´d be. if they are just 20 bucks i buy one myself and can use it, whenever i need it. however does it work properly (though i don´t see how low quality glass would tamper with simple physics)? and what´s the material? I just can repeat what was scolded for. Don´t know what the fuck he paid for it. given his reactioin WAY to much
I wouldn't say they're $20, but we use soxhlets all the time in our lab. Even a cheap small 100 mL sox will do, the yield you'd get with a sox vs. doing repeated extractions yourself is immeasurable. PLUS the labour, haha
Interesting method, thank you for sharing.
Only thing I might add is that the plant is called cacao, not cocoa. Cocoa originated from a misspelling when first introduced in England, which became commonplace thus its constant usage, nowadays its mostly used to refer to processed cacao powder, which is used in cooking/making hot chocolate.
Several languages use the spelling cacao as well, from the plants scientific name theobroma cacao.
Keep up the good work!
We call it cacao in Italian :)
Using a different non-polar solvent does work. I just finished extracting some theobromine using an acid-base extraction with "naptha" (generally, a combination of alkane fractions) as the organic solvent and yielded some beautiful crystals.
This really made me wanna see you make caffein using theobromine honestly.
Coffee also has theobromine in it.
It is also a metabolite of caffeine
Do you really need to heat the fish? -it seems cruel -just let them eat at their own pace.
This video keeps me up at night
wow finally seeing nile red its just different lol
Why not use a Soxhlet extractor for this extraction? Something that you extract in two steps and still get such low yield seems like a perfect scenario to use a Soxhlet extractor to me. Do you just not have one, or do you want to keep it to relatively basic equipment?
he does have one. he used it in the Capsaicinoids video. the problem is that he would need to mix it with celite so the soxhlet could drain. he don't have any celite right now.
Nice video, for the piranha solution issues have you tried base piranha (Ammonia+ H2O2)? i have heard that it is more manageable than the acid version.
Besides it would make a good video alongside the one you made about the acid version, there is no video on the subject and the way it works is not clear to me (i just know it works)
Base piranha solutions can eat away the sintered glass; acid is easier on the equipment.
You are a legend!
God man watching the vacuum filter is so satisfying.
why not use a soxhlet extraxtor?
What percentage of the total amount of theobromine in the cocoa powder do you think you extracted? Also, do you think this process could be more efficient?
awesome video thanks for the upload
Holy crap it's him! The one, the only, the legendary NileRed!
OMG YOU LOOK EXACTLY LIKE.......NIELS BOHR!!!!!
not really though
pipe down i need likes to feed my family
i dont think so
Holy crap, Niels Bohr looks just like Jorge Luis Borges.
I think he looks more like Paul Nixon
When someone told me to not give chocolate to my dog, I gave it to one of my cats. 1 funeral later and I watched what my pets ate and never bought chocolate again.
woah holy shit this channel has everything!
new sub~
Awesome video. Thanks
Do NOT use cocoa powder. Use CACAO powder. Cacao has much more theobromine than cocoa does as it's been unprocessed so you'll get a higher yield with cacao.
could you make theobromime from caffeine?
Yes
Vacuum filters are so satisfying
Can i just say this is an amazingly old video i remeber the days of that bacground then u went to the other side with a back drop and now ur in ur lab
I didn't know what you looked like til now and OMG YOU'RE SO CUTE I C A N T
I see you have good taste
Can you make a Dextromethorphan extraction from HCl video in the future?
Andrew R lol why
K0ester so you can snort DXM?
K0ester because cough medicine
K0ester It'd be nice to have a tutorial from him because he explains and illustrates steps very well unlike others and would be nicer than following text instructions.
I dunno if he wants that kind of traffic from those kinds of videos, I mean the freebasing one was kind of a joke about clandestine chemistry.
But technically it's legal in the US (except in Illinois), there was apparently an exemption in the CSA for it: under the CSA, all optical isomers of listed Schedule II opiates are automatically Schedule II substances. Since dextromethorphan is an optical isomer of the Schedule II opiate levomethorphan (but does not act like an opiate), an exemption was necessary to keep it a non-controlled substance. The Federal Analog Act does not apply to dextromethorphan because a new drug application has been filed for it.
But that's Wikipedia, so... Don't bet your free life on it.
I'm in love with the Coco
This guy, man...lol. Chief, you have one hell of a future ahead of you.
Next should be DMT extraction...
AwesomeMediaify Decarboxylise L-Tryptophan and add formaldehyde to it. Then recrystalize. Isnt all that hard is it ;) (Nothing everyone one the internet can tell you, so legal loophole telling ya)
No. Go to school if you want to learn and make drugs with your own knowledge.
Pretty sure that's illegal to synthesize. Providing video evidence for prosecution doesn't seem like a wise idea. Written instructions with drawings when needed is much safer!
He should synthesize DPT then.
@My middle name is regret And? It's not illegal to make.
Not gonna lie. I'd have snorted that.
Abradolf Honkler made my stomach roll a little bit... also checked both nostrils
@@Highstranger951 Oh, you modern kids... back in the day we'd snort everything we'd get our hands on. Horse tranquilizers, table salt, chalk, you name it. Now it's all Molly this, de-worming medicine that... everything's going to heck in a handbasket I tells ya! [shakes fist]
Theo is no bro of mine, but if he was, I'd just hire mercenaries for the extraction.
I can listen to nile red with my wireless headphones to relax and go to sleep. This is actually how I became a musician when I was a young idiot listened to bass music and one day picked up a guitar and felt natural. Although science is neat and all I don't think I can just pick it up the same wouldn't know where to start lol.
Extract TheBronies from Reddit
how about no
Gar Zz how about everybody has an opinion
Then see how they react to zyklon b.... FOR SCIENCE
Memerooney found the brony
Doubt even hot piranha solution can remove that.
forget that junk take the cocoa plant and make cocaine lol
ben smith that's the coca plant, not Cocoa
Profanity are you telling me that there are 2 different totally different plants that cocaine and chocolate comes from what a rip off
basically yeah. pretty sure if cocaine was in chocolate, we'd all be wired as shit.
Profanity I'm so disapointed I've spent pretty much all my life believing that it was the same plant learned something new
Everyone has those moments in their life.
You inconveniently dirtied your filter for us, how sweet :)
You should start a series where you make chemicals used in cool chemistry projects from household products. I'm in Highschool and find Chemistry interesting (even though it's not a field I'm probably going into) and I like to try different projects.
Especially with the addition of your shop allowing for easier access to cheap Chemistry
@@camoman619 You could have never predicted how far we have come...
Wow, I had to extract Theobromine in uni a couple of weeks ago. My prep we were given took WAY longer, produced a LOT more waste and the yield was WAY lower.
Damn, if should have followed your method lol
Awesome stuff
The new white background is pretty nice!
I'm in love with the cocoa