At 3:16 it looks like one of our sources got cut off. It should read: The American Journal of Psychiatry Hey, while you're here, thanks for watching and have a nice day :)
Would have been even better if you covered how CBD counteract the intoxicating effect of THC on the brain, and how it reduces memory impairment and its anxiolytic effects. For more in-vitro and in-vivo studies, take a look at Cannabinoids and the Brain by Linda A. Parker, MIT Press. 2018.
for bone issues yes for the CBD oil works for the other stuff you talked about medical cannabis works stupid people like you need to understand medical cannabis contains THC and iditos like you making these types of vids helps keep cannabis illegal so youtubers who smoke cannabis might end up losing their medication why do you want people like professor weed to lose their medication because medical cannabis might be the reason he functions since him being alive somewhat surprising since he decided to drink scotch after taking xanex i know the hospitals are bankrupt and i doubt that you care about that but would you rather people smoke cannabis with THC or take xanex that is extremely addictive and might take it with scotch because the xanex makes them feel normal the cannabis saved professor weed that and maybe shrooms and the illegal substances that work better then any big pharma medication
@@Q269 except that CBD oil gets used to help out bone issues sometimes a few other things like mild insomnia again for that it depends on the person when people talk about medical marijuana they are talking about THC but idiots that want to make cannabis illegal pretend that CBD gets talked about the green cards are for THC and what everybody tries to make legal because anybody with half a brain understands CBD tends to not be enough but better then nothing unless some idiot trying to get people to buy the useless big pharma drugs that cause more health issues and do about the same as CBD so where is your research about that and i learnt a good amount of this from professor weed he might tell me where i might be off on this because i havent listened to his pot talks in awhile but i am sure the base to this pretty accurate
My dad got addicted to pain medication after a back injury and a traumatic back surgery. It was a horrible time in all of our family. He started taking CBD tincture, which was recommended to him by a friend who was a practicing doctor, and after six months my dad was completely off of pain medication. A couple months after that he stopped taking the CBD tincture and it was truly like a miracle. I got my Dad back. I will forever be in support of CBD as a medical aid because I’ve seen how life changing it can be.
might want to mention maintenance dosages to him ... cannabis as a preventative medication helps with severe disease but also via those same metabolic pathways in our cells prevents those very diseases ... for severe disease or ailments you ingest more ... for maintenance dose it is less ingested over time ... the endocananbinoid system that is being targeted with those cannabis metabolites can be augmented with essential fatty acids too ... omega three becomes endocannabinoids in our cells ... that is how we make them ... ingesting cannabis phytocananbinoids mimics that
I completely understand, seeing something like that in your life will have a strong impact. It's still just an anecdote and thus won't convince me, but it doesn't matter. I'm just happy that your dad is doing well! :)
Perhaps it was the CBD, but perhaps it was simply your fathers will to get off pain medication. That's the problem with anecdotal stories. We have no way of knowing what actually happened. That's why we need good stron studies, which sadly we do not have yet. So at least from a medical point of view we can't say CBD is really effective at very much.
It might have been worth spending 20 seconds explaining WHY there's no good studies on CBD in the USA. Until not long ago, it was really hard to run those trials. CBD is still regulated Schedule 1, and until 2018 was treated as harshly as Heroin, LSD, Ecstasy, and the dreaded killer drug THC. Getting permission to even study it was near impossible.
all while cannabinoid drugs have been a thing since mid 80's starting with Marinol . why they did not make real THC legal at the same time is well , who knows ?
It's because it was nearly impossible to do studies that were hoping to test for positive side effects from CBD or THC usage. It was basically illegal and just impossible to do studies with because the powers that be had already decided that we weren't allowed to use that plant because it could have interfered in a white man's ability to get rich. And they just don't allow that to happen...
@@larrytate1657 In America only though, where it is still frowned upon in a lot of states and getting funding from anyone to do the research when looking for positive effects of use is still nearly impossible because people who fund studies usually want to benefit financially from the research. Pharmaceutical companies don't want people benefiting from a drug that can not be patented and owned. Some people say that CBD on its own is not as effective as CBD with even small quantities of THC added so that could be another factor.
Just wanted to mention : I have a brother with a bad mental condition which trigerred multiple epileptic seizures per day. After starting on a hemp oil treatment, his seizures have decreased by 100x. This has given his brain a respite and has improved his quality of life
everyone seems to want to pick apart at others medications while completely ignoring the fact that they are in a better state ... that is so great that your loved one found help regardless where it is from ... with proof like that any prohibitionists trying to shame them can stick their head further into the muck and just stop breathing altogether . I've lost so much patience dealing with people who outright ignore cannabis as a medicine and make up crazy laws limiting people from it etc...
Why aren’t large scale studies being done? Are there regulatory barriers? Or is it a lack of interest? It seems crazy how it’s blown up so much based on pure anecdotes
Yeah, in the US at least, cannabis has been severely regulated, comparable to stuff like heroin. This limited access, supply, and funding of cannabis research.
@@TheRustyLM The top 3 funders of medical research fund nearly 60% of all research, are the US, China, and Japan, if none of them are interested in the research then there is a good chance no one will bother with it. There are only even 2 EU members(and 2 non-EU European states) in the top 10, so they really need to put more funding into medical research.
Hey can you do a video on all the different types of Water that people claim have health benefits like high PH water and things like that that? Or the black water?
I would love for more trials to be done with CBD. It has helped me in a limited way with pain and anxiety, but I know that type of anecdotal evidence isn't worth much in the medical community. It would be nice to see more clinical trials and less peddling of it without any studies.
I found CBD excellent for inflammation reduction if taken at a high dose. It works even better than ibuprofen. However, as noted, it is expensive. I have many illnesses, take many medications, and wonder about CBD's possible effects on the liver. It is a shame that more studies have not been done. I don't take ibuprofen regularly because of liver, kidney, and stomach issues. For now, I wait for the trials.
CBD supports COX/ LOX and does not harm liver or kidneys as a result ... ibuprofen is a COX block , tis how it works via blocking that pathway ... that stops pain but is toxic to liver ... phytocannabinoids actually support those pathways and make them perform better not blocking in any way . people have found way better results ingesting whole plant formulas such as FECO/ RSO ... CBD alone is not all that and as an example ... adding a few mg of THC to any CBD formula makes that 75% more effective ... ingest whole plant or whole plant formulas and you receive even way more information for your cells to do things with ( molecular information being metabolized into realization()
CBD 10mg/day has been a major help to reduce my pain, eczema, and pain related lethargy. Just a personal attestation from someone who experienced a major stress-induced autoimmune condition some years ago.
The reason we can't just trust the many anecdotal reports like yours is that we already know the placebo effect is present and can be very strong, the effectiveness of the drug in question has to compare favorably in double blind trials with a significant sample size funded by groups with no conflict of interest.
@@ospritely8144 when I went off CBD for a couple weeks, my condition deteriorated; the pain and other symptoms returned, big time. I had to go back on CBD.
@@davioustube I'm the same in that I was barely able to function and CBD absolutely saved me and when I went off it every thing got worse again... But I don't think that means we can rule out placebo! I do think that it's plausible that large trials would confirm its good for some types of pain/inflammation because the small trials said that and that seems to fit the anecdotes of where it works but equally it may just be that our bodies should be doing something but don't, then we take the CBD and the placebo effect gets our bodies doing the thing they should always have been doing anyway. I stopped taking CBD a couple of times because I figured it basically had to be a placebo but then my body just stopped working eventually so I've gone back on every time and I'll continue to buy it. I feel a little silly buying something I think may be a placebo but it's a heck of a lot better than the alternative! Point is I don't think we can know, for sure, it isn't a placebo just because it works for us.
@@StephenRichmond89 That's taking things a bit far and you are unnecessarily doubting your own experience in the face of scientific inquiry. We all welcome scientific studies to understand what works in the aggregate for which conditions. And, these studies are just preliminary. At the same time, I hope that scientific person and even people in general would be curious or at least considerate that CBD has been demonstrated effective for me and others in particular. Autoimmune issues are complex and have a psychological component; but, when it's the difference between unbearable pain and a workable life, there has to be some dignity and respect for that.
@@davioustube The thing is, contrary to what you believe, you're story doesn't demonstrate that you aren't in fact 'victim' of the placebo effect, since you knew full well you weren't taking it anymore when you stopped doing so. It's because the scientific community is well aware of this problem that we need well constructed double blind studies with large enough sample size. No one is saying you're not feeling the relief you get from taking CBD. But what we're saying is you can't know if it's because of an actual biological effect of the molecule, or if it's your brain being tricked. I know it's hard to believe, but human perception is an incredibly flawed way of understanding the universe.
Unfortunately, a big part of the reason we see so few studies on the benefits (or lack of) from CBD and/or THC is due to it being a Schedule I substance (though CBD made from Hemp was recently excluded from the Controlled Substances Act). For those that don't know, a Schedule I drug is considered to have both a high risk of abuse and no medicinal value. The problem this creates is that not only is it nearly impossible to get funding for research in this area, in many cases it's actually illegal. Let's hope in the near future congress either removes marijuana/THC/CBD from the controlled substances act, or at least reclassifies it into a different schedule so we can get some serious research going.
there is so much research that does not make it into mainstream news media ... did you know there are 40 or more cannabinoid drugs available to be prescribed from a doctor in America ? Started with Marinol in 1985 ... there too are botnanical drug substances made from living cannabis plants - Epidiolex and Sativex .... tat is real plant grown , then the actives are solvent extracted with grain alcohol to make tincture with .... all this while the real cannabis plant in parliament remains a schedule one drug no medical value whatsoever ... whoever trusts this has head so deep in the sand I'm surprised they can even take a breath of fresh air. cannabis was even renamed to marijuana so as to make it illegal that way ... in reality the cannabis plant is not even illegal only marijuana is ... when trying to find any real botanical info on a marijuana plant it is impossible to do so - try as you will = phylum of marijuana / taxonomy of marijuana ... 100% political wording to make it illegal
Also most of the benefits seem to show themselves in the form of Full Spectrum Oil's and Products that include the whole plant extract rather than CBD isolates
I'm probably going to stop spending money on CBD after hearing this. I was kind of on the fence, and the effect was minimal. I think I would be better off saving the money and spending it on more massages or legal cannabis edibles when they become available, to deal with pain and anxiety.
Personally, i think a pattern of evidence for the limitations of current broad "general study" *must affect All parties with little side effects* are becoming clearer. We probably don't have the detailed information for specific definition relative to individual reactions, especially given how many testing regimes & biomarkers are still being defined, refined & discovered. But the pattern that we all react specifically & individually to All Medical conditions & treatments is undeniable. An approach to medication that can better account for this & give standards for individual customisation that is more informed than the current trial & error would be redefining for the industry, life-saving, & life changing for the patients involved. If we could find relative testable signs & causalities for issues, side effects, we could drastically increase treatment effectiveness & efficiency.
That poor one transplant patient who felt no changes. I imagine that using other pain relief was limited - at least for a bit. Ouch! There's a THC medication here in Canada that's used often, Nabilone. I wish there was more research and avaliable regulated pharmaceuticals that use CBD and THC
Israel uses phytocannabinoid therapies in their hospitals fro years now ... they have used volcano vaporizers in there over 15 years now to treat heart conditions ... a few years ago the first medical dispensary of cannabis had 35% of their clientele as pediatrics
@@TheRustyLM In the Netherlands cannabis isn't legal, it's "allowed" as in we turn a blind eye to it. It is still a drug and if you have more than a minor amount of it you go to jail.
@@DarkAvador thank you. I wasn’t implying weed is legal in your country, only that your laws & medical system are more driven by science & health information, that there would be valuable studies. Here in USA, studies of weed here have been unlawful, therefore a paucity of data. I’m a nurse. In places with heavy marijuana use we are having more psychosis and cases of intractable vomiting.
@@mcozy333 Its a different chemical compound so I doubt it acts the exact same and the few studies I've seen on it say it acts different but with some similar effects. But given how few studies look at it I think there needs to be a lot more research on it.
@@falconJB THC-a as a carbon active form directs to cannabinoid type 2 receptors in the immunological system and the Mitochondria ... all of the Acidic form / carbon active phytocananbinoids metabolize as such .. only Decarboxylated / non acidic form / carbon neutral phytocannabinoids access cb1 receptors ( THC)
@@falconJB as to research ... we have only researched two cb receptors while elucidating to a third one however there are 300 cannabinoid receptors in all of our cells each capable of transporting and degrading a multitude of lipids from nature ( Diet) ... endocannabinoid system is our lipid transport system in our cells making biochemicals from them all the time ... predicited that 70 trillion cells make up ECS ... each cell that is part of metabolically active tissue is eCS ... each cell signals 15,000 biochemicals a second per cell to maintain the cell and connect to the other 70 trillion. those are cannabinoid messages ... each cannabinoid signal touches interior of cell 7 times before finalizing. access to all other cells is via TRPV1 and back cross talk ( lipid rafts) ... 7 trans membrane super family of receptors
I’m curious, why are there so many studies that do not have a control group? This, along with tiny sample sizes raises the question: are these studies worth doing in the first place? I honestly don’t know, but my guess is that ethics comes into play when it comes to studies without control groups.
www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=801.415 It is dangerous and has no medical benefit. The FDA doesn't allow it around sick people and only in extremely low levels in general as it causes irritation to mucus membranes and pulmonary edema.
I would love for there to be more studies on CBD and pain management. I have a connective tissue disorder that results in a lot of random pain. My doctor recommended I try one specific brand of CBD that has good testing standards, from the point of view of "it could help, and probably won't hurt." More or less the same way she suggested I take a D vitamin; nothing specific, but give it a try. I can't tell if the CBD helps or not, because I don't know what a good recommended dosage or schedule should be. Mostly, it just tastes really awful. XD
Generally CBD treats immunological based pains via cannabinoid type 2 receptors ... THC treats nerve related pain via cannabinoid type one receptors .. cb1 is central nervous system ... cb2 is immunological system CBD and THC are the same compound with one pyran ring difference in the two , which directs CBD to cb2 and thc to cb1 ....
What is the minimum amount of test participants to be considered an effective amount for a good trial (or, one that doesn't earn an eyeroll for ineffectiveness)?
does not help second the studies dont show possitive results it lands up same place as the cv injections they archive the studies in certain of the studies i follow on othr things it was round 20 to 40 k people
Why no mention of this study using the A Meta-Analysis and Meta-Regression methodology found good results for CBD pain mangment. "2019 Effects of Cannabinoid Administration for Pain: A Meta-Analysis and Meta-Regression" "When considering reductions in self-reported pain, we observed that cannabinoid administration was associated with a ‘medium-to-large’ (Cohen, 1988) pooled effect size across included studies. Importantly, cannabinoid administration was associated with statistically significant greater pain reduction than placebo administration, which yielded a ‘small-to-medium’ (Cohen, 1988) pooled effect size. Indeed, placebo administration has been shown to enhance expectations about pain reduction" "When considering cannabis’s effect on pain, our primary meta-analysis outcomes suggest that cannabinoids may represent a viable option regarding pain management and treatment- outperforming corresponding placebo conditions across included studies." This is extremely good evidence for pain management analysis including placebo testing.
I think it's great that you highlight that there is no scientific evidence backing CBD (yet). Hope for chronic pain and illness is great but not when it means lying to patients/consumers to possibly only produce a placebo effect while gladly taking their money.
Likely there will be larger scale studies. A few of the things have enough evidence to warrant a further look. But one of the main things to note is the effective dosage in the studies is far far higher than what is currently available.
Well, considering the high variety in tested dosage, the wide range of effects, and the half effectiveness in some of these groups, that would indicate a placebo to me. Even so, if good studies show a minor effect, or effectiveness in some people - that still may be noise in the data. Repeat studies could cancel it out in systematic analysis; wouldnt be the first either.
no studies cuz there was no profit in just running tests with cbd on a grand scale??? only tested on an fda approved pharma med based on cbd??? very very suspicous
cannabinoid drugs have been a thing in pharma about 40 years now starting with Marinol... we have known how medical cannabis is for a long time while studies only benefited from smoke research ( NIDA) to support prohibition
Can you do a video on palmitoylethanolamide for treating chronic pain?.... There's soooo many studies on it but I'm not sure how to interpret them all.
I've been researching that one and have found that the anti oxidants effects of phytocannabinoids in our cells is directly linked to that Specific pathway .
here is a direct link, just reading this one this morning and then seen your post www.researchgate.net/publication/342219178_Palmitoylethanolamide_and_Related_ALIAmides_Prohomeostatic_Lipid_Compounds_for_Animal_Health_and_Wellbeing
here is the title without link if youtube decides to block the live link- Palmitoylethanolamide and Related ALIAmides: Prohomeostatic Lipid Compounds for Animal Health and Wellbeing
@@mcozy333 I've read at least 20+ studies so far on PEA... I stumbled on it a few years ago when I was researching which med worked better for sciatica (amitriptyline vs gabapentin) but study after study claimed PEA was better than either of those... My dad was in so much pain that I caved and bought some for him to try out... It was a slow reduction in pain for him- so much so that he didn't think it was helping so stopped it... But once he stopped it the pain came roaring back and he opted to start it again... So he takes it every day now. What I was shocked by (and still find hard to believe) is that it has a NNT (number needed to treat) of 1.5! Well, it has a NNT of 1.5 for chronic nerve pain anyway. But if it's that effective why don't doctors recommend it in the USA? It makes me feel like I'm missing something. Which is why I'd LOVE to see a video about it on Healthcare Triage!
Y'all being starky in the comments but absence of evidence is not evidence of absence. I could do a 5 person "study" to determine that broccoli is good for me, but the fact that that is low quality evidence does not mean eating broccoli is just a placebo. All of this is encouraging and should be studied further before making conclusions.
But thats not how it works in biologic/medical research. We humans are complex systems, and testing anything requires you isolate the test to your best of abilities. There are SO many small scale tests that showed promise, but were of little value in the long run. Heck, there is even bais in many of these small studies, because a smaller study with no result (or no positive result) is often thrown out instead of published. Besides, in the medical world, evidence based practice is used. EBP means, you need a lot of research before a treatment becomes the standard. Its not until something new and well studied comes along that it replaced the previous standard treatment. Preferably you would want to set up CBD vs mainstream painkiller vs placebo, for a randomized group with blind researchers. Having that knowledge is key. For example, take morphine: we know safe dosages, when know in which cases it can be used effectively, we know its side effects. We know the lethal dosage, we know how long it stays in the body, we know how the effects build up, etc. We have fast acting and long lasting morphine products. Given the wide variety of tested dosages in the studies mentioned in the video - its not even known which dosage is appropriate. Your broccoli example is much easier: test it for its components. Research the vitamines in your data base and you get a good picture of the nutritional value of broccolli. The research has already been done in that way. You just dont have it for CBD.
I could do a 5 person "study" to determine that eating batteries is good for me, but the fact that that is low quality evidence does not mean eating batteries is just a placebo.
While we wait for peer reviewed studies, it might be worth looking at anecdotal evidence. For example, it took us decades to evidence cigarettes cause cancer, though we did have 10+ MILLION anecdotal examples. We are yet to prove that vaping is the best way to quit cigarettes, but we do have 3+ Million anecdotal examples. We've now shown CBD helps limit seizures but before that evidence, we did have 10,000+ anecdotal examples. We are yet to prove a benefit of CBD/THC for Parkinsons, yet I still remember the documentary on the BBC in the 1980's where a guy with Parkinsons and immense shakes that essentially incapacitated him, partook in some weed and ten minutes later he is riding a bicycle down the road. There are videos on youTube showing CBD controling parkinson shakes within 2-3 minutes. The anecdotal evidence for many alleged benefits is pretty overwhelming. Praying is a placebo effect. Here we have chemical effect and benefit which can be studied and can be evidenced. As a reminder, President Biden has the authority to declassify any drug of his choice WITHOUT need of Congress. Same for Obama who stated he was for decriminalization during campaigning, but then did nothing. The pharma industry would lose tens of billions of dollars each year as people drop their opiod and benzo prescriptions and transition to CBD (/THC). Just a coincidence I'm sure.
@@OrthodoxAtheist we can’t prove if praying is placebo. However yes you’re right Biden has done nothing to help this country in over 50 years in govt. And ironic enough the reason CBD is even legal is thanks to Trumps 2017 Farm Bill.
4:57 All studies so far, sound like they are a result of placebo effects. The high variety in dosage, the wide range of effects, and in some groups roughly half of them working. If they take a small bottle of concentrated H2O (not to be confused with H2O2), they may experience similar effects.
@@samevans1289 You can buy the concentrated H2O in most placebo stores actually. Sometimes homepathic store also carry a few bottles. Tends to be stored in unlabled bottles in the back.
I found the "2019 Effects of Cannabinoid Administration for Pain: A Meta-Analysis and Meta-Regression" Study that seems to provide the opposite results. "When considering reductions in self-reported pain, we observed that cannabinoid administration was associated with a ‘medium-to-large’ (Cohen, 1988) pooled effect size across included studies. Importantly, cannabinoid administration was associated with statistically significant greater pain reduction than placebo administration, which yielded a ‘small-to-medium’ (Cohen, 1988) pooled effect size. Indeed, placebo administration has been shown to enhance expectations about pain reduction" "When considering cannabis’s effect on pain, our primary meta-analysis outcomes suggest that cannabinoids may represent a viable option regarding pain management and treatment- outperforming corresponding placebo conditions across included studies."
@@nathanmitchell7961 Apart form the topic, as a criteria for good inclusion criteria... is including a 1988 study in a 2019 meta still valid information? If there is no better, or insufficient available studies since 2000, I would consider including older studies... but this would make my scrutinize this meta analysis a bit more.
I use CDB oil and I use a small dose, It doesn't stop all the pain but it takes most of the edge off to continue with my normal activities. I believe if I try more to stops all pain then there there is something wrong because most of my knee cartilage is mostly gone. Pain is your red line to prevent serious injuries. Common sense and science are never perfect but should be used together as partners to be the answer.
not only does it mask pain somewhat the lipids actually provide more plasticity to cells too ... a physical lipid adding more mass to cells increases the plasticity of the cells leading to capability of more movement in the entire body etc....
Because there are plenty of other kinds of studies other than randomized controlled trials and researchers are limited by all kinds of factors beyond their control like people dropping out of studies, funding, etc. Sometimes they just can't find many participants who fit the criteria for inclusion.
It can still be helpful to the scientific community to publish small studies, because your results can help other scientists design and decide whether to conduct larger studies. If a small study shows interesting results, those results can be investigated further in larger studies.
Preliminary research can encourage more RCTs later. If you want funding for an RCT it's handy to be able to talk about that stuff and also it might give you some ideas about pitfalls
Deploarization induce suppression of excitation of neurotransmitter release ( DSE) ... cannabinoids are second messengers acting in retrograde sequences to provide cells pro homeostasis response . phytocannabinoids are non selective metabolites that express direct into cb receptors
Well one creates more carbon pollution than all of New Zealand, and the other helps people get help for medical issues without the horrible side effects of typical pharmaceuticals. I have personal experience backing that up. However, both are far too expensive for the average person to even think about being able to use to improve their life. All the CBD bullshit you buy at your corner store is so diluted you don’t even get anything for paying through the roof. You have to buy it in concentrate form, but again costs an arm and a leg
@@OrthodoxAtheist Yeah there is a small number of things that we know it does actually work for, even people with those it frequently fails to have an effect and we don't know why, but 99% of people that use it probably get little to nothing more than a placebo, but we need more large scale studies so we can find the things and people that it does work for and why it works. Also, it is so sad her seizures led to her death last year, hopefully one day with more research we can figure out exactly why it helps those it does make even better medicine for them.
I would like to know your thoughts on Delta 8 THC products. Claims are it gives a "good high" like Delta 9 THC but without the psychoactive effects. Any studies on it in regards to pain, anxiety, etc?
Saw a display for CBD in the window of a vape shop recently that said something like "It's supposed to be good for this stuff!" and a whole ton of ailments. Snake oil indeed, at least until the science comes in!
I think you could do more on this subject. Neither of your videos have talked at all about how THC and CBD interact with the endocannabinoid system. I understand that there is little research available, but your reticence to even discuss these topics with enthusiasm speaks volumes about the entrenchment of moral panic. I imagine you don't consider yourself bias, but ask yourself: would you be doing this same debunking if we were talking about some other fringe medicine?
This is a good point. I usually reference Meat and Vegetables, as they work similarly to offset each others negative effects and work in tandem. By isolating one CBD and away from Full Spectrum/Whole pant extracts we see less effects.
This. Any video on the topic of CBD which doesn't mention the near-miraculous benefit many have experienced in supression of seizures, is an incomplete and questionable video. Zero mention of "Charlotte's Web". Disappointing indeed.
@@OrthodoxAtheist exactly cannabis's (and particularly CBD's) effect on seizures is the entire reason it first got legalized fir medical usage and led to the entire legal industry that exists now. To gloss over it completely shows a bias that is very disappointing.
I'm half way through this video and all I've learned is that you guys make videos without actual data. What is the fucking point of this video, if every study you're reviewing is less than 100 people? This is absolute bullshit clickbait.
At 3:16 it looks like one of our sources got cut off. It should read: The American Journal of Psychiatry
Hey, while you're here, thanks for watching and have a nice day :)
You have a nice day too
Would have been even better if you covered how CBD counteract the intoxicating effect of THC on the brain, and how it reduces memory impairment and its anxiolytic effects. For more in-vitro and in-vivo studies, take a look at Cannabinoids and the Brain by Linda A. Parker, MIT Press. 2018.
for bone issues yes for the CBD oil works for the other stuff you talked about medical cannabis works
stupid people like you need to understand medical cannabis contains THC and iditos like you making these types of vids helps keep cannabis illegal so youtubers who smoke cannabis might end up losing their medication
why do you want people like professor weed to lose their medication because medical cannabis might be the reason he functions since him being alive somewhat surprising since he decided to drink scotch after taking xanex
i know the hospitals are bankrupt and i doubt that you care about that but would you rather people smoke cannabis with THC or take xanex that is extremely addictive and might take it with scotch because the xanex makes them feel normal
the cannabis saved professor weed that and maybe shrooms and the illegal substances that work better then any big pharma medication
#Research is doing a lot of fucking heavy lifting here, dude. The entire video is just saying there's no actual study. What the hell; why even bother?
@@Q269 except that CBD oil gets used to help out bone issues sometimes a few other things like mild insomnia again for that it depends on the person
when people talk about medical marijuana they are talking about THC but idiots that want to make cannabis illegal pretend that CBD gets talked about the green cards are for THC and what everybody tries to make legal because anybody with half a brain understands CBD tends to not be enough but better then nothing
unless some idiot trying to get people to buy the useless big pharma drugs that cause more health issues and do about the same as CBD
so where is your research about that and i learnt a good amount of this from professor weed
he might tell me where i might be off on this because i havent listened to his pot talks in awhile but i am sure the base to this pretty accurate
My dad got addicted to pain medication after a back injury and a traumatic back surgery. It was a horrible time in all of our family. He started taking CBD tincture, which was recommended to him by a friend who was a practicing doctor, and after six months my dad was completely off of pain medication. A couple months after that he stopped taking the CBD tincture and it was truly like a miracle. I got my Dad back. I will forever be in support of CBD as a medical aid because I’ve seen how life changing it can be.
might want to mention maintenance dosages to him ... cannabis as a preventative medication helps with severe disease but also via those same metabolic pathways in our cells prevents those very diseases ... for severe disease or ailments you ingest more ... for maintenance dose it is less ingested over time ... the endocananbinoid system that is being targeted with those cannabis metabolites can be augmented with essential fatty acids too ... omega three becomes endocannabinoids in our cells ... that is how we make them ... ingesting cannabis phytocananbinoids mimics that
I completely understand, seeing something like that in your life will have a strong impact. It's still just an anecdote and thus won't convince me, but it doesn't matter. I'm just happy that your dad is doing well! :)
@@smirbelbirbel look up your endocannabinoid system
Stop lying.
Perhaps it was the CBD, but perhaps it was simply your fathers will to get off pain medication. That's the problem with anecdotal stories. We have no way of knowing what actually happened. That's why we need good stron studies, which sadly we do not have yet. So at least from a medical point of view we can't say CBD is really effective at very much.
It might have been worth spending 20 seconds explaining WHY there's no good studies on CBD in the USA. Until not long ago, it was really hard to run those trials. CBD is still regulated Schedule 1, and until 2018 was treated as harshly as Heroin, LSD, Ecstasy, and the dreaded killer drug THC. Getting permission to even study it was near impossible.
all while cannabinoid drugs have been a thing since mid 80's starting with Marinol . why they did not make real THC legal at the same time is well , who knows ?
Good points
So America is the only country where we run these kinds of studies?
@@gyozakeynsianism Cannabinoid science has been ongoing in countries other than America ... it is taking off everywhere now
@@mcozy333 That's my point. The OP is ignoring the rest of the world.
Blown away by the fact there isn't more research done on CBD as a replacement therapy for opioids.
It's because it was nearly impossible to do studies that were hoping to test for positive side effects from CBD or THC usage. It was basically illegal and just impossible to do studies with because the powers that be had already decided that we weren't allowed to use that plant because it could have interfered in a white man's ability to get rich. And they just don't allow that to happen...
@@jodyknight CBD has been federally legal since 2017 Trumps Farm Bill. They could’ve at least studied CBD isolate over the last nearly 5 years.
@@larrytate1657 In America only though, where it is still frowned upon in a lot of states and getting funding from anyone to do the research when looking for positive effects of use is still nearly impossible because people who fund studies usually want to benefit financially from the research. Pharmaceutical companies don't want people benefiting from a drug that can not be patented and owned. Some people say that CBD on its own is not as effective as CBD with even small quantities of THC added so that could be another factor.
Just wanted to mention : I have a brother with a bad mental condition which trigerred multiple epileptic seizures per day. After starting on a hemp oil treatment, his seizures have decreased by 100x. This has given his brain a respite and has improved his quality of life
everyone seems to want to pick apart at others medications while completely ignoring the fact that they are in a better state ... that is so great that your loved one found help regardless where it is from ... with proof like that any prohibitionists trying to shame them can stick their head further into the muck and just stop breathing altogether . I've lost so much patience dealing with people who outright ignore cannabis as a medicine and make up crazy laws limiting people from it etc...
@@mcozy333 i agree with you 1000 percent the statistics don't lie.
@@xtc0 I feel so shameful making that post ... it is what it is and my patience has left thebuilding
Maybe if cannabis wasn't a Schedule 1 drug we could find some real reliable studies then!
the Gov has them, - cannabinoid search pubmed.ncbi.nlm.nih.gov/?term=cannabinoid
What he said.
Why aren’t large scale studies being done? Are there regulatory barriers? Or is it a lack of interest? It seems crazy how it’s blown up so much based on pure anecdotes
Regulatory barriers. It's _really_ difficult to get clearance to do proper studies on CBD owing to the panic around THC.
Yeah, in the US at least, cannabis has been severely regulated, comparable to stuff like heroin. This limited access, supply, and funding of cannabis research.
Are we to believe that European researchers have never looked at CBD/THC???
I'm suprised Canada hasn't studied this more
@@TheRustyLM The top 3 funders of medical research fund nearly 60% of all research, are the US, China, and Japan, if none of them are interested in the research then there is a good chance no one will bother with it. There are only even 2 EU members(and 2 non-EU European states) in the top 10, so they really need to put more funding into medical research.
I hope the CBD information continues to get passed on to the public, thank you for sharing this!
Hey can you do a video on all the different types of Water that people claim have health benefits like high PH water and things like that that? Or the black water?
Afro-american water*
It seems crazy that so many people are taking something and research funds are so nonexistent that we only test people 7 at a time.
I would love for more trials to be done with CBD. It has helped me in a limited way with pain and anxiety, but I know that type of anecdotal evidence isn't worth much in the medical community. It would be nice to see more clinical trials and less peddling of it without any studies.
I found CBD excellent for inflammation reduction if taken at a high dose. It works even better than ibuprofen. However, as noted, it is expensive. I have many illnesses, take many medications, and wonder about CBD's possible effects on the liver. It is a shame that more studies have not been done. I don't take ibuprofen regularly because of liver, kidney, and stomach issues. For now, I wait for the trials.
CBD supports COX/ LOX and does not harm liver or kidneys as a result ... ibuprofen is a COX block , tis how it works via blocking that pathway ... that stops pain but is toxic to liver ... phytocannabinoids actually support those pathways and make them perform better not blocking in any way . people have found way better results ingesting whole plant formulas such as FECO/ RSO ... CBD alone is not all that and as an example ... adding a few mg of THC to any CBD formula makes that 75% more effective ... ingest whole plant or whole plant formulas and you receive even way more information for your cells to do things with ( molecular information being metabolized into realization()
@@mcozy333 adding thc also scrambles your mind though so.
CBD 10mg/day has been a major help to reduce my pain, eczema, and pain related lethargy. Just a personal attestation from someone who experienced a major stress-induced autoimmune condition some years ago.
The reason we can't just trust the many anecdotal reports like yours is that we already know the placebo effect is present and can be very strong, the effectiveness of the drug in question has to compare favorably in double blind trials with a significant sample size funded by groups with no conflict of interest.
@@ospritely8144 when I went off CBD for a couple weeks, my condition deteriorated; the pain and other symptoms returned, big time. I had to go back on CBD.
@@davioustube I'm the same in that I was barely able to function and CBD absolutely saved me and when I went off it every thing got worse again... But I don't think that means we can rule out placebo! I do think that it's plausible that large trials would confirm its good for some types of pain/inflammation because the small trials said that and that seems to fit the anecdotes of where it works but equally it may just be that our bodies should be doing something but don't, then we take the CBD and the placebo effect gets our bodies doing the thing they should always have been doing anyway.
I stopped taking CBD a couple of times because I figured it basically had to be a placebo but then my body just stopped working eventually so I've gone back on every time and I'll continue to buy it. I feel a little silly buying something I think may be a placebo but it's a heck of a lot better than the alternative! Point is I don't think we can know, for sure, it isn't a placebo just because it works for us.
@@StephenRichmond89 That's taking things a bit far and you are unnecessarily doubting your own experience in the face of scientific inquiry. We all welcome scientific studies to understand what works in the aggregate for which conditions. And, these studies are just preliminary. At the same time, I hope that scientific person and even people in general would be curious or at least considerate that CBD has been demonstrated effective for me and others in particular. Autoimmune issues are complex and have a psychological component; but, when it's the difference between unbearable pain and a workable life, there has to be some dignity and respect for that.
@@davioustube The thing is, contrary to what you believe, you're story doesn't demonstrate that you aren't in fact 'victim' of the placebo effect, since you knew full well you weren't taking it anymore when you stopped doing so. It's because the scientific community is well aware of this problem that we need well constructed double blind studies with large enough sample size.
No one is saying you're not feeling the relief you get from taking CBD. But what we're saying is you can't know if it's because of an actual biological effect of the molecule, or if it's your brain being tricked. I know it's hard to believe, but human perception is an incredibly flawed way of understanding the universe.
Unfortunately, a big part of the reason we see so few studies on the benefits (or lack of) from CBD and/or THC is due to it being a Schedule I substance (though CBD made from Hemp was recently excluded from the Controlled Substances Act). For those that don't know, a Schedule I drug is considered to have both a high risk of abuse and no medicinal value. The problem this creates is that not only is it nearly impossible to get funding for research in this area, in many cases it's actually illegal. Let's hope in the near future congress either removes marijuana/THC/CBD from the controlled substances act, or at least reclassifies it into a different schedule so we can get some serious research going.
there is so much research that does not make it into mainstream news media ... did you know there are 40 or more cannabinoid drugs available to be prescribed from a doctor in America ? Started with Marinol in 1985 ... there too are botnanical drug substances made from living cannabis plants - Epidiolex and Sativex .... tat is real plant grown , then the actives are solvent extracted with grain alcohol to make tincture with .... all this while the real cannabis plant in parliament remains a schedule one drug no medical value whatsoever ... whoever trusts this has head so deep in the sand I'm surprised they can even take a breath of fresh air. cannabis was even renamed to marijuana so as to make it illegal that way ... in reality the cannabis plant is not even illegal only marijuana is ... when trying to find any real botanical info on a marijuana plant it is impossible to do so - try as you will = phylum of marijuana / taxonomy of marijuana ... 100% political wording to make it illegal
Also most of the benefits seem to show themselves in the form of Full Spectrum Oil's and Products that include the whole plant extract rather than CBD isolates
I'm probably going to stop spending money on CBD after hearing this. I was kind of on the fence, and the effect was minimal. I think I would be better off saving the money and spending it on more massages or legal cannabis edibles when they become available, to deal with pain and anxiety.
My experience too. Placebo is real though, but once you figure out something really doesn't do what they say it does, the jig is up.
Personally, i think a pattern of evidence for the limitations of current broad "general study" *must affect All parties with little side effects* are becoming clearer.
We probably don't have the detailed information for specific definition relative to individual reactions, especially given how many testing regimes & biomarkers are still being defined, refined & discovered.
But the pattern that we all react specifically & individually to All Medical conditions & treatments is undeniable. An approach to medication that can better account for this & give standards for individual customisation that is more informed than the current trial & error would be redefining for the industry, life-saving, & life changing for the patients involved.
If we could find relative testable signs & causalities for issues, side effects, we could drastically increase treatment effectiveness & efficiency.
That poor one transplant patient who felt no changes. I imagine that using other pain relief was limited - at least for a bit. Ouch! There's a THC medication here in Canada that's used often, Nabilone. I wish there was more research and avaliable regulated pharmaceuticals that use CBD and THC
I'm suprised this hasn't been studied more in countries where cannabis has been legal for awhile now with a bigger sample size
Exactly! Portugal & Netherlands, I would expect they’d have data that was significant.
Those countries don't spend money on medical research.
Israel uses phytocannabinoid therapies in their hospitals fro years now ... they have used volcano vaporizers in there over 15 years now to treat heart conditions ... a few years ago the first medical dispensary of cannabis had 35% of their clientele as pediatrics
@@TheRustyLM In the Netherlands cannabis isn't legal, it's "allowed" as in we turn a blind eye to it. It is still a drug and if you have more than a minor amount of it you go to jail.
@@DarkAvador thank you.
I wasn’t implying weed is legal in your country, only that your laws & medical system are more driven by science & health information, that there would be valuable studies.
Here in USA, studies of weed here have been unlawful, therefore a paucity of data.
I’m a nurse. In places with heavy marijuana use we are having more psychosis and cases of intractable vomiting.
Better than your previous attempts at tackling this topic. Though your dislike for it is still quite intense.
Yea i noticed this too.
I really wish we could have more trials on this stuff, it would also be great if we had more THCa studies.
in our bods THC-a acts exactly like CBD
@@mcozy333 Its a different chemical compound so I doubt it acts the exact same and the few studies I've seen on it say it acts different but with some similar effects. But given how few studies look at it I think there needs to be a lot more research on it.
@@falconJB THC-a as a carbon active form directs to cannabinoid type 2 receptors in the immunological system and the Mitochondria ... all of the Acidic form / carbon active phytocananbinoids metabolize as such .. only Decarboxylated / non acidic form / carbon neutral phytocannabinoids access cb1 receptors ( THC)
@@falconJB as to research ... we have only researched two cb receptors while elucidating to a third one however there are 300 cannabinoid receptors in all of our cells each capable of transporting and degrading a multitude of lipids from nature ( Diet) ... endocannabinoid system is our lipid transport system in our cells making biochemicals from them all the time ...
predicited that 70 trillion cells make up ECS ... each cell that is part of metabolically active tissue is eCS ... each cell signals 15,000 biochemicals a second per cell to maintain the cell and connect to the other 70 trillion. those are cannabinoid messages ... each cannabinoid signal touches interior of cell 7 times before finalizing. access to all other cells is via TRPV1 and back cross talk ( lipid rafts) ... 7 trans membrane super family of receptors
I’m curious, why are there so many studies that do not have a control group? This, along with tiny sample sizes raises the question: are these studies worth doing in the first place? I honestly don’t know, but my guess is that ethics comes into play when it comes to studies without control groups.
Please do an episode on Ozone therapy!
www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=801.415
It is dangerous and has no medical benefit. The FDA doesn't allow it around sick people and only in extremely low levels in general as it causes irritation to mucus membranes and pulmonary edema.
I would love for there to be more studies on CBD and pain management. I have a connective tissue disorder that results in a lot of random pain. My doctor recommended I try one specific brand of CBD that has good testing standards, from the point of view of "it could help, and probably won't hurt." More or less the same way she suggested I take a D vitamin; nothing specific, but give it a try. I can't tell if the CBD helps or not, because I don't know what a good recommended dosage or schedule should be. Mostly, it just tastes really awful. XD
Generally CBD treats immunological based pains via cannabinoid type 2 receptors ... THC treats nerve related pain via cannabinoid type one receptors ..
cb1 is central nervous system ... cb2 is immunological system
CBD and THC are the same compound with one pyran ring difference in the two , which directs CBD to cb2 and thc to cb1 ....
I would like for you guys to add articles references in the description. It would help greatly. Thank you
What is the minimum amount of test participants to be considered an effective amount for a good trial (or, one that doesn't earn an eyeroll for ineffectiveness)?
Probably once you get into 4 digits.
does not help second the studies dont show possitive results it lands up same place as the cv injections they archive the studies in certain of the studies i follow on othr things it was round 20 to 40 k people
Depends on what variables you're interested in. Generally, a p value of less than 0.05 is sought after for clinical trials.
Why no mention of this study using the A Meta-Analysis and Meta-Regression methodology found good results for CBD pain mangment.
"2019 Effects of Cannabinoid Administration for Pain: A Meta-Analysis and Meta-Regression"
"When considering reductions in self-reported pain, we observed that cannabinoid administration was associated with a ‘medium-to-large’ (Cohen, 1988) pooled effect size across included studies. Importantly, cannabinoid administration was associated with statistically significant greater pain reduction than placebo administration, which yielded a ‘small-to-medium’ (Cohen, 1988) pooled effect size. Indeed, placebo administration has been shown to enhance expectations about pain reduction"
"When considering cannabis’s effect on pain, our primary meta-analysis outcomes suggest that cannabinoids may represent a viable option regarding pain management and treatment- outperforming corresponding placebo conditions across included studies."
This is extremely good evidence for pain management analysis including placebo testing.
I think it's great that you highlight that there is no scientific evidence backing CBD (yet).
Hope for chronic pain and illness is great but not when it means lying to patients/consumers to possibly only produce a placebo effect while gladly taking their money.
Given existing results, is it likely that more bigger scale studies will be conducted, or are the results such that it does not look worthwhile?
Likely there will be larger scale studies. A few of the things have enough evidence to warrant a further look. But one of the main things to note is the effective dosage in the studies is far far higher than what is currently available.
Well, considering the high variety in tested dosage, the wide range of effects, and the half effectiveness in some of these groups, that would indicate a placebo to me.
Even so, if good studies show a minor effect, or effectiveness in some people - that still may be noise in the data. Repeat studies could cancel it out in systematic analysis; wouldnt be the first either.
If the US ever legalizes cannabis we will likely see larger studies.
@@falconJB Good point the current gray legal area definitely reduces the likelihood of a large study.
I mean, if you gave me 300 mg of cbd that would be too much and I wouldn't be able to sleep well.
no studies cuz there was no profit in just running tests with cbd on a grand scale??? only tested on an fda approved pharma med based on cbd??? very very suspicous
cannabinoid drugs have been a thing in pharma about 40 years now starting with Marinol... we have known how medical cannabis is for a long time while studies only benefited from smoke research ( NIDA) to support prohibition
Can you do a video on palmitoylethanolamide for treating chronic pain?.... There's soooo many studies on it but I'm not sure how to interpret them all.
I've been researching that one and have found that the anti oxidants effects of phytocannabinoids in our cells is directly linked to that Specific pathway .
here is a direct link, just reading this one this morning and then seen your post www.researchgate.net/publication/342219178_Palmitoylethanolamide_and_Related_ALIAmides_Prohomeostatic_Lipid_Compounds_for_Animal_Health_and_Wellbeing
here is the title without link if youtube decides to block the live link- Palmitoylethanolamide and Related ALIAmides:
Prohomeostatic Lipid Compounds for Animal
Health and Wellbeing
@@mcozy333 I've read at least 20+ studies so far on PEA... I stumbled on it a few years ago when I was researching which med worked better for sciatica (amitriptyline vs gabapentin) but study after study claimed PEA was better than either of those... My dad was in so much pain that I caved and bought some for him to try out... It was a slow reduction in pain for him- so much so that he didn't think it was helping so stopped it... But once he stopped it the pain came roaring back and he opted to start it again... So he takes it every day now. What I was shocked by (and still find hard to believe) is that it has a NNT (number needed to treat) of 1.5! Well, it has a NNT of 1.5 for chronic nerve pain anyway. But if it's that effective why don't doctors recommend it in the USA? It makes me feel like I'm missing something. Which is why I'd LOVE to see a video about it on Healthcare Triage!
Y'all being starky in the comments but absence of evidence is not evidence of absence. I could do a 5 person "study" to determine that broccoli is good for me, but the fact that that is low quality evidence does not mean eating broccoli is just a placebo. All of this is encouraging and should be studied further before making conclusions.
But thats not how it works in biologic/medical research. We humans are complex systems, and testing anything requires you isolate the test to your best of abilities. There are SO many small scale tests that showed promise, but were of little value in the long run. Heck, there is even bais in many of these small studies, because a smaller study with no result (or no positive result) is often thrown out instead of published.
Besides, in the medical world, evidence based practice is used. EBP means, you need a lot of research before a treatment becomes the standard. Its not until something new and well studied comes along that it replaced the previous standard treatment. Preferably you would want to set up CBD vs mainstream painkiller vs placebo, for a randomized group with blind researchers.
Having that knowledge is key. For example, take morphine: we know safe dosages, when know in which cases it can be used effectively, we know its side effects. We know the lethal dosage, we know how long it stays in the body, we know how the effects build up, etc. We have fast acting and long lasting morphine products.
Given the wide variety of tested dosages in the studies mentioned in the video - its not even known which dosage is appropriate.
Your broccoli example is much easier: test it for its components. Research the vitamines in your data base and you get a good picture of the nutritional value of broccolli. The research has already been done in that way. You just dont have it for CBD.
I could do a 5 person "study" to determine that eating batteries is good for me, but the fact that that is low quality evidence does not mean eating batteries is just a placebo.
answer........................could be.
So in the study where pain was lower in all groups, does that include the placebo group?
I can get the benefits of the placebo effect without spending 10 bux on a gummi bear.
Eat a Snickers
While we wait for peer reviewed studies, it might be worth looking at anecdotal evidence. For example, it took us decades to evidence cigarettes cause cancer, though we did have 10+ MILLION anecdotal examples. We are yet to prove that vaping is the best way to quit cigarettes, but we do have 3+ Million anecdotal examples. We've now shown CBD helps limit seizures but before that evidence, we did have 10,000+ anecdotal examples. We are yet to prove a benefit of CBD/THC for Parkinsons, yet I still remember the documentary on the BBC in the 1980's where a guy with Parkinsons and immense shakes that essentially incapacitated him, partook in some weed and ten minutes later he is riding a bicycle down the road. There are videos on youTube showing CBD controling parkinson shakes within 2-3 minutes. The anecdotal evidence for many alleged benefits is pretty overwhelming.
Praying is a placebo effect. Here we have chemical effect and benefit which can be studied and can be evidenced. As a reminder, President Biden has the authority to declassify any drug of his choice WITHOUT need of Congress. Same for Obama who stated he was for decriminalization during campaigning, but then did nothing. The pharma industry would lose tens of billions of dollars each year as people drop their opiod and benzo prescriptions and transition to CBD (/THC). Just a coincidence I'm sure.
@@OrthodoxAtheist we can’t prove if praying is placebo. However yes you’re right Biden has done nothing to help this country in over 50 years in govt. And ironic enough the reason CBD is even legal is thanks to Trumps 2017 Farm Bill.
I'm helping myself with Weedborn CBD. I think this is the best medicine.
4:57 All studies so far, sound like they are a result of placebo effects. The high variety in dosage, the wide range of effects, and in some groups roughly half of them working.
If they take a small bottle of concentrated H2O (not to be confused with H2O2), they may experience similar effects.
How does one get "concentrated" H2O?
@@samevans1289 You can buy the concentrated H2O in most placebo stores actually. Sometimes homepathic store also carry a few bottles.
Tends to be stored in unlabled bottles in the back.
I found the "2019 Effects of Cannabinoid Administration for Pain: A Meta-Analysis and Meta-Regression" Study that seems to provide the opposite results.
"When considering reductions in self-reported pain, we observed that cannabinoid administration was associated with a ‘medium-to-large’ (Cohen, 1988) pooled effect size across included studies. Importantly, cannabinoid administration was associated with statistically significant greater pain reduction than placebo administration, which yielded a ‘small-to-medium’ (Cohen, 1988) pooled effect size. Indeed, placebo administration has been shown to enhance expectations about pain reduction"
"When considering cannabis’s effect on pain, our primary meta-analysis outcomes suggest that cannabinoids may represent a viable option regarding pain management and treatment- outperforming corresponding placebo conditions across included studies."
@@nathanmitchell7961 Apart form the topic, as a criteria for good inclusion criteria... is including a 1988 study in a 2019 meta still valid information?
If there is no better, or insufficient available studies since 2000, I would consider including older studies... but this would make my scrutinize this meta analysis a bit more.
There should be mention of effect size more so than sample size in your videos. Just because a sample is small doesn't mean the effect was small.
I use CDB oil and I use a small dose, It doesn't stop all the pain but it takes most of the edge off to continue with my normal activities. I believe if I try more to stops all pain then there there is something wrong because most of my knee cartilage is mostly gone. Pain is your red line to prevent serious injuries. Common sense and science are never perfect but should be used together as partners to be the answer.
not only does it mask pain somewhat the lipids actually provide more plasticity to cells too ... a physical lipid adding more mass to cells increases the plasticity of the cells leading to capability of more movement in the entire body etc....
How does one publish a paper without controls? And why are these studies using tiny sample sizes without controls?
Because there are plenty of other kinds of studies other than randomized controlled trials and researchers are limited by all kinds of factors beyond their control like people dropping out of studies, funding, etc. Sometimes they just can't find many participants who fit the criteria for inclusion.
It can still be helpful to the scientific community to publish small studies, because your results can help other scientists design and decide whether to conduct larger studies. If a small study shows interesting results, those results can be investigated further in larger studies.
here is the database - cannabinoid pubmed.ncbi.nlm.nih.gov/?term=cannabinoid
Preliminary research can encourage more RCTs later. If you want funding for an RCT it's handy to be able to talk about that stuff and also it might give you some ideas about pitfalls
close to 30,000 peer reviews on cannabis type metabolites in that link
What about studies on CBD and Autism. I've heard there were studies underway to look into this but I haven't seen anything published yet.
Your episode did not state the mechanism of action for the Rx anti seizure CBD drug. That may have been informative🤷. Is it a anti inflammatory?
Probably because the mechanism by which it is anti-convulsant isn't known
Deploarization induce suppression of excitation of neurotransmitter release ( DSE) ... cannabinoids are second messengers acting in retrograde sequences to provide cells pro homeostasis response . phytocannabinoids are non selective metabolites that express direct into cb receptors
CBD is like Bitcoin, it can make a lot of money but what does it really do?
Correct.
Well one creates more carbon pollution than all of New Zealand, and the other helps people get help for medical issues without the horrible side effects of typical pharmaceuticals. I have personal experience backing that up.
However, both are far too expensive for the average person to even think about being able to use to improve their life. All the CBD bullshit you buy at your corner store is so diluted you don’t even get anything for paying through the roof. You have to buy it in concentrate form, but again costs an arm and a leg
@@Jenny-tm3cm Does it actually help people or is it just another way to pollute to get something that does nothing for 99% of the people that use it?
Reduces Charlotte's seizures from 1200 per month, to 2-3. (The world's largest library is at your fingertips.)
@@OrthodoxAtheist Yeah there is a small number of things that we know it does actually work for, even people with those it frequently fails to have an effect and we don't know why, but 99% of people that use it probably get little to nothing more than a placebo, but we need more large scale studies so we can find the things and people that it does work for and why it works.
Also, it is so sad her seizures led to her death last year, hopefully one day with more research we can figure out exactly why it helps those it does make even better medicine for them.
I would like to know your thoughts on Delta 8 THC products. Claims are it gives a "good high" like Delta 9 THC but without the psychoactive effects. Any studies on it in regards to pain, anxiety, etc?
Yes, it does. Whenever my spine is sore, my CBD gummies make my spine no longer sore.
I need to smoke on it
Saw a display for CBD in the window of a vape shop recently that said something like "It's supposed to be good for this stuff!" and a whole ton of ailments. Snake oil indeed, at least until the science comes in!
Potheads trying to make medical sense is like conservatives trying to make scientific sense.
Phoenix tears cured cancer be it placebo or not.
💙💙💙
I think you could do more on this subject. Neither of your videos have talked at all about how THC and CBD interact with the endocannabinoid system. I understand that there is little research available, but your reticence to even discuss these topics with enthusiasm speaks volumes about the entrenchment of moral panic. I imagine you don't consider yourself bias, but ask yourself: would you be doing this same debunking if we were talking about some other fringe medicine?
Do other fringe medicines have the same level of popularity?
This is a good point. I usually reference Meat and Vegetables, as they work similarly to offset each others negative effects and work in tandem. By isolating one CBD and away from Full Spectrum/Whole pant extracts we see less effects.
I'm disappointed by how little you went into seizures. I expected more from you
This. Any video on the topic of CBD which doesn't mention the near-miraculous benefit many have experienced in supression of seizures, is an incomplete and questionable video. Zero mention of "Charlotte's Web". Disappointing indeed.
@@OrthodoxAtheist exactly cannabis's (and particularly CBD's) effect on seizures is the entire reason it first got legalized fir medical usage and led to the entire legal industry that exists now. To gloss over it completely shows a bias that is very disappointing.
@@driverjayne someone you love has epilepsy?
First? I kinda hate myself for perpetuating it 😅
Damn you beat me by seconds
@@MarieC333 hah, both of us have Healthcare Triage's notifications on speed dial
in before all the butthurt CBD MLM distributors.
First one here 👆
Just kidding - I reloaded & I’m the second 😂
I'm half way through this video and all I've learned is that you guys make videos without actual data. What is the fucking point of this video, if every study you're reviewing is less than 100 people?
This is absolute bullshit clickbait.