It can cause significant drug interactions; therefore, therapeutic drug monitoring may be necessary to ensure optimal dosing and avoid any adverse effects or treatment failure.
Once a drug enters the body, the process of elimination begins (hepatic, biliary, and urinary). Elimination involves both metabolism and excretion. When considering the sequence of events leading up to the removal of the drug from the body, phase 2 metabolism usually occurs before then. It involves conjugation reactions that make the drug or phase 1 metabolites more suitable for excretion. However, if the metabolites from phase 1 are sufficiently polar, they can be excreted by the kidneys. Many phase 1 metabolites are still too lipophilic so phase 2 occurs. I hope that helps!
![Cytochrome P450 [Drug Interactions]](http://i.ytimg.com/vi/jPTgj4ogonA/mqdefault.jpg)
I hope you get lots more views and subscribers! Your content is top notch 💎
Appreciate you! Glad you found the channel 🥹
Thanks alot. I've been watching your series on Pharmacokinetics. It's very well explained and clear. Keep up the great work.
You make the concept crystal clear, pls make more pharmacology videos
Thank you so much. This is greatly educative 🎉
Literally the best and only video that helped me clear my concepts ❤.
Happy to hear it helped 🫶🏼
Amazing quality video!
Thank you!
Thanks you for your good very educative concept of metabolism
Happy to hear it was helpful!
How induction and inhibition affect drug dosing? (Prodrug or convectional drug)❤ Thank you so much
It can cause significant drug interactions; therefore, therapeutic drug monitoring may be necessary to ensure optimal dosing and avoid any adverse effects or treatment failure.
@@EKGScience thank you , I hope elimination will be soon, before my exam 🥰🌹❤
great work.
Very helpful
Thank you very 😊, what best book can I use to understand Pharmacology more?
Rang and Dale’s Pharmacology!
I bave questin- Which phase of metabolism is just before the elimination?
Once a drug enters the body, the process of elimination begins (hepatic, biliary, and urinary).
Elimination involves both metabolism and excretion.
When considering the sequence of events leading up to the removal of the drug from the body, phase 2 metabolism usually occurs before then. It involves conjugation reactions that make the drug or phase 1 metabolites more suitable for excretion.
However, if the metabolites from phase 1 are sufficiently polar, they can be excreted by the kidneys. Many phase 1 metabolites are still too lipophilic so phase 2 occurs.
I hope that helps!