V. Narry Kim (IBS and SNU) 1: microRNA Biogenesis and Regulation
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- Опубликовано: 21 июл 2024
- www.ibiology.org/genetics-and...
Part 1: microRNA Biogenesis and Regulation: Narry Kim takes us through the steps in microRNA biogenesis and explains the importance of microRNAs in regulating protein-coding mRNAs.
Part 2: Tailing in the Regulation of microRNA and Beyond: Modifications, such as uridylation, of the 3’ tail of both microRNAs and mRNAs can regulate RNA function by targeting it for degradation.
Talk Overview:
Small RNAs (~20-30 nucleotides in length) are found in many eukaryotes and act to guard against unwanted RNA such as viruses, transposons and mRNAs. One family of small RNAs called microRNAs regulates protein-coding mRNAs by binding to the 3’UTR and repressing translation or inducing mRNA decay. microRNAs play a key role in animal development and diseases such as cancer. In her first talk, Dr. Narry Kim gives a step-by-step description of the microRNA biogenesis pathway and the points at which the pathway can be regulated.
In her second talk, Kim focuses on the regulation of microRNA function. A small percentage of microRNAs are modified with untemplated nucleotides, usually A or U, added to their 3’ end or “tail”. “Tailing” can modify the microRNA function and in some cases it can act as a molecular switch resulting in developmental and pathological transitions. Kim’s lab was interested in knowing if tailing occurs on other RNAs such as mRNA. They developed a novel method to sequence the 3’ tail region of mRNA allowing them to measure polyA tail length and detect 3’ terminal modifications. Interestingly, they found widespread uridylation of mRNAs and showed that 3’ polyU modification serves to mark mRNA for decay.
Speaker Biography:
Narry Kim is Director of the Institute for Basic Science and a Professor at Seoul National University. Her lab studies RNA-mediated gene regulation using stem cells, early embryos, and neuronal cells as model systems.
Kim received her BA and MS degrees in microbiology from Seoul National University and her DPhil in biochemistry from Oxford University. She was a postdoctoral fellow at the University of Pennsylvania in Gideon Dreyfuss’ lab before returning to Seoul National University as a faculty member.
Kim is on the editorial board of a number of journals and has helped to organize many meetings on RNA biology. Her research and contributions to the life sciences community have been recognized with numerous awards including the Women in Science Award from L’Oreal-UNESCO (2008) and the Ho-Am Prize in medicine (2009). In 2014, Kim was elected to the Korean Academy of Science and Technology and the National Academy of Sciences USA.
Learn more about Dr. Kim’s research here: www.narrykim.org/en/ 
Наука
Thanksa whole lot for this. Got my Molecular Biology exam tomorrow and I am back here for the final touches.
김빛내리 교수님! 명강의 감사합니다! ❤
Thank you very much for making this interesting lecture available here.
Thank you very much for making this easy-to-understanding lecture.
Thanks for this great video. It's an excellent summary of the topic.
Excellent video
Professor Kim was my personal hero when I was an undergrad. Thank you so much for this video.
You prolly dont give a damn but does anybody know of a tool to log back into an Instagram account..?
I stupidly forgot the account password. I appreciate any tips you can offer me!
@Kairo Rayden instablaster :)
@Beau Coen Thanks so much for your reply. I got to the site through google and I'm waiting for the hacking stuff atm.
Seems to take quite some time so I will get back to you later with my results.
@Beau Coen it did the trick and I actually got access to my account again. I am so happy:D
Thanks so much you really help me out !
@Kairo Rayden you are welcome :)
Love you ma'am....nobody can explain like u
What's the point of having apical and basal junction when they are bound to be cleaved by Drosha and Dicer respectively? I can't fathom the fact they are being wasted. We once that introns were being wasted after alt. splicing, but that was not the case. I wonder, what happens to those cleaved nucleotides sequence?
Please, could you explain the function of piRNA?
Wonderful explanation
Mam really awesome and helpful vedio
Thank you
I loved it
very nice lecture
nice talk!
Excellent lecture. Thank you Dr Kim.
I have two questions.
1.what is intronic region of non coding gene?
2.what is mirtron in miRNA genes.
thankyou ibiology team
for 1, I guess it is the intron in any RNA-coding genes (lncRNA-, other miRNA-encoding), where pri-miRNA can be produced
Adam Li thanks for your time. do you mean RNA coding genes also have exons and introns?
mature RNAs are also transcribed from their coding genes and normally spliced, like every protein-coding gene does.
An miRNA gene isn't non-coding. It codes fir an miRNA
Hello there, I have been trying to reach Professor Narry Kim about a possible PhD assistantship for sometime now, I even tried to reach members of her lab, no answer was received unfortunately. If someone can help, please let me know.
hi, i know this is very late, but i have also contacted her about a potential undergraduate internship at her lab just 2 months ago. I use email tracking so i saw that she read the email but she didn't respond. so unprofessional honestly
You should go through the recruitment avenues of the graduate program her lab is associated with.
How long a cell or an organism survive without any of these parts in it? If they evolve randomly at different times, maybe millions years later, then how the cell could wait and survive those times?
They work much more efficient than any sophisticated machine or system designed by human genuity.
There is so much to learn from this nano robots and they inspire us.
Dummy.. You survived just fine without a brain when you were a one-celled to many celled embryo. Who knows you may be surviving just fine without one now.
"nan-robots"🤣
Nano anty robots are good to learn about molecular rulers.
❤️❤️❤️😍😍😍😍😍
☺
Don’t mention the word evolved.
You know better!
You don't know anything. Every derived feature in biology evolved.