Testosterone, DHT, and Prostate Cancer | Peter Attia & Ted Schaeffer
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- Опубликовано: 28 дек 2023
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This clip is from episode 273 - Prostate health: common problems, cancer prevention, screening, treatment, and more with Ted Schaeffer, M.D., Ph.D.
In this clip, Peter and Ted discuss:
- The relationship between testosterone, DHT, and prostate cancer
- Different types of prostate cancers
- What Ted looks for when examining tumors
- And more
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About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
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Thank you for your work TED!!
Excellent info. Had I had this info when I was diagnosed with prostate cancer, it could have influenced my treatment decision.
I went from 334 to 960 in around 3 months all natural no TRT. This book should be essential reading for all men. Written by a 50s guy with natural T levels of a 20s guy
Complete guide to testosterone by james Francis
Could it be one’s body intuitively knows there is a threat of cancer brewing and lowers T accordingly as a protective measure? Meaning it’s not low T that causes cancer but rather is a sign of the body trying to prevent it….
Oh my god. I have been bugging my health care provider for years about getting help for low T with no result and I just found out today that I have prostate cancer. 😠
Dr. Peter I am a stage 4 Large B cell Lymphoma cancer survivor. My test range is around 230...will TRT treatment interfere in any way with my current fight. I have had RCHOP chemo and Car-T. I will await your comments!
How can I convey my existing situation, in regard to many things that have happened/what Ive gpne through for the last 20 years. I am NOT getting help or answers, from either my family doctor, OR the urologist. I really need some answers...
As far as im concerned, this is the important question to ask:
If a man is at an increased risk of developing prostate cancer (which is an alarmingly high percentage), should the man avoid or limit exposure to substances that can increase the risk of dying from prostate cancer (like eggs, DHT, testosterone etc., for example).
DHT blockers such as Finasteride, may contribute to the proliferation of more aggressive prostate cancer cells.
Wish i could get on and talk with you Mr. Attia. So much is being missed with gut and food.
I have a theory, now this is completely anecdotal. My uncle and grandfather were both diagnosed with prostate cancer at 61 years old, so some genetics may be involved. Now as stated in this discussion, men with high testosterone when they're young, don't seem to be susceptible to prostate cancer, but older men are more likely to be diagnosed when their testosterone is at its lowest. My theory is not the drop in testosterone, but the increase in Estrogen. Drops in Testosterone are directly correlated to rising Estrogen through aromatase activity, and this is occurs as one gains body fat as we age. Fat cells increase aromatase activity, leading to the conversion of Testosterone to Estrogen. I've been taking Testosterone replacement since I turned 40 years old, I'm now 56. With the Testosterone I take half a mg of Anastrazole 3 times a week with 150mg of Testosterone Cypionate once a week, with 20mg of Proviron on alternate days. This keeps my Free Testosterone on the high side of normal, and my Estrogen on the low side of normal. Currently I have no signs of prostatic hyperplasia. And my PSA is lower than a 20 year olds at 0.35ng/ml. Now in no ways am I invoking a logical fallacy here, and the data set is obviously too small, but I'm seeing similar results with people I'm working with. I intuitively feel it's more related to elevated Estrogen.
Yes, totally agree with your theory. It's really an increase in estrogen/dht and prolactin in ageing men combined with a gradual natural decline in total and free testosterone along with genetics/lifestyle that cause prostate cancer. Young men with naturally high levels of testosterone and lower levels of estrogen never get prostate cancer. The theory of testosterone causing or worsening existing prostate cancer was based on one patient from a doctor Huggins in 1941 which has since been discredited in recent years by a prominent urologist Dr Morgentaler. It's, in fact, low testosterone levels in ageing men that causes a higher grade of prostate cancer rather than higher levels. Higher testosterone to lower estrogen levels is actually protective of prostate cancer! Are we seriously saying that a newly diagnosed 75 or 80 year man for prostate cancer was caused by high testosterone levels!!😅
@@dominictucci6030 Thanks for the response.
@GlenKrog Your welcome. There is a lot of misinformation about this subject which is leading men with low grade cancer ( Gleason 6 or grade 1) into unnecessary treatment with lifelong complications to deal with.
So my big question would be how can we avoid to get prostate cancer. Any thoughts about this would be much appreciated.
Yes , yes, read dr DeanOrnish 1:59 studies about healthy life styles especially sugar, refined carb, Insulin resistance ( listen to my you tube videos about healthy life styles, no cow milk and it’s products , no gluten, no processed foods with added chemicals.
Bank your semen and have your prostate removed.
That’s easy, don’t be a man
Cancer cells proliferate more quickly in a high Glucose/Insulin environment. Any analysis must examine metabolic factors.
We must ask what the relationship is between high or low T and all-cause mortality. Also, how does Estrogen affect male all-cause mortality?
Cancer cause and cancer growth seem to be two separate issues. HGH won't cause cancer, but it will feed it once it's there. Testosterone won't cause prostate cancer, but it will feed it once it's there. You get cancer from genetic abnormalities. What happens after is dependent on what feeds that cancer.
That’s logical with growth hormone, not so sure about testosterone. Higher test will lead to a larger prostrate, which in turn is linked with higher cancer risk. The evidence still isn’t strong and taking trt may be ok in this regard, but be careful writing things like this off as genetics.
If you´re not sure, be careful writing things like this off as genetics. @@HkFinn83
@@HkFinn83 When I say genetics I mean in cell replications vs hereditary. The environment affects cell replications, and that's why old people get cancer more often. Eventually, mistakes are made. The longer you go, the higher the odds. Environment and genes affect those odds.
That makes sense. Like eggs and prostate cancer, right? Eggs don't increase the chance of developing prostate cancer, but eggs increase the chances of dying from prostate cancer.
So the question arises...if one is at an increased risk of developing prostate cancer, should we limit or avoid things that can increase the risk of dying from prostate cancer?
How well does the Gleason grade group and presence of ductal subtype correlate with the molecular basal type? Are the basal molecular subtypes all ductal histology and Gleason 5 acinar subtypes? (The molecular findings sound similar to breast molecular categories.) Thanks. -a pathologist.
The Jackie Gleason score
I remember reading about Finasteride and dutasteride that people on it for hair loss who got prostate cancer had a much higher mortality rate than those that were not on the medications. Now we know why.
Have you heard about the association with pumpkin seeds and testosterone disruption and baldness?
That study (PCPT) was disproven for that finding. It only showed that because the prostate volume was reduced considerably by 5 alpha reductase and therefore the biopsy was better at detecting cancer in a smaller prostate, thus giving the impression that the drug caused aggressive prostate cancer which it did not. It only made the biopsy more accurate. In fact the PCPT study show a benefit of 5AR therapy (overall almost 25% reduced risk of all prostate cancer). Here is the title : Revisiting 5α-reductase Inhibitors and the Risk of Prostate Cancer (NIH) from 2018 - the PCPT study ended in 2003.
@@bingohhhhhhhhhhhh ,is your reply for me, or John Wayne?
@@jondel3304The Duke.
That has been debunked, per my urologist.
read "Great Prostate Hoax" by Richard Ablin
I am 72 with mild BPH taking TongKat Ali and ashwagansa supplemnet but have man boobs and a belly that is an embarrassment and I can not lose weitht (10kg overweight) Urologist did not order TST or PSA?? and said he would not prescribe TRT even though I never mentioned it.. I was there for antother reason so I wonder if TRT is going to affect BPH or cause it to get worse? History TURP 17 years ago and it is still in good working order and no prostrate pain unlike when I had a ton of pain prior to surgery.. What say you?
Keep trying different doctors until you find one that will. You are 72 though. We eventually have to accept undesirable things about ourselves. I’m 52. Getting older is hard
@@lockyp204idk if you necessarily do? Why would you accept lower quality of life in your last years just because you’re “old”. There’s loads of stuff men can do to improve it. Personally I would rather have 10 years as a 70 and live great than 15 of being immobile or overweight to the point of not living life.
So should I not take finasteride for hair loss?
excellent question.
0:22 to get to the content
😁
Men on KETO/Carnivore diet have double Testosterone compared to SAD diet. I'm willing to bet that the KETO/Carnivore group have significantly lower incidence of prostate cancer for their age than the. SAD diet group.
Luminal and Basal
This discussion makes it sound like prostate cancer is natural and inevitable. We can't possibly have evolved to naturally get prostate cancer. Don't diet and lifestyle have a profound effect on the occurance of prostate cancer?
Porterhouse every second day