Pro-clotting VS Anti-clotting Factors - vWF, Heparin, Anti-thrombin III, Prostacyclins,Prostaglandin

😍🖼Animated Mnemonics (Picmonic): www.picmonic.c...
- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
Disclaimer: I use affiliate links....
►👨‍🏫💊Antibiotics Lectures: www.medicosisp... ... Check out my brand new "Electrolytes" course at www.medicosisp... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Blood coagulation is the most important decision in your body...Too much coagulation and you form an unwanted clot (such as myocardial infarction, DVT/PE or a stroke)...Too little coagulation and you may bleed to death.
That's why blood clotting/coagulation is balanced by anti-clotting mechanisms VS pro-clotting mechanisms counteracting each other.
In the previous video of this series, I have discussed the anti-clotting mechanisms (such as heparin, heparan sulfate, prostacyclin,...etc): • Anti-clotting Mechanisms
To watch all of my bleeding and coagulation videos, click here: goo.gl/Dt41Bg
Primary hemostasis is balanced on the dynamic harmonious antagonism between the smooth endothelium (that prefers laminar blood flow) and thrombocytes (which favor clotting and thrombosis).
Platelets are called thrombocytes "cells of thrombus".
The smooth endothelium is squamous epithelium that lines the blood and lymphatic vessels from the inside.
When platelets roll over the smooth endothelium, nothing happens.
But, once there is an injured endothelium, platelets adhere, activate and aggregate to form a temporary platelet plug (primary hemostasis).
Then, the coagulation factors are stimulated "thanks to subendothelial collagen, tissue thromboplastin and platelet factor 3), coagulation cascade ensues until fibrinogen is converted into fibrin fibers trapping the RBCs and forming a stronger thrombus (secondary hemostasis).
After that, fibrinolysis occur (thanks to tissue plasminogen activator or tPA) to destroy the clot and restore function and flow.
Hemostasis is defined as “cessation of blood bleeding”.
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets).
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
Get all of my notes and CASES here: / medicosis
► If you love MNEMONICS, check out this amazing website www.picmonic.c...
► If you need some flashcards to memorize better, try firecracker: mbsy.co/gcHHP
*** Here are 2 FREE audiobooks from Audible amzn.to/2FQurW0 ...Learning has never been easier.
*** Also, try Amazon Kindle unlimited for FREE, they have some good medical books that you can read for FREE. amzn.to/2UceoG2
Books that I use for this series:
► Guyton and Hall Medical Physiology Textbook goo.gl/yZoeS9
► Goljan Rapid Review Pathology, amzn.to/2MufTPw
► Harrison’s Internal Medicine amzn.to/2OJiVNf
► Goldman-Cecil Medicine amzn.to/2N0v93u
► Davidson’s Principles and Practice of Medicine amzn.to/2vTmf1p
Disclaimer 1: The information provided here is for educational purposes only, and not to provide medical advice…If you have any symptoms or medical questions, you should talk to your doctor.
Disclaimer 2: I use affiliate links.
To be able to answer exam questions, Try to think of primary hemostasis and secondary hemostasis as two separate entities. 1ry hemostasis involves platelets and 2ry hemostasis involves the coagulation cascade. If you like my videos, please consider leaving a tip at www.paypal.me/...
► Visit my website: www.medicosisp... My Favorite Productivity App: airtable.com/i... 📱Save on your mobile phone bill: fbuy.me/q6bMj 🏦 Qbank (TrueLearn): truelearn.refe...

[@MedicosisPerfectionalis]

50 hematology cases- written by me- are NOW available on www.patreon.com/medicosis/
Warning ⚠️: You will NEVER get a 100% score on them...Yes, many of them are difficult.

[@mubarakeleid6996]

Best doctor habibi

[@ahmadaljazeeri9287]

Congratulations on reaching your goal of 360,000 subscribers 🥳
You deserve it. I hope the number doubles in the coming months. 😄

[@MedicosisPerfectionalis]

Thank you so much 😊
I appreciate you!

[@miesarmaqbool3203]

Wow sir....u r da best teachr...👍👍

[@MedicosisPerfectionalis]

Thank you, dear

[@saintmohammedalaa8556]

sir, what about HMWK and kinins, aren't they pro-clotting factors as they stimulate the intrinsic pathway? plz answer :(

[@MedicosisPerfectionalis]

Yes!
I have made a whole video titled: “HMWK”

[@mohamadalswaifi1872]

❤

[@harshitbansal5983]

Hello sir, do you have any videos on ophthalmology or ENT?

[@MedicosisPerfectionalis]

Not yet

[@aasthatilekar809]

👏nicee👏😊#eduhub