TIMESTAMPS 00:00 Start 04:50 Overview and webinar one recap 06:28 What are cancer mutational signatures and why are they important? 09:04 Mathematical concepts to define mutational signatures 12:38 What do mutational signatures look like (with examples)? 16:15 Extracting and checking mutational signatures 20:23 Caveats to extraction 24:10 Assigning mutational signatures to samples 29:12 Examples 33:22 Clinically relevant signatures summary table 35:22 Mutational signatures: HR deficiency 41:17 Mutational signatures: MMR deficiency 45:12 Mutational signatures: POLE dysregulation 49:05 Mutational signatures: MBD4 mutated cancers 51:03 Mutational signatures: NTHL1 loss 51:18 Mutational signatures: Biallelic MUTYH mutation 55:10 Mutational signatures: Long tandem duplicators 56:12 Mutational signatures to watch out for 57:36 Acknowledgements and Q&A
TIMESTAMPS
00:00 Start
04:50 Overview and webinar one recap
06:28 What are cancer mutational signatures and why are they important?
09:04 Mathematical concepts to define mutational signatures
12:38 What do mutational signatures look like (with examples)?
16:15 Extracting and checking mutational signatures
20:23 Caveats to extraction
24:10 Assigning mutational signatures to samples
29:12 Examples
33:22 Clinically relevant signatures summary table
35:22 Mutational signatures: HR deficiency
41:17 Mutational signatures: MMR deficiency
45:12 Mutational signatures: POLE dysregulation
49:05 Mutational signatures: MBD4 mutated cancers
51:03 Mutational signatures: NTHL1 loss
51:18 Mutational signatures: Biallelic MUTYH mutation
55:10 Mutational signatures: Long tandem duplicators
56:12 Mutational signatures to watch out for
57:36 Acknowledgements and Q&A