In this episode, we discuss: 0:00:11 - Testosterone and DHT: mechanisms of action, regulation of muscle growth, and influence on male and female characteristics 0:07:38 - TRT in women: the complexities and potential risks associated with testosterone use in women 0:22:08 - DHEA supplementation: exploring the benefits and risks for women, and the differing effects on men vs. women 0:28:38 - The role of progesterone in both men and women, pros and cons of supplementation, the importance of tailored doses, and more 0:38:32 - Measuring levels of free testosterone 0:43:42 - The trend towards earlier interest in TRT, and the risks of underground sources of testosterone 0:48:00 - The complexities and considerations surrounding the use of Clomid, E-Clomid, and hCG in TRT 0:56:46 - Low testosterone: diagnosis, potential causes, treatment options, and other considerations 1:07:44 - Growth hormone-releasing peptides: rationale and implications of the recent FDA categorization as high-risk substances 1:20:00 - Follistatin gene therapy and myostatin inhibition for increasing muscle mass: the recent hype online, human and animal data, and the need for more research 1:39:53 - Simple tips for lowering calorie intake and losing fat 1:48:32 - Methods of sustainable fat loss with muscle preservation: insights gleaned from bodybuilders 2:05:11 - Could prolonged fasting impact testosterone levels? 2:06:56 - High-protein ice cream 2:12:36 - Exploring fat loss supplements and drugs: L-carnitine, yohimbine, and more 2:23:57 - Potential remedies for individuals experiencing metabolic dysfunction due to hypercortisolemia 2:31:17 - The cornerstones of body composition improvement remain nutrition and exercise, even in the presence of exogenous testosterone 2:36:12 - The importance of approaching health advice found online with a critical eye and a healthy dose of skepticism
lol Derik explains complex biochemistry/physiology pathways. Peter - “yep makes perfect sense” Explains making protein based ice cream in the ninja creami - 5min long explanation 😂 Creami is a game changer! It will blow your mind Peter 🤯
The night before: 6oz a2 organic whole milk, 3 scoops whey (ideally one scoop of mark bells carnivore protein powder with the organ blend), handful of ice. Blend it. Freeze. Night of: 4min blend with lite ice cream setting in the creami. Flatten the top and then make a tiny well in the middle. add a scoop of PB2 and 2 scoops of Himalayan tartary buckwheat sprout powder from big bold health. Then 2 min with the mix in feature. Serve it up. This makes 3 nice scoops. Repeat step one. Every night. And feed to your kids!
The V-Shred ads are going to go crazy on this one! Always a great time sitting down with Peter. We filmed another podcast right on the back of this one as well that I'll post in the next few weeks.
@@TheTykusright? You’d think it would be another physician with similar accolades. It’s pretty impressive considering Greg doesn’t have a post-grad degree.
@@aaronbailey23it's not impressive at all having a degree doesn't mean anything. 😂 someone who has a passion for any field that a degree can teach you can learn more in 3-6 months than any degree will ever teach you in 4-8 years.
I dont understand why they make so hard to get TRT and as Attia says he thinks many clinics are going to be shut down. Ive been suffering from low T more than a decade, I was always in low end ofthe range but not below the range. I just had enough and went to Asia and to TRT clinic. Results after a year: I bacically had no libido before now I think its what men normally have. I have had erection dysfunction 10-15 years. Now that things is more like it was in my 20s. High cholesterol has went to normal High fasting blood sugar (Im T2 diabetic) has went to normal which metformin could never do. I feel the pump and energy at the gym that I felt in my 20s (Im 50 now) --> I want to go to gym again, not force myself like past decade More lean (which of course contributes to many others things but TRT was the catalyst for me to get there. back lean that I used to be) Everything in my life is better and bloodwork too. In the long run I really dont care if this is going to take few years of my life or make me live few years longer (which I believe is more likely since I do everything better, even my diet) since that life is woth living and not being living dead. For me TRT was solution. Who does it hurt if people who has these symptoms tries TRT if he has low T?? I just dont get it..I dont have any other reasonable answer for this but medical companies fighting againsnt TRT so they can sell more antidepressant which lower even more T and their bussiness is shining. Guys, if you cant get help where you live, if you can go to places where you can try but dont go to black market since you never know what you get there.
note that there are few studies on tongkat and the long term health effectsare not known. Not saying it's not worth considering if you really can't get testosterone; I have tried it myself before; but if available to you, TRT has a ton of research backing it and is well-understood @@austintascious
Great episode. I'm a female, and though Derek is geared toward the guys, I found his explanations MORE informative than I've heard from anyone else! Great!
I was around Peter Attias testosterone levels when i started trt. Started when i was 36 and been on it for 2.5 years now. It was the best decision i made personally. My mental health has dramatically improved, didnt take it for any fitness gains. Started it for energy and better sexual function, it exceeded my expectations in that area tbh, its actually kind of annoying now, in the libido department lol. The best thing i got out of it is the dramatically improved mental health, and im so fortunate for that. Kinda sucks being on another medication for life, but i think i made the right choice.
At least it’s a bio identical medication. If you’re quality of life has improved that much don’t second guess yourself. If you didn’t do it you’d be living a lesser quality of life wondering what if you did do it
@elliottrichardson8213 Yeah, very true! And it did get me off a couple different anti depressants/anxiety meds. So I think im healthier just in that regard. Just want to be as healthy as possible for longevity and quality of life, as you mentioned.
I’m 34, and just got my first bloodwork before starting TRT through a clinic. Do you honestly notice a big difference? It’s been 15 years since I’ve felt “normal” and have just accepted it as it is what it is. I’m very excited to see how it’s going to improve my life. Especially sleep. I have not slept through the night or more than 4 hours in 20 years….
@@tk4084and background, I’m a lifelong athlete. I train 24/7 have been in the fitness industry for a long time. I’ve put this off so long so it’s nice to hear feedback from people who it’s also helped.
@chasincreationz9364 It made a huge difference for me personally. Everybody will be different, though, obviously. About the sleep, it helps with some more than others. For me, it helped a little but nothing to Wright home about, I still get boughts of insomnia here and there but better than it was. For me it was more mental health, energy, and sexual function that has improved dramatically. I feel amazing compared to how I felt before starting.
I make my protein "shake" similar way to Attia, I use half/half unflavored and flavor whey powder mix, milk substitute, frozen berries and a tablespoon of greek yogurt plus one additional ingredient that makes all the difference which is GELATIN (soaked & melted). The end result is protein mousse that I can eat with the spoon (frozen berries set the gelatin in few minutes) as liquids don't induce the satiety in me.
Using it right now after shoulder surgery w/ TB4. I think it's helping but the truth is you'll heal anyways and you probably shouldn't take chances on destroying a surgical repair, so erring on the conservative side seems wise. I'm WAY ahead of the PT schedule but it's not really possible to know how much the peptides contribute.
I had no idea what it was about DHEA and when I got my bloodwork done my DHEA SULFATE level was 1000 51.7-295.0 ug/dl. Estradiol was 49.9 7.02-49.06 pg/ml. Testosterone tot. 369.2 193.-740.0 ng/dl free Testosterone 77.72. 30.0-150.0 pg/ml SHBG 25.4. 19.3-76.4 nmol/L I wasn’t on it very long, but now I’m on TRT no AI dose of .1mg a day of 200mg/ml. Have only been on it for 3 weeks. 🥩👍
So appreciate the Gary Brecka call out. That Rogan podcast was a disaster. Brecka seemed to be confusing his own topics more than anything else. Tough to follow. Loved this! Both of you do amazing work. Thank you for sharing.
Derek has gone to another level doing these two podcasts. I've watched his podcast many times, which is good, but he's never been quite this good. I love it!
Progesterone is not the same thing as the many synthetic progestins in oral contraceptives and IUD’s. Natural progesterone converts to the “feel good hormone”allopregnenalone, but synthetic progestins do not. Synthetic progestins are implicated in risk for blood clots and cancers. Natural progesterone is available in US pharmacies by prescription so I don’t see why anyone would prescribe or use synthetic progestins.
The reality is most men don’t want to go to an endocrinologist for TRT because most of them are absolutely awful at understanding testosterone and male sex hormones in general. I know it’s a big claim to say a hormone doctor doesn’t know about hormones, but I have experienced this myself and read about absolutely WILD protocols Endos put their patients on every day on various forums where people come for help.
For anyone that wants to see a condensed version of Derek's weight loss advice through calorie control I highly recommend the 10-minute, 2019 video on his channel titled "Why You Still Aren’t Shredded Eating Less Than 2000 Calories Per Day." I wish I had had access to that sort of info 25 years ago, but it's never too late. Great stuff if you're willing to count calories.
BHRT pellets here 1.5 months in. 300mg Oral progesterone at night with no negative side effects. I keep hearing 200 is max. Does the extra progesterone suppress my estrogen to a point I’m not going to see the benefits of it?
Good stuff very informative- very interested in peptides . Have shoulder surgery coming up - wondering if BPC 157 would speed up healing . Mention it to my orthopedic - he’s doing some research on it.
Hi Peter. I really love your podcast and the effort you make to really understand stuff. You are really into working out in the traditional Arnold Schwarzenegger style, I wonder if you maybe did some podcast about yoga, difrences about Iengar and ashtanga yoga, wu shu, Tai Chi on fisilogoy emotional and mental health? Could you send me the link to the episode or make one?
I took IPA and BPC and it completely SHUT me down, my test was under 100. It’s taken me several months to feel better and I haven’t gotten to my previous base levels yet.
Very interesting point on fasting as i wanted to continue my 10 days water fast few times a year,i had some benefits and always sought it was actually increasing GH and T but I guess it my not be the case,can anyone share if had experience and tested levels(I only measured BG)
Fantastic podcast, thanks guys. I'll take Chris Masterjohn over Gery Brecka any day of the week, not even a question. Said goodbye to Brecka, Gundry, Asprey & co a long time ago, and (n=1) that alone probably helped me to have more money, be less stressed, worry about less things, do more of the right things, be better, have a much better scientific approach, thinking and language.
How is that law change going to affect Meric Health?! Also, I had not heard anything about that. Very important update for me to have heard nothing about it.
Great work guys, although I think you should split these 2-3 hours podcasts into smaller units. BTW, you can get cheaper ice-cream makers than Ninja's brand.
Did anyone break down the details of his protein ice cream solution? Did he just buy ingredients and a blender or was there another device? What were the ingredients?
Is it safe to stack a GHRP like Tesamorelin with a GLP-1 Agonist like Tirzepatide? Trying to retain as much muscle as possible while in a significant caloric deficit
I'm 58, recently put on testosterone. I'm thinking of also starting HCG to keep things the same size, etc. Will HCG increase this risk of hair loss, blood platelet size and blood pressure by increasing DHT? Thanks
@@spike8683 It can with some people. More so with those that have male pattern baldness genetic traits. I personally have only been on TRT for 6 weeks.
Nobody is studying it. This pod at least they make point to say repeatedly that its not something to embark on lightly, this is serious health choice you are making...
Hi, so far great as always! But Is it really true that DHEA has no utility? I’d argue about that one. I think cortisol:dhea ratio actually can say a lot and can be a very valuable biomarker. No utility for T… maybe (for men). No utility at all. Debatable IMO. What about for example Dehydroepiandrosterone ability to protect hippocampal cells from oxidative stress-induced damage?
I was answering in the context of its impact on Testosterone levels as that was my interpretation of the question, although in hindsight I can see how you might take that clip as if I was giving a sweeping answer for all applications. I think it has context dependent utility for men and women. But for backfilling Testosterone levels, my answer is the same as shown in the podcast.
Wow. This is a lot of info for even the most educated viewer. I would recommend having a third person in these type of videos to act as a moderator or an advocate for the average viewer. For example, these guys were about 5 minutes into talking about Clomid in great detail before either of them said enough for me to infer that it is a drug to help improve testosterone (if that is even the case). I would also be concerned (especially in today’s environment) that a viewer would hear this conversation, smart guys talking with big words, and just assume all of this means they should be taking or doing something that may not even be advocated for directly here. This is excluding all the people who can (and will likely) pull short clips of this video to advocate for their point of view or theory.
strength athletes typically have high rates of muscle protein turnover. This constant remodeling is essential for maintaining muscle quality and function. Myostatin inhibition could potentially disrupt the balance between muscle protein synthesis and degradation, leading to accumulation of less functional muscle proteins. Some studies report normal or even reduced specific force (force per unit cross-sectional area) in myostatin-deficient mice, suggesting compromised muscle quality.
I would like to know your thoughts on injections for women. Especially for those that have absorption issues and don't love the pellets. The studies for women are so lacking, and I've seen such conflicting opinions.
I'm 58 and my T is 42.7 nmol/L or 1231 ng/dL. I take no PEDs but am purdy cranky at times. I've measured it multiple times at different labs and hv seen an endo., but am told it's "just a finding"?!
I seriously doubt they will shut down telemedicine testosterone prescribing. It’s too necessary for transgender individuals in unfriendly states. They have the political clout to ensure there won’t be a federal shut down. IMHO.
Derek is a gentleman, scholar, and bro-scientist with significant clinical experience. Do you think Dr Attia’s low T is related to frequent sauna use? Common sense tells me slow cooking your testicles in sauna cannot be good for your total T. Thoughts?
@@Magar6I mean I doubt he uses it naked so it won’t get to the temperature the sauna is set at. Not to mention the exposure will likely be less than 30 minutes. Lastly there is no data I’ve seen suggesting frequent sauna use will reduce T.
@@elliottrichardson8213No data doesn’t mean sauna doesn’t reduce T. Studies show that sauna use reduce sperm counts, mobility and quality, which indicates testicles are in suboptimal state. It’s reasonable that this will reduce T.
@@elliottrichardson8213 one always goes to a sauna naked, they will be cooler but that's caused by the evaporative cooling (as it is with the rest of your body)
Ultra low dose Anastrazole, .25mg 3x/week has been great for me... I've used both clomid and Test gel and the Anastrazole has been better for sex drive, mood then both by far... I'm someone Who has high but normal estradiol low normal total test very low free test and high shbg... I also was on finasteride for almost 10 years about 20 years ago Which I believe is the reason for my hormonal levels now... But I wish they would talk more about low dose anastrozole..
Be careful. Estrogen is very important. You do not want to have chronic low estrogen. Derek talked about this with that influnencer Joe before he passed away.
Dereck's delts actually look human without the retro wood and air-conditioner/radio behind him. The man is no doubt an encyclopedia of pharmakia though.
53:00 I don't believe Telemed TRT will be shut down in any way. There are too many social issues around this and politically both the Left and Right would presumably be in agreement on making testosterone easier to obtain.
Estrogen is anabolic because it requires energy generated by catabolic reactions. Therefore, the estrogen increases metabolism by creating a route through the cell membrane toward the nucleus, in which it stimulates various genes to regulate protein synthesis.
Peter, you were saying about clitóris enlargement in your patient on testosteron. How big here clitóris get? Do you know how big clitóris gets in people on testosterone who are aming for sex change?
You should not be proud of shooting an innocent animal. We can get every nutrient we need from a plant-based diet. Therefore it's cruel to kill a whitetail. You could teach your kids that food comes from plants. Live and let live.
I have a silly question, why Pharmaceutical m0bsters always have to put at least one ingredient that is unhealthy, for example, BENZYL ALCOHOL? isn't there any healthier alternative?? Is there cypionate/propionate WITHOUT benzyl alcohol?
In this episode, we discuss:
0:00:11 - Testosterone and DHT: mechanisms of action, regulation of muscle growth, and influence on male and female characteristics
0:07:38 - TRT in women: the complexities and potential risks associated with testosterone use in women
0:22:08 - DHEA supplementation: exploring the benefits and risks for women, and the differing effects on men vs. women
0:28:38 - The role of progesterone in both men and women, pros and cons of supplementation, the importance of tailored doses, and more
0:38:32 - Measuring levels of free testosterone
0:43:42 - The trend towards earlier interest in TRT, and the risks of underground sources of testosterone
0:48:00 - The complexities and considerations surrounding the use of Clomid, E-Clomid, and hCG in TRT
0:56:46 - Low testosterone: diagnosis, potential causes, treatment options, and other considerations
1:07:44 - Growth hormone-releasing peptides: rationale and implications of the recent FDA categorization as high-risk substances
1:20:00 - Follistatin gene therapy and myostatin inhibition for increasing muscle mass: the recent hype online, human and animal data, and the need for more research
1:39:53 - Simple tips for lowering calorie intake and losing fat
1:48:32 - Methods of sustainable fat loss with muscle preservation: insights gleaned from bodybuilders
2:05:11 - Could prolonged fasting impact testosterone levels?
2:06:56 - High-protein ice cream
2:12:36 - Exploring fat loss supplements and drugs: L-carnitine, yohimbine, and more
2:23:57 - Potential remedies for individuals experiencing metabolic dysfunction due to hypercortisolemia
2:31:17 - The cornerstones of body composition improvement remain nutrition and exercise, even in the presence of exogenous testosterone
2:36:12 - The importance of approaching health advice found online with a critical eye and a healthy dose of skepticism
lol Derik explains complex biochemistry/physiology pathways. Peter - “yep makes perfect sense”
Explains making protein based ice cream in the ninja creami - 5min long explanation 😂
Creami is a game changer! It will blow your mind Peter 🤯
The night before: 6oz a2 organic whole milk, 3 scoops whey (ideally one scoop of mark bells carnivore protein powder with the organ blend), handful of ice. Blend it. Freeze.
Night of: 4min blend with lite ice cream setting in the creami. Flatten the top and then make a tiny well in the middle. add a scoop of PB2 and 2 scoops of Himalayan tartary buckwheat sprout powder from big bold health. Then 2 min with the mix in feature. Serve it up. This makes 3 nice scoops.
Repeat step one. Every night. And feed to your kids!
@@benparker5775 I use a creami to make mango icecream bars. My wife insists that she have a supply of them always on hand. Great stuff.
EXCELLENT EXCELLENT PODCAST!!! YOU AND DERRICK HAVE DONE IT AGAIN !!
Two seriously intelligent people in this area of science. Both of you two have met your matches in this interview!
The V-Shred ads are going to go crazy on this one!
Always a great time sitting down with Peter. We filmed another podcast right on the back of this one as well that I'll post in the next few weeks.
Thanks Dr Derek MPMD
But what was the gift you @moreplatesmoredates gave to Peter?
You're the best man, i can listen to you talk for hours and still want more. Should start a podcast.
DUde, why are you not creating content for own chanel? Like reddit reactions etc?
🐀
Aren’t they so good together?! I don’t know why it’s so great.
Perfect combo honestly
I agree. And I wouldn’t of actually guessed it.
@@TheTykusright? You’d think it would be another physician with similar accolades. It’s pretty impressive considering Greg doesn’t have a post-grad degree.
@@aaronbailey23the guys brilliant. He has a lot of good stuff on his channel ‘more plates more dates’
@@aaronbailey23it's not impressive at all having a degree doesn't mean anything. 😂 someone who has a passion for any field that a degree can teach you can learn more in 3-6 months than any degree will ever teach you in 4-8 years.
Can we get this duo regularly on a podcast please?!?!?!? Like once a month a podcast regarding hormones🙏
There’s only so much information they can go over for hormones and they are doing pretty well in these podcasts we already have now.
not gonna happen
@@brandonyoung4910agree 🙏
Get your TRT, be done with it
I would absolutely love a four-way podcast between Attia, Derek, Huberman and Galpin!
They mostly agree on everything tho. 😂 Just a huge echo chamber. Who can we toss in to mix it up a bit? Layne Norton?
swap huberman with norton and you sold me.
and BIden
The way you guys give the info is so well explained Derek should be invited more often to your podcast for educational purposes.
💎Looking forward to my interview with Derek. He is awesome. Peter your content and research findings just keeps getting better and better! 🤓🤓🤓
I dont understand why they make so hard to get TRT and as Attia says he thinks many clinics are going to be shut down. Ive been suffering from low T more than a decade, I was always in low end ofthe range but not below the range. I just had enough and went to Asia and to TRT clinic.
Results after a year:
I bacically had no libido before now I think its what men normally have.
I have had erection dysfunction 10-15 years. Now that things is more like it was in my 20s.
High cholesterol has went to normal
High fasting blood sugar (Im T2 diabetic) has went to normal which metformin could never do.
I feel the pump and energy at the gym that I felt in my 20s (Im 50 now) --> I want to go to gym again, not force myself like past decade
More lean (which of course contributes to many others things but TRT was the catalyst for me to get there. back lean that I used to be)
Everything in my life is better and bloodwork too. In the long run I really dont care if this is going to take few years of my life or make me live few years longer (which I believe is more likely since I do everything better, even my diet) since that life is woth living and not being living dead.
For me TRT was solution. Who does it hurt if people who has these symptoms tries TRT if he has low T?? I just dont get it..I dont have any other reasonable answer for this but medical companies fighting againsnt TRT so they can sell more antidepressant which lower even more T and their bussiness is shining.
Guys, if you cant get help where you live, if you can go to places where you can try but dont go to black market since you never know what you get there.
Couldn't have said it better myself!!
It’s very easy to get trt.
Try Tongkat Ali! My husband and I have seen HUGE benefits in testosterone, energy and strength.
@@austintascious It's just another worthless supplement.
note that there are few studies on tongkat and the long term health effectsare not known. Not saying it's not worth considering if you really can't get testosterone; I have tried it myself before; but if available to you, TRT has a ton of research backing it and is well-understood @@austintascious
Great discussion yall! Thoroughly enjoy the conversation when both of you are on a podcast together.
Great episode. I'm a female, and though Derek is geared toward the guys, I found his explanations MORE informative than I've heard from anyone else! Great!
2:13:45
Derek unintentionally got Dr. Peter Attia to say "super superphysiologic doses". My life is complete :)
😂
@@MorePlatesMoreDates 🐀
Supra
I was around Peter Attias testosterone levels when i started trt. Started when i was 36 and been on it for 2.5 years now. It was the best decision i made personally. My mental health has dramatically improved, didnt take it for any fitness gains. Started it for energy and better sexual function, it exceeded my expectations in that area tbh, its actually kind of annoying now, in the libido department lol. The best thing i got out of it is the dramatically improved mental health, and im so fortunate for that. Kinda sucks being on another medication for life, but i think i made the right choice.
At least it’s a bio identical medication. If you’re quality of life has improved that much don’t second guess yourself. If you didn’t do it you’d be living a lesser quality of life wondering what if you did do it
@elliottrichardson8213 Yeah, very true! And it did get me off a couple different anti depressants/anxiety meds. So I think im healthier just in that regard. Just want to be as healthy as possible for longevity and quality of life, as you mentioned.
I’m 34, and just got my first bloodwork before starting TRT through a clinic. Do you honestly notice a big difference? It’s been 15 years since I’ve felt “normal” and have just accepted it as it is what it is. I’m very excited to see how it’s going to improve my life. Especially sleep. I have not slept through the night or more than 4 hours in 20 years….
@@tk4084and background, I’m a lifelong athlete. I train 24/7 have been in the fitness industry for a long time. I’ve put this off so long so it’s nice to hear feedback from people who it’s also helped.
@chasincreationz9364 It made a huge difference for me personally. Everybody will be different, though, obviously. About the sleep, it helps with some more than others. For me, it helped a little but nothing to Wright home about, I still get boughts of insomnia here and there but better than it was. For me it was more mental health, energy, and sexual function that has improved dramatically. I feel amazing compared to how I felt before starting.
I make my protein "shake" similar way to Attia, I use half/half unflavored and flavor whey powder mix, milk substitute, frozen berries and a tablespoon of greek yogurt plus one additional ingredient that makes all the difference which is GELATIN (soaked & melted). The end result is protein mousse that I can eat with the spoon (frozen berries set the gelatin in few minutes) as liquids don't induce the satiety in me.
I used bpc-157 in a postoperative orthopedic context and can confirm it works… well. Healed in half the time
Same - fixed my rotator cuff tear in 3 weeks instead of 3 months I experienced on a similar tear before. Amazing !!
@@geoffreyannesley8593 Did you use oral or injectable? Thanks!
how do you know half the time?
Using it right now after shoulder surgery w/ TB4. I think it's helping but the truth is you'll heal anyways and you probably shouldn't take chances on destroying a surgical repair, so erring on the conservative side seems wise. I'm WAY ahead of the PT schedule but it's not really possible to know how much the peptides contribute.
I had no idea what it was about DHEA and when I got my bloodwork done my DHEA SULFATE level was 1000 51.7-295.0 ug/dl. Estradiol was 49.9 7.02-49.06 pg/ml. Testosterone tot. 369.2 193.-740.0 ng/dl free Testosterone 77.72. 30.0-150.0 pg/ml
SHBG 25.4. 19.3-76.4 nmol/L
I wasn’t on it very long, but now I’m on TRT no AI dose of .1mg a day of 200mg/ml. Have only been on it for 3 weeks. 🥩👍
So appreciate the Gary Brecka call out. That Rogan podcast was a disaster. Brecka seemed to be confusing his own topics more than anything else. Tough to follow. Loved this! Both of you do amazing work. Thank you for sharing.
Brecka doesn’t seem to know biochemistry, everything is “methylation” with him.
Derek has gone to another level doing these two podcasts. I've watched his podcast many times, which is good, but he's never been quite this good. I love it!
Just an incredibly insightful, indulgent and informative episode, thanks guys 💪🙏🙌
Derek with excited expectation "What was her testosterone?". This was a great interview and you couldn't pick a better pair.
Derek should be given a PhD, he's basically as knowledgeable as a endocrinologist
The king of bro science and King on RUclips dr.'s is a great duo!
Another fantastic episode, gentlemen. I thank you both for the quality of information shared.
Progesterone is not the same thing as the many synthetic progestins in oral contraceptives and IUD’s. Natural progesterone converts to the “feel good hormone”allopregnenalone, but synthetic progestins do not. Synthetic progestins are implicated in risk for blood clots and cancers. Natural progesterone is available in US pharmacies by prescription so I don’t see why anyone would prescribe or use synthetic progestins.
Awesome discussions. Thanks Peter.
My favorite podcast duo ever
Gentlemen, yet another enjoyable and informative top-tier chat!
It would be great to have an episode like Egg Boxing where Peter teaches Derek to cook, including making the protein ice cream.
Love nerdy stuff like this. Derek is so knowledgeable
The reality is most men don’t want to go to an endocrinologist for TRT because most of them are absolutely awful at understanding testosterone and male sex hormones in general. I know it’s a big claim to say a hormone doctor doesn’t know about hormones, but I have experienced this myself and read about absolutely WILD protocols Endos put their patients on every day on various forums where people come for help.
For anyone that wants to see a condensed version of Derek's weight loss advice through calorie control I highly recommend the 10-minute, 2019 video on his channel titled "Why You Still Aren’t Shredded Eating Less Than 2000 Calories Per Day." I wish I had had access to that sort of info 25 years ago, but it's never too late. Great stuff if you're willing to count calories.
Very interesting discussion! Love ❤️ you both!!!
BHRT pellets here 1.5 months in. 300mg Oral progesterone at night with no negative side effects. I keep hearing 200 is max. Does the extra progesterone suppress my estrogen to a point I’m not going to see the benefits of it?
Good stuff very informative- very interested in peptides . Have shoulder surgery coming up - wondering if BPC 157 would speed up healing . Mention it to my orthopedic - he’s doing some research on it.
that collab i didn't know i needed!!!
Just watched the first part that came out a while ago. Very informative info from Peter and Derik
Glad to hear Peter mention Promix - amazing protein quality and great digestion.
What's Derek's last name? I want to see more of his content but can't find his full name or name of podcast?
Search "More dates more plates"
not even joking, no one knows his last name lol
Amazing episode. Love that Aryton Senna tshirt
I don' watch a lot of Peter's content but I love when he talks to Derek.
Hi Peter. I really love your podcast and the effort you make to really understand stuff. You are really into working out in the traditional Arnold Schwarzenegger style, I wonder if you maybe did some podcast about yoga, difrences about Iengar and ashtanga yoga, wu shu, Tai Chi on fisilogoy emotional and mental health? Could you send me the link to the episode or make one?
Two of my favourite evidence based blokes droppin the knowledge
I took IPA and BPC and it completely SHUT me down, my test was under 100. It’s taken me several months to feel better and I haven’t gotten to my previous base levels yet.
You either took something different or were that low before. Ipa and bpc shouldn't interact with the hpta like that
MPMD almost looks like a qualification when juxtaposed with Peter's titles, lol.
Thought the same thing lol
@@mikeallen86 Peter MD, Derek MPMD lol
So what does MPMD stands for? 🤔
@@habibmalik1619 More Plates, More Dates. Its a super popular youtube channel of which Derek is the creator
@@habibmalik1619More Plates More Dates
Very interesting point on fasting as i wanted to continue my 10 days water fast few times a year,i had some benefits and always sought it was actually increasing GH and T but I guess it my not be the case,can anyone share if had experience and tested levels(I only measured BG)
I wanna hear about Peter and his Ninja Creami recipes in the future 😂
Fantastic podcast, thanks guys. I'll take Chris Masterjohn over Gery Brecka any day of the week, not even a question. Said goodbye to Brecka, Gundry, Asprey & co a long time ago, and (n=1) that alone probably helped me to have more money, be less stressed, worry about less things, do more of the right things, be better, have a much better scientific approach, thinking and language.
How is that law change going to affect Meric Health?! Also, I had not heard anything about that. Very important update for me to have heard nothing about it.
What about Biote pellet therapy for women? What do you think of that?
Great work guys, although I think you should split these 2-3 hours podcasts into smaller units. BTW, you can get cheaper ice-cream makers than Ninja's brand.
Did anyone break down the details of his protein ice cream solution? Did he just buy ingredients and a blender or was there another device? What were the ingredients?
Is it safe to stack a GHRP like Tesamorelin with a GLP-1 Agonist like Tirzepatide? Trying to retain as much muscle as possible while in a significant caloric deficit
Sure
I'm 58, recently put on testosterone. I'm thinking of also starting HCG to keep things the same size, etc. Will HCG increase this risk of hair loss, blood platelet size and blood pressure by increasing DHT?
Thanks
does trt increase hairloss?
@@spike8683 It can with some people. More so with those that have male pattern baldness genetic traits. I personally have only been on TRT for 6 weeks.
Awesome I needed this talk !
I find very little info available on experience of being on TRT long term. If you get on it at 40, what is ur life going to be like at 60? Etc...
Nobody is studying it. This pod at least they make point to say repeatedly that its not something to embark on lightly, this is serious health choice you are making...
Swole
What’s your life going to be like if you have a Test level in the 100s at 40 and you continue to decline for the next 20 years?
Hi, so far great as always! But Is it really true that DHEA has no utility? I’d argue about that one. I think cortisol:dhea ratio actually can say a lot and can be a very valuable biomarker. No utility for T… maybe (for men). No utility at all. Debatable IMO. What about for example Dehydroepiandrosterone ability to protect hippocampal cells from oxidative stress-induced damage?
I was answering in the context of its impact on Testosterone levels as that was my interpretation of the question, although in hindsight I can see how you might take that clip as if I was giving a sweeping answer for all applications. I think it has context dependent utility for men and women. But for backfilling Testosterone levels, my answer is the same as shown in the podcast.
Peter looks sold on the Ninja Creamy thing
Its funny how they list "Peter Attia, MD and then Derek, MPMD," LOL
Cow elk tag in colorado for a resident is $50 out of state is $500+ but either way if you have a successful hunt you have roughly 500lbs of meat
You'll get maybe 250 at most out of a cow, 500 on the hoof, maybe.
Wow. This is a lot of info for even the most educated viewer. I would recommend having a third person in these type of videos to act as a moderator or an advocate for the average viewer. For example, these guys were about 5 minutes into talking about Clomid in great detail before either of them said enough for me to infer that it is a drug to help improve testosterone (if that is even the case).
I would also be concerned (especially in today’s environment) that a viewer would hear this conversation, smart guys talking with big words, and just assume all of this means they should be taking or doing something that may not even be advocated for directly here. This is excluding all the people who can (and will likely) pull short clips of this video to advocate for their point of view or theory.
Amazing episode
strength athletes typically have high rates of muscle protein turnover. This constant remodeling is essential for maintaining muscle quality and function. Myostatin inhibition could potentially disrupt the balance between muscle protein synthesis and degradation, leading to accumulation of less functional muscle proteins.
Some studies report normal or even reduced specific force (force per unit cross-sectional area) in myostatin-deficient mice, suggesting compromised muscle quality.
Derek is a legend
I'm loving this combination
Should one one testosterone take enclomiphene concurrently? That is what i was prescribed, along with anastrazole.
But what present Derek gave to Peter???
I would like to know your thoughts on injections for women. Especially for those that have absorption issues and don't love the pellets. The studies for women are so lacking, and I've seen such conflicting opinions.
Waiting for Part 3!!!
Youre not shut down on TrT if youre also taking HcG or a LH mimicking agent
You will still get shutdown. But yes it will stimulate LH. As soon as you get off, your htpa will still be shut down
I'm 58 and my T is 42.7 nmol/L or 1231 ng/dL. I take no PEDs but am purdy cranky at times. I've measured it multiple times at different labs and hv seen an endo., but am told it's "just a finding"?!
I seriously doubt they will shut down telemedicine testosterone prescribing. It’s too necessary for transgender individuals in unfriendly states. They have the political clout to ensure there won’t be a federal shut down. IMHO.
Yup, and they don’t even care about the straight men with low T
What a stud Derek. Love from Canada!
Please get Dave Lee on
Derek is a gentleman, scholar, and bro-scientist with significant clinical experience. Do you think Dr Attia’s low T is related to frequent sauna use? Common sense tells me slow cooking your testicles in sauna cannot be good for your total T. Thoughts?
Yes. There is a reason why the testes are outside the body, to stay cool. He is cooking em.
@@Magar6I mean I doubt he uses it naked so it won’t get to the temperature the sauna is set at. Not to mention the exposure will likely be less than 30 minutes. Lastly there is no data I’ve seen suggesting frequent sauna use will reduce T.
@@elliottrichardson8213No data doesn’t mean sauna doesn’t reduce T. Studies show that sauna use reduce sperm counts, mobility and quality, which indicates testicles are in suboptimal state. It’s reasonable that this will reduce T.
Has it been studied though? If not, the fact that there is no data is not surprising, eh?@@elliottrichardson8213
@@elliottrichardson8213 one always goes to a sauna naked, they will be cooler but that's caused by the evaporative cooling (as it is with the rest of your body)
I’m loving the Ayrton Senna shirt.
Love this stuff!!!!!
Ultra low dose Anastrazole, .25mg 3x/week has been great for me... I've used both clomid and Test gel and the Anastrazole has been better for sex drive, mood then both by far... I'm someone Who has high but normal estradiol low normal total test very low free test and high shbg... I also was on finasteride for almost 10 years about 20 years ago Which I believe is the reason for my hormonal levels now... But I wish they would talk more about low dose anastrozole..
Be careful. Estrogen is very important. You do not want to have chronic low estrogen. Derek talked about this with that influnencer Joe before he passed away.
Dereck's delts actually look human without the retro wood and air-conditioner/radio behind him. The man is no doubt an encyclopedia of pharmakia though.
The Ninja Creami is ⭐️⭐️⭐️⭐️⭐️. You will love it
It's the brand of the machine though right?
How's there so much scrutiny on peptides while SARMs are let go wild, when most of them are clearly dangerous in the dosages they are sold?
53:00 I don't believe Telemed TRT will be shut down in any way. There are too many social issues around this and politically both the Left and Right would presumably be in agreement on making testosterone easier to obtain.
Facts. The FTM movement could be what saves us lol
@@MarylandGuy-ey3st agreed
if telemedicine shuts down, the underground market will explode. so I don’t see how shutting down telemedicine trt clinics helps the situation.
It doesnt.
Inj L-Carn is frfr btw. He seems to be downplaying it but I find it to be fantastic.
Estrogen is anabolic because it requires energy generated by catabolic reactions. Therefore, the estrogen increases metabolism by creating a route through the cell membrane toward the nucleus, in which it stimulates various genes to regulate protein synthesis.
Anyone else notice him saying that tele health are for sure shutting down for trt?? Did I miss something
Banger as always 🔥
Peter, you were saying about clitóris enlargement in your patient on testosteron. How big here clitóris get? Do you know how big clitóris gets in people on testosterone who are aming for sex change?
Key takeaways? If your test is at 400 should you TRT?
Ice cream is way better with added stabilizers. A tenth of a percent xanthan gum will make a miraculous difference to an imperfect ice cream recipe.
Literally got a V-shred ad right after this video lolololol GO AWAY VINCE! 😅
You don't mention Derek's last name anywhere on these show notes.
Its his choice
Per Derek’s request
Yohimbine is such a dirty stimulant. It gives me the jitters and makes my face red. It works, I'll give it that much, but damn, it's a rough ride.
essentially exclusively typically
What again already?? Heck yeah!!!
Searle 2.5 footballs. Best Ever.
W duo
Literally’bang for your buck’
I’m a bow hunter and I get one whitetail a year. I use the whole animal. I am proud to feed my family and teach them where food comes from.
You should not be proud of shooting an innocent animal. We can get every nutrient we need from a plant-based diet. Therefore it's cruel to kill a whitetail. You could teach your kids that food comes from plants. Live and let live.
Thank you for the transparency in such a long conversation format! Delve into the weeds!
42:50 classic MPMD
I have a silly question, why Pharmaceutical m0bsters always have to put at least one ingredient that is unhealthy, for example, BENZYL ALCOHOL? isn't there any healthier alternative?? Is there cypionate/propionate WITHOUT benzyl alcohol?
Ahhh yes of course, I understood all of the words in this podcast