ANCA Associated Vasculitis (Anti-Neutrophil Cytoplasmic Antibody) - Causes, Pathophysiology, Types
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- Опубликовано: 6 май 2019
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"Small Vessel Vasculitis Vasculitis is inflammation of the blood vessels resulting in damaged vessels leading to potential complication such as tissue ischaemia from lumen narrowing or from thromboembolic events from platelet consumption during vessel repair. Primary vasculitides are classified into the size of the blood vessels affected; large vessel, medium vessel and small vessel vasculitis. The small vessel vasculitis can be further divided into ANCA associated vasculitis (AAVs) and immune complex mediated vasculitis.
ANCA associated vasculitis is so called this because in the person's blood there is presence of ANCA which is an abbreviated to antineutrophil cytoplasmic antibody. AAVs usually tends to affect small and medium sized arteries. There are three main types of ANCA
- Microscopic polyangiitis
- Granulomatosis with polyangiitis
- Eosinophilic granulomatosis with polyangiitis
The pathophysiology of AAV involve presence of ANCA and also granulomatosis.
ANCA target certain proteins in the cytoplasmic granules of neutrophils and monocytes. The neutrophil for example contains enzymes myeloperoxidase and proteinase 3 in granules. What it thought to happen is that during inflammation cytokines such as TNFa and IL1 stimulates the translocation of proteinase 3 and myeloperixoidase to the cell membrane allowing these enzymes to be exposed."
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Amazing way to start the day: watch a new video of my favorite youtube! Thanks 👍
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Cheers for the video content! Sorry for the intrusion, I am interested in your opinion. Have you heard about - Ganrayden Peerless Gratification (probably on Google)? It is a good one off product for eradicating your urticaria without the hard work. Ive heard some pretty good things about it and my close friend Aubrey after a lifetime of fighting got cool results with it.
This is amazing work. You are amazingly talented, both with your descriptions and your drawings! You should write a textbook - thank you so much for helping me with understanding this topic.
Diagnosed "Necrotising glomerular nephritis" ANCA associated. Really helping me to understand underlying cause through your video...
Thank you very much ! Well structred and well presented
Huge thanks sir! Your videos are always the best!
Thank you so much for your videos!!!
It's so cool! Man I need more videos on small topics, which are clinically so important.
Amazing presentation.
bloody awesome video
thanks
Excellent
Thanks for such a nice video
Thank you
Good video
Your drawings and handwriting are extremely aesthetically pleasing! I wish i could draw like that!
Excellent Video! Apologies for butting in, I would appreciate your initial thoughts. Have you considered - Ganrayden Peerless Gratification (probably on Google)? It is an awesome one of a kind guide for eradicating your urticaria without the headache. Ive heard some interesting things about it and my good mate called Gray after many years got excellent results with it.
brilliant
Hey man, great quality video!! Can I ask for some advice? I am starting a PhD vlog channel and am wondering if you have any tips? Thanks a million man!
Thank you for the thorough presentations about vasculitis. I am wondering why polymyalgia rheumatica was not discussed in the small vessel category.
Good
Interesting ❤️ 😀🙏❤
Tq
I actually suffer from this.......the c ANCA type,........It baffled a lot of doctors just to diagnose it. I’ll be ok, but it was a pretty close thing
Im in the process of getting a diagnosis myself. Best wishes that yours is manageable!
what were your symptoms, if you don't mind me asking
I may have this. My cANCA was positive and PR3 negative.
How are you? I'm dealing too.
@@lillyrocks2011 3 years after it first started, I'm doing ok, I guess.
I'm on SSDI,semi retired and walk slowly with a cane....pretty short of breath, and my feet are numb
My kidneys are functioning at about 50%, but I don't need dialysis, just have to keep to a low salt diet......the GOOD news is that after all the insane treatments, I had my 4th rituxan Infusion in March, and remain ANCA negative!
Just today I have a pediatric patient with suspected granulomatosis with polyangiitis. Your video helps a lot in further understanding the disease. Thanks a lot!
Btw orang Indonesia kah, dok?
In Which year do medical students study this material?
Great channel and amazing work!
I'm in 4th year but I dont think i'll remember it in this detail xD
Which software do you use?
Would Zika infection cause vasculitis?
unable to find the image in your store, help?
Does ANCA vasculitis cause reactive amyloidosis? I have diagnosis of severe autoimmune Neutropenia and Aa amyloidosis. I have anca antibodies but no diagnosis of certain vasculitis
Any chronic state of inflammation (like Rheumatoid arthritis etc) can cause Amyloidosis (AA type). AA type Amyloidosis is due to large amounts of a protein (AA protein) produced by the liver during states of inflammation depositing in various organs
Podrías estar en español..!
Hey can you please re-upload the brain physiology video. Also thanks to your Kidney videos i got 350/ 360 in my test
I got 600, I win
Why do the B cells produce antibodies against the bodies own enzymes?
Like every Rheumatological disease - unknown, a lot of maybes, genetics, environmental factors.
@@armandohasudungan antibodies are nonspecific. Meaning the body is trying to get rid of something but in the meantime the own tissues are attacked. It is 99% of the time environmental toxin or stress.
What is that large kidney shaped thing supposed to represent?
Lymph nodes
480
Kaplan题库ANCA 相关血管炎。
You are great but you are focusing more on pathophysiology and neglecting the clinical presentation 😕
He'll get to that later when he starts clinical rounds
Why do the B cells produce antibodies against the bodies own enzymes?