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It's actually kind of scary that you can give mice and therefore probably also humans this injectable toxin CdtB that causes IBS/SIBO.

Thank you Dr. Leite and team for sharing this knowledge on medications to treat ibs and sibo. Kind regards miss Reimara

May improve lol

What's the dosage for humans?

how do you deal with wiping out the healthy gut microbiome though? Rifaxin cured my sibo but I ended up with c.diff :(

This is great. I am finding clues to get closer to curing my eczema. I will get there.

hydrogen sulfide

So if you're fat and have Sibo just lose the weight? I have suffered with high methane Sibo for 25 to 30 years and I can not afford to get treated since most Gi's don't know how to treat Sibo and you need to do more for the average people that can not afford treatment the 3k medication for Sibo it is impossible for many to get. I took Accutane and after that my digestion was ruined along with my gallbladder and my whole life ruined by Sibo.

Thank you GOD for this amazing man trying to help us from misery with all his research. Most of doctors don't care about all of the symptoms we go thu. I'm bloated 24/7, diagnosed with ibs but now I think I have methane sibo.

Thank you for the work you do I really believe you will find a cure in my lifetime.

I have suffered with Sibo for over 22 years because I can not afford a good doctor to help me. I wish you would find a cure for Methane and other types of Sibo that us poor people can afford.

Now the question is, if there is already something one can do against CdtB

Sibo & chronic gastritis diet the same?

I do like Pimentel but his research is going too slow due to funding from our institutions. Also China and Japan researchers already have most of these findings and have for years. They are way ahead of us in microbiome research and have cures for most of these issues. Pimentel' team should seek public funding from the american public, many researchers do this, and conduct studies simultaneously based on various theories to flush out what will work and get real solutions to suffering public. These studies are taking way too long and costing people suffering too much money. Time to be resourceful.

thank you Dr. Pimentel. I have more clarity now on dibo, Simon, imo and particularly the efficacy of prucalopride. I have been using this prokinetic agents and really helps my gut motility. I look forward to more of your q and a, webinars, podcasts etc on RUclips. please keep sharing your wisdom with the world. many thanks, Reimara

To the viewers: don't forget that the effect of artificial sweeteners on the human microbiome is a rather young field of research with more unknowns than knowns. So while this topic is surely interesting to the general public, you'll probably have to wait at least a decade for any somewhat reliable information. It is far too early to derive dietary advice from this or other studies other than what's common sense: not consuming them is safer than consuming them. But it is still overwhelmingly clear that artificial sweeteners are less harmful than sugar.

Is elemental diet more helpfull against ibs-d than rifaximin ?

I have battled methane and hydrogen SIBO for yrs with chronic constipation. I have to treat myself with herbals bc most drs have no clue about SIBO or treating it. My dr gave me rifaximin only bc I told him I tested positive at home but I didn’t take it bc I didn’t feel it would be enough to treat. If we treat with RX drugs, won’t SIBO come back bc we have no idea how we all got into this mess in the 1st place? Is it dairy, wheat, grains, gmo? Who knows. I feel like I’m in a losing battle here, it’s so sad

Dr we APPRECIATE your work! We must find the link between imo,pcos,estrogen dominance,herpes simplex,hashimoto’s, and lower heart rate (except when I take ginger!) I wish I understood why that happens! I take it for constipation and sometimes it works and sometimes not. I’d like to know why? I have all of these symptoms and am finding out that many others with imo do as well. Any info on this? I have found little. Since imo is genetic maybe the missing link is in those who were bottle fed vs breast fed?

An overgrowth of methanogens in the gut can suppress motility and create constipation. But absorbed methane can also inhibit bladder function creating urinary symptoms.

Dear RUclips, Why I found this channel after so many years. Its a ray of hope. Its the first channel for which I have presses bell icon.

Dear Doc, Can fasting give relief from SIBO ?

WOW… thanks so much to all the people involved in this research. You can hear all day long that being outside is good for you and that sunlight is good for you but when you see research like this it just has a different impact. Thank you

What’s the percentage that Rifaxami work on

This man gets it. He understands the day to day suffering of microbiome distress!! So grateful I found him+ so grateful for his hard work in this area ❤️⚡💪❤️😍

He deserves a Nobel Prize ❤

Enough of this garbage. If you don’t kill the bacteria in the small intestine you won’t ever get rid of it

I'm struggling with high anti-vinculin antibodies but I don't have SIBO, I have post infectious IBS. I'm going to try Xifaxan. I'll report back!

Can sibo lead to Crohn's diseases

if we can't take any probiotics, how do we repopulate the gut properly after antibiotics?

Hey there, great video! really well articulated and Marks attitude shines of hope and determination. May I ask when the next Q&A video may be? Any chance of doing an AMA (ask me anything) on the SIBO subreddit? this would be profound and I imagine, through Reddits upvote system, would distill down some very important questions. Cheers!

So are things like Kefir and Kombucha, no-no's?

Can Bactrim treat SIBO?

If you don’t travel outside of the country, but you still get food poisoning more than a normal person, how do you take steps to prevent yourself from getting food poisoning? I only got food poisoning once from eating out once, total five times. My first time I was late 40s seems after that I was prone to nausea and getting it again.

My money is on Dr P for curing and abolishing the antibodies that cause IBS for good!!! 👏👏👏👏🙏

Brilliant! Thank you so much for you research!A new universe is opening when I heard about the antibodys! 🙏🙏🙏

Does anyone ever recover from SIBO after the prescribed antibiotics? I developed post infectious IBS-M after cdiff six years ago. My eating is so restricted; no gluten, hardly any fruit, minimal vegetables, no nuts (except for PB). I can eat dairy though...thank God! At least I can now function but am wondering if I have SIBO. Sitting here on my couch listening to my stomach churn after dinner. This always happens and I haven't given it much thought.

Thank you . I am learning a lot my IBD. I have inflammation in my gut. But luckily no symptoms. Except the small amount of blood a few times a year. Hopefulll I won’t be worse over the years. I am 55 years of age

Excellent, clear presentation of this necessary research. Bravo to the professionals studying these side effects. And suctioning tiny rat small intestines.

Fascinating research, thanks so much for sharing

Nobel Prize worthy research

Very interesting the part on 14:00 about the link and influence on metabolism pathways

Thank You Colon Cancer 7 years Ago This INFO Will Help Me To Manage TY

I've done in depth research and I have ibs (recently diagnosed) myself and I traced back to stress..when your're stressed for a prolonged period your body breaks down from the inside but when you stop stressing that's when the inflammation and symptoms start so therefore you don't panic from it but accept it and relax. Healing is happening and the more relaxed and calm you're the faster ibs, ibd will subside, it usually takes about a year but you will heal. Take it from me guys, I've healed from bipolar and benzodiazepine withdrawal and that's no easy task and those r diseases from the mind but so is ibs.

I'm designing a Biogas Digester and this information is very helpful...

shannon index and all those diversity indexes are complete BS.. have no clinical utility whatsoever - bad math applied by people who don't understand math.. otherwise good video

Very informative. Thank you for your research

Is Lactulose still the best substrate for Breath test.

Can hyper Parathyroid Exacerbate see Beau and Anti’s Vinculin Antibodies

I ve lived with IBS constipation for 25 years, I recently tested positive for Sibo, both methane and hydrogen. My Doctor didn't know what SIBO was and refused to give me Rifaximin and Neomycin. He also told me there no test for IBS. He was happy to give costly colonoscopy test which came back normal!!!! When will the rest of the World catch up? When will our Doctors get training. So, so grateful for your work xx