- Видео 214
- Просмотров 259 982
The Broken Science Initiative
США
Добавлен 1 авг 2022
In 2022, Greg Glassman and Emily Kaplan launched The Broken Science Initiative to free any man from the tyranny of broken science and its scientists. Through a shared interest in the replication crisis in medicine, this intellectual exploration led to a fascination with predictability and the lack of probability theory in most of science (we joke, all the ologies and medicine). We'll break down why p-values, confidence intervals, and a misplaced emphasis on method are tools of Broken Science. Then we'll share alternative ways of deriving validation --in fact, we'll argue our ways are the only real ways to find predictable outcomes. We will show you how and why we've gotten things so dangerously wrong, who's responsible and hopefully provide you with a new perspective on what science is and what it is not. When predictive value is replaced by consensus thinking, one is left with nonsense that won't replicate, that's Broken Science.
Chris Palmer - Brain Energy: The Metabolic Theory of Mental Disorders and New Treatment Strategies
Chris Palmer - Brain Energy: The Metabolic Theory of Mental Disorders and New Treatment Strategies
Просмотров: 23 060
Видео
Cancer as a Mitochondrial Metabolic Disease: Thomas Seyfried
Просмотров 73 тыс.Месяц назад
Cancer as a Mitochondrial Metabolic Disease: Thomas Seyfried
Emily Unleashed Bonus Ep: Anton Garrett & James Franklin
Просмотров 353Месяц назад
Emily Unleashed Bonus Ep: Anton Garrett & James Franklin
Emily Unleashed Episode 7 with James Franklin
Просмотров 573Месяц назад
Emily Unleashed Episode 7 with James Franklin
Emily Unleashed Episode 6 with Dr. Ed Calabrese
Просмотров 4772 месяца назад
Emily Unleashed Episode 6 with Dr. Ed Calabrese
Emily Unleashed - Josh Vietti Trailer
Просмотров 942 месяца назад
Emily Unleashed - Josh Vietti Trailer
Emily Unleashed Episode 5 with Josh Vietti
Просмотров 1822 месяца назад
Emily Unleashed Episode 5 with Josh Vietti
PREVIEW: Emily Unleashed Episode 3 with Pashtana Durrani
Просмотров 1752 месяца назад
PREVIEW: Emily Unleashed Episode 3 with Pashtana Durrani
MetFix-The Metabolic Fix, coming soon #bsi #gregglassman
Просмотров 1,5 тыс.2 месяца назад
MetFix-The Metabolic Fix, coming soon #bsi #gregglassman
Emily Unleashed Episode 4 with Dr. Jay Bhattacharya
Просмотров 6 тыс.2 месяца назад
Emily Unleashed Episode 4 with Dr. Jay Bhattacharya
Emily Unleashed Episode 3 with Pashtana Durrani
Просмотров 2592 месяца назад
Emily Unleashed Episode 3 with Pashtana Durrani
PREVIEW: Emily Unleashed Episode 2 with Dr. Drew
Просмотров 1742 месяца назад
PREVIEW: Emily Unleashed Episode 2 with Dr. Drew
The Three-Dimensional Definition of Fitness and Health
Просмотров 8852 месяца назад
The Three-Dimensional Definition of Fitness and Health
Emily Unleashed Episode 2 with Dr. Drew
Просмотров 7262 месяца назад
Emily Unleashed Episode 2 with Dr. Drew
Emily Unleashed Episode 1 with Adam Carolla
Просмотров 2,8 тыс.3 месяца назад
Emily Unleashed Episode 1 with Adam Carolla
PREVIEW: Emily Unleashed Ep. 1 - Adam Carolla
Просмотров 6493 месяца назад
PREVIEW: Emily Unleashed Ep. 1 - Adam Carolla
Journal Club 2 Preview: The Broken Science Initiative
Просмотров 2573 месяца назад
Journal Club 2 Preview: The Broken Science Initiative
The Method and Meaning of True Science - Greg Glassman
Просмотров 1,1 тыс.3 месяца назад
The Method and Meaning of True Science - Greg Glassman
Evolution of the Revolution Tour. New dates added.
Просмотров 1333 месяца назад
Evolution of the Revolution Tour. New dates added.
Sunday Discussion, Part 3: Epistemology Camp 2024
Просмотров 3184 месяца назад
Sunday Discussion, Part 3: Epistemology Camp 2024
Sunday Discussion, Part 2: Epistemology Camp 2024
Просмотров 3515 месяцев назад
Sunday Discussion, Part 2: Epistemology Camp 2024
Sunday Discussion, Part 1: Epistemology Camp 2024
Просмотров 8036 месяцев назад
Sunday Discussion, Part 1: Epistemology Camp 2024
5 Buckets of Death | And The Covid Trashcan Fire
Просмотров 11 тыс.6 месяцев назад
5 Buckets of Death | And The Covid Trashcan Fire
Intersections of Probability, Philosophy, and Physics: Anton Garrett
Просмотров 1,6 тыс.7 месяцев назад
Intersections of Probability, Philosophy, and Physics: Anton Garrett
this guy is the real deal!
Thanks for the update~ the description link to the source goes to an error page though
Off the couch and off the carbs
prostate cancer?jim kelmuns protocoll,fenbendazol,b17,vit c infus.,coriander tinture,avoid elektro mag,smog,methylen blue+red light,cdl, blue berries,d3+k2 etc...
How about the high cost for regular people to access and read scientific studies? Every time some nutritionist makes a claim about what I should eat or not eat, they cite a study that I can't afford to look at myself. We as a society should be spreading knowledge. Not making everything just a way for some greed-head at a choke-point in the economy to demand a payoff.
So only papers that support the climate change lie are allowed.
Concentrated government power that leads to things like Fauchi claiming that HE was science.
we have a mental health crisis because people are overworked and overstimulated and unhealthy AF we know perfectly well how to deal with it but people would rather engage in their dumb cultural wars than deal with this shit, yeah the rich ruin the world and the politicians are bought but you could have voted someone like Bernie Sanders in, but you didnt ultimately the US gets the shity dystopian country its people deserve for their ignorance
There are many corelents with mental health and health period. There is not likely one major cause but the most profound solutions lie with personal agency. Best case guidance with therapy that doesn't support victimhood and promotes agency. These labels trade responsibility for agency.
Emily, @25:35, Agent Orange was a chemical used in Vietnam to defoliate trees, which contained the carcinogen Dioxin. You are probably thinking of nitrogen mustard, which lead to using chemicals for cancer treatment, ie chemotherapy....not radiation therapy, which uses X-rays or radioactive isotope exposure to treat cancer. Otherwise, this was a very informative interview. Thanks.
We need to defund the NIH since they do nothing but collect money for sitting around on their fat asses.
Anybody knows how to donate to Dr. Seyfried's research?
He’s got a donation button on his website 😊
He should be in the next administration.
One of the best explanations I've found - made it easy to understand. One suggestion though - axe the background music, it's distracting.
Sugar and plastics??
Very simple, keto will cure dementia. But no money in telling the truth about that. They want an on going treatment. That is where the money is.
more they created a problem and arent looking for a cure but a way to manage it forever at great expense.
"Cancer" is actually the CURE, meaning that the body will encapsule toxins in tumours, so it will not reach the vital organs and cause harm. Most "cancer"-patients have a (long) history of using pharmaceuticals, prior to "getting" "cancer". CHEERs! :)
“Popper rejected inductive logic” - that’s fundamentally inaccurate. Conversely, Popper pointed out that induction is THE method of science. Contradictions, which are negative-deductions, are just means of chipping away at the fundamental guess which each scientific theory represents, and experiments are designed to provide base for each contradiction. Once a theory’s main assumption is contradicted, the theory becomes proven to be false. To illustrate, the theory that Popper rejected induction as means of scientific process has been contradicted by my explanation above. I find Popper’s “Realism and the Aim of Science” 1983, as an excellent reference for those who want to get the essence of the topic from Popper himself.😊
Marvellous explanation. I am awestruck with your explanation.
Summary of the book is all diseases are due to dysfunction of metabolism. The mitochondria control the metabolism. So look after the mitochondria all body will heal.
This gives me some hope for the women in Afghanistan
May i pay for virtual time with Dr? have CPTD and after seeing dr he prescribed tab for heightend seratonen the rx caused me to lose conscious to lose consciousness while driving. now nearly full amnesia, therapist waste of time. ---i work with brain fog now but lost almost evrything--clients-racing yacht not in the water no earnings while recoverings . About 14 months ago-not improving, deeply depressed- i isolate aside fr personsl trainer early daily. nothing is normal . Sad. i will write to your office pb
Very good summary. I wish you had the names and emails of the 38 million diabetics in the USA and listen to this short video
THANK YOU!! More people need to hear this 👏🏻👏🏻👏🏻
Government is a fraud magnet.
😳!!!!
Wow
MEN cause depression in women then they profit from it. They have no interest in fixing it because it's their cash cow.
🥩🧈🥓🍳 that's the cure for Alzheimer's
The big pharma might not be fond of this idea. I hope Prof. Seyfried stays well and healthy! Thank you for your research ❤
Soooo close to the truth. Missing the requirement for invasiveness. Cancer Is A Metabolic Disease aka Invasive Inflammation Malignant Neoplasia is a multifaceted metabolic disease that has at least three requirements. First, Apoptosis needs to be turned off via dysfunction of the Mitochondria and/or the Mitochondrial - Lysosomal Interaction, down-regulation of Death Receptors and/or Endoplasmic Reticulum dysfunction. Second, “fuel(s)” or out-of-range hormone(s) need be present ie: insulin, cortisol, prolactin, estrogen, progesterone, androgens like testosterone, etc (these first two make up the cellular definition of inflammation.) Examples of fuels: Alcohol alters many hormone levels, sugars and carbohydrates are the driver of elevated fasting insulin, stress is the driver of elevated cortisol and prolactin, endocrine disruptors like corticosteroids lower TSH, LH, etc and birth controls alter estrogen, progesterone and other levels, etc. And third is Nuclear Alterations need be present which allow the cells to become invasive, this is through disruption of the Wnt/β-catenin signaling pathway which controls cellular replication. Nuclear Alterations can be caused by dysbiosis, malnutrition and carcinogens, some of which also act as fuels and are toxic enough to turn off the Apoptosis pathways like Alcohol, Tobacco Products, Certain Chronic Fungal, Viral, Bacterial and Parasitic Infections, Birth Control, etc. How to treat properly = remove the carcinogen(s) + change to an organic ketogenic or carnivore diet + use extremely high doses of specific antioxidants that have very low toxicity to healthy cells (Cannabinoids, Astaxanthin, Alpha and Beta Santalol, Linalyl Acetate and Linalool, Vitamin D, IV Vitamin C, Punicic Acid, Anthocyanins, Polyphenols, etc.) + repair the gut microbiome using specific dietary additions (ACV Pickles, Kimchi, Sauerkraut, Olives, etc) and probiotics (60B Probiotic Blend, Lactobacillus Salivarius.) Oxidative stress and metabolic diseases: Relevance and therapeutic strategies www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.994309/full Cancer as a metabolic disease nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-7-7 Cancer as a Metabolic Disorder www.ncbi.nlm.nih.gov/pmc/articles/PMC8835572/ Cancer as a metabolic disease: implications for novel therapeutics www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/ Cancer and Obesity: The Link is Insulin medicine.yale.edu/news-article/cancer-and-obesity-the-link-is-insulin/ Diabetic-level glucose spikes seen in healthy people med.stanford.edu/news/all-news/2018/07/diabetic-level-glucose-spikes-seen-in-healthy-people.html New Clarity on the Warburg Effect www.cancer.gov/research/key-initiatives/ras/news-events/dialogue-blog/2021/vander-heiden-warburg-effect Ivermectin: A Multifaceted Drug With a Potential Beyond Anti-parasitic Therapy pmc.ncbi.nlm.nih.gov/articles/PMC11008553/ Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways www.nature.com/articles/s41598-018-30158-6 Wnt/β-catenin signaling: function, biological mechanisms, and therapeutic opportunities www.nature.com/articles/s41392-021-00762-6 Wnt signaling in cancer www.nature.com/articles/onc2016304#:~:text=The%20APC%20gene%20was%20found,4/%CE%B2%2Dcatenin%20signaling.&text=These%20findings%20established%20a%20direct,signaling%20and%20human%20colorectal%20cancer. Wnt/β-catenin signaling in cancers and targeted therapies www.nature.com/articles/s41392-021-00701-5#:~:text=As%20an%20evolutionarily%20conserved%20signaling,%2Dcatenin%2Dassociated%20targeted%20therapies. Targeting the Wnt/β-catenin signaling pathway in cancer pmc.ncbi.nlm.nih.gov/articles/PMC7716495/#:~:text=The%20aberrant%20Wnt/%CE%B2%2Dcatenin,%CE%B2%2Dcatenin%20signaling%20in%20cancer. Apoptosis www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/apoptosis#:~:text=Mitochondria%20play%20a%20central%20role,Danial%20and%20Korsmeyer%2C%202004). Lysosomal-mitochondrial cross-talk during cell death www.sciencedirect.com/science/article/pii/S1567724910001376#:~:text=lysosomal%20content%20into%20the%20cytosol%20can%20initiate,links%20to%20the%20mitochondrial%20cytochrome%20c%20release Connecting lysosomes and mitochondria - a novel role for lipid metabolism in cancer cell death pmc.ncbi.nlm.nih.gov/articles/PMC6664539/ Caspase‐mediated programmed cell death pathways as potential therapeutic targets in cancer pmc.ncbi.nlm.nih.gov/articles/PMC6495317/#:~:text=Caspases%20are%20involved%20in%20two,subsequently%20activated%20by%20caspase%E2%80%909 The Death Receptor Pathway of Apoptosis pmc.ncbi.nlm.nih.gov/articles/PMC8805650/ Mitochondrial apoptosis: killing cancer using the enemy within www.nature.com/articles/bjc201585 The Mitochondrion www.ncbi.nlm.nih.gov/books/NBK26894/#:~:text=Mitochondria%20can%20use%20both%20pyruvate,fatty%20acids%20come%20from%20fats. 3 Genetics and Health www.ncbi.nlm.nih.gov/books/NBK19932/#:~:text=Although%20there%20are%20many%20possible%20causes%20of ***Analyzing the role of cannabinoids as modulators of Wnt/β-catenin signaling pathway for their use in the management of neuropathic pain pubmed.ncbi.nlm.nih.gov/30871771/ ***Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review pmc.ncbi.nlm.nih.gov/articles/PMC9899821/ ***Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression pmc.ncbi.nlm.nih.gov/articles/PMC3005548/ Needs To Be Taught In Medschool: - [ ] The Gut Microbiome & Dysbiosis - [ ] The EndoCannabinoid System - [ ] Liver-Renal Axis & Lipogenesis - [ ] Inflammation and Metabolic Diseases - [ ] Natural Low Toxicity Antioxidants in Full Spectrum Form - [ ] Proper Nutrition & Diet All Human Ailments Stem From One Or More Of The Following: - [ ] Acute Cell Death - [ ] Acute Inflammation - [ ] Chronic Inflammation - [ ] Dysbiosis - [ ] Infection - [ ] Malnutrition - [ ] Physical Trauma - [ ] Truly Genetic (5%) - [ ] Birth Defects (3%) - 20% of which are genetic
I don't think we mostly ate meat in our ancient past. Likely it is the opposite with very little meat according to current peer reviewed research
Yesss! Finally! Halleluja! Thank you, thank you, thank you! Some 20+ years ago, being obese and a wreck after several waves of burnout, I was called depressed but could feel in the core of my soul that wasn't the problem, so I rejected the pills. Started testing and investigating, vitamins and minerals, amino acids and low carb diets. I got better. Still obese but less so. Diagnose of PTSD and eventually hypothyrodism (after having been called hypocondriac for four years). Constant stress, got double sided iritis from the shock (but succeeded to heal myself from this incurable disease). Fast-forward to 2022. I am still unable to work (totally arbitrary sleep patterns and non-functional GI system, now mostly controlled by stomach enzymes and Betaine HCl) one health care worker started seeing a pattern. Psychologists investigated: Asperger's. Remembering that the psychiatrist dr William Walsh had found that 96% of 3000 of his patients with Asperger's had a mutation in the MTHFR gene, I compared my own earlier findings about needed supplements with his prescribed panel of supplements. It coincided almost to the T with my own. I'm so glad science is catching up. Maybe I may even get som actual help before it's too late. Hoping at least that I co-inspired someone to give diet and nutrients a try.
What is the research of Prof Thomas Seyfried on Mega Dose Vitamin D
Dr Matthew Phillips, a neurologist living in Hamilton New Zealand . He is originally Canadian and is head of Neurology at his hospital. The role of mitochondria and our metabolism is at the very heart of neurological disorders. He is a pioneer in his field and gives lectures internationally. He has been conducting clinical studies over the past few years . nosilverbullet4pd
Where can a mother in Mississippi get help for her son??? Please I want to get involved. I want to help however I can, starting with my son ❤️🙌🏼❤️
Same here. I need help with my son and would love to get involved!
Professor have you ever studied mitochondria in Rett syndrome? My daughter has been 32 years in to this Syndrome. I am always searching how to improve her life. Mitochondria in Rett syndrome are swollen, also Mitochondria in Rett have altered respiratory rates and leaks protons. Thanks
wow honestly I dont understand how people can do this. are they really that stupid and unknowledgeable? did they never present their study in WIPs or conferences ? noone thought it was dodgy? IT GOT PUBLISHED?? science really isnt what my profs in undergrad made it out to be... now that I have a PhD myself I left the field... too much bullshiting from people pretending they only care about knowledge and not the prestige and money and bullshiting.
Yes. It's a horror I've had to go broke fighting cancer....and do it on my own, as no insurance will cover any method except chemo
When I heard this doctor trying to push statins on people I knew he was batting the wrong way
Well, that’s what happens when objective truth is no longer valued.
once you go carnivore, everything gets better... sleep quality, thinking, movement, agility, vision... my 1600m swim time got 3 mins faster after cutting out carbs and going full (90%) carnivore. Just like pretty much everything else the government tells you, its 180 degrees wrong. We have to take back responsibility from the corrupt medico/pharma cabal. Do your research... see how medicine was corrupted by Rockefeller in 1913. I wish you well in your journey of truth...
The metabolical HYPOTHESIS of mental disorder and IF in the future the HYPOTHESIS isn’t disprove THEN treatment(s) …
He's got a promising career in pharmaceuticals and / or government health agencies. I hear Fauci is looking for an assistant. Rule 1 it's more important to seem right than to be right.
Redox Signaling Molecules are the foundation of cellular health. If your cells aren't healthy you can't be healthy. I drink them every day to replenish them
What if someone doesn't have insurance and can't afford treatment?
Fasting is cheap
So interesting coming from a wonan who had ER breast cancer 3 years ago . Had mastectomy, radiation but refused chemo as all pushed on to me . Then oh you must take letrozole for 5/10 years . A hormones blocker . Horrendous side effects. I did my own research on everything i could find . I was on hrt before diagnosis. Told to immediately stop yet my estrogen level monday gone is the same as back in 2022 . Scratching my head , so all those side effects yet wasn't lowering my estrogen. Ps stopped taking letrozole few weeks back . My poor body just suffering . Oh and recently taking L glutamine for muscle, joints . Threw them in the bin . 😮
So should we give up all fermented foods?
The relationship between cancer and metabolism isn’t a straightforward cause-and-effect scenario; rather, for cells to become cancerous, they must go through numerous steps and acquire a range of complex characteristics. These include proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis, as well as reprogramming energy metabolism and evading immune detection. Achieving this intricate array of changes requires multiple genetic, chemical, physical, and electrical alterations, painting a picture of immense complexity. Consequently, while there are many potential targets for treatment, pinpointing the specific few that could disrupt this formidable machinery remains a significant challenge.