- Видео 134
- Просмотров 73 702
Psychiatric Genomics Consortium
Добавлен 23 июн 2016
The purpose of the Psychiatric Genomics Consortium (PGC) is to unite investigators around the world to conduct meta- and mega-analyses of genome-wide genomic data for psychiatric disorders. With over 800 investigators from 38 countries and samples from more than 900,000 individuals currently in analysis, the PGC is the largest consortium and the largest biological experiment in the history of psychiatry. The PGC is passionate about open, inclusive, participatory, and democratic science. Given the importance of the problems we study, we are committed to rapid progress.
PGC WWL: Functional Genomics working group
Cathryn Lewis will host this webinar, and we will hear from the following speakers:
Mary-Ellen Lynall, University of Cambridge
PGC Functional Genomics working group Co-chair
Jens Hjerling-Leffler, Karolinska Institutet
PGC Functional Genomics working group Co-chair
Janitza Montalvo-Ortiz, Yale University
PGC Functional Genomics working group Project lead
Agenda:
Introduction to the new Functional Genomics workgroup (Mary-Ellen Lynall, 10-15 mins)
Large-scale meta-epigenome wide association studies to identify biomarkers of psychiatric disorders (Janitza Montalvo-Ortiz, 20 mins)
The neuroscientist’s guide to schizophrenia: a data-driven prioritization of cells and circuits (Jens Hjerling-Leffler,...
Mary-Ellen Lynall, University of Cambridge
PGC Functional Genomics working group Co-chair
Jens Hjerling-Leffler, Karolinska Institutet
PGC Functional Genomics working group Co-chair
Janitza Montalvo-Ortiz, Yale University
PGC Functional Genomics working group Project lead
Agenda:
Introduction to the new Functional Genomics workgroup (Mary-Ellen Lynall, 10-15 mins)
Large-scale meta-epigenome wide association studies to identify biomarkers of psychiatric disorders (Janitza Montalvo-Ortiz, 20 mins)
The neuroscientist’s guide to schizophrenia: a data-driven prioritization of cells and circuits (Jens Hjerling-Leffler,...
Просмотров: 161
Видео
PGC WWL Bioinformatics with Michael Love, Oliver Pain, and Patrick Sullivan
Просмотров 2137 месяцев назад
Cathryn Lewis will host this webinar, and we will hear from the following speakers: Oliver Pain, Maurice Wohl Clinical Neuroscience Institute, King’s College London GenoPred: A comprehensive and scalable pipeline for polygenic scoring Patrick Sullivan, UNC Genetics and Psychiatry GeneMatrix: gene-based data frame for psychiatric genomics Michael Love, Genetics Department, UNC-Chapel Hill Tidyom...
Nordic Tryggve Consortium: Advancements in Distributed Computing system, Applications, and Beyond
Просмотров 1008 месяцев назад
Agenda: Chair: Ole Andreassen Talk 1. Overview of the Tryggve consortium: Lu Yi - 5’ Talk 2. Tryggve infrastructure - distributed container tutorial: Bayram Akdeniz & Oleksandr Frei - 15' Talk 3-4. Nordic effort on MDD & SCZ: Alfonso Buil, Kaarina Kowalec - 15’ Discussant: Stephan Ripke - 10' Q&A 15’ Summary of session: Nordic Tryggve Consortium: Advancements in Distributed Computing system, Ap...
PGC WWL: Polygenic Risk Prediction with Naomi Wray, Xiaotong Wang, and Jian Zeng
Просмотров 44810 месяцев назад
PGC WWL: Polygenic Risk Prediction with Naomi Wray, Xiaotong Wang, and Jian Zeng
2023 Working Group updates from the Psychiatric Genomics Consortium
Просмотров 357Год назад
2023 Working Group updates from the Psychiatric Genomics Consortium
An Introduction to the Psychiatric Genomics Consortium with Dr Patrick Sullivan
Просмотров 233Год назад
An Introduction to the Psychiatric Genomics Consortium with Dr Patrick Sullivan
Hand-on tutorial of using PRS-CSx to perform multi-ancestry PRS analysis with Yunfeng Ruan
Просмотров 818Год назад
Hand-on tutorial of using PRS-CSx to perform multi-ancestry PRS analysis with Yunfeng Ruan
PGC WWL: Africa Working Group
Просмотров 205Год назад
This WWL meeting was led by the PGC Africa Working Group, and will cover four different psychiatric genetics initiatives in Africa. The speakers were: • Akena Dickens - NeuroGAP (Makerere University College of Health Sciences, Uganda) • Celia van der Merwe - NeuroDev (Broad Institute, USA) • Niran Okewole - DepGenAfrica (Neuropsychiatric Hospital, Aro, Nigeria) • Conrad Iyegbe - PGC Africa Work...
Estimating vertical transmission and genetic nurture using polygenic scores with Jared Balbona
Просмотров 116Год назад
Estimating vertical transmission and genetic nurture using polygenic scores with Jared Balbona
History of Psychiatric Genetics Part II with Kenneth Kendler
Просмотров 277Год назад
History of Psychiatric Genetics Part II with Kenneth Kendler
Polygenic risks in disorders of aging with Valentina Escott- Price
Просмотров 71Год назад
Polygenic risks in disorders of aging with Valentina Escott- Price
Tracking 12 years of genetic architecture estimates of schizophrenia with Naomi Wray
Просмотров 188Год назад
Tracking 12 years of genetic architecture estimates of schizophrenia with Naomi Wray
Family-based GWAS analysis: SAIGE with Wei Zhou
Просмотров 815Год назад
Family-based GWAS analysis: SAIGE with Wei Zhou
Gene set identification: PRSet with Judit Garcia Gonzalez
Просмотров 193Год назад
Gene set identification: PRSet with Judit Garcia Gonzalez
Genome-wide association study with Hailiang Huang
Просмотров 148Год назад
Genome-wide association study with Hailiang Huang
Polygenic risk scores: PRSice & lassosum with Shing Wan Choi
Просмотров 1,5 тыс.Год назад
Polygenic risk scores: PRSice & lassosum with Shing Wan Choi
How to Run Quality Control on Genome Wide Genotyping Date with Jonathan Coleman
Просмотров 130Год назад
How to Run Quality Control on Genome Wide Genotyping Date with Jonathan Coleman
Introduction to PsychENCODE with Chunyu Liu
Просмотров 120Год назад
Introduction to PsychENCODE with Chunyu Liu
GWAS with admixed individuals : Tractor with Elizabeth Atkinson
Просмотров 268Год назад
GWAS with admixed individuals : Tractor with Elizabeth Atkinson
Estimating SNP-based heritability with GCTA-GREML with Jian Yang
Просмотров 1,3 тыс.Год назад
Estimating SNP-based heritability with GCTA-GREML with Jian Yang
Conditional and joint trait analysis: mtCOJO with Zhihong Zhu
Просмотров 239Год назад
Conditional and joint trait analysis: mtCOJO with Zhihong Zhu
Gene/gene set identification: H-MAGMA with Nancy Sey
Просмотров 172Год назад
Gene/gene set identification: H-MAGMA with Nancy Sey
Genotype calling/imputation on the cloud: MoChA pipeline with Giulio Genovese
Просмотров 57Год назад
Genotype calling/imputation on the cloud: MoChA pipeline with Giulio Genovese
How to Perform Epigenome Wide Association Studies with Adam Maihofer
Просмотров 163Год назад
How to Perform Epigenome Wide Association Studies with Adam Maihofer
Improving Polygenic Prediction in Ancestrally Diverse Populations with Tian Ge
Просмотров 470Год назад
Improving Polygenic Prediction in Ancestrally Diverse Populations with Tian Ge
Joint genetic architecture: genomic SEM with Andrew Grotzinger
Просмотров 348Год назад
Joint genetic architecture: genomic SEM with Andrew Grotzinger
Polygenic risk scores: PRS-CS with Tian Ge & Yunfeng Ruan
Просмотров 936Год назад
Polygenic risk scores: PRS-CS with Tian Ge & Yunfeng Ruan
What if a certain SNP that is associated with more alcohol consumption is also associsted with more smoking consumption, wouldnt that mean you havent controlled for confounders? Genes may not be causal for just one single thing and may in fact predispose to other behaviours also?
Ma 7ata n2ezet. Ma n2ezet law n2ezet i would have known everything I did was on purpose. I would never hurt myself.so ma sar Shi
It's normal feeling just think of the feeling you would know immediately if you feel any pain yeah
I like the question section at the end!
没有人吗?
Nice video! Two questions: 1) Why would one want to exclude CNAs that overlap specific regions? Improve computational speed? 2) What would be the justification for setting the % exclusion zone overlap? E.g. why would I set overlap threshold to 50% and not 75%? Thanks!
Excellent presentation on SAIGE! I learned a lot about the tool.
Please where I can find the codes if possible
Very clear. Thank you!
Hello can you explain why the copy number values are seen as 2,3,9,51 like this and not like 0,1,and 2 while downloading the data from tcga
dear Jian Yang very nicely explained
TS and OCD are somewhat similar.
What is meant by the effect size of an allele? What is the context for that?
Imagine researchers conduct a GWAS and find a particular allele (let's call it "T-allele") of a genetic marker (a SNP) that's associated with height. People who possess the T-allele at this SNP are, on average, taller than those who don't. After analyzing the data, researchers find that the T-allele is associated with an average increase in height of 2 centimeters (cm). In simple terms: If you have the T-allele, you might be, on AVERAGE, 2 cm taller than if you didn't have that allele. This 2 cm is the effect size of the T-allele for height. However, remember that height is influenced by many genetic factors and environmental factors (like nutrition). So, even if you possess the T-allele, it doesn't guarantee you'll be exactly 2 cm taller than if you didn't. It just gives an average measure of the effect of that specific allele.
I don't understand why this only has 124 views?
What?
Him, its a interesting talk. I'm trying to use mtCOJO for my analysis by following instructions on GCTA webpage. I'm getting nan values for bC bC_se bC_pval Can you please suggest, what could be going wrong?
I'm still bewildered why at least 30 percent of World's population wasn't already sequenced? With so lowering exceeding even "Moores Law" costs! But Great Job guys! Keep going.
Long Live Polygenomic Testing Revolution! Long Live Robert Plomin, George Church and Noble He Jiankui!
Long Live Polygenomic Testing Revolution! Long Live Robert Plomin, George Church and Noble He Jiankui!
Long Live Polygenomic Testing Revolution! Long Live Robert Plomin, George Church and Noble He Jiankui!
Long Live Polygenomic Testing Revolution! Long Live Robert Plomin, George Church and Noble He Jiankui!
Long Live Polygenomic Testing Revolution! Long Live Robert Plomin, George Church and Noble He Jiankui!
Thanks nerd
Long Live George Church and He Jiankuis Heroism of Germ Line Crispr Editing potential for enhancing mental health and capabilities of society! Long Live Polygenic Testing Revolution initiated by Robert Plomin and collaborators!
Glory to Robert Plomin, George Church, He Jiankui and every other person engaged in (Poly)Genomic Revolution and betterments for future citizens of the world, as well as for more sophisticated diagnostics for contemporary humanity!
Are there any established links between Neanderthal alleles and schizofrenia susceptibility? And why? Is it because they were less social according to some anthropologists?
Long Live George Church and He Jiankuis Revolution! Long Live Robert Plomin and Polygenic Genomics!
Thank you!
While limiting your children's access to alcohol may seem important due to those statistics, it is important to note that teenagers will almost always drink regardless. The level of monitoring will have to be so extreme that it can easily drive a boundary between parents and their children, and will most likely result in the children obtaining and consuming alcohol in dangerous ways. The kids that truly don't drink until they're 21 probably have incredibly low genetic risk to AUD in the first place, or simply don't want to drink due to other factors. The ones that do drink before 21 are usually doing so under less than ideal circumstances due to the parenting. Be very careful to the advice you listen to on the internet, and think long and hard about things like this. They can change your children's life.
Thank you
Thank you!
Thank you for the lecture
Interesting presentation
Thanks for posting that! Cheers.
Optimal/ Delayed/ Deferred Umbilical cord clamping with no vitamin K unless absolutely essential if there were a big bleed.,,I think needs to be practised.
Research the genetic mutation MTHFR. ..AND Leaky gut. Gluten problems can sometimes cause leaky gut as well.
Excellent insights in the field of ADHD and genetics.
Why do you think you only replicate 69 out of the 109 risk loci reported in Lee et al. when you are using the same or even updated GWAS summary statistics as in their paper?
though I was looking for the use of GWAS in agriculture
thank u for this!
HDAC2 enzyme lower levels?
Thank
Rapid cycling is defined (at least in the DSM-5) as four or more mood episodes in 12 months.
Would love to be part of your thesis. Robin you were 26 years of age when I met you ...as a SHO ...I was 16 years of age and you made more sense than your hierarchy and the only person that I connected with at that very vulnerable period of my life....unfortunately you moved on as you were still in training.... Would be interested in being involved in any of your studies . Retired Public Health Specialist ...Alexandra Munro ( Glasgow)
Hello 😎everyone, very interesting 🙃videos you have thank 👍you very much, 😍good and🔥 prosperous to 💐you and your channel.❤️
Why the Chinese Prof. George Fu Gao became a member of the German National Academy of Sciences Leopoldina (adviser of the German Government) in 2020 ??? What's going on here?
brilliant!
I still only understand every other word! Good to know you're still in genetic research
I saw no clear evidence in presentations that suicide is biologically distinct from certain otherwise known psychiatric symptoms (e.g. depression, disinhibition, ...).
Will any transcript or closed captions(CC)/subtitles become available?