Видео 19
Просмотров 36 184

R-Loops: An active player in Cancer and Diseases

22:10

Extrachromosomal circular DNAs- The extraordinary eccDNAs in cancer and diseases

34:53

The latest highlights on circRNA in cancer

31:09

New discoveries in m6A epitranscriptomics - From cancer, cardiovascular, to covid-19

33:43

Raising the bar of multi-transcriptomic profiling of small RNAs

35:42

Explore Circular RNA Functions and Biomarker Potentials

31:42

Go Beyond RNA: Unveiling Downstream-of-Gene Transcripts (DoG RNAs)

Downstream-of-gene (DoG) RNAs are the RNAs transcribed continuously beyond the host gene transcription termination sites. They occur in ~10% protein coding genes in the cells, with typical sizes between 5~200 kb. Due to their extended lengths, some DoGs can further produce DoG-derived chimera RNAs and circular RNAs. DoG RNAs have many unique properties and important biological functions. They are often associated with cancers and diseases.
This webinar will cover:
• What DoG RNAs are
• DoG RNA Biogenesis
• DoG-derived chimera RNAs and circular RNAs
• DoG functions and diseases
• DoG RNA profiling and research roadmap ahead

Видео

R-Loops: An active player in Cancer and Diseases

22:10

R-Loops: An active player in Cancer and Diseases

Просмотров 4246 месяцев назад

R-loops are RNA:DNA three-stranded hybrid loop structure occurring in genomic DNA. They are formed during nascent RNA transcription in coding and noncoding regions in the genome. R-loops have important biological functions and are clinically linked to cancer, neural, and cardiovascular diseases. DRIPc-seq is an effective way to profile R-loops to discover and understand their functions, mechani...

Extrachromosomal circular DNAs- The extraordinary eccDNAs in cancer and diseases

34:53

Extrachromosomal circular DNAs- The extraordinary eccDNAs in cancer and diseases

Просмотров 1 тыс.Год назад

Extrachromosomal circular DNAs (eccDNA) are widely present in normal and cancer tissues. eccDNAs can carry and amplify oncogenes, drug resistance genes, and regularory elements that cause cancers and regulate other diseases. Their heterogeneity and disease association can be excellent diagnostic and prognostic markers. In recent years, eccDNAs have become one of the hotspots in cancer research....

The latest highlights on circRNA in cancer

31:09

The latest highlights on circRNA in cancer

Просмотров 1,1 тыс.2 года назад

circRNAs have been attracting more and more attention lately with many new discoveries in their biological and clinical functions. In particular, circRNAs play important roles in many types of cancers. Their unique circular structure has special properties in cancer biofluid biomarker uses. circRNAs can be epitranscriptomically modified, which has been discovered as a new critical player in gen...

New discoveries in m6A epitranscriptomics - From cancer, cardiovascular, to covid-19

33:43

New discoveries in m6A epitranscriptomics - From cancer, cardiovascular, to covid-19

Просмотров 1,3 тыс.2 года назад

m6A epitranscriptomic modification is an important layer of gene regulation. With the advancement of m6A profiling technologies, exciting new discoveries are continually being made. In last year alone, many diseases, from cancers, cardiovascular diseases to Covid19 viral infection, have been found to be caused or associated with aberrant m6A modification, highlighting the significance of profil...

Raising the bar of multi-transcriptomic profiling of small RNAs

35:42

Raising the bar of multi-transcriptomic profiling of small RNAs

Просмотров 3232 года назад

Small RNAs, including miRNAs, pre-miRNAs, tRNAs, tsRNAs, and snoRNAs, perform fundamental functions in the cells and in diseases. Due to their enriched abundance in biofluids, these small RNAs have been studied as a new type of biomarkers. Profiling their expression is essential for studying them in biological and clinical sciences. Here we introduce Arraystar Small RNA Array that surpasses cur...

Explore Circular RNA Functions and Biomarker Potentials

31:42

Explore Circular RNA Functions and Biomarker Potentials

Просмотров 8123 года назад

Increasingly, circRNAs are discovered to play important molecular roles in normal biology and clinical pathology. They have unique characteristics of expression derived from their backsplice sites (circular junctions). Due to the lack of free 5’ and 3’-ends, circRNAs are resistant to exonuclease degradation and are stabilized in biofluids for biomarker applications. This webinar will cover: • C...

25:18

Why and how to profile small RNA modifications?

Просмотров 5403 года назад

Small RNAs, including miRNAs and tRNA-derived small RNAs (tsRNAs), harbor a diversity of RNA modifications such as o8G, m7G, m6A, Ψ, and m5C. These modifications modulate small RNA activities in pathophysiological conditions. Quantitative profiling of modified small RNA levels and stoichiometry provides opportunities to uncover their new functional roles and use them as disease biomarkers. Arra...

How to study lncRNA expression and modifications

34:15

How to study lncRNA expression and modifications

Просмотров 3,8 тыс.3 года назад

LncRNAs make up a long non-coding portion of the transcriptome, often expressed at low levels. Yet, with their important roles in gene regulation, cell proliferation/differentiation, organism development, biological pathways, and disease pathogenesis, lncRNA expression profiling has become an essential component of gene expression profiling studies in biology and clinical sciences. Moreover, ln...

How to study Circular RNA expression and modifications?

30:58

How to study Circular RNA expression and modifications?

Просмотров 7 тыс.3 года назад

Circular RNAs are an unusual class of non-coding RNA loops having gene regulatory functions by multiple mechanisms. Due to the lack of free 5’ and 3’-ends, circRNAs are resistant to exonuclease degradation and are stabilized for biomarker applications. With its important roles in pathogenesis and organism development, circRNA exosomal delivery and circRNA sequestration of pathogenic miRNAs are ...

The latest development of LncRNA profiling technology

23:35

The latest development of LncRNA profiling technology

Просмотров 2174 года назад

- Arraystar LncRNA Arrays newly released in 2019 Learn the latest publications about the limitations of RNA-seq for LncRNA profiling, and what’s new our recently updated LncRNA microarrays can offer.

Quantify the percentage of modification at transcript level

18:07

Quantify the percentage of modification at transcript level

Просмотров 1264 года назад

Current transcriptome-wide RNA modification profiling methods deal mostly with mapping the modification sites but are unable to achieve modification stoichiometry. The lack of such quantitative information has been a major concern for scientists. This slideshow presents how Arraystar Epitranscriptomic two-color channel microarrays quantify the percentage of RNA that is modified for each transcr...

tRNAs: The rising star of wobble gene regulators

23:29

tRNAs: The rising star of wobble gene regulators

Просмотров 4344 года назад

tRNAs are not only the fundamental component in protein translation, but also new found regulatory molecules. Changing biological dynamics are always accompanied with variation of tRNA repertoire. tRNA isoacceptor wobble effect profoundly impacts translation efficiency, mRNA stability and cancer progression. tRNA isodecoder tissue specificity controls neurogenesis. Dysregulation of tRNAs causes...

Rapid Quantitative m6A Epitranscriptomic Profiling at Single-base Resolution

31:27

Rapid Quantitative m6A Epitranscriptomic Profiling at Single-base Resolution

Просмотров 5344 года назад

m6A epitranscriptomic modification of mRNA and lncRNA transcripts is a layer of gene regulation under hot research. Arraystar m6A Single Nucleotide Arrays uses methyl-sensitive MazF RNase to precisely locate the m6A site and microarray for ultrasensitive detection. The webinar covers: • m6A epitranscriptomics in mRNA and lncRNA • The roles of m6A in human cancers and diseases • Single-, Poly- a...

36:13

SE lncRNAs - The master regulators

Просмотров 8136 лет назад

Super-enhancers are top ranking master gene regulators that program the cell lineages, types, identities, and diseases. Super-enhancer lncRNAs (SE-lncRNA) transcribed from the super-enhancers activate the target coding genes by multiple mechanisms. Arraystar SE-lncRNA microarrays simultaneously profile SE-lncRNAs and their target genes, with high sensitivity, unambiguous isoform detection, comp...