@DoctorNajeeb @UnacademyLiveNEETPG @PrepLaddermedpg • Protein content of diet controls concentration of urine: Urea content of tubular fluid depends mainly on the urea filtered in the glomerular filtering membrane, which depends on the protein content of the diet. High protein diet makes more urea and this in-turn makes the urine concentrated.
• Urea transported in collecting duct also greatly helps in generating osmotic gradient in the medullary pyramid. In renal tubule, some quantity of urea is reabsorbed in PCT. However, except in the inner medullary portion of the collecting duct, the rest of tubular epithelium is relatively impermeable to urea. Some amount of urea is secreted into tub...