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Animal proteins are the only source of alpha-synuclein (A-SYN) in the human diet. Plant foods do not contain A-SYN as it is only made by vertebrate animals such as cows, pigs, sheep, fish, and poultry and it is also found in eggs and dairy. Most of the misfolding of the A-SYN proteins happens in the gut during digestion, though the proteins may also be damaged (misfolded) during the processing and heat (cooking) of animal-sourced foods. 2017 Study: Vertebrate food products as a potential source of prion-like α-synuclein I am not sure why there is not more focus and education on the dietary source of alpha-synuclein, other than telling people the actual dietary cause of PD is simply not as profitable as the treatment (and drugs) after the disease has already developed. Not only are animal proteins the only source of A-SYN, dietary polyphenols, which are made by plants, (and algae and fungi) not animals, have been shown to inhibit the detrimental effects of A-SYN: 2024 Study: Gut-Brain Axis in Focus: Polyphenols, Microbiota, and Their Influence on α-Synuclein in Parkinson’s Disease

I have been stumped for quite a while about this question. When I have a bowel movement in a bedside commode and I clean it out. There is usually it looks like a rice thinner left in the pot after I dump it out before rinse it. I’ve had Dr tested for parasites and it came out negative both times. Do you have any idea what this could be, I figure maybe have leaky gut and it’s something to do with that

Such awful audio quality !!!!!!! 😔

“We don’t know” seems to be the most used phrase these experts used. Interesting for sure. 🤔

Chemicals in our food, wheat, rice, oats, beans, all processed/highly refined foods are bad for us. Pesticides sprayed on everything may be contributing to PD and yet they suggest eating grains. Seems backwards to me.

My husband is fasting, keto diet and exercise. He is doing very well. When he goes off his diet and exercise he has more tremors and pains.

It would be interesting to hear panelists' thoughts about autophagy in the brain, and the ways to facilitate it, i.e. by fasting. Thx.

I think neurologist should recommend inflammatory diet exercise it should be mandatory just like med are necessary

Missed the live transmission but had a few questions for the panel: Do seasonal allergies like hay fever which presumably increase inflammation increase PD progression? I am a sufferer and not only does it increase PD symptoms but affects cognition giving me lethargy and brain fog. Second question - is a rise in CRP a measure of acute or chronic peripheral inflammation? Would a rise in CRP be associated with corresponding rise in TNF and interleukins? Thanks!

Bless you for getting involved Mike. I'm 64 and was diagnosed with Parkinson's 18 mths ago. I used to mountain bike , ski , play tennis and more.... and these are the less embarrassing symptoms 😅! Anything that can be done to find a cure! Best Mark D.

I believe a Low Fat-High Carbohydrate Diet contributes to the Chronic Diseases of Metabolic Syndrome, of which Parkinson’s Disease is one. The Hyperinsulinemia resulting from a High Carb Diet creates the Oxidative Stress that causes Inflammation in the Brain, leading to damaged Brain Blood Vessels and damaged Neurons, resulting in neurological diseases. I also believe Chronic Stress is what brings you to many neurological diseases. Stress suppresses the Immune System and Digestion, making you more prone to infection. It also affects Digestion, resulting in poor absorption of Essential Nutrients, leading to Nutritional Deficiencies. Nutritional Deficiencies further compromise the Immune System and cause Leaky Gut and Leaky Blood/Brain Barrier. This allows foreign proteins and pathogens to avoid Digestion and directly enter the Bloodstream, making their way into the Brain. Once there, he more Cytotoxic response of the compromised Immune System causes collateral damage to the Blood Vessels and Neurons. The Leaky Gut and Leaky Blood/Brain Barrier provide 2 breaks in the Body’s defenses. These create the 2 origins of Gut PD and Nose PD. It is simply a matter of which area is overcome by foreign proteins or pathogens first. Ultimately, the result is a chronically dysfunctional more cytotoxic Immune System that results in Brain Inflammation. This damage leads not only to symptoms of Parkinson’s, but Multiple Sclerosis, Alzheimer’s, other forms of Dementia, Long COVID, Chronic Fatigue Syndrome/ME, Chronic Lyme Disease, Fibromyalgia, POTS, MCAS, Depression , Anxiety, and other neurological diseases. The chronically dysfunctional Immune System also allows other pathogens, such as Epstein-Barr Virus, the Shingles Virus, and the Spirochete that causes Lyme Disease to come out of Remission and cause new infections, with some of the symptoms similar to Parkinson’s Disease. There may also be increased susceptibility to Molds and Environmental Toxins, further complicating diagnosis and treatment. Any treatment program must 1) address the Chronic Stress root cause, 2) correct the Nutritional Deficiencies to Optimize the Immune System, and 3) restore integrity to the Gut and Blood/Brain Barrier. Addressing Chronic Stress can include a Change of Attitude, such as offered by Eckhart Tolle’s “The Power of NOW” to break the repetitive cycle of negative thoughts. Improved Sleep Habits, Breathing Exercises, Meditation, and Exercise may also help to reduce Stress. Getting out in the sunshine will not only reduce stress, but produce Vitamin D3 to help the compromised Immune System, and provide intracellular Melatonin, one of the Body’s most powerful Antioxidants. Following a Low Inflammatory, Whole Foods Ketogenic Diet with Intermittent Fasting can help reduce Inflammation in the Brain, provide neuroprotective Ketones as an alternative fuel source to Insulin Resistant neurons, as well as stimulate Autophagy to help repair damaged Body and Brain components. The Fasting will give the Leaky Gut a break from Digestion, so it can heal, as well as help rebuild the Immune System. Supplementation can further aid the recovery process, particularly with Vitamin D3/K2, Zinc, Trace Elements (Iodine, Copper, Selenium’) to bolster the Immune System. N-acetylcisteine (NAC) and Vitamin C can help to boost Antioxidants. Benfotiamine can help to reduce stress and protect neurons. In summary, Chronic Stress and a High Carb Diet can result in chronic dysfunction of the Immune System, as well as Gut issues, Autoimmune Diseases, and Neurological Diseases. Many with Parkinson’s Disease have all of these problems. Ketogenic Diets with Intermittent Fasting are not only Preventative for Parkinson’s Disease, they are part of an important treatment for it.

We don´t have FUS FOCUSED treatment to efficient cure in South America Hospitals. Even though each year more people gets sick.

Thank you , Helen!

#Haters/FDA

Very funny, as ever. All the best to you and your family Paul.

You've made me laugh, Paul ;-) I'll send this to family .. let's see if they can guess which show you co-wrote (which we hearty enjoy, thank you!) Best wishes to you.

Seems you are silent on or blind to gut Short chain fatty acids demonstrated in studies to be much higher in high meat eaters sans fiber than plant eaters.

“So clearly the dietician is the answer.” I know of no dietician who would cause more good than harm. “90 percent of Parkinson’s patients don’t have access to a dietician.” Outcomes would be worse if they had such access.

Was “the Mediterranean diet” defined here?

I believe I hear mistaken ideas. What is unhealthy about high animal fat?

I found this presentation particularly interesting because I was only diagnosed with PD 4 years ago (in Feb 2020) but I had pain & stiffness and anosmia six years before that in 2014! So I really have had PD for 10 years. I am only in the past year starting to develop GI issues (with slow motility).

For me proteins and medication are a problem, and it could be interesting to have no ptotein during the day and have them late on the evening, but protein for dinner gives me rls, how do you handle that ?

Guys you can spend thousands or maybe MILLIONS on DANGERIOUS stem cell invasive therapy, or $2800 USD on an Aquacure AC50? no surgary.. Harmless and it does your entire body!! daaaaah? NO BRAINER RIGHT???

I take TUDCA supplement, and it works in the same way to UDCA, TUDCA has been shown to work better than UDCA with mitochondria energy production. I take 1200mg a day. I will up to 1800mg a day.

Why are they bothering with a question on ethnicity. Wasting time of the questions. Woke or what.DEI rubbish.

What happened to the UDCA liver drug repurpose research.

Very Very very Expensive.... Or Just buy an Aquacure AC50... $2800 USD and it does a way better job and is 100% PERMANANT and fixes all your bodies STEM CELLS...not just the ones you pay for to get fixed??? Parkinson's Disease & Dementia and brain cancer especially are where this Brown's Gas Hydrogen device does some of it's truly amazing best work NO BRAINER RIGHT????????? DAAAAH..🙏🙏

Kieran Tuohy, all carbs need to be stopped. You are way off the mark. This is why I have no faith in people like you. You are the type of person who would put a type 2 diabetic on whole food carbs like brown bread and brown rice. A keto diet of higher fat does not cause disease. A keto diet reduces the non motor symptoms of Parkinson's. I follow a keto diet, and my non motor parkinson's symptoms are reduced, and anxiety has gone.

I am 65 i take sinemet after taking dose 1 and half hour truner and shaking by hand arm jawas start very badly for 2 to hours what I do decrease the dose of sinemet

I have been on a ketogenic diet for 10 years. It does not cause kidney issues. In that time I have had two zero cac scores. At 73 it gives me boundless energy and very stable weight. See the work of doctors Stephen Phinney and Jeff Volek.

Great presentation - on the topic of the ketogenic diet - I find it extremely easy to follow. nutritious and delicious with no problems maintaining my weight - you can eat the prebiotic fibers on a ketogenic diet as well - you can blend the med and keto diets very easily

I am taking 3-4 magnesium malate at bedtime - no more constipation!!

Thank you all for such an interesting webinar. I suffer from EO PD - diagnosed in 2008 and I am now 63 - and the absorption (or lack of) of Levadopa/diet is definitely my major problem and as was mentioned has taken over my entire life. I have a dietician but, as mentioned, we are all different and, for example, I get severe constipation if I eat carbs during the day but then the protein upsets the Levadopa etc.etc. I live in Italy so I can take advantage of the Med diet and great fresh food but it is still so, so difficult. And as Dr. Flanagan said - sometimes the meds just don't even get to where they are supposed to go. I am going to start the apomorphine pump soon so here's hoping. Would there be any possibility of doing a webinar on this new treatment ? Thank you all again for the excellent insights,

Great webinar. Thank you! Question: for last 5 years my wife has hand tremor periodically L>R when holding a cup or plate with fingers of floppy/relaxed hand. The liquid in the cup or food on the plate end up on the floor from shaking. When she squezzes the handle of the cup with her fingers, the tremor decreases or goes away. She has poor sleep, but not other classical symptoms. Is it a sign of Parkinson's? Any hope for reversing it with the passage of time (fasting OMAD & long 5-7 days fasts, organic whole & fermented food, sleep, exercise)? Thx. BTW, she is 70 yrs old, no other health problems, no meds.

Thank you for this great Webinar - have learnt a great deal today. Wondering whether, in the early stages, regular fasting helps Parkinson pts.

Is it available in India?

I wish people on webinars would make sure they have decent miçrophones and connectivity when agreeing to webinars. It spoils a great discussion

@9:58 PD clinicial trials for Ursodeoxycholic Acid a *biliary cholangitis* drug repurposed for PD.

why not call it UPDCA, meaning un-PD capsule

What about focussed ultra sound as a way to deliver stem cells across the BBB .

I get a lot of headaches from Parkinson’s medications. I am interested in the stem cell therapy.

When it be available in Pakistan

Excellent présentation !

This was really interesting for me. My Dads birthday was June 14th, he passed in May this year. My Dad was very physically sick after cancer 15 years before. My husband has Parkinsons, it's harder in so many ways for me. My husband and son both big rugby players and fans of you. Thank you for doing this Mike, so appreciated x

Still too slow.

The people who won't change how trials are done are healthy and have more time.

The research is too slow. People with parkinsons don't have 10 years plus the trials take. The drugs need to be fast tracked.

Are there concerns with anesthesia negatively impacting Parkinson's symptoms? I have gone through two kidney stone, where my Parkinson;s symptoms grew in intensity.

My father suffered from PD , he was 36 years old , when he was told , lived until 67 years died of stroke . I know this illness very well , i never saw him standing straight , without shaking , or without involuntary movement when he was on L -dopa , until he died and i saw him in the hispital dead lying on bed , i regonized then that he was a tall and a handsome man , because all his muscles are somehow relaxed and not stiffened .

Can find a cure for parkinson 🎉