- Видео 206
- Просмотров 270 223
Cure Parkinson's
Великобритания
Добавлен 4 июн 2015
We’re here for the cure. Cure Parkinson’s is working with urgency to find new treatments to slow, stop and reverse Parkinson’s. Our funding and innovation has redefined the field of Parkinson’s research, enabling the world’s leading researchers to prioritise the next generation of drugs for clinical trial. Together we will conquer Parkinson’s.
2024 Tom Isaacs Award honours Parkinson’s expert Professor Oliver Bandmann
Cure Parkinson’s and Van Andel Institute (VAI) are delighted to announce Professor Oliver Bandmann as the winner of the 2024 Tom Isaacs Award, which honours researchers who closely collaborate with the Parkinson’s community.
Read the full awards announcement on our website: cureparkinsons.org.uk/2024/09/2024-tom-isaacs-award-honours-parkinsons-expert-professor-oliver-bandmann/
Read the full awards announcement on our website: cureparkinsons.org.uk/2024/09/2024-tom-isaacs-award-honours-parkinsons-expert-professor-oliver-bandmann/
Просмотров: 160
Видео
What is gene therapy? (Rallying 2024)
Просмотров 225Месяц назад
Rallying to the Challenge 2024 - Day 2 Dr Matthias Luz, AskBio Dr Matthias Luz from AskBio, a pharmaceutical company, gives an overview of what gene therapy is, how AAV is used to administer gene therapy, and why gene therapy is of interest for Parkinson's. This talk was given as a part of the Rallying to the Challenge meeting, hosted by Cure Parkinson's and the Van Andel Institute in Grand Rap...
How the MiND program is contributing to our knowledge of Parkinson’s disease? (Rallying 2024)
Просмотров 113Месяц назад
Rallying to the Challenge 2024 - Day 1 Dr Erin Williams, Van Andel Institute Dr Erin Williams, from Van Andel Institute, explores how the West Michigan Neurodegenerative Diseases (MiND) programme contributes to our understanding of Parkinson’s. By collecting various types of biological samples, the programme aims to identify genetic and epigenetic changes that may play roles in Parkinson’s. Thi...
Ask Bio: AAV2 GDNF Trials for Parkinson's (Rallying 2024)
Просмотров 695Месяц назад
Rallying to the Challenge 2024 - Day 2 Dr Alan Whone, University of Bristol Dr Alan Whone from the University of Bristol discusses the set-up and results from the phase 1b trial of GDNF - a neurotrophic factor - for Parkinson's, as well as the upcoming phase 2 trial of the same therapy, titled "REGENERATE PD". The therapy is created by the pharmaceutical company AskBio and differs from previous...
What is Cell Replacement Therapy for Parkinson's? (Rallying 2024)
Просмотров 597Месяц назад
Rallying to the Challenge 2024 - Day 2 Professor Roger Barker, Cambridge University Professor Roger Barker of Cambridge University gives an overview of what cell replacement therapy for Parkinson's is, how cell replacement therapy works, the challenges associated with these therapies, and why this treatment is of interest for Parkinson's. Professor Barker is one of the Principal Investigators f...
How can we see if a treatment might work in humans - iPSC cell modelling (Rallying 2024)
Просмотров 105Месяц назад
Rallying to the Challenge 2024 - Day 1 Dr Edward Fon, McGill University Dr Edward Fon, from McGill University, provides an overview of how stem cells can be used to better understand the biology of Parkinson’s. He discusses the process of generating dopamine-producing neurons from induced pluripotent stem cells (iPSCs) in the lab and how these cells are being used to investigate the underlying ...
Mitochondria as a treatment target: An overview of what’s going on (Rallying 2024)
Просмотров 78Месяц назад
Rallying to the Challenge 2024 - Day 1 Aleksandra Pilcicka, Cure Parkinson's Aleksandra Pilcicka, Research Liaison Officer for Cure Parkinson's, gives an overview of the clinical trial landscape for therapies targeting mitochondrial dysfunction. This presentation is based off of the 2024 Parkinson's Pipeline paper, written in a collaboration between Cure Parkinson's, Parkinson's research advoca...
Mitochondrial DNA damage - a biomarker for PD? (Rallying 2024)
Просмотров 55Месяц назад
Rallying to the Challenge 2024 - Day 1 Dr Laurie Sanders, Duke University Dr Laurie Sanders, from Duke University, explores the potential of mitochondrial DNA damage as a biomarker for Parkinson’s. Laurie also provides insight into her team's development of the Mito DNADX assay, a tool designed to detect mitochondrial DNA damage, which could play a crucial role in evaluating the effectiveness o...
Genetics as a treatment target: an overview of what’s going on? (Rallying 2024)
Просмотров 43Месяц назад
Rallying to the Challenge 2024 - Day 1 Aleksandra Pilcicka, Cure Parkinson's Aleksandra Pilcicka, Research Liaison Officer for Cure Parkinson's, gives an overview of the clinical trial landscape for therapies targeting genetic variations, specifically GBA1 and LRRK2 mutations. This presentation is based off of the 2024 Parkinson's Pipeline paper, written in a collaboration between Cure Parkinso...
What cell replacement and gene therapy studies for Parkinson's are underway? (Rallying 2024)
Просмотров 110Месяц назад
Rallying to the Challenge 2024 - Day 2 Aleksandra Pilcicka, Cure Parkinson's Aleksandra Pilcicka, Research Liaison Officer for Cure Parkinson's, gives an overview of the clinical trial landscape for therapies involving cell replacement and gene therapy. This presentation is based off of the 2024 Parkinson's Pipeline paper, written in a collaboration between Cure Parkinson's, Parkinson's researc...
What can go wrong with cells in Parkinson’s 1: Genetics (Rallying 2024)
Просмотров 89Месяц назад
Rallying to the Challenge 2024 - Day 1 Vanessa Howland, Van Andel Institute Vanessa Howland, a PhD candidate at Van Andel Institute, gives an overview of the role of genetic variations in Parkinson's risk and progression and how these genetic risk factors are identified through a case study of a recently discovered genetic risk factor, TMEM230. This talk was given as a part of the Rallying to t...
What do cells do in response to protein aggregation? (Rallying 2024)
Просмотров 74Месяц назад
Rallying to the Challenge 2024 - Day 1 Thomas Goralski, Van Andel Institute Thomas Goralski, a PhD candidate at Van Andel Institute, gives an overview of the aggregation of proteins, specifically alpha-synuclein, in Parkinson's and how this contributes to progression of the condition. Thomas also discusses his ongoing research which aims to identify which cells are most vulnerable to this patho...
What do we mean by "Cell Vulnerability and Therapies"? (Rallying 2024)
Просмотров 107Месяц назад
Rallying to the Challenge 2024 - Day 1 Dr Simon Stott, Cure Parkinson's Dr Simon Stott, Director of Research at Cure Parkinson's, opens the 2024 Rallying to the Challenge meeting by giving an overview of this year's theme, "Cell Vulnerability and Therapies", and why it is important for people with Parkinson's. This talk was given as a part of the Rallying to the Challenge meeting, hosted by Cur...
Webinar: Innovations in gene therapies for Parkinson's
Просмотров 7242 месяца назад
This webinar discussses the latest research news regarding the development of gene therapies, with emphasis on neurotrophic or nerve growth factors, for Parkinson’s. Professor Tilo Kunath is joined by Professor Aideen Sullivan from University College Cork, Dr Melanie Brandabur from Capsida Therapeutics, and Tom Phipps, a Parkinson's research advocate and first participant on the 2017 Bristol GD...
Team Cure at the TCS London Marathon 2024
Просмотров 1005 месяцев назад
On Sunday 21 April, 44 Cure Parkinson’s supporters ran the iconic TCS London Marathon to raise vital funds and awareness for our research.
Webinar: Inflammation & Parkinson's
Просмотров 3,7 тыс.6 месяцев назад
Webinar: Inflammation & Parkinson's
Brook Huxford: Parkinson’s disease and type 2 diabetes severity: a case-control biomarker study
Просмотров 2016 месяцев назад
Brook Huxford: Parkinson’s disease and type 2 diabetes severity: a case-control biomarker study
Georgia Pittwood & Selen Yalkic: PD Frontline - Get Trial Ready
Просмотров 1396 месяцев назад
Georgia Pittwood & Selen Yalkic: PD Frontline - Get Trial Ready
Simona Jasaityte & Matilda Fenn: Parkinson's and Movement Disorders Families Project
Просмотров 996 месяцев назад
Simona Jasaityte & Matilda Fenn: Parkinson's and Movement Disorders Families Project
Impacts of the international Linked Clinical Trials (iLCT) programme - Dr Richard Wyse
Просмотров 2706 месяцев назад
Impacts of the international Linked Clinical Trials (iLCT) programme - Dr Richard Wyse
Cure Parkinson's Research Update Spring 2024 - with Dr Simon Stott
Просмотров 3 тыс.6 месяцев назад
Cure Parkinson's Research Update Spring 2024 - with Dr Simon Stott
Results and Findings from the LixiPark trial - Professor Olivier Rascol
Просмотров 8816 месяцев назад
Results and Findings from the LixiPark trial - Professor Olivier Rascol
Update on the MONTPARK trial - Professor Per Svenningsson
Просмотров 7366 месяцев назад
Update on the MONTPARK trial - Professor Per Svenningsson
Advancing Inclusivity Efforts in Parkinson's Research - Anaya Navangul
Просмотров 1216 месяцев назад
Advancing Inclusivity Efforts in Parkinson's Research - Anaya Navangul
Cure Parkinson's joins the Movers & Shakers at Downing Street
Просмотров 3497 месяцев назад
Cure Parkinson's joins the Movers & Shakers at Downing Street
Women with Parkinson’s: Addressing sex and gender gaps in research
Просмотров 2848 месяцев назад
Women with Parkinson’s: Addressing sex and gender gaps in research
Webinar: The Gut-Brain Axis and Nutrition in Parkinson's
Просмотров 26 тыс.9 месяцев назад
Webinar: The Gut-Brain Axis and Nutrition in Parkinson's
Webinar: Stem Cell Research for Parkinson's - latest updates
Просмотров 4,9 тыс.11 месяцев назад
Webinar: Stem Cell Research for Parkinson's - latest updates
The UK Parkinson's Disease Clinical Studies Group - Emma Davies
Просмотров 185Год назад
The UK Parkinson's Disease Clinical Studies Group - Emma Davies
Repurposing anti-gout medications for Parkinson's - Rachel Hughes
Просмотров 576Год назад
Repurposing anti-gout medications for Parkinson's - Rachel Hughes
what about anxiety/depression and PD? how are they connected and will anti anxiety meds help PD symptoms?
Ok got it I don’t want anything in life. I’ll be ok alone in silence til I die. Yall enjoy life. I’m not alllwed. I’ll be PUNISHED… So I gotta sit here and suffer. That’s all I know secrets I don’t wana talk to nobody I’d like to die alone That’s all I want for ME
Thank you for this talk... keep up the good work.
Extremely interesting. Thank you for putting this up 👍
I would like to be entered into this trial but I’m not sure if I’m gonna be allowed to as I have been diagnosed with Parkinsonism scans have shown a deficiency of dopamine producing cells in the right side basal ganglia compared to the left. My ability to move my lower body is deteriorating really quickly so I am anxious to try anything that might arrest the deterioration
Regenerate PD Study Professor Alan Whone University of Bristol AB-1005 Gene Therapy GDNF (for anyone trying to find this video via search, since there's no video description added.)
Is there any research on a Parkinsonian response from the administration of Azithromycin?
Keep up the great work, youre making a difference
Hello, its nearly 2025, please give some updates
Animal proteins are the only source of alpha-synuclein (A-SYN) in the human diet. Plant foods do not contain A-SYN as it is only made by vertebrate animals such as cows, pigs, sheep, fish, and poultry and it is also found in eggs and dairy. Most of the misfolding of the A-SYN proteins happens in the gut during digestion, though the proteins may also be damaged (misfolded) during the processing and heat (cooking) of animal-sourced foods. 2017 Study: Vertebrate food products as a potential source of prion-like α-synuclein I am not sure why there is not more focus and education on the dietary source of alpha-synuclein, other than telling people the actual dietary cause of PD is simply not as profitable as the treatment (and drugs) after the disease has already developed. Not only are animal proteins the only source of A-SYN, dietary polyphenols, which are made by plants, (and algae and fungi) not animals, have been shown to inhibit the detrimental effects of A-SYN: 2024 Study: Gut-Brain Axis in Focus: Polyphenols, Microbiota, and Their Influence on α-Synuclein in Parkinson’s Disease
I have been stumped for quite a while about this question. When I have a bowel movement in a bedside commode and I clean it out. There is usually it looks like a rice thinner left in the pot after I dump it out before rinse it. I’ve had Dr tested for parasites and it came out negative both times. Do you have any idea what this could be, I figure maybe have leaky gut and it’s something to do with that
Such awful audio quality !!!!!!! 😔
“We don’t know” seems to be the most used phrase these experts used. Interesting for sure. 🤔
Chemicals in our food, wheat, rice, oats, beans, all processed/highly refined foods are bad for us. Pesticides sprayed on everything may be contributing to PD and yet they suggest eating grains. Seems backwards to me.
My husband is fasting, keto diet and exercise. He is doing very well. When he goes off his diet and exercise he has more tremors and pains.
It would be interesting to hear panelists' thoughts about autophagy in the brain, and the ways to facilitate it, i.e. by fasting. Thx.
I think neurologist should recommend inflammatory diet exercise it should be mandatory just like med are necessary
Missed the live transmission but had a few questions for the panel: Do seasonal allergies like hay fever which presumably increase inflammation increase PD progression? I am a sufferer and not only does it increase PD symptoms but affects cognition giving me lethargy and brain fog. Second question - is a rise in CRP a measure of acute or chronic peripheral inflammation? Would a rise in CRP be associated with corresponding rise in TNF and interleukins? Thanks!
Excellent questions.
Bless you for getting involved Mike. I'm 64 and was diagnosed with Parkinson's 18 mths ago. I used to mountain bike , ski , play tennis and more.... and these are the less embarrassing symptoms 😅! Anything that can be done to find a cure! Best Mark D.
I believe a Low Fat-High Carbohydrate Diet contributes to the Chronic Diseases of Metabolic Syndrome, of which Parkinson’s Disease is one. The Hyperinsulinemia resulting from a High Carb Diet creates the Oxidative Stress that causes Inflammation in the Brain, leading to damaged Brain Blood Vessels and damaged Neurons, resulting in neurological diseases. I also believe Chronic Stress is what brings you to many neurological diseases. Stress suppresses the Immune System and Digestion, making you more prone to infection. It also affects Digestion, resulting in poor absorption of Essential Nutrients, leading to Nutritional Deficiencies. Nutritional Deficiencies further compromise the Immune System and cause Leaky Gut and Leaky Blood/Brain Barrier. This allows foreign proteins and pathogens to avoid Digestion and directly enter the Bloodstream, making their way into the Brain. Once there, he more Cytotoxic response of the compromised Immune System causes collateral damage to the Blood Vessels and Neurons. The Leaky Gut and Leaky Blood/Brain Barrier provide 2 breaks in the Body’s defenses. These create the 2 origins of Gut PD and Nose PD. It is simply a matter of which area is overcome by foreign proteins or pathogens first. Ultimately, the result is a chronically dysfunctional more cytotoxic Immune System that results in Brain Inflammation. This damage leads not only to symptoms of Parkinson’s, but Multiple Sclerosis, Alzheimer’s, other forms of Dementia, Long COVID, Chronic Fatigue Syndrome/ME, Chronic Lyme Disease, Fibromyalgia, POTS, MCAS, Depression , Anxiety, and other neurological diseases. The chronically dysfunctional Immune System also allows other pathogens, such as Epstein-Barr Virus, the Shingles Virus, and the Spirochete that causes Lyme Disease to come out of Remission and cause new infections, with some of the symptoms similar to Parkinson’s Disease. There may also be increased susceptibility to Molds and Environmental Toxins, further complicating diagnosis and treatment. Any treatment program must 1) address the Chronic Stress root cause, 2) correct the Nutritional Deficiencies to Optimize the Immune System, and 3) restore integrity to the Gut and Blood/Brain Barrier. Addressing Chronic Stress can include a Change of Attitude, such as offered by Eckhart Tolle’s “The Power of NOW” to break the repetitive cycle of negative thoughts. Improved Sleep Habits, Breathing Exercises, Meditation, and Exercise may also help to reduce Stress. Getting out in the sunshine will not only reduce stress, but produce Vitamin D3 to help the compromised Immune System, and provide intracellular Melatonin, one of the Body’s most powerful Antioxidants. Following a Low Inflammatory, Whole Foods Ketogenic Diet with Intermittent Fasting can help reduce Inflammation in the Brain, provide neuroprotective Ketones as an alternative fuel source to Insulin Resistant neurons, as well as stimulate Autophagy to help repair damaged Body and Brain components. The Fasting will give the Leaky Gut a break from Digestion, so it can heal, as well as help rebuild the Immune System. Supplementation can further aid the recovery process, particularly with Vitamin D3/K2, Zinc, Trace Elements (Iodine, Copper, Selenium’) to bolster the Immune System. N-acetylcisteine (NAC) and Vitamin C can help to boost Antioxidants. Benfotiamine can help to reduce stress and protect neurons. In summary, Chronic Stress and a High Carb Diet can result in chronic dysfunction of the Immune System, as well as Gut issues, Autoimmune Diseases, and Neurological Diseases. Many with Parkinson’s Disease have all of these problems. Ketogenic Diets with Intermittent Fasting are not only Preventative for Parkinson’s Disease, they are part of an important treatment for it.
We don´t have FUS FOCUSED treatment to efficient cure in South America Hospitals. Even though each year more people gets sick.
Thank you , Helen!
#Haters/FDA
Very funny, as ever. All the best to you and your family Paul.
You've made me laugh, Paul ;-) I'll send this to family .. let's see if they can guess which show you co-wrote (which we hearty enjoy, thank you!) Best wishes to you.
Seems you are silent on or blind to gut Short chain fatty acids demonstrated in studies to be much higher in high meat eaters sans fiber than plant eaters.
“So clearly the dietician is the answer.” I know of no dietician who would cause more good than harm. “90 percent of Parkinson’s patients don’t have access to a dietician.” Outcomes would be worse if they had such access.
😅
Was “the Mediterranean diet” defined here?
I believe I hear mistaken ideas. What is unhealthy about high animal fat?
High animal fat is NOT unhealthy. Anyone who says so is very behind the times.
I have been following the keto diet (with a lot of meat) for over 4 years. I am very strict about that even though I don't have Parkinson's. In those 4 years I have watched hundreds of RUclips films on this subject. The latest science shows time and time again that meat IN COMBINATION WITH OTHER HEALTHY Keto FOODS is an excellent diet. There are excellent RUclips channels about (high fat and low carb) keto including 1) Low Carb Down Under 2) Metabolic mind 3) Dr Eric Westman
I found this presentation particularly interesting because I was only diagnosed with PD 4 years ago (in Feb 2020) but I had pain & stiffness and anosmia six years before that in 2014! So I really have had PD for 10 years. I am only in the past year starting to develop GI issues (with slow motility).
For me proteins and medication are a problem, and it could be interesting to have no ptotein during the day and have them late on the evening, but protein for dinner gives me rls, how do you handle that ?
Guys you can spend thousands or maybe MILLIONS on DANGERIOUS stem cell invasive therapy, or $2800 USD on an Aquacure AC50? no surgary.. Harmless and it does your entire body!! daaaaah? NO BRAINER RIGHT???
I take TUDCA supplement, and it works in the same way to UDCA, TUDCA has been shown to work better than UDCA with mitochondria energy production. I take 1200mg a day. I will up to 1800mg a day.
Why are they bothering with a question on ethnicity. Wasting time of the questions. Woke or what.DEI rubbish.
What happened to the UDCA liver drug repurpose research.
Very Very very Expensive.... Or Just buy an Aquacure AC50... $2800 USD and it does a way better job and is 100% PERMANANT and fixes all your bodies STEM CELLS...not just the ones you pay for to get fixed??? Parkinson's Disease & Dementia and brain cancer especially are where this Brown's Gas Hydrogen device does some of it's truly amazing best work NO BRAINER RIGHT????????? DAAAAH..🙏🙏
Kieran Tuohy, all carbs need to be stopped. You are way off the mark. This is why I have no faith in people like you. You are the type of person who would put a type 2 diabetic on whole food carbs like brown bread and brown rice. A keto diet of higher fat does not cause disease. A keto diet reduces the non motor symptoms of Parkinson's. I follow a keto diet, and my non motor parkinson's symptoms are reduced, and anxiety has gone.
I am 65 i take sinemet after taking dose 1 and half hour truner and shaking by hand arm jawas start very badly for 2 to hours what I do decrease the dose of sinemet
I have been on a ketogenic diet for 10 years. It does not cause kidney issues. In that time I have had two zero cac scores. At 73 it gives me boundless energy and very stable weight. See the work of doctors Stephen Phinney and Jeff Volek.
I eat a diet high in ruminant fat in mostly a 5 hour eating window along with leafy greens and small amount of berries. This gives wonderful satiety and enjoyment of life. The fat and leafy greens help prevent constipation. See the work of the PKD Paleomedicina team
Great presentation - on the topic of the ketogenic diet - I find it extremely easy to follow. nutritious and delicious with no problems maintaining my weight - you can eat the prebiotic fibers on a ketogenic diet as well - you can blend the med and keto diets very easily
Glad you commented, i couldnt believe what he said about the 'social aspect'
I am taking 3-4 magnesium malate at bedtime - no more constipation!!
Thank you all for such an interesting webinar. I suffer from EO PD - diagnosed in 2008 and I am now 63 - and the absorption (or lack of) of Levadopa/diet is definitely my major problem and as was mentioned has taken over my entire life. I have a dietician but, as mentioned, we are all different and, for example, I get severe constipation if I eat carbs during the day but then the protein upsets the Levadopa etc.etc. I live in Italy so I can take advantage of the Med diet and great fresh food but it is still so, so difficult. And as Dr. Flanagan said - sometimes the meds just don't even get to where they are supposed to go. I am going to start the apomorphine pump soon so here's hoping. Would there be any possibility of doing a webinar on this new treatment ? Thank you all again for the excellent insights,
Great webinar. Thank you! Question: for last 5 years my wife has hand tremor periodically L>R when holding a cup or plate with fingers of floppy/relaxed hand. The liquid in the cup or food on the plate end up on the floor from shaking. When she squezzes the handle of the cup with her fingers, the tremor decreases or goes away. She has poor sleep, but not other classical symptoms. Is it a sign of Parkinson's? Any hope for reversing it with the passage of time (fasting OMAD & long 5-7 days fasts, organic whole & fermented food, sleep, exercise)? Thx. BTW, she is 70 yrs old, no other health problems, no meds.
Possibility of regeneration of substantia nigra?
Hmmm .... strange pattern? Correction: We have noticed that it is not so much about floppy/relaxed hand, but her 4th and 5th fingers shake, so if she holds a cup with 1+2+3 fingers without touching by 4+5 fingers, it is okay. This is exactly what happens when she squezzes the handle of the cup = her 1+2+3 fingers are at work but not 4+5. Is it normal or strange? Looks like an ulnar pattern?
Thank you for this great Webinar - have learnt a great deal today. Wondering whether, in the early stages, regular fasting helps Parkinson pts.
Is it available in India?
I wish people on webinars would make sure they have decent miçrophones and connectivity when agreeing to webinars. It spoils a great discussion
@9:58 PD clinicial trials for Ursodeoxycholic Acid a *biliary cholangitis* drug repurposed for PD.
why not call it UPDCA, meaning un-PD capsule
What about focussed ultra sound as a way to deliver stem cells across the BBB .
I get a lot of headaches from Parkinson’s medications. I am interested in the stem cell therapy.