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Cure Parkinson's
Великобритания
Добавлен 4 июн 2015
We’re here for the cure. Cure Parkinson’s is working with urgency to find new treatments to slow, stop and reverse Parkinson’s. Our funding and innovation has redefined the field of Parkinson’s research, enabling the world’s leading researchers to prioritise the next generation of drugs for clinical trial. Together we will conquer Parkinson’s.
Team Cure at the TCS London Marathon 2024
On Sunday 21 April, 44 Cure Parkinson’s supporters ran the iconic TCS London Marathon to raise vital funds and awareness for our research.
Просмотров: 93
Видео
Webinar: Inflammation & Parkinson's
Просмотров 3,5 тыс.3 месяца назад
Understanding its role & recent advances in research. This hour-long webinar is for the Parkinson’s community and allows the opportunity to hear first-hand from experts in the field, to learn more about the underlying mechanisms of Parkinson's and progress being made within the research arena. The panel of experts, including Professor Malu Tansey, Dr Kirsten Scott, and Alison Anderson discuss i...
Brook Huxford: Parkinson’s disease and type 2 diabetes severity: a case-control biomarker study
Просмотров 1743 месяца назад
Early career researchers share the focus of their research in these presentations from our Spring Research Update Meeting 2024. Full abstract: Background and Objectives: Type 2 diabetes (T2D) is a risk factor for Parkinson’s disease (PD) and PD severity, with inflammation and glycaemic control as potential drivers of this relationship. This cross-sectional biomarker study investigated whether T...
Georgia Pittwood & Selen Yalkic: PD Frontline - Get Trial Ready
Просмотров 1283 месяца назад
Early career researchers share the focus of their research in these presentations from our Spring Research Update Meeting 2024. Full abstract: PD Frontline is a remote study, part of the RAPSODI GD longitudinal study, with the prime purpose of identifying people with Parkinson Disease (PD) and testing for changes in two PD risk factor genes: GBA1 and LRRK2. Aims: To identify participants eligib...
Simona Jasaityte & Matilda Fenn: Parkinson's and Movement Disorders Families Project
Просмотров 853 месяца назад
Early career researchers share the focus of their research into Parkinson's these presentations from our Spring Research Update Meeting 2024. Full abstract: Objectives: Parkinson's and Movement Disorders Families Project is a UK-wide study aimed at identifying genetic variations associated with familial and early-onset Parkinson's disease (PD) and other movement disorders. Methods: We are recru...
Impacts of the international Linked Clinical Trials (iLCT) programme - Dr Richard Wyse
Просмотров 2503 месяца назад
In 2012, Cure Parkinson's in partnership with the Van Andel Insitute established the international Linked Clinical Trials (iLCT) programme to help increase the number of clinical trials involving disease-modifying treatments for Parkinson's. In this talk, Dr Richard Wyse - Cure Parkinson's Director of Clinical Development - walks us through the story of how iLCT was established, how the program...
Cure Parkinson's Research Update Spring 2024 - with Dr Simon Stott
Просмотров 2 тыс.3 месяца назад
In this talk, Dr Simon Stott, Cure Parkinson's Director of Research, gives an update on our new and ongoing research projects, as well as a look at what is to come over the next year.
Results and Findings from the LixiPark trial - Professor Olivier Rascol
Просмотров 7413 месяца назад
Earlier this month, the results of the Cure Parkinson's co-funded phase 2 clinical trial of lixisenatide (LixiPark study) were published in the New England Journal of Medicine. The researchers reported that the trial had met its primary outcome, indicating that lixisenatide may be able to delay the progression of motor symptoms in Parkinson’s. In this talk, Professor Olivier Rascol - one of the...
Update on the MONTPARK trial - Professor Per Svenningsson
Просмотров 6853 месяца назад
MONTPARK is a multicenter study taking place in Sweden, where participants will be taking either montelukast or a placebo (dummy drug) twice daily for 18 months. The primary objective will be to evaluate if montelukast slows the progression of Parkinson’s motor symptoms. In this talk, Professor Per Svenningsson, the lead investigator of the MONTPARK study, will discuss the trial background and ...
Advancing Inclusivity Efforts in Parkinson's Research - Anaya Navangul
Просмотров 1073 месяца назад
Parkinson's affects patients across all ages, racial, ethnic, socio-economic, geographic, and gender demographics; despite this, promoting equality, diversity, and inclusion (EDI) remains a challenge in Parkinson's research. In this, Cure Parkinson's Recruitment and Retention Officer, Anaya Navangul, discusses why EDI is important for research and highlights several projects seeking to improve ...
Cure Parkinson's joins the Movers & Shakers at Downing Street
Просмотров 2884 месяца назад
“It’s time that we now end Parkinson’s.” Inspiring words from our CEO Helen Matthews outside Downing Street. The Cure Parkinson’s team joined the Movers & Shakers alongside Parkinson's UK and Spotlight YOPD as they handed in their Parky Charter petition signed by more than 20,000 people. Find out more and sign the petition on our website at www.cureparkinsons.org.uk.
Women with Parkinson’s: Addressing sex and gender gaps in research
Просмотров 2605 месяцев назад
To mark International Women’s Day, Cure Parkinson’s in partnership with The Michael J. Fox Foundation hosted a webinar discussing research focusing on the need for a sex and gender-inclusive approach in Parkinson’s research from bench to bedside. Since the publication of the paper “Unmet Needs of Women Living with Parkinson’s Disease: Gaps and Controversies” in Jan 2022, there has been increase...
Webinar: The Gut-Brain Axis and Nutrition in Parkinson's
Просмотров 22 тыс.6 месяцев назад
Presented by the University of Edinburgh, Journal of Parkinson’s Disease and Cure Parkinson’s, the next in this quarterly webinar series focused on the role of the gut-brain axis and nutrition in Parkinson’s with Edinburgh University’s Professor Tilo Kunath as chair. Prof Kunath was joined by Professor Per Borghammer of Aarhus University who studies body-first models of Parkinson's; Professor K...
Webinar: Stem Cell Research for Parkinson's - latest updates
Просмотров 4,4 тыс.8 месяцев назад
Presented by Edinburgh University, Journal of Parkinson’s Disease and Cure Parkinson’s, this webinar discusses the latest research news in cell replacement therapies for Parkinson’s with Edinburgh University’s Professor Tilo Kunath as chair. Professor Kunath is joined by: Associate Professor Agnete Kirkeby from the University of Copenhagen who is involved with the STEM-PD study; Dr Cheney Drew ...
The UK Parkinson's Disease Clinical Studies Group - Emma Davies
Просмотров 1809 месяцев назад
The UK Parkinson's Disease Clinical Studies Group - Emma Davies
Repurposing anti-gout medications for Parkinson's - Rachel Hughes
Просмотров 5619 месяцев назад
Repurposing anti-gout medications for Parkinson's - Rachel Hughes
UDCA: the discovery and assessment of this promising drug for Parkinson’s -Professor Oliver Bandmann
Просмотров 19 тыс.9 месяцев назад
UDCA: the discovery and assessment of this promising drug for Parkinson’s -Professor Oliver Bandmann
EJS-ACT-PD: The multi-arm, multi-stage clinical trials platform for Parkinson's - Georgia Mills
Просмотров 2019 месяцев назад
EJS-ACT-PD: The multi-arm, multi-stage clinical trials platform for Parkinson's - Georgia Mills
Cure Parkinson’s Research Update Autumn 2023 - with Dr Simon Stott, Director of Research
Просмотров 5 тыс.9 месяцев назад
Cure Parkinson’s Research Update Autumn 2023 - with Dr Simon Stott, Director of Research
Therapeutic Development 4: The challenges of developing combination therapies (Rallying 2023)
Просмотров 19310 месяцев назад
Therapeutic Development 4: The challenges of developing combination therapies (Rallying 2023)
Could Prasinezumab be reducing motor progression in the PASADENA Open-Label Extension? -Rallying 23
Просмотров 1 тыс.10 месяцев назад
Could Prasinezumab be reducing motor progression in the PASADENA Open-Label Extension? -Rallying 23
Therapeutic development 2: Lysosomal function overview Bial, Ambroxol (Rallying 2023)
Просмотров 48310 месяцев назад
Therapeutic development 2: Lysosomal function overview Bial, Ambroxol (Rallying 2023)
Therapeutic development 1: Disease modifying trials an overview. (Rallying 2023)
Просмотров 35610 месяцев назад
Therapeutic development 1: Disease modifying trials an overview. (Rallying 2023)
A review of the stages of clinical trials (Rallying 2023)
Просмотров 6910 месяцев назад
A review of the stages of clinical trials (Rallying 2023)
Communications implications and use of language of a new staging system (Rallying 2023)
Просмотров 5110 месяцев назад
Communications implications and use of language of a new staging system (Rallying 2023)
Why is a staging system for Parkinson's so urgently needed? (Rallying 2023)
Просмотров 22510 месяцев назад
Why is a staging system for Parkinson's so urgently needed? (Rallying 2023)
Defining the biology of Parkinson's more precisely (Rallying 2023)
Просмотров 14710 месяцев назад
Defining the biology of Parkinson's more precisely (Rallying 2023)
What is better than L’dopa? (Rallying 2023)
Просмотров 19310 месяцев назад
What is better than L’dopa? (Rallying 2023)
Protein Pathologies 2: Tau pathology and its impact in Parkinson’s (Rallying 2023)
Просмотров 19910 месяцев назад
Protein Pathologies 2: Tau pathology and its impact in Parkinson’s (Rallying 2023)
A-syn seeding assay: what is it and how can it support clinical trials? (Rallying 2023)
Просмотров 11010 месяцев назад
A-syn seeding assay: what is it and how can it support clinical trials? (Rallying 2023)
Animal proteins are the only source of alpha-synuclein (A-SYN) in the human diet. Plant foods do not contain A-SYN as it is only made by vertebrate animals such as cows, pigs, sheep, fish, and poultry and it is also found in eggs and dairy. Most of the misfolding of the A-SYN proteins happens in the gut during digestion, though the proteins may also be damaged (misfolded) during the processing and heat (cooking) of animal-sourced foods. 2017 Study: Vertebrate food products as a potential source of prion-like α-synuclein I am not sure why there is not more focus and education on the dietary source of alpha-synuclein, other than telling people the actual dietary cause of PD is simply not as profitable as the treatment (and drugs) after the disease has already developed. Not only are animal proteins the only source of A-SYN, dietary polyphenols, which are made by plants, (and algae and fungi) not animals, have been shown to inhibit the detrimental effects of A-SYN: 2024 Study: Gut-Brain Axis in Focus: Polyphenols, Microbiota, and Their Influence on α-Synuclein in Parkinson’s Disease
I have been stumped for quite a while about this question. When I have a bowel movement in a bedside commode and I clean it out. There is usually it looks like a rice thinner left in the pot after I dump it out before rinse it. I’ve had Dr tested for parasites and it came out negative both times. Do you have any idea what this could be, I figure maybe have leaky gut and it’s something to do with that
Such awful audio quality !!!!!!! 😔
“We don’t know” seems to be the most used phrase these experts used. Interesting for sure. 🤔
Chemicals in our food, wheat, rice, oats, beans, all processed/highly refined foods are bad for us. Pesticides sprayed on everything may be contributing to PD and yet they suggest eating grains. Seems backwards to me.
My husband is fasting, keto diet and exercise. He is doing very well. When he goes off his diet and exercise he has more tremors and pains.
It would be interesting to hear panelists' thoughts about autophagy in the brain, and the ways to facilitate it, i.e. by fasting. Thx.
I think neurologist should recommend inflammatory diet exercise it should be mandatory just like med are necessary
Missed the live transmission but had a few questions for the panel: Do seasonal allergies like hay fever which presumably increase inflammation increase PD progression? I am a sufferer and not only does it increase PD symptoms but affects cognition giving me lethargy and brain fog. Second question - is a rise in CRP a measure of acute or chronic peripheral inflammation? Would a rise in CRP be associated with corresponding rise in TNF and interleukins? Thanks!
Excellent questions.
Bless you for getting involved Mike. I'm 64 and was diagnosed with Parkinson's 18 mths ago. I used to mountain bike , ski , play tennis and more.... and these are the less embarrassing symptoms 😅! Anything that can be done to find a cure! Best Mark D.
I believe a Low Fat-High Carbohydrate Diet contributes to the Chronic Diseases of Metabolic Syndrome, of which Parkinson’s Disease is one. The Hyperinsulinemia resulting from a High Carb Diet creates the Oxidative Stress that causes Inflammation in the Brain, leading to damaged Brain Blood Vessels and damaged Neurons, resulting in neurological diseases. I also believe Chronic Stress is what brings you to many neurological diseases. Stress suppresses the Immune System and Digestion, making you more prone to infection. It also affects Digestion, resulting in poor absorption of Essential Nutrients, leading to Nutritional Deficiencies. Nutritional Deficiencies further compromise the Immune System and cause Leaky Gut and Leaky Blood/Brain Barrier. This allows foreign proteins and pathogens to avoid Digestion and directly enter the Bloodstream, making their way into the Brain. Once there, he more Cytotoxic response of the compromised Immune System causes collateral damage to the Blood Vessels and Neurons. The Leaky Gut and Leaky Blood/Brain Barrier provide 2 breaks in the Body’s defenses. These create the 2 origins of Gut PD and Nose PD. It is simply a matter of which area is overcome by foreign proteins or pathogens first. Ultimately, the result is a chronically dysfunctional more cytotoxic Immune System that results in Brain Inflammation. This damage leads not only to symptoms of Parkinson’s, but Multiple Sclerosis, Alzheimer’s, other forms of Dementia, Long COVID, Chronic Fatigue Syndrome/ME, Chronic Lyme Disease, Fibromyalgia, POTS, MCAS, Depression , Anxiety, and other neurological diseases. The chronically dysfunctional Immune System also allows other pathogens, such as Epstein-Barr Virus, the Shingles Virus, and the Spirochete that causes Lyme Disease to come out of Remission and cause new infections, with some of the symptoms similar to Parkinson’s Disease. There may also be increased susceptibility to Molds and Environmental Toxins, further complicating diagnosis and treatment. Any treatment program must 1) address the Chronic Stress root cause, 2) correct the Nutritional Deficiencies to Optimize the Immune System, and 3) restore integrity to the Gut and Blood/Brain Barrier. Addressing Chronic Stress can include a Change of Attitude, such as offered by Eckhart Tolle’s “The Power of NOW” to break the repetitive cycle of negative thoughts. Improved Sleep Habits, Breathing Exercises, Meditation, and Exercise may also help to reduce Stress. Getting out in the sunshine will not only reduce stress, but produce Vitamin D3 to help the compromised Immune System, and provide intracellular Melatonin, one of the Body’s most powerful Antioxidants. Following a Low Inflammatory, Whole Foods Ketogenic Diet with Intermittent Fasting can help reduce Inflammation in the Brain, provide neuroprotective Ketones as an alternative fuel source to Insulin Resistant neurons, as well as stimulate Autophagy to help repair damaged Body and Brain components. The Fasting will give the Leaky Gut a break from Digestion, so it can heal, as well as help rebuild the Immune System. Supplementation can further aid the recovery process, particularly with Vitamin D3/K2, Zinc, Trace Elements (Iodine, Copper, Selenium’) to bolster the Immune System. N-acetylcisteine (NAC) and Vitamin C can help to boost Antioxidants. Benfotiamine can help to reduce stress and protect neurons. In summary, Chronic Stress and a High Carb Diet can result in chronic dysfunction of the Immune System, as well as Gut issues, Autoimmune Diseases, and Neurological Diseases. Many with Parkinson’s Disease have all of these problems. Ketogenic Diets with Intermittent Fasting are not only Preventative for Parkinson’s Disease, they are part of an important treatment for it.
We don´t have FUS FOCUSED treatment to efficient cure in South America Hospitals. Even though each year more people gets sick.
Thank you , Helen!
#Haters/FDA
Very funny, as ever. All the best to you and your family Paul.
You've made me laugh, Paul ;-) I'll send this to family .. let's see if they can guess which show you co-wrote (which we hearty enjoy, thank you!) Best wishes to you.
Seems you are silent on or blind to gut Short chain fatty acids demonstrated in studies to be much higher in high meat eaters sans fiber than plant eaters.
“So clearly the dietician is the answer.” I know of no dietician who would cause more good than harm. “90 percent of Parkinson’s patients don’t have access to a dietician.” Outcomes would be worse if they had such access.
😅
Was “the Mediterranean diet” defined here?
I believe I hear mistaken ideas. What is unhealthy about high animal fat?
High animal fat is NOT unhealthy. Anyone who says so is very behind the times.
I have been following the keto diet (with a lot of meat) for over 4 years. I am very strict about that even though I don't have Parkinson's. In those 4 years I have watched hundreds of RUclips films on this subject. The latest science shows time and time again that meat IN COMBINATION WITH OTHER HEALTHY Keto FOODS is an excellent diet. There are excellent RUclips channels about (high fat and low carb) keto including 1) Low Carb Down Under 2) Metabolic mind 3) Dr Eric Westman
I found this presentation particularly interesting because I was only diagnosed with PD 4 years ago (in Feb 2020) but I had pain & stiffness and anosmia six years before that in 2014! So I really have had PD for 10 years. I am only in the past year starting to develop GI issues (with slow motility).
For me proteins and medication are a problem, and it could be interesting to have no ptotein during the day and have them late on the evening, but protein for dinner gives me rls, how do you handle that ?
Guys you can spend thousands or maybe MILLIONS on DANGERIOUS stem cell invasive therapy, or $2800 USD on an Aquacure AC50? no surgary.. Harmless and it does your entire body!! daaaaah? NO BRAINER RIGHT???
I take TUDCA supplement, and it works in the same way to UDCA, TUDCA has been shown to work better than UDCA with mitochondria energy production. I take 1200mg a day. I will up to 1800mg a day.
Why are they bothering with a question on ethnicity. Wasting time of the questions. Woke or what.DEI rubbish.
What happened to the UDCA liver drug repurpose research.
Very Very very Expensive.... Or Just buy an Aquacure AC50... $2800 USD and it does a way better job and is 100% PERMANANT and fixes all your bodies STEM CELLS...not just the ones you pay for to get fixed??? Parkinson's Disease & Dementia and brain cancer especially are where this Brown's Gas Hydrogen device does some of it's truly amazing best work NO BRAINER RIGHT????????? DAAAAH..🙏🙏
Kieran Tuohy, all carbs need to be stopped. You are way off the mark. This is why I have no faith in people like you. You are the type of person who would put a type 2 diabetic on whole food carbs like brown bread and brown rice. A keto diet of higher fat does not cause disease. A keto diet reduces the non motor symptoms of Parkinson's. I follow a keto diet, and my non motor parkinson's symptoms are reduced, and anxiety has gone.
I am 65 i take sinemet after taking dose 1 and half hour truner and shaking by hand arm jawas start very badly for 2 to hours what I do decrease the dose of sinemet
I have been on a ketogenic diet for 10 years. It does not cause kidney issues. In that time I have had two zero cac scores. At 73 it gives me boundless energy and very stable weight. See the work of doctors Stephen Phinney and Jeff Volek.
I eat a diet high in ruminant fat in mostly a 5 hour eating window along with leafy greens and small amount of berries. This gives wonderful satiety and enjoyment of life. The fat and leafy greens help prevent constipation. See the work of the PKD Paleomedicina team
Great presentation - on the topic of the ketogenic diet - I find it extremely easy to follow. nutritious and delicious with no problems maintaining my weight - you can eat the prebiotic fibers on a ketogenic diet as well - you can blend the med and keto diets very easily
Glad you commented, i couldnt believe what he said about the 'social aspect'
I am taking 3-4 magnesium malate at bedtime - no more constipation!!
Thank you all for such an interesting webinar. I suffer from EO PD - diagnosed in 2008 and I am now 63 - and the absorption (or lack of) of Levadopa/diet is definitely my major problem and as was mentioned has taken over my entire life. I have a dietician but, as mentioned, we are all different and, for example, I get severe constipation if I eat carbs during the day but then the protein upsets the Levadopa etc.etc. I live in Italy so I can take advantage of the Med diet and great fresh food but it is still so, so difficult. And as Dr. Flanagan said - sometimes the meds just don't even get to where they are supposed to go. I am going to start the apomorphine pump soon so here's hoping. Would there be any possibility of doing a webinar on this new treatment ? Thank you all again for the excellent insights,
Great webinar. Thank you! Question: for last 5 years my wife has hand tremor periodically L>R when holding a cup or plate with fingers of floppy/relaxed hand. The liquid in the cup or food on the plate end up on the floor from shaking. When she squezzes the handle of the cup with her fingers, the tremor decreases or goes away. She has poor sleep, but not other classical symptoms. Is it a sign of Parkinson's? Any hope for reversing it with the passage of time (fasting OMAD & long 5-7 days fasts, organic whole & fermented food, sleep, exercise)? Thx. BTW, she is 70 yrs old, no other health problems, no meds.
Possibility of regeneration of substantia nigra?
Hmmm .... strange pattern? Correction: We have noticed that it is not so much about floppy/relaxed hand, but her 4th and 5th fingers shake, so if she holds a cup with 1+2+3 fingers without touching by 4+5 fingers, it is okay. This is exactly what happens when she squezzes the handle of the cup = her 1+2+3 fingers are at work but not 4+5. Is it normal or strange? Looks like an ulnar pattern?
Thank you for this great Webinar - have learnt a great deal today. Wondering whether, in the early stages, regular fasting helps Parkinson pts.
Is it available in India?
I wish people on webinars would make sure they have decent miçrophones and connectivity when agreeing to webinars. It spoils a great discussion
@9:58 PD clinicial trials for Ursodeoxycholic Acid a *biliary cholangitis* drug repurposed for PD.
why not call it UPDCA, meaning un-PD capsule
What about focussed ultra sound as a way to deliver stem cells across the BBB .
I get a lot of headaches from Parkinson’s medications. I am interested in the stem cell therapy.
When it be available in Pakistan
Excellent présentation !
This was really interesting for me. My Dads birthday was June 14th, he passed in May this year. My Dad was very physically sick after cancer 15 years before. My husband has Parkinsons, it's harder in so many ways for me. My husband and son both big rugby players and fans of you. Thank you for doing this Mike, so appreciated x
Still too slow.
The people who won't change how trials are done are healthy and have more time.
The research is too slow. People with parkinsons don't have 10 years plus the trials take. The drugs need to be fast tracked.
Are there concerns with anesthesia negatively impacting Parkinson's symptoms? I have gone through two kidney stone, where my Parkinson;s symptoms grew in intensity.
My father suffered from PD , he was 36 years old , when he was told , lived until 67 years died of stroke . I know this illness very well , i never saw him standing straight , without shaking , or without involuntary movement when he was on L -dopa , until he died and i saw him in the hispital dead lying on bed , i regonized then that he was a tall and a handsome man , because all his muscles are somehow relaxed and not stiffened .
Can find a cure for parkinson 🎉