In this episode, we discuss: 0:00:38 - Alzheimer’s disease: Rhonda’s evolved thinking on neurodegenerative diseases 0:08:00 - The breakdown of the blood-brain barrier in neurodegenerative disease 0:16:03 - An explanation for the observation that type 2 diabetes increases risk of Alzheimer’s disease 0:20:53 - The role of omega-3 fatty acids (EPA and DHA) in brain health and prevention of neurodegeneration 0:35:30 - Comparing the preventable nature of type 2 diabetes, atherosclerosis, cancer, and dementia 0:38:53 - Blood pressure: an important modifiable lifestyle factor that can affect Alzheimer's disease risk 0:43:08 - Rhonda’s outlook on “precision medicine” as it pertains to one’s genetic predispositions 0:51:28 - Possible mechanisms by which exercise reduces the risk of Alzheimer’s disease 1:01:09 - Building your aerobic pyramid: neurobiological effects of exercise, benefits of lactate peaks, and more 1:06:55 - Maximizing mitochondrial biogenesis: alternative training approaches and strategies 1:19:44 - Possible brain benefits of sauna, and Rhonda’s personal protocol 1:27:30 - The relationship between cardiorespiratory fitness and dementia risk 1:33:45 - How exercise may reduce the risk of cancer 1:49:09 - The overarching impact of exercise of health, and the importance of focusing the factors that matter most 1:55:07 - Impact of alcohol consumption on breast cancer risk and overall health 2:00:45 - Exercise as an intervention for poor sleep habits 2:05:25 - The longevity benefits of consuming adequate protein and strength training to preserve muscle mass and strength 2:27:15 - How to get enough of the right kind of protein in your diet 2:35:35 - Fasting: weighing the risk vs. reward 2:39:38 - How Rhonda’s views have shifted on diet and exercise 2:46:17 - How to follow Rhonda’s work and more about the benefits of lactate for the brain
I appreciate discussion on brain health, exercise, etc, I made a choice that I can very well adapt my food protein not to harm, torture, kill animals, which is the reality of the chopped up dead animal on your plate. Please try to include in discussion and not promoting fresh kill etc. It can be done. Our lives are interwoven with animals, we as a species are myopic in terms of our desires. Being kind and good is good for heart soul and body.
I did my PhD in Pharmacology in the 90s and published several research papers and wrote my dissertation on one of the first drugs to treat Alzheimers Disease called Tacrine. It was hoped this drug was in some way slowing progression, but it turned out the relief was only symptomatic. I pivoted after graduate school and was no longer involved in Alzheimers research, but have followed Alzheimers research since that time. It is depressing how little progress has been made, yet in the past several years, I have renewed hope that we are getting closer to finding preventative interventions for this disease. I have suspected from the beginning that there are multiple causes with a final common pathway. Thank you so much for this wonderful discussion.
I'm convinced annual flu shots for seniors are contributing massively to this problem. Heavy metals cause inflammation in the brain & it's very hard to remove them over a person's lifetime. We STILL have metals in our brains from our childhood vaccines, plus contaminants from the modern diet. Then when you check into senior living facility, they make all the residents get flu shots (as a condition of recieving federal govt funding). No wonder most people deteriorate rapidly in govt-funded "Care Homes".
Unfortunately, the research will always fail because they are looking to make money, when all people need to do is change what they eat and avoid all pharmaceutical medications, especially vaccines.
The best moment for me was Rhonda's observation that working out even if tired because of broken sleep was beneficial! "I'm going to work out no matter what!" Thank you Rhonda!
I'd not buy into that thinking if means blasting yourself... If you're crushed and go training it will overwhelmingly wreck your health, but walking in a nice area is where it's at when you're dealing with that.
And in COMPLETE CONTRADICTION to what his buddy Matthew Walker PhD said recently. Sleep is the foundation of fighting AD. The brain-cleaning mechanism of the brain has been identified, and it stops working when you awaken.
I went to a neurologist for the long covid symptoms and terrible dizziness and vestibular migraines I started having.. had an MRI done and it showed the lesions Rhonda described the white hypertensities... yet the neurologist told me those didn't mean anything. They called to tell me the test looked normal. I asked specifically if i had lesions and they said no. Luckily the test resulrs get put onto an app so we can see it and saw it did say i had lesions. When I then called back and spoke with the nurse, she told me the lesions indicate small vessel disease but the only thing they do for that is tell ppl to take an anti-inflammatory and it wasn't anything to worry about. I'm only 38. I was shocked and disgusted and stopped goin to them.
@BronsteinEmily I've been passed from Dr to Dr. No one can tell me a definitive diagnosis. Every dr has given me a new one and tried to give me meds. But I am not goin to take things that can worsen issues when they are not addressing it as a whole. One dr says central nervous system disorder, another says peripheral. One says vestibular migraines. Another says panic disorder. Another says I just needed the covid jab and it would resolve all my symptoms. Smh it's sad the Dr's I've been to have no idea how covid can damage the nervous system along with many other organs in the body. A nurse at the neurologist office said its small vessel disease but they don't do anything to treat it and it doesn't put u at risk to develop other degenerative neurological disorders, but I already have severe cognitive symptoms that interfere with my daily life. I am a server and I have got to the point that I need to write everything down or I'll forget. It feels like I developed dementia or something, it's like concussion symptoms that came on suddenly without ever hitting my head, and not much helps other than altering my diet and lifestyle choices now. I can't live like I used to but no one can tell me why or acknowledge it was obv the covid infection that caused it. I'm reading all kinds of research online that validates this information I'm saying but when I go to each one of these Dr's, they just blankly look at me as tho idk what I'm talking about and go on to label it some new diagnosis and offer a med that I don't end up taking. At which pt they tell me there's nothing they can do for me.
I have seen this in my practice and helped vertigo/dizziness. I am a Gonstead Chiropractor in MN. You can search online to find a thorough chiro who actually does an analysis and specific adjustment. Search Gonstead Chiropractor search and see if you can find someone
I’ve been experiencing this same thing for the last six months. I had Flu A the week before Christmas and Covid the week after. My dizziness and this crazy random buzz that I get in my right ear from time to time is getting better, but still catches me off guard when it happens. My doctor and just about everyone else that I’ve mentioned this to have just looked at me like I have two heads. I don’t even talk about it anymore. I’m just trying to stay focused on maintaining daily movement and eating healthy. I hadn’t utilized doctor’s offices for anything other than yearly checkups for 22 years because I hadn’t been sick, outside of allergy flares, but when I did actually need good care-what a disappointment. I hope that your symptoms improve!!
and what about her bullshiting on jre about covid? she was total big pharma whore. i found it just few min before this comment. she was wrong in everything. you can see also in this discussion that most of scientists have no brain to think out of box and be creative. they created their virtual domain and messing around within and going nowhere. they create hypotheses out of thin air without any real proof. most of their evidence is wrong interpretation of facts...
I recently left senior living after 12 years. One of the many frustrating things that I noticed was how little research is being done inside of memory care units. There are literally thousands of patients in a locked down community just sitting there wasting away, living a horrible life, who would be willing to participate in trials. Like so many health issues, cures aren't profitable. Makes me sick to my stomach.
@ayo9057 The most respect in what context? In terms of laymen? You find this weird? So the people who communicate scientific findings to people who don't have the desire or ability to go to the source material and interpret complex studies and biological mechanisms are respected more by those individuals than scientific researchers is something you can't clearly understand? Who do you think 'gets the most respect' in the academic world? Is it Rhonda Patrick, or is it the scientific researchers publishing novel findings? Would you find it weird to know that its the researchers? Very dumb comment from you.
Rhonda is always a pleasure, along with Peter as always; and together is a real treat! The wealth of knowledge on this channel is second to none. Thank you for providing this public education! I took notes. I’m ready for the pop quiz 🤓
Haven't finished this episode yet but wanted to let Rhonda know how clear her remote setup was. I am hard-of-hearing and I felt like you were here sitting in the room with me. I watch a ton of podcasts and shows and this one was so easy to listen to. Also, Peter, I was watching this when under Zone 2 on an elliptical! The cognitive juices were definitely flowing. Thank you and keep up the great work !
A talk between Titans!! Doctors, my family thanks you both for your class and quality. Your work has added time to our lives and decreased our anxiety when facing and researching our family health history. You are both an absolute gift 🎁🎁!!
Trying to digest all what you discussed, bcuz I am just a house wife, but it feels so encourage to see a woman scientist to be so knowledgeable, passionate, and hands-on of your teachings. Thank you so much for sharing this episode with us. 🙌
Phospholipids/Omega 3's and the Blood Brain Barrier connection is worthy of a podcast of its own.Would love to see a podcast with Dr. Dhavamani and his research with LPC-DHA and macular degeneration and levels of Omega 3's in the brain and eye.
@Sukhjote Singh Not that I know of which is why I would like to see an interview with him...but at least,most of his studies aren't behind a pay wall.Very exciting data in latest paper.
Two of the best in the game when talking about longevity. Rhonda Pattrick got me diving down the rabbit hole of longevity and living my best life. I owe her a lot. Then Peter's mindset to optimize everything when it comes to your health and getting the most out of life is inspiring. I've listened to this once and plan to do it again. Why Rhonda isn't making the rounds on more podcasts is beyond me. The information about lactic acid was great to hear. Time to hit those HIIT days harder! Lets go everyone!!
Lactate is different from lactic acid. Search for Andy Galpin (also on Petter's podcasts) and lactate who has a 5, 25 and 55 minute version of the low down on lactate.
Thank you for this important information, I started a ketogenic diet 8 yrs ago however I went on and off during this time. This past year I went back to a standard American diet and the inflammation in my body was so out of control to the point that made me almost unable to walk. I went to my dr and was told I needed a complete ankle replacement. At my age “77” . decided to go on on a carnivore diet ,. I have been eating carnivore for 8 months now and my body is at a very healthy place, I have lost 35 pounds and my body feels wonderful. I wish I knew this earlier in my life, thank you for trying to get the information out to the older people. I have my life back….
@Casey Muller That’s nice, I have Been diagnosed with a cancer and I will definitely need her help and would also want to know how to get in touch with her. I hope she cures other sickness also?
Great talk. It's really refreshing to have general-audience intended videos about med/health that do not dumb down the material into uselessness, but instead give one actual mechanisms and keyphrases about biochemistry one can research in-depth yourself.
Thanks Rhonda and peter! Both of you inspire me to exercise! And today is day number 522 of my omad diet! I've lost 50 lb and another 35 lb to lose with your continued inspiration!
@@p-Claud73 I can't find the controversy you and Dale are alluding to. No thanks. Maybe someone who isn't as troll like will reveal this supposed quackery.
Very interesting! Loss of Pericytes are the main root cause of the breakdown in the blood retinal barrier in diabetic retinopathy as well. Thanks for sharing!
The Queen of Knowledge interviewed by the King of Longevity and Performance ... This channel seems to get better and better. Fresh cutting edge content, always research driven but action focused. Thank you ☺️
Of which knowledge? I remember her at a few podcasts talking as if she just read some info from wikipedia. Like her cringy covid vaccine stance on Rogan where she could not state any valid data or a concrete research...
@@nebo2073 I believe thr most knowledgeable and wise people change their views on matters. Especially when new data emerge and when contexts change, science evolves.
Listening to you both Peter & Rhonda I feel my age reversing. You guys are such a positive force and so helpful to so many. Thank you for your time in spreading this information. Godspeed.
This episode has my mind buzzing! At 67 I’ve always been fit and active and then a month ago I had my left knee explode. A complex Baker’s cyst that burst. The MRI also indicated meniscus tear among other ligament issues and 2-4 stage osteoarthritis. I have a shortened leg by 2 inches from an accident so the overall thinking is that that has attributed to my muscle imbalance which then led to osteoarthritis. I stopped my daily beach walks and most exercise during Covid. I started mountain biking in 2021, but stopped after my husband had an injury in 2022. What is clear to me by this conversation and my own experience is vigorous, strenuous, exercise, and strength training is key in longevity and health. I got lost in the numbers but the gist of what I understood was that HITT training as Peter described, VO2 Max and lactic acid and strength training are all key factors in cognitive and physical health. Although I am vegan, I will add in fish oil. My physical therapist highly recommended. I take fish oil. Hearing your conversation today as me realize that’s another place I would do well to make a shift. Thank you, Peter and Rhonda!💪🏻
The correlation between Alzheimer's disease and high blood pressure, as well as type 2 diabetes, is alarming and demands our utmost attention. It is crucial that we recognize the significance of this link and take necessary measures to address and mitigate these risk factors.
I completely agree with you! The connection between Alzheimer's disease and high blood pressure, as well as type 2 diabetes, is a serious concern. It's essential that we raise awareness of this link and take necessary steps to manage and reduce these risk factors. This could include regular exercise, maintaining a healthy diet, and managing stress levels. It's also important to seek medical advice and treatment if you have high blood pressure or type 2 diabetes.
Please focus on main practical effective teaching tool to help others like ordinary lay people who needs most help.God blessings.Thanks for sharing your information and time.
This is a really great / interesting talk - you both bring a lot to the table here. Having older family suffering with health problems, I'm always looking for a new way to motivate them. Hearing Dr Rhonda Patrick say without exercise / bloodflow tiny blood vessels in the brain "fall off" & cancer reduction 50%, might just be enough to motivate some of them to exercise! Thank You. 🙏
Love hearing Rhonda talk and i especially like that she is not affiliated with any supplement companies. Her and Peter are two of the brightest minds in this space. Did i hear her say she does 16 Tabata rounds 5x a week? That cant be, that seems like alot
Usually, when I see almost 3 hours long, I cringe but with these 2, I am thrilled. (Dealing with this now and it's somewhat sad as they can seem rather lost) Throw out vegetable oil-eat well. I will listen later..family duty calls. I enjoyed the talk and although my mother could not get me to like broccoli, Rhonda sure did! Thank you~ Happy Mother's Day!
@@roustabout4fun "however Veg Oil is so very bad for us that it is a given." That's a given to you or me, but I watched many talks of Rhonda and Peter and never saw them talking about the elephant in the room. I find this odd.
My parents are well into their 90’s and live independently and are very active. Apart from starting weights in their 90’s because they thought they were getting weaker they have done nothing discussed in this podcast! They drink alcohol, have been exposed to toxic chemicals, have been obese, never did cardio but they rarely if ever are fast food and ate home cooked meals and also eat cake every day.
Right?!? Go figure... it's almost like trying too hard, like described here, is the problem. Also, on the other end of just eating total garbage, being completely sedentary is the problem. Animals don't think or analyze how to live...they just do it. Why is it so hard or confusing for humans...
Dr. Attia I hope you see this. At around minute 40:00, you are discussing blood pressure and keeping it in a lower (proper range). However as a nurse i have seen the devastating effects of trying to keep BP lower in elderly (falls). It has been my gut feeling and conclusion that bp rises with age naturally, and it would make sense if as you felt atherosclerosis is inevitable with age. Think of arterial wall that hardens. In order to get the nutrients where they need to go would it not makes sense to you that as we age our arteries and vessel's do harden, then it would take an increase in blood "pressures " to continue to get blood and oxygen and nutrients to flow throughout the body, especially to the brain. So as we age our vessel's naturally harden and bp tends to naturally rise. Seems like a natural way our body is coping to get the nutriends and blood and oxygen to still get to all our tissues and organs. Then we as Drs go and prescribe a medication to keep BP low, and with age vessels harden, now without the pressure we get less and less nutrients to our brains and body. I have always felt with age keeping BP in the 120s is definitely going against the bodys natural defense to hardening of arteries and vessels and we cause more harm than good. Thoughts??
I guess lowering blood pressure in a person who's been hypertensive their whole lives and have remodeled brain vessels is different than maintaining a low blood pressure throughout your entire life so that the vessel wall is not so damaged and the lower BP works well enough
I agree with you. I think the BP does naturally rise with age. (for what reason we don't know yet) But I don't think it should be any higher than 140/90. There are several longevity studies of older people who lived the longest and they all had higher blood pressure. Here is my thought, do we have solid evidence that high blood pressure (not sky high) damages the body -- ALONE? Since we know that Insulin Resistance and Diabetes also damage the body -- causing kidney failure, Heart attack and stroke, are we blaming blood pressure for what sugar did?
Hello Dr. Attia!! I just want to say Thank You! For being you and everything you do!! I've read your book. Watch most of your podcasts, short clips,etc. I'm obsessed with the unlimited knowledge that you provide. In short, I'm a stepdad with two amazing boys, 6 & 8 and a phenomenal future wife. I've been in the fire service for several years, so not beneficial in the sleep or carcinogens department. I am a 40 yr old male, physically healthy (if you ask me), train hard, eat fairly well. My annual physical is coming up and I have a whole list of things I want to ask since following you! Is there a breakdown list on blood tests, questions, tests, etc. that you have somewhere in your arsenal???
Great content! I’m a health coach and I work in ith Alzheimer’s patients. Diet and exercise slow th progression of th disease significantly. I think the anti inflammatory effects of exercise improve brain health.
My wife is also heterozygous for APOE4. Rhonda has been searching for any thing that she can that will reduce the likelihood of her developing Altzheimer’s. We have been doing everything that we can to help to improve my wife’s Altzheimer’s. She is not able to formally exercise, other than using the stairs and walking using an aid such as a supermarket trolley ! Or even a wheelchair, which is then useful if she needs it. Exercise is clearly beneficial. Over the past year or so, we have both been able to improve our Metabolic Flexibility. Using low carb, high healthy fats, fatty fish, green and cruciferous vegetables. And intermittent fasting. I hardly have to fast, and to some extent I am not able to, in order to maintain my body mass, but my wife still needs to fast for 36hrs in order to achieve a ketone level of 1.5 mmol/L or more. This is rather a ‘stress’ for her system, but it is accompanied by a slight improvement in her ADL’s subsequently. Various people describe a ketone level above 1.5 as being in the ‘therapeutic range’. It seems to me therefore that fasting is the ‘Silver Bullet’, allowing the glucose levels to reduce to fairly dramatically low levels, and also the Insulin levels to return to low normal levels. It appears that chronically elevated insulin levels are likely to increase the development of many Cancers, and the corollary being that low levels of insulin will tend to have the opposite effect. It’s not so easy to measure insulin, but glucose and ketones can be measured with a finger prick. And a Glucose/Ketone index of 1 is highly likely to negatively affect the abnormal metabolism of cancer cells, which rely on anaerobic fermentation for their energy production because of damage to the mitochondria. When I was at Med School we were told that you are as old as your arteries, but I don’t recall any expansion of the statement or explanation. Dr Joseph Kraft in his book, Diabetes Epidemic and You states that the origin of many diseases is the damage caused to the vascular system, throughout the body, to both large and small vessels, by raised insulin levels, which disrupt the intimal layer of the vessels, and allow the subsequent development of atheromatous plaques. It was his suggestion that disruption of the tiny vessels in the inter ventricular muscle of the heart, is likely to be the pathological condition leading to Auricular Fibrillation. We therefore have to try to avoid too much insulin at all costs for all sorts of diseases…..
An interesting point re. VEGF, but somewhat surprised to hear this coming from someone who's previously leaned very heavily towards sulforaphane-rich vegetables. In 2018 a study titled "the effect of sulforaphane on vascular endothelial growth factor and hypoxia-inducible factor-1α in normobaric hypoxia." was published in the journal High Altitude Medicine & Biology, the thrust of which was that sulforaphane reduced VEGF levels in the blood. I wonder how Dr Patrick squares this. Would be fantastic if someone could shed any light. Anyway, I love these two - and thanks to Dr Patrick I've got a sauna on my to-buy list:)
They should include PhD Mark Mattson and Prof Valter Longo who has lots of research on protein requirements, IGF1 Fasting and gerontology and brain health.
Magnificent podcast! Thank you both for sharing your knowledge with the world!!! Dr. Attia, I must say I really love your book! I am learning so much from you, young man! Please keep up the great work! You truly are helping tons of people with the Drive! Stay healthy and stay strong 💪
Just fantastic info from both of you , as a 75 year old athlete now working as a bike taxi transporter( pedicab no electric motor) bringing jubilant fans to Warrior games and Giant games the surges are ridiculous , talk about lactic burn😅then strength training 3x a week where I am now more focusing on the eccentric phase yet explosive on the concentric and working out in a fasted state on a time restricted feeding window has been fantastic.
The amount of times Peter interrupted her as she was trying to say what the three best things to do for preventing a leaky blood brain barrie had me ready to scream. Anyway... LOVE this collaboration! Two of my favorites, and even better together. She's a little better at putting the data together, and he's a little better at making it make sense to me, so this is just my ideal pairing. Wish it was more regular I'm a 2x APOE4, have watched most of my relatives suffer from Alzheimer's (if a heart attack didn't take them first), and am in my 50s. Luckily, I've had an extreme exercise addiction since middle school, and have had a total of about 5 drinks in the last 20 years. Personal trainer for 35 years but am in nursing school now, so not as much exercise as my usual, but will be right back up there in a year I also do a fast every couple of months... most people think I'm in my 30s, and when I mention that I have kids in my 20s, they always stop me to say... "wait... how old are you?!" So at least on the outside, everything I'm doing is helping.
What was driving me crazy was her saying "like" a lot. Great information from her but her filler word use was very high for someone who does presentations often.
I’m APOE4 1x, my Dad with x2 with Alzheimer’s. Per her conversation with Andrew Huberman, take Nordic Naturals fish oil, keep it in the fridge. Rhonda takes several a day. Also, watch the Rudy Tanzi talk on Cure Alzheimer’s fund 5 months ago starting about 40 minutes in. On his presentation, there is nicotinomide riboside, and Resveratrol, so I’m taking those. And Talley health supplement with Fisetin.
My mother died from Alzheimers so I wanted to be proactive and get tested. I’m 72 so I got an MRI, brain scan and spinal tap, to determine if I had a high probability of getting it. Well, I found out that I have the medical signs so I wanted to be proactive. I have started medications such as Memantine and Prevagin. I’m taking Percepta, fish oil and fish oil capsules, all recommended by my neurologist. So far so good. Some short term memory issues but since taking these meds, my short term memory has improved. The Prevagin is very expensive but fortunately, my husband has been a very good investor so the cost is not impacting our lifestyle. I’m also a pescatarian and have given up all meat, fowl and processed foods except tofu and tempeh. Hubby and I also walk 5 miles a day which also helps.
I watched my poor parents sit motionless for years doing crosswords and sudoku. They told everyone who would listen that they were " keeping their brain active".From morning til night they did them. They refused to exercise; even to walk to the corner store. They refused to join anything outside the house. Both got dementia after a few years retirement. One died quickly; the other is bed bound now. Crosswords and puzzles do not work to keep dementia away.
15:50 Hippocampus relies on glut4 transporter, that is insulin dependent. Parietal lobes rely on glut1 this explains the different etiologies of the various forms of alzheimers.
Ronda;.....!! So surprised you didn't even mention sulforaphane. You are the Queen of this phytochemical; you've turned me onto it so many years ago with the intensity of your preaching about it. And now? Not even a mention?
I can only catch small bits and pieces and that keeps me listening. Most of the conversation is way above my level and I have to use Google to help me understand. I will still listen.
I’m living proof that what they say is true. I am 87 on no meds. I do something every day, aerobics , tennis, tap, weights, yoga and dance every chance I get. I do a sauna every day, magnesium baths, and eat beef , lamb and bison, eggs,kefir and veggies .
Thank you Dr, this was great, I really appreciate your sorting out the protein requirement issues away from older thinking, sarcopaenia is my concern. Thanks again
Great conversation! Thank you! On a different note- I am wondering why a menopausal woman's vasilations between intense hot flashes and freezing to the point of shivering don't seem to increase brown fat. Why aren't hot, flashy- then freezing women becoming more metabolically efficient?
Hooray for science and fitness! Hooray for researchers and clinicians studying prevention AND practicing it all on yourselves. There is definitely hope for humanity. Can we please get more research going about the metabolic and hormonal benefits of exercise for women, specifically lifting heavier weights combined with cardiovascular training, specifically women over 50? That may or may not be my demographic. 😁
Supplemented with 10,000 IU of vitamin D (+K2) per day this winter and my bloodwork in March showed a level of 103. Two years ago it was 62 on a much lower dose. 8 years ago, before any supplementation, it was almost zero!! N=1
36:42 atherosclerosis is preventable, it is a dynamic balance and sclerotic plaques can reduce in size: glynac to maintain endothelial function (by maintaining glutathione levels and reducing albumin back to mercatoalbumin) seems protective (especially to protect from methylglyoxal), which is indeed reflected in circulating sVCAM levels. Then adding berberine (to reduce TMAO levels) appears to be able main sclerotic plaque levels to an extent whereby a clinical phase of atherosclerosis will never be reached. (Think of the calcified sclerotic deposits as a protective mechanism to prevent leakage, if no leaks, then no sclerotic plaques. sVCAM is basically a measure of leakage). Also think of the glucose hypomethabolism in AD as a protective mechanism, just as much as amyloid beta is a protective peptide: The cell needs to down regulate all genes related to glucose metabolism (which includes downregulating the GLUT transporters), to prevent toxic glucose from entering the cell when it doesnt have enough functional mitochondria to process the glucose. The cell will automatically upregulate those genes once the mitochondrial dysfunction is resolved by either nutrient deprivation (fasting), increased atp demand in an hypoxic environment via exercise (forget irisin and lactate, they correlate, but are less causal, hypoxic waves via HIIT is most stimulating towards mitophagy), ingesting uncouplers (polyphenols, ketones) or raising endogeneous antioxidants (glutathione and melatonin (both will raise SIRT3). All these interventions will rebalance the mitochondria and upregulate glucose metabolism genes, inclusive of GLUT4 expression in the hippocampus, which should halt the age-related AD disease process. Then to recover, endogeneous stem cell activation and differentiation to neurons is required which you can stimulate via l-arginine but its a cumbersome slow process. The important thing to realise is that AD is indeed preventable by maintaining mitochondrial density, by compensating for reduced endogeneous production of glycine and cystine by exogeneous consumption. This should indeed prevent most geriatric diseases (inclusive of AD by avoiding the need for APP to cleave at the beta site)
A ton of great knowledge just in one comment. Thank you very much! To add a bit I've been using berberine for just a few months and the effect on blood-pressure has been shocking! I also get into keto much faster (apple cider vinegar, cold shower, glycogen-depleting exercises) with how it works on my blood-sugar.
Thanks a lot for this extremely interesting podcast episode! I am also genetically predisposed. As I am a scientist, I have access to all scientific publications. However, I really enjoy listening to you because you integrate all those different perspectives and help me think of new connections between findings. This episode in particular inspired me to think about OXYTOCIN. Have you ever read of a study on oxytocin and dementia? I realized that this hormone might be one variable that correlated with many factors known to prevent dementia, as for example: giving birth, being married, having sex, meditate, being touched, being in contact with people, having animals, eating fruits, especially berries and green leaves as well as seeds and curcumin. All of those raise oxytocin. In contrast older age leads to less contact and sex and the elderly are very rarely touched, especially in care. Might oxytocin (also as a supplement) be a factor to further reduce the risk?
This talk can be summarize by saying "we need more studies." They don't give anything that you can really hang your hat on to improve other than the basics we already know.
Glad for any voices cutting through the noise like this. Appreciate Peter pointing out money wasted on bs treatments instead of finding the root of the pathology.
In the beginning of this interview, Dr. Patrick expresses that her interest in Alzheimer’s research is somewhat due to her own family history. I’m not a doctor, so I do not know the warning signs of Alzheimer’s, but as a listener, I observed Dr.Patrick’s speech patterns. I have heard other presenters who changed their train of thought often during their presentations. It is very difficult for listeners to focus and to grasp the message with this happening. I would encourage Dr. Patrick to listen to this video and practice speaking without these interruptions, not only would it be great for improving her presentation skills, it may also challenge her brain and add to her prevention regimen.
Every time I see a video like this, I immediately get a sense of ineluctable doom as a 3/4 APOE carrier...what I would have given for a 2/3....yet I am still drawn to listening, thus amplfying my worries and concerns.
You do realize we all have to die right? All this paranoia about something you have little control over seems odd. Go live your life and have a good time doing it.
@@forcefedapocalypse I have no problem dying. I don't mind dying from other causes but there is something especially pernicious about becoming a mindless meat sack before you finally drop dead.
We owe it to ourselves and our strained healthcare system to experiment and find out what suits us best on an individual basis as far as diet and exercise go. I did this and am improving my health incredibly. I've eliminated a long list of issues by eliminating certain foods from my diet. And, I've lost a significant amount of weight. I think the right diet can be different for all of us. But, I also think there are foods that can harm all of us. Seed/vegetable oils, refined and processed foods, cane sugar, fructose, alcohol etc etc. I think it's important to not be dogmatic about how we eat if it makes us feel better. I really don't think there's one right diet for every single person on the planet. Figure it out. It's not hard. Your body will tell you. Just Listen to it! I think there is a whole lot that science and medicine have gotten wrong about diet. This isn't one size fits all. Nothing is.
Thank you so much for saying T2 diabetes rather than just diabetes about because it is something different from T1, but as a T1 I’m wondering how my high blood glucoses are affecting all these same areas. I know the research is done with T2’s because there are so many more of them but it seems like the effects would be the same.
2:03:00 Rhonda states study proved "Poor Sleep" participants have a Higher All Cause Mortality. BUT only those people who weren't Physically Active!😅... So Exercise even w/ poor sleep IS going to be Beneficial... So glad I saw this💯
It's a step forward accepting that insulin resistance is causing damage to the biology of blood vessels to be causative of Alzheimer's. I hope Peter soon accepts that insulin also damages the biology of arteries and indeed is the main cause of CVD rather than LDL levels in the blood.
@@erastvandoren I meant insulin resistance. The whole package of metabolic illness. On the other hand, and within the same context, I could make a similar insulting phrase for you: "BS. Glucose is absolutely crucial for human life". But I won't. Both Glucose and Insulin are crucial, but the problem is their excess and deregulation: insulin resistance or metabolic syndrome.
And on top of sickened biology of blood vessels and heart due to insulin resistance (metabolic illness) there is the part of sickened biology of blood, blood cells and lipoproteins and particles. All sickened by Insulin resistance (metabolic illness). BTW, 95% of the US population is metabolically ill. That is alarming and the reason why LDL seems causative of CVD, because almost everyone has sickened biology.
In this episode, we discuss:
0:00:38 - Alzheimer’s disease: Rhonda’s evolved thinking on neurodegenerative diseases
0:08:00 - The breakdown of the blood-brain barrier in neurodegenerative disease
0:16:03 - An explanation for the observation that type 2 diabetes increases risk of Alzheimer’s disease
0:20:53 - The role of omega-3 fatty acids (EPA and DHA) in brain health and prevention of neurodegeneration
0:35:30 - Comparing the preventable nature of type 2 diabetes, atherosclerosis, cancer, and dementia
0:38:53 - Blood pressure: an important modifiable lifestyle factor that can affect Alzheimer's disease risk
0:43:08 - Rhonda’s outlook on “precision medicine” as it pertains to one’s genetic predispositions
0:51:28 - Possible mechanisms by which exercise reduces the risk of Alzheimer’s disease
1:01:09 - Building your aerobic pyramid: neurobiological effects of exercise, benefits of lactate peaks, and more
1:06:55 - Maximizing mitochondrial biogenesis: alternative training approaches and strategies
1:19:44 - Possible brain benefits of sauna, and Rhonda’s personal protocol
1:27:30 - The relationship between cardiorespiratory fitness and dementia risk
1:33:45 - How exercise may reduce the risk of cancer
1:49:09 - The overarching impact of exercise of health, and the importance of focusing the factors that matter most
1:55:07 - Impact of alcohol consumption on breast cancer risk and overall health
2:00:45 - Exercise as an intervention for poor sleep habits
2:05:25 - The longevity benefits of consuming adequate protein and strength training to preserve muscle mass and strength
2:27:15 - How to get enough of the right kind of protein in your diet
2:35:35 - Fasting: weighing the risk vs. reward
2:39:38 - How Rhonda’s views have shifted on diet and exercise
2:46:17 - How to follow Rhonda’s work and more about the benefits of lactate for the brain
0:00 We are being priced out of life because of Artificial Inflation.
0:01 Licking ice cream through glass.
I’m gonna fast my ass off!
Thanks!
Thanks
I appreciate discussion on brain health, exercise, etc, I made a choice that I can very well adapt my food protein not to harm, torture, kill animals, which is the reality of the chopped up dead animal on your plate. Please try to include in discussion and not promoting fresh kill etc. It can be done. Our lives are interwoven with animals, we as a species are myopic in terms of our desires. Being kind and good is good for heart soul and body.
I did my PhD in Pharmacology in the 90s and published several research papers and wrote my dissertation on one of the first drugs to treat Alzheimers Disease called Tacrine. It was hoped this drug was in some way slowing progression, but it turned out the relief was only symptomatic. I pivoted after graduate school and was no longer involved in Alzheimers research, but have followed Alzheimers research since that time. It is depressing how little progress has been made, yet in the past several years, I have renewed hope that we are getting closer to finding preventative interventions for this disease. I have suspected from the beginning that there are multiple causes with a final common pathway. Thank you so much for this wonderful discussion.
I'm convinced annual flu shots for seniors are contributing massively to this problem.
Heavy metals cause inflammation in the brain & it's very hard to remove them over a person's lifetime.
We STILL have metals in our brains from our childhood vaccines, plus contaminants from the modern diet.
Then when you check into senior living facility, they make all the residents get flu shots (as a condition of recieving federal govt funding).
No wonder most people deteriorate rapidly in govt-funded "Care Homes".
Unfortunately, the research will always fail because they are looking to make money, when all people need to do is change what they eat and avoid all pharmaceutical medications, especially vaccines.
Sugar
Must be difficult to see how little progress has been made. Thanks for your work regardless.
who knew diet and exercise is the best drug combo for many ailments.
The best moment for me was Rhonda's observation that working out even if tired because of broken sleep was beneficial! "I'm going to work out no matter what!" Thank you Rhonda!
From one Debbie Hall to another… sad to hear but no slacking…. Even when we’re tired!
I'd not buy into that thinking if means blasting yourself... If you're crushed and go training it will overwhelmingly wreck your health, but walking in a nice area is where it's at when you're dealing with that.
@@alexanderohanlon8825 No. Rhonda is far more intelligent than you. She will work out intelligently not "blast".
And in COMPLETE CONTRADICTION to what his buddy Matthew Walker PhD said recently. Sleep is the foundation of fighting AD. The brain-cleaning mechanism of the brain has been identified, and it stops working when you awaken.
@@bardsamok9221 That was an insulting comment.
I went to a neurologist for the long covid symptoms and terrible dizziness and vestibular migraines I started having.. had an MRI done and it showed the lesions Rhonda described the white hypertensities... yet the neurologist told me those didn't mean anything. They called to tell me the test looked normal. I asked specifically if i had lesions and they said no. Luckily the test resulrs get put onto an app so we can see it and saw it did say i had lesions. When I then called back and spoke with the nurse, she told me the lesions indicate small vessel disease but the only thing they do for that is tell ppl to take an anti-inflammatory and it wasn't anything to worry about. I'm only 38. I was shocked and disgusted and stopped goin to them.
have you seen anyone else about it and are there things you can do to address the issue?
@BronsteinEmily I've been passed from Dr to Dr. No one can tell me a definitive diagnosis. Every dr has given me a new one and tried to give me meds. But I am not goin to take things that can worsen issues when they are not addressing it as a whole. One dr says central nervous system disorder, another says peripheral. One says vestibular migraines. Another says panic disorder. Another says I just needed the covid jab and it would resolve all my symptoms. Smh it's sad the Dr's I've been to have no idea how covid can damage the nervous system along with many other organs in the body. A nurse at the neurologist office said its small vessel disease but they don't do anything to treat it and it doesn't put u at risk to develop other degenerative neurological disorders, but I already have severe cognitive symptoms that interfere with my daily life. I am a server and I have got to the point that I need to write everything down or I'll forget. It feels like I developed dementia or something, it's like concussion symptoms that came on suddenly without ever hitting my head, and not much helps other than altering my diet and lifestyle choices now. I can't live like I used to but no one can tell me why or acknowledge it was obv the covid infection that caused it. I'm reading all kinds of research online that validates this information I'm saying but when I go to each one of these Dr's, they just blankly look at me as tho idk what I'm talking about and go on to label it some new diagnosis and offer a med that I don't end up taking. At which pt they tell me there's nothing they can do for me.
@@candyland8903 I'm sorry you have to go through this. I hope that there is research going on and doctors being educated that will some day help you.
I have seen this in my practice and helped vertigo/dizziness. I am a Gonstead Chiropractor in MN. You can search online to find a thorough chiro who actually does an analysis and specific adjustment. Search Gonstead Chiropractor search and see if you can find someone
I’ve been experiencing this same thing for the last six months. I had Flu A the week before Christmas and Covid the week after. My dizziness and this crazy random buzz that I get in my right ear from time to time is getting better, but still catches me off guard when it happens. My doctor and just about everyone else that I’ve mentioned this to have just looked at me like I have two heads. I don’t even talk about it anymore. I’m just trying to stay focused on maintaining daily movement and eating healthy. I hadn’t utilized doctor’s offices for anything other than yearly checkups for 22 years because I hadn’t been sick, outside of allergy flares, but when I did actually need good care-what a disappointment. I hope that your symptoms improve!!
Rhonda is amazing! Been following her for over 5 years now.
Love you Peter!
and what about her bullshiting on jre about covid? she was total big pharma whore. i found it just few min before this comment. she was wrong in everything. you can see also in this discussion that most of scientists have no brain to think out of box and be creative. they created their virtual domain and messing around within and going nowhere. they create hypotheses out of thin air without any real proof. most of their evidence is wrong interpretation of facts...
Amazing--maybe, but she says "you know" too much. Ugh.
@@ritazita1111 and you say "ugh" too much.
I recently left senior living after 12 years. One of the many frustrating things that I noticed was how little research is being done inside of memory care units. There are literally thousands of patients in a locked down community just sitting there wasting away, living a horrible life, who would be willing to participate in trials. Like so many health issues, cures aren't profitable. Makes me sick to my stomach.
Wow, you left after 12 years? You are about 100+ now?
I think he meant he left his job at a senior living facility.
@@x-techgaming I worked in senior living for 12 years. I'm not sure what you are trying to point out.
Rhonda's knowledge of the aging process and ways we may be able to slow it down is incredible. Thank you Dr Patrick and Dr Attia!
She knows nothing.
@Ayo agreed .They wants to sell and profit.Make it complex .It is simple ,go back to nature.Enviroment istoxic.
@Ayo well, because we only know what we know, so far.
@Ayo would you prefer they make it up?
@ayo9057 The most respect in what context? In terms of laymen? You find this weird? So the people who communicate scientific findings to people who don't have the desire or ability to go to the source material and interpret complex studies and biological mechanisms are respected more by those individuals than scientific researchers is something you can't clearly understand?
Who do you think 'gets the most respect' in the academic world? Is it Rhonda Patrick, or is it the scientific researchers publishing novel findings? Would you find it weird to know that its the researchers?
Very dumb comment from you.
The availability of information contained in podcasts like this is one of the wonderful things about the time in which we live. Thank you. ❤
Rhonda is always a pleasure, along with Peter as always; and together is a real treat! The wealth of knowledge on this channel is second to none. Thank you for providing this public education! I took notes. I’m ready for the pop quiz 🤓
Awesome, right?!
So what are you wearing?
@@backfru cringe
@@backfru i'm not wearing anything.
Haven't finished this episode yet but wanted to let Rhonda know how clear her remote setup was. I am hard-of-hearing and I felt like you were here sitting in the room with me. I watch a ton of podcasts and shows and this one was so easy to listen to. Also, Peter, I was watching this when under Zone 2 on an elliptical! The cognitive juices were definitely flowing. Thank you and keep up the great work !
A talk between Titans!! Doctors, my family thanks you both for your class and quality. Your work has added time to our lives and decreased our anxiety when facing and researching our family health history. You are both an absolute gift 🎁🎁!!
Agreed. Thank-you for your great doctors.
Trying to digest all what you discussed, bcuz I am just a house wife, but it feels so encourage to see a woman scientist to be so knowledgeable, passionate, and hands-on of your teachings. Thank you so much for sharing this episode with us. 🙌
Please do not refer to yourself as just a housewife. Housewives are the most diverse courageous problem
solving bad ass people I know!
"Just a housewife"? No, a good wife is the backbone of a family.
You are raising members of the next generation. You have the most important job. Never forget how indispensable you and your role are.
Oops, my mistake. I completely agree with all of you! Thanks for reminding me what a housewife means!
Thanks for always having timestamps. It makes a huge positive difference to me! I can zero-in on topics if interest.
Phospholipids/Omega 3's and the Blood Brain Barrier connection is worthy of a podcast of its own.Would love to see a podcast with Dr. Dhavamani and his research with LPC-DHA and macular degeneration and levels of Omega 3's in the brain and eye.
Has he got any videos on RUclips?
@Sukhjote Singh Not that I know of which is why I would like to see an interview with him...but at least,most of his studies aren't behind a pay wall.Very exciting data in latest paper.
Two of the best in the game when talking about longevity. Rhonda Pattrick got me diving down the rabbit hole of longevity and living my best life. I owe her a lot. Then Peter's mindset to optimize everything when it comes to your health and getting the most out of life is inspiring. I've listened to this once and plan to do it again. Why Rhonda isn't making the rounds on more podcasts is beyond me. The information about lactic acid was great to hear. Time to hit those HIIT days harder! Lets go everyone!!
Lactate is different from lactic acid. Search for Andy Galpin (also on Petter's podcasts) and lactate who has a 5, 25 and 55 minute version of the low down on lactate.
Ronda love her, your podcast are on point every time. you ask the right questions. At 66 still learning so much to increase my health span.
Always nice to hear Rhonda! Thanks for bringing her on Peter :)
Thank you for this important information, I started a ketogenic diet 8 yrs ago however I went on and off during this time. This past year I went back to a standard American diet and the inflammation in my body was so out of control to the point that made me almost unable to walk. I went to my dr and was told I needed a complete ankle replacement. At my age “77” . decided to go on on a carnivore diet ,. I have been eating carnivore for 8 months now and my body is at a very healthy place, I have lost 35 pounds and my body feels wonderful. I wish I knew this earlier in my life, thank you for trying to get the information out to the older people. I have my life back….
Did you get your ankle replacement then?
This one potcast is the best I ve heard about answering all my questions related to health and wellness.
Having to Live with one of the worse sickness can be exhausting but I still have to believe I can be healed.
@Casey Muller That’s nice, I have Been diagnosed with a cancer and I will definitely need her help and would also want to know how to get in touch with her. I hope she cures other sickness also?
@Casey Muller Thank you a lot you are a life saver. I have found her website on the internet.
Great talk. It's really refreshing to have general-audience intended videos about med/health that do not dumb down the material into uselessness, but instead give one actual mechanisms and keyphrases about biochemistry one can research in-depth yourself.
Thanks Rhonda and peter! Both of you inspire me to exercise! And today is day number 522 of my omad diet! I've lost 50 lb and another 35 lb to lose with your continued inspiration!
Rhonda “It’s Been Shown” Patrick. Love her.
I love it when she says, "...in fact..."❤❤
like, totally. it's like yeah, like i know like um fer sure, like uh huh.
She fudged up her credibility with COVID.
@@dalejames486 her along with Chris Masterjohn. Peter should avoid having quacks on his podcast.
@@p-Claud73 I can't find the controversy you and Dale are alluding to. No thanks. Maybe someone who isn't as troll like will reveal this supposed quackery.
Very interesting! Loss of Pericytes are the main root cause of the breakdown in the blood retinal barrier in diabetic retinopathy as well. Thanks for sharing!
The Queen of Knowledge interviewed by the King of Longevity and Performance ...
This channel seems to get better and better. Fresh cutting edge content, always research driven but action focused.
Thank you ☺️
Of which knowledge? I remember her at a few podcasts talking as if she just read some info from wikipedia. Like her cringy covid vaccine stance on Rogan where she could not state any valid data or a concrete research...
@@nebo2073 I believe thr most knowledgeable and wise people change their views on matters. Especially when new data emerge and when contexts change, science evolves.
This is so far and for me the bible of health discussions. Thanks very much to both of you.
Rhonda Patrick is my favorite nerdy girl. Her research and advice has greatly improved my health.
She is really trying and very well educated on the topic. Wish you long and happy life Rhonda ❤
Listening to you both Peter & Rhonda I feel my age reversing. You guys are such a positive force and so helpful to so many. Thank you for your time in spreading this information. Godspeed.
This episode has my mind buzzing! At 67 I’ve always been fit and active and then a month ago I had my left knee explode. A complex Baker’s cyst that burst. The MRI also indicated meniscus tear among other ligament issues and 2-4 stage osteoarthritis. I have a shortened leg by 2 inches from an accident so the overall thinking is that that has attributed to my muscle imbalance which then led to osteoarthritis. I stopped my daily beach walks and most exercise during Covid. I started mountain biking in 2021, but stopped after my husband had an injury in 2022. What is clear to me by this conversation and my own experience is vigorous, strenuous, exercise, and strength training is key in longevity and health. I got lost in the numbers but the gist of what I understood was that HITT training as Peter described, VO2 Max and lactic acid and strength training are all key factors in cognitive and physical health. Although I am vegan, I will add in fish oil. My physical therapist highly recommended. I take fish oil. Hearing your conversation today as me realize that’s another place I would do well to make a shift. Thank you, Peter and Rhonda!💪🏻
The correlation between Alzheimer's disease and high blood pressure, as well as type 2 diabetes, is alarming and demands our utmost attention. It is crucial that we recognize the significance of this link and take necessary measures to address and mitigate these risk factors.
I completely agree with you! The connection between Alzheimer's disease and high blood pressure, as well as type 2 diabetes, is a serious concern. It's essential that we raise awareness of this link and take necessary steps to manage and reduce these risk factors. This could include regular exercise, maintaining a healthy diet, and managing stress levels. It's also important to seek medical advice and treatment if you have high blood pressure or type 2 diabetes.
Good to see Rhonda back on the podcast. Been a minute indeed.
Two of the best minds saving us from the ravages of aging. Thank you both for this back and forth 🙏
She is not the same as those studied medicine all their lives.Imitatation of the truth.Cave story ( Plato).
Please focus on main practical effective teaching tool to help others like ordinary lay people who needs most help.God blessings.Thanks for sharing your information and time.
Leaky gut leads to leaky brain.Inflammation.Make. It simple,what to do on daily basis to save our bodies and the brain.Thanks.
LPS endotaxaemia.Depression,mood changes,mental health related to gut health.
Focus on natural Whole Foods not supplements please.Evidence is good for prevention as early as possible.
This is a really great / interesting talk - you both bring a lot to the table here. Having older family suffering with health problems, I'm always looking for a new way to motivate them. Hearing Dr Rhonda Patrick say without exercise / bloodflow tiny blood vessels in the brain "fall off" & cancer reduction 50%, might just be enough to motivate some of them to exercise! Thank You. 🙏
Love hearing Rhonda talk and i especially like that she is not affiliated with any supplement companies. Her and Peter are two of the brightest minds in this space. Did i hear her say she does 16 Tabata rounds 5x a week? That cant be, that seems like alot
Love Rhonda! She's great, and always refreshing to hear a conversation with a woman on your show.
Highly recommend doing a podcast with Dr. Dean & Ayesha Sherzai. Leading neurologists in the field of Alzheimers and dementia 😃 🌱
Usually, when I see almost 3 hours long, I cringe but with these 2, I am thrilled. (Dealing with this now and it's somewhat sad as they can seem rather lost) Throw out vegetable oil-eat well.
I will listen later..family duty calls.
I enjoyed the talk and although my mother could not get me to like broccoli, Rhonda sure did! Thank you~ Happy Mother's Day!
I don't see them ever talking about seed oils. Did I miss something?
@@s.schattenprophet I still have about 15 minutes to watch as being extremely busy however Veg Oil is so very bad for us that it is a given.
@@roustabout4fun "however Veg Oil is so very bad for us that it is a given." That's a given to you or me, but I watched many talks of Rhonda and Peter and never saw them talking about the elephant in the room. I find this odd.
@@s.schattenprophet Veg Oil Omega 6 and inflammation risk (I only mentioned it for personal reasons) Have a good day!
Instant like for my favorite podcast duo ever. Going to be listening to this one two or three times probably
Absolutely love listening to the two of you discuss these topics!
My parents are well into their 90’s and live independently and are very active. Apart from starting weights in their 90’s because they thought they were getting weaker they have done nothing discussed in this podcast! They drink alcohol, have been exposed to toxic chemicals, have been obese, never did cardio but they rarely if ever are fast food and ate home cooked meals and also eat cake every day.
Right?!? Go figure... it's almost like trying too hard, like described here, is the problem. Also, on the other end of just eating total garbage, being completely sedentary is the problem. Animals don't think or analyze how to live...they just do it. Why is it so hard or confusing for humans...
@@x.y.7385because we don't want to die in our 50s or 60s like our forefathers and keep trying to extend our lifespan.
Dr. Attia I hope you see this. At around minute 40:00, you are discussing blood pressure and keeping it in a lower (proper range). However as a nurse i have seen the devastating effects of trying to keep BP lower in elderly (falls). It has been my gut feeling and conclusion that bp rises with age naturally, and it would make sense if as you felt atherosclerosis is inevitable with age. Think of arterial wall that hardens. In order to get the nutrients where they need to go would it not makes sense to you that as we age our arteries and vessel's do harden, then it would take an increase in blood "pressures " to continue to get blood and oxygen and nutrients to flow throughout the body, especially to the brain. So as we age our vessel's naturally harden and bp tends to naturally rise. Seems like a natural way our body is coping to get the nutriends and blood and oxygen to still get to all our tissues and organs. Then we as Drs go and prescribe a medication to keep BP low, and with age vessels harden, now without the pressure we get less and less nutrients to our brains and body. I have always felt with age keeping BP in the 120s is definitely going against the bodys natural defense to hardening of arteries and vessels and we cause more harm than good. Thoughts??
I guess lowering blood pressure in a person who's been hypertensive their whole lives and have remodeled brain vessels is different than maintaining a low blood pressure throughout your entire life so that the vessel wall is not so damaged and the lower BP works well enough
I agree with you. I think the BP does naturally rise with age. (for what reason we don't know yet) But I don't think it should be any higher than 140/90. There are several longevity studies of older people who lived the longest and they all had higher blood pressure. Here is my thought, do we have solid evidence that high blood pressure (not sky high) damages the body -- ALONE? Since we know that Insulin Resistance and Diabetes also damage the body -- causing kidney failure, Heart attack and stroke, are we blaming blood pressure for what sugar did?
Great podcast. I was going to ask questions, but you soon answered them all. Thank you.
Incredible podcast. Two of my favorites. Thank you 🙏 ❤
Hello Dr. Attia!! I just want to say Thank You! For being you and everything you do!! I've read your book. Watch most of your podcasts, short clips,etc. I'm obsessed with the unlimited knowledge that you provide. In short, I'm a stepdad with two amazing boys, 6 & 8 and a phenomenal future wife. I've been in the fire service for several years, so not beneficial in the sleep or carcinogens department. I am a 40 yr old male, physically healthy (if you ask me), train hard, eat fairly well. My annual physical is coming up and I have a whole list of things I want to ask since following you! Is there a breakdown list on blood tests, questions, tests, etc. that you have somewhere in your arsenal???
Great content! I’m a health coach and I work in ith Alzheimer’s patients. Diet and exercise slow th progression of th disease significantly. I think the anti inflammatory effects of exercise improve brain health.
2:39:16 "Peter, you're 60??? You look great!" 🤣🤣🤣
My wife is also heterozygous for APOE4.
Rhonda has been searching for any thing that she can that will reduce the likelihood of her developing Altzheimer’s.
We have been doing everything that we can to help to improve my wife’s Altzheimer’s.
She is not able to formally exercise, other than using the stairs and walking using an aid such as a supermarket trolley ! Or even a wheelchair, which is then useful if she needs it.
Exercise is clearly beneficial.
Over the past year or so, we have both been able to improve our Metabolic Flexibility. Using low carb, high healthy fats, fatty fish, green and cruciferous vegetables.
And intermittent fasting.
I hardly have to fast, and to some extent I am not able to, in order to maintain my body mass, but my wife still needs to fast for 36hrs in order to achieve a ketone level of 1.5 mmol/L or more.
This is rather a ‘stress’ for her system, but it is accompanied by a slight improvement in her ADL’s subsequently.
Various people describe a ketone level above 1.5 as being in the ‘therapeutic range’.
It seems to me therefore that fasting is the ‘Silver Bullet’, allowing the glucose levels to reduce to fairly dramatically low levels, and also the Insulin levels to return to low normal levels.
It appears that chronically elevated insulin levels are likely to increase the development of many Cancers, and the corollary being that low levels of insulin will tend to have the opposite effect.
It’s not so easy to measure insulin, but glucose and ketones can be measured with a finger prick. And a Glucose/Ketone index of 1 is highly likely to negatively affect the abnormal metabolism of cancer cells, which rely on anaerobic fermentation for their energy production because of damage to the mitochondria.
When I was at Med School we were told that you are as old as your arteries, but I don’t recall any expansion of the statement or explanation.
Dr Joseph Kraft in his book, Diabetes Epidemic and You states that the origin of many diseases is the damage caused to the vascular system, throughout the body, to both large and small vessels, by raised insulin levels, which disrupt the intimal layer of the vessels, and allow the subsequent development of atheromatous plaques. It was his suggestion that disruption of the tiny vessels in the inter ventricular muscle of the heart, is likely to be the pathological condition leading to Auricular Fibrillation.
We therefore have to try to avoid too much insulin at all costs for all sorts of diseases…..
You have no idea how much I appreciate your fabulous timestamps! ❤
I will add that getting a sleep study is important for many people because sleep apnea can cause severe cognitive decline ❤
I could listen to these two all day, they are awesome
Love and appreciate these two!
Excellent podcast!!! Have heard rhonda before and she’s also a wealth of knowledge. Thanks for continuing to put out great content Peter!
This is the collaboration I've been waiting for.
An interesting point re. VEGF, but somewhat surprised to hear this coming from someone who's previously leaned very heavily towards sulforaphane-rich vegetables. In 2018 a study titled "the effect of sulforaphane on vascular endothelial growth factor and hypoxia-inducible factor-1α in normobaric hypoxia." was published in the journal High Altitude Medicine & Biology, the thrust of which was that sulforaphane reduced VEGF levels in the blood. I wonder how Dr Patrick squares this. Would be fantastic if someone could shed any light. Anyway, I love these two - and thanks to Dr Patrick I've got a sauna on my to-buy list:)
Incredible conversation thank you for so much greatness
They should include PhD Mark Mattson and Prof Valter Longo who has lots of research on protein requirements, IGF1 Fasting and gerontology and brain health.
Magnificent podcast! Thank you both for sharing your knowledge with the world!!! Dr. Attia, I must say I really love your book! I am learning so much from you, young man! Please keep up the great work! You truly are helping tons of people with the Drive! Stay healthy and stay strong 💪
Just fantastic info from both of you
, as a 75 year old athlete now working as a bike taxi transporter( pedicab no electric motor) bringing jubilant fans to Warrior games and Giant games the surges are ridiculous
, talk about lactic burn😅then strength training 3x a week where I am now more focusing on the eccentric phase yet explosive on the concentric and working out in a fasted state on a time restricted feeding window has been fantastic.
The amount of times Peter interrupted her as she was trying to say what the three best things to do for preventing a leaky blood brain barrie had me ready to scream.
Anyway... LOVE this collaboration! Two of my favorites, and even better together. She's a little better at putting the data together, and he's a little better at making it make sense to me, so this is just my ideal pairing. Wish it was more regular
I'm a 2x APOE4, have watched most of my relatives suffer from Alzheimer's (if a heart attack didn't take them first), and am in my 50s.
Luckily, I've had an extreme exercise addiction since middle school, and have had a total of about 5 drinks in the last 20 years. Personal trainer for 35 years but am in nursing school now, so not as much exercise as my usual, but will be right back up there in a year
I also do a fast every couple of months... most people think I'm in my 30s, and when I mention that I have kids in my 20s, they always stop me to say... "wait... how old are you?!" So at least on the outside, everything I'm doing is helping.
timestamp? what are the three best things?
What was driving me crazy was her saying "like" a lot. Great information from her but her filler word use was very high for someone who does presentations often.
I’m APOE4 1x, my Dad with x2 with Alzheimer’s. Per her conversation with Andrew Huberman, take Nordic Naturals fish oil, keep it in the fridge. Rhonda takes several a day. Also, watch the Rudy Tanzi talk on Cure Alzheimer’s fund 5 months ago starting about 40 minutes in. On his presentation, there is nicotinomide riboside, and Resveratrol, so I’m taking those. And Talley health supplement with Fisetin.
My mother died from Alzheimers so I wanted to be proactive and get tested. I’m 72 so I got an MRI, brain scan and spinal tap, to determine if I had a high probability of getting it. Well, I found out that I have the medical signs so I wanted to be proactive. I have started medications such as Memantine and Prevagin. I’m taking Percepta, fish oil and fish oil capsules, all recommended by my neurologist. So far so good. Some short term memory issues but since taking these meds, my short term memory has improved. The Prevagin is very expensive but fortunately, my husband has been a very good investor so the cost is not impacting our lifestyle. I’m also a pescatarian and have given up all meat, fowl and processed foods except tofu and tempeh. Hubby and I also walk 5 miles a day which also helps.
You need meat and fat for your brain
Great to see both of you!
Great conversation - always a pleasure to see you two engage with each other. As far as brain power goes, you hit zone 5 at least. 🤓
I watched my poor parents sit motionless for years doing crosswords and sudoku. They told everyone who would listen that they were " keeping their brain active".From morning til night they did them. They refused to exercise; even to walk to the corner store. They refused to join anything outside the house. Both got dementia after a few years retirement. One died quickly; the other is bed bound now. Crosswords and puzzles do not work to keep dementia away.
People forget Rhonda called the vitamin D link with covid when everyone was saying it was ridiculous.
Awesome podcast! Two the best "translational science" type podcasters together for one episode!
15:50 Hippocampus relies on glut4 transporter, that is insulin dependent. Parietal lobes rely on glut1 this explains the different etiologies of the various forms of alzheimers.
So great to see Rhonda looking well and get her latest (your guys' latest) takes.
Ronda;.....!! So surprised you didn't even mention sulforaphane. You are the Queen of this phytochemical; you've turned me onto it so many years ago with the intensity of your preaching about it. And now? Not even a mention?
I can only catch small bits and pieces and that keeps me listening. Most of the conversation is way above my level and I have to use Google to help me understand. I will still listen.
I’m living proof that what they say is true. I am 87 on no meds. I do something every day, aerobics , tennis, tap, weights, yoga and dance every chance I get. I do a sauna every day, magnesium baths, and eat beef , lamb and bison, eggs,kefir and veggies .
The Dynamic Duo!!!✊🏽❤️
Thank you Dr, this was great, I really appreciate your sorting out the protein requirement issues away from older thinking, sarcopaenia is my concern.
Thanks again
This was absolutely fantastic 👏 👏👏👏👏
Great production quality Peter and Rhonda. Without video, I would have assumed you were in the same room.
What an amazing conversation...thank you both for the great information.
Great conversation! Thank you!
On a different note- I am wondering why a menopausal woman's vasilations between intense hot flashes and freezing to the point of shivering don't seem to increase brown fat. Why aren't hot, flashy- then freezing women becoming more metabolically efficient?
Hooray for science and fitness! Hooray for researchers and clinicians studying prevention AND practicing it all on yourselves. There is definitely hope for humanity.
Can we please get more research going about the metabolic and hormonal benefits of exercise for women, specifically lifting heavier weights combined with cardiovascular training, specifically women over 50? That may or may not be my demographic. 😁
Great podcast. Watched every minute. Time well spent.
Love these guys. They’re SO GOOD!
Supplemented with 10,000 IU of vitamin D (+K2) per day this winter and my bloodwork in March showed a level of 103. Two years ago it was 62 on a much lower dose. 8 years ago, before any supplementation, it was almost zero!! N=1
36:42 atherosclerosis is preventable, it is a dynamic balance and sclerotic plaques can reduce in size: glynac to maintain endothelial function (by maintaining glutathione levels and reducing albumin back to mercatoalbumin) seems protective (especially to protect from methylglyoxal), which is indeed reflected in circulating sVCAM levels. Then adding berberine (to reduce TMAO levels) appears to be able main sclerotic plaque levels to an extent whereby a clinical phase of atherosclerosis will never be reached. (Think of the calcified sclerotic deposits as a protective mechanism to prevent leakage, if no leaks, then no sclerotic plaques. sVCAM is basically a measure of leakage). Also think of the glucose hypomethabolism in AD as a protective mechanism, just as much as amyloid beta is a protective peptide: The cell needs to down regulate all genes related to glucose metabolism (which includes downregulating the GLUT transporters), to prevent toxic glucose from entering the cell when it doesnt have enough functional mitochondria to process the glucose. The cell will automatically upregulate those genes once the mitochondrial dysfunction is resolved by either nutrient deprivation (fasting), increased atp demand in an hypoxic environment via exercise (forget irisin and lactate, they correlate, but are less causal, hypoxic waves via HIIT is most stimulating towards mitophagy), ingesting uncouplers (polyphenols, ketones) or raising endogeneous antioxidants (glutathione and melatonin (both will raise SIRT3). All these interventions will rebalance the mitochondria and upregulate glucose metabolism genes, inclusive of GLUT4 expression in the hippocampus, which should halt the age-related AD disease process. Then to recover, endogeneous stem cell activation and differentiation to neurons is required which you can stimulate via l-arginine but its a cumbersome slow process. The important thing to realise is that AD is indeed preventable by maintaining mitochondrial density, by compensating for reduced endogeneous production of glycine and cystine by exogeneous consumption. This should indeed prevent most geriatric diseases (inclusive of AD by avoiding the need for APP to cleave at the beta site)
I’d love to dive deeper into your informative post. What resources you can point to on this subject?
A ton of great knowledge just in one comment. Thank you very much! To add a bit I've been using berberine for just a few months and the effect on blood-pressure has been shocking! I also get into keto much faster (apple cider vinegar, cold shower, glycogen-depleting exercises) with how it works on my blood-sugar.
We all going to age but chronic diseases are preventable with diet, exercise, managing stressors and creating a therapeutic environment for your self.
Thanks a lot for this extremely interesting podcast episode! I am also genetically predisposed. As I am a scientist, I have access to all scientific publications. However, I really enjoy listening to you because you integrate all those different perspectives and help me think of new connections between findings. This episode in particular inspired me to think about OXYTOCIN. Have you ever read of a study on oxytocin and dementia? I realized that this hormone might be one variable that correlated with many factors known to prevent dementia, as for example: giving birth, being married, having sex, meditate, being touched, being in contact with people, having animals, eating fruits, especially berries and green leaves as well as seeds and curcumin. All of those raise oxytocin. In contrast older age leads to less contact and sex and the elderly are very rarely touched, especially in care. Might oxytocin (also as a supplement) be a factor to further reduce the risk?
This talk can be summarize by saying "we need more studies." They don't give anything that you can really hang your hat on to improve other than the basics we already know.
51:00 EXERCISE
2:03:00 “I have to work out no matter what. No matter what, it’s beneficial”
2:18:00
Sarcopenia is my greatest fear of getting old and also losing the strength and endurance in doing enjoyable sports. Tkz for this remarkable interview.
Glad for any voices cutting through the noise like this. Appreciate Peter pointing out money wasted on bs treatments instead of finding the root of the pathology.
In the beginning of this interview, Dr. Patrick expresses that her interest in Alzheimer’s research is somewhat due to her own family history. I’m not a doctor, so I do not know the warning signs of Alzheimer’s, but as a listener, I observed Dr.Patrick’s speech patterns. I have heard other presenters who changed their train of thought often during their presentations. It is very difficult for listeners to focus and to grasp the message with this happening. I would encourage Dr. Patrick to listen to this video and practice speaking without these interruptions, not only would it be great for improving her presentation skills, it may also challenge her brain and add to her prevention regimen.
Thank you both SO much.
Every time I see a video like this, I immediately get a sense of ineluctable doom as a 3/4 APOE carrier...what I would have given for a 2/3....yet I am still drawn to listening, thus amplfying my worries and concerns.
It could be worse, you could be a 4/4 like me 😢
You do realize we all have to die right? All this paranoia about something you have little control over seems odd. Go live your life and have a good time doing it.
@@forcefedapocalypse I have no problem dying. I don't mind dying from other causes but there is something especially pernicious about becoming a mindless meat sack before you finally drop dead.
@@skp2073 Sorry about that.
Do you find that you clear infections better than most other people?
We owe it to ourselves and our strained healthcare system to experiment and find out what suits us best on an individual basis as far as diet and exercise go. I did this and am improving my health incredibly. I've eliminated a long list of issues by eliminating certain foods from my diet. And, I've lost a significant amount of weight. I think the right diet can be different for all of us.
But, I also think there are foods that can harm all of us. Seed/vegetable oils, refined and processed foods, cane sugar, fructose, alcohol etc etc.
I think it's important to not be dogmatic about how we eat if it makes us feel better. I really don't think there's one right diet for every single person on the planet. Figure it out. It's not hard. Your body will tell you. Just Listen to it! I think there is a whole lot that science and medicine have gotten wrong about diet. This isn't one size fits all. Nothing is.
I’m doing the same. It’s worth it. It’s necessary.
Have you ever saw them talking about seed oils?
Thank you so much for saying T2 diabetes rather than just diabetes about because it is something different from T1, but as a T1 I’m wondering how my high blood glucoses are affecting all these same areas. I know the research is done with T2’s because there are so many more of them but it seems like the effects would be the same.
My two favorite.. the dynamic duo
2:03:00 Rhonda states study proved "Poor Sleep" participants have a Higher All Cause Mortality. BUT only those people who weren't Physically Active!😅...
So Exercise even w/ poor sleep IS going to be Beneficial... So glad I saw this💯
New subscriber here. Fellow car racer and enthusiast but looking for longevity tips! Thank you for sharing information on the latest research.
It's a step forward accepting that insulin resistance is causing damage to the biology of blood vessels to be causative of Alzheimer's. I hope Peter soon accepts that insulin also damages the biology of arteries and indeed is the main cause of CVD rather than LDL levels in the blood.
BS. High glicose is damaging, not insulin. Insulin is an absolutely crucial hormone.
@@erastvandoren I meant insulin resistance. The whole package of metabolic illness.
On the other hand, and within the same context, I could make a similar insulting phrase for you: "BS. Glucose is absolutely crucial for human life". But I won't. Both Glucose and Insulin are crucial, but the problem is their excess and deregulation: insulin resistance or metabolic syndrome.
And on top of sickened biology of blood vessels and heart due to insulin resistance (metabolic illness) there is the part of sickened biology of blood, blood cells and lipoproteins and particles. All sickened by Insulin resistance (metabolic illness).
BTW, 95% of the US population is metabolically ill. That is alarming and the reason why LDL seems causative of CVD, because almost everyone has sickened biology.
This discussion is above my pay grade LOL Smart people!!
" Exercise can forgive a lot of sins " - Rhonda Patrick. Amen to that!
Thank you!