@@PatKellyTeachesHe's not exaggerating. Been watching this channel since the malaria video and probably before had two channels. Nice to see you make progress on subscriber count. Thanks for creating this content. I use this channel to refresh my memory and learn new things.
Awesome video man. Loved hearing the historical perspective. I’m genuinely considering my first merch - a line of entirely placebo health supplements 😅
I used to have bad headaches because of rhinitis, and I always had yoghurt right after taking the painkiller. I noticed that after a while, just eating the yoghurt made me feel a bit better. I Pavloved myself with yoghurt placebo. (It didn't stop the pain completely, but it helped)
When my mum was dying from pneumonia, she was convinced she needed a certain medicine, I can't remember which. For context, the doctors didn't know she was dying at the time. I asked the doctor if they could give her a placebo, just to relieve her distress. They agreed. She died a couple of days later (from her illnesses, not placebo). I feel so much guilt to this day that I lied to her, but I know it was for her own peace of mind.
I'm so sorry to hear about the loss of your mom. I had a very similar situation whenever my mom was dying from lung cancer. They also had no idea she was even sick until she had recurrent pneumonia and fluid in her lungs but whenever she told me she had cancer, I knew it was stage 4 based on the way they found it and chose not to say anything. I couldn't bring myself to tell her the truth and I just instead supported her and said I was there for her. She didn't really talk to me again before she died (just who she was, not that she was upset with me because of this), but I think we will always wonder (and hope) we did the right thing. I think at the end of the day, our moms know that we loved them and wanted them to be at peace. Carrying that guilt with you is something that's difficult to get through but I'm sure she would help you carry it if she could. I'm sending so much love to you and your family.
Sorry to hear about your loss. Sometimes palliative care is as much helping look after ourselves as it is the person who’s passing. I’m sure she wouldn’t blame you in the slightest.
Hopefully, you learned not to try and control others. Being a narcissist is a hell of a drug. No hate, just truth. Imagine telling a grown human they can't have a drug to help them. They only lived longer than all of us and clearly knew more about their own body.
Hopefully ethical use of placebo can help us fight the progression of antibiotic resistance via overprescription. Too many people want one "just to feel better" when they have a virus 🤦♂️😫 That said, a bigger culprit for resistance is the unethical side of agriculture industry abusing the heck out of them, which this guy goes into phenomenal detail on the history of in his antibiotics series!
From what I have heard the two countries doing best in terms of limiting antibiotic resistent bacteria are Norway and The Netherlands. However sometimes there are problems with under prescription like when a friend of mine who worked on a ship far away did not get antibiotics for his teeth even though he could not get to pharmacy later for multiple weeks if it became a big problem.
It's wild to me that it's possible to feel the placebo effect even if you KNOW what you're taking isn't real. The mind, the body, our memories, our perception... what an incredible system we are.
My parents are pharmacists. When they were first practicing it was common if a patient came back saying a drug wasn't working to send them away with some 'new' pills, which were actually the same drug just a different colour. There are also clinical studies that show that red anti depressants are more effective than blue ones. Even now they get patients regularly telling them that their new/old pills are better when all that's happened is that either there's been a packaging change or a new brand but the same drugs.
interesting, all the antidepressants I've ever taken were blue or white. My ADHD meds are orange/pink. I wonder if there's an unconscious association with blue/white being downers and reddish pills being uppers?
@internetfox I'm surprised you have coloured pills at all, though I'm assuming they are capsules which is a bit different. In the UK where I am, there has been a move away from coloured pills to reduce accidental poisonings from children thinking they are sweets.
My SNRI is always blue, DNRI was mostly pink with one exception, across manufacturers. Just by recalling which manufacturer gave me certain results alters the effectiveness, I'm sure.
Oh my god I love your videos so much! I didn't know medical history was so fascinating and important until I discovered your channel. Thank you for doing what you're doing 🩺💙
I am allergic to quite a few pain pills. Therefore, I don’t like to take any just in case. I found that if I mimed taking a super duper pain pill, my pain would go away. I also imagined the pill in my blood stream going to the source of the pain and dissolving it. Worked for me anyway.
Thank you so much for this, I've always wondered the history of this. I feel like people give waaaay to much credit to the placebo, the regression to the mean makes perfect sense.
Laughed so hard my ribs hurt from “rich people nonsense.” The mind is a powerful and at times a scary place. I have had, based on symptoms, fibromyalgia since age twelve (triggered by drowning). Until recently it was considered a disorder of hysterical women seeking attention. It left me with very mixed feelings about placebos, among other issues. Became even worse when I developed many other conditions after surviving bacterial meningitis at 50 (23 years ago). I could write a book in the positive consequences for a patient of a caring compassionate provider and the negative consequences of one who is not. It took years to find the good ones and frankly the process of getting there was incredibly stressful for someone already stressed by severe constant pain. Great presentation…learned a lot, which always makes me happy.
Your videos are really awesome, I’m super interested in both medicine & history and your work hits the spot fr. Wish I’d found your channel sooner but that I just means I have more to binge watch now :)
Absolutely fascinating stuff. Me and a mate were discussing what the ‘worst’ thing placebo has ‘healed’ recently, while neither of us really understood how it worked. A fun chat but not very informative for either of us 😂😂😂. Great to see this pop up so I can go and school that idiot.
Or doesn't work. I had some pretty nasty nocebo being forced to take sugar pills (homeopathy) daily for multiple months because I knew they were just sugar pills [edit: and I believed it wasn't good for me to take random quality-unchecked sugar pills because how could you even trust they had the quality of plain properly manufactured sugar and weren't contaminated by anything like lack of good enough factory upkeep] and my mother wouldn't listen to me. Could also have been the alcohol tincture of mistletoe I also was forced to take though, I am not sure it was a homeopathic solution too. Of course I did have worse depression at the time, but I had depression since kindergarten (undiagnosed ADHD) so it couldn't have been that. Medical child neglect/abuse sucks, nocebo makes it worse.
On the one hand, wtf does a placebo cost $25?! On the other, having it be expensive does lend it some legitimacy, similar to how we equate cost for quality.
Shipping, listing cost, manufacturing with sterile equipment, food grade ingredients, convincing packaging, and profits are all in the formula. You may get something like vitamin c cheaper, but I bet the packaging is less ornate, the seller moves more in bulk for shipping, the machines to process the pills have been spread out over many more orders, and the manufacturer probably buys much higher quantities of the ingredients for a cheaper price.
Ironically, the price of the placebo actually has an add placebo effect. They’ve done some studies with 150$ placebos vs 50$ placebos and studies with a 2.50$ vs a 10c with the more expensive having greater placebo effect.
I think the placebo effect is the reason why many alternative medicine/treatments exist: They rely mostly on the patients expectations to the treatment. However, it seems unethical to me not disclosing such things and make a profit out of it. (Eg, homeopathy, hypnosis, miracle supplements) Thanks a lot for your videos, I love them!
Messing with people's pain is so messed up... As someone who has been suffering from slipped and herniated discs for the last 15 years, without any medicine for many many of those years. Then when it was at it's worst after reinjury, being given Tylenol that messed up my liver and gave no relief. I can't imagine having surgery and then being given NOTHING. TWICE. Being given naloxone that makes the pain worse?... I've already been in so much agony for so long I was seriously considering ending it just to escape the pain.. I'd absolutely throw a fit and have heads on platters. Yeah your experiment doesn't work if they know, but giving someone something they expect to help with pain, knowing that does nothing, or with naloxone does the OPPOSITE. That's absolutely criminal. Do those tests on your own family and see how you feel about it after.
As much as I love learning about this stuff, it's really hard to watch it and take it without the real world context of knowing that marginalized groups are underrepresented in medical trials, poor people are often taken advantage of by them, and a lot of people(especially women and people with chronic illnesses) have their health issues and pain ignored by doctors and told it's all just in their head. I do feel like especially in a conversation like this, those are relevant points to bring up.
As a physician I hate the disregard of the placebo effect. It is really the power of intention and it might be one of the stronger forces on earth. Once researchers get real about this and learn to apply it appropriately we may have a true medical breakthrough.
There is another effect going on here that is not even mentioned. Just having a bit of attention, being asked about your pain and being listened to, maybe even a kind hand to the shoulder plays a major role in stress reduction and feeling better.
Hey Patrick! I would love to see you make a video about the story of William. J Bailey, Radithor and it's most notorious victim, Eben Byers. I feel like it's a really relevant topic to your channel!
Liquid death has the best placebo effect! It feels like I’m drinking something with special powers just because it looks cool. Normalize water being cool.
The founder was inspired by Red Bull Tour Water a product handed to those who are sponsored by Red Bull so they do not have to consume to much energy drink.
21:40 perhaps "experimental" was a typo for some variation of "expectorating"? I mean distinguishing wet and dry coughs seems a useful thing Dr Beecher might have wanted to do in his proto-meta-analysis just a thought
Have they researched whether the placebo effect is different in patients with mental health conditions? These neurotransmitters are also involved in Depression and ADHD.
Well done. People with Young Onset Parkinson's Disease on average endure anywhere from 15-24 months of additional diagnostic delay in what should be their prime, watching their lives unravel while desperately seeking genuine evidence-based, biomedical diagnosis and treatment. When I encountered the claim that reduction of PD symptoms in response to a placebo is evidence of a psychogenic/functional movement disorder, I nearly lost it. I don't understand how a person can undergo 10-12 years of intense training and specialization for movement disorders, only to ignore the effect of anticipation on dopamine release. I hope you've changed that for at least a few people.
That Liquid Death part I just want to point this out: It doesn't look like an energy drink, it looks alcoholic canned drink. Which is the purpose of these drinks to look like you're drinking alcohol. It's even marketed as being canned from Austrian Alp water, it's quite literally pulling on Austria's famous wine, and Germany's famous beer reputation. It was inspired by people drinking water out of monster cans at concerts but it's biggest pull and intent is to look like an alcoholic drink similar to that of White Claw and Mikes Hard.
Pointing metal objects or any instrument at pain or wound, then approaching that spot can cause the pain to stop briefly from the anxiety or nervous fear response. The idea that a worse pain is about to happen, causes something to happen mentally or physically. I have felt it plenty of times.
I’ve wondered if side effects are sometimes coincidental in that telling someone to look for them or, if someone is hyper vigilant, they just happened to be cold, etc. and blamed it on the medication. I’ve observed this in acquaintances, family and friends. Drives me crazy…and often seems to happen when a med is working.
Dude, you don't have to spend that much on fancy blue and white capsules. I use saccharine tablets in propmaking and got a bottle of a thousand of them for five bucks. As a bonus, just like many real medications, you WILL REGRET letting it touch your tongue! 😅
I think a really interesting line of placebo investigation is with GLP-1 medications, especially some of the newest ones in clinical trials, CagriSema and retatrutide. Both of them are exceedingly potent at causing weight loss and Aunt, the ladder is extremely potent at improving cardiometabolic measures such as cholesterol and triglycerides, it makes me wonder is it ethical to continue to do placebo-controlled trials when we know something works that well? And how do you keep it truly blinded when patients are losing a quarter of their body weight over the course of a year. Really makes for an interesting dilemma for trial design And brings up questions of ethicality with placebos
13:17 I just had my second wisdom tooth removed and man I would not want to be in the Naloxone group, that sounds horrific. Hopefully it was a slightly less severe dental surgery than the one I underwent.
I feel like I deal with Nocebo a lot. A lot of the medicine I take has nausea as a possible side effect but the thing about nausea is that it's obviously really easy to self induce so it's difficult for me to figure out whether I feel nauseous because of the medicine or because I expected to feel it. It's especially hard because a low level of nausea is obviously easy to ignore so when I'm busy I won't necessarily feel nauseous. Honestly Nocebo is just really annoying, it really is the evil twin of Placebo because with both even if you're aware of them they can still happen, but with Placebo that's a good thing because that means I can exploit it but with Nocebo it's a bad thing because it leaves me unsure all the time.
Question. Are those ear wax candles a placebo? I now know that the “ear wax” that is found in the candle after doing the treatment is only a chemical reaction to the heat that is created by the flame. Someone I know says that “the Chinese have done it for centuries but I guess they’ve been wrong this whole time” I have tried to convince them that the biggest placebo market is when it pertains to a “health cure”. Just look at snake oils. If you say something will do something, and provide “evidence” it’s more likely someone will fall for it.
What is the ethical justification for conducting placebo tests on a disorder like Parkinson's, which is known to be degenerative? Any period of "tricking" patients by not really medicating them seems cruel and unethical, allowing the degenerative effects of the disease to go unchecked/unopposed.
It is same thing when a doctor says he does not cure people with mircle drugs... Despite cures and mircle drugs being a thing IRL. Edit: It is the same I mean.
Generally in this case it would be adding the placebo along with regular treatment. See if there's a difference when the actual drug is added into the regular treatment. They do this with non degenerative conditions as well.
Huh. Weird, I could have sworn this was a channel on Nebula, but I guess not? Maybe I'm thinking about the guy that does documentaries about mental healthcare. Anyway, this totally belongs on there, hope you'll consider looking into that if it's possible, because the ads on RUclips are really unbearable these days.
The fact that I said that Legally Blonde quote along with you…. 😅 and was then disappointed to come to the comment section and not seeing any mention of it
Also I don’t think there are nearly enough books or videos to teach us about Medical History out there and your high quality videos do an amazing job of filling that gap. Anyways, thank you for everything you do to put out these videos.
To me all these double-blind placebo effects studies may well be proving that methodology of these studies is wrong. Historically placebos were often sugar pills, and sugar makes some of us feel slow and lethargic. This made any medicine being tested somewhat more effective than the placebo. Another issue is that the studies have to assume all the participants are identical. Because of genetic variation we each have a slightly different metabolism. One person with an unusual metabolic response will have little effect on the outcome of the study, but they are used to prescribe treatments for everyone: including those who have the unusual response. Most people over 70 have bad experiences with medicine and little faith in doctors.
The sugar in the so called 'sugar pills' isn't only present in the placebos. It's used as a filling agent in all pills, to make a pill of a convenient size out of what is often a very very tiny amount of active ingredient. The placebos are specifically developed for each medication, and are composed of exactly the same things as the other pills are, except the active ingredient being tested.
Check out the recommended reading for this one. Placebos by Kathryn T Hall was an especially helpful primer for this topic.
*Scishow* *crashcourse* *Patrick kelly* the trinity of reliable and interesting education 😄
Thank you
@@taylortimbrook2030 No, thank you! That is great company to be included with
@@PatKellyTeachesHe's not exaggerating. Been watching this channel since the malaria video and probably before had two channels. Nice to see you make progress on subscriber count.
Thanks for creating this content. I use this channel to refresh my memory and learn new things.
As a child I would announce that I had farted when I really hadn’t and people would hallucinate a smell. It was crazy.
As someone who went to an all boys high school, this comment is relatable
A born scientist
This reminds me of my grandmother who was a hypochondriac and her doctor gave her plenty of placebos. It really works!
Reminiscent of William Cullen’s thing!
Awesome video man. Loved hearing the historical perspective. I’m genuinely considering my first merch - a line of entirely placebo health supplements 😅
Dude! We’ve gotta find you a designer to make a patent medicine style label for that placebo bottle
I've heard the honourable Dr. Gwyneth Paltrow offers fantastic business advice on selling placebos.
You couldn’t find a more saturated market
Don´t overdose on these globulis. :)
@@craign6341 I mean honest placebos are a somewhat under exploited market.
I used to have bad headaches because of rhinitis, and I always had yoghurt right after taking the painkiller. I noticed that after a while, just eating the yoghurt made me feel a bit better. I Pavloved myself with yoghurt placebo. (It didn't stop the pain completely, but it helped)
Plus, the yogurt contains all sorts of lovely aminos that help some migraines. I always wondered why I craved and chugged milk so much all of my life.
When my mum was dying from pneumonia, she was convinced she needed a certain medicine, I can't remember which. For context, the doctors didn't know she was dying at the time. I asked the doctor if they could give her a placebo, just to relieve her distress. They agreed. She died a couple of days later (from her illnesses, not placebo). I feel so much guilt to this day that I lied to her, but I know it was for her own peace of mind.
I'm so sorry to hear about the loss of your mom. I had a very similar situation whenever my mom was dying from lung cancer. They also had no idea she was even sick until she had recurrent pneumonia and fluid in her lungs but whenever she told me she had cancer, I knew it was stage 4 based on the way they found it and chose not to say anything. I couldn't bring myself to tell her the truth and I just instead supported her and said I was there for her. She didn't really talk to me again before she died (just who she was, not that she was upset with me because of this), but I think we will always wonder (and hope) we did the right thing. I think at the end of the day, our moms know that we loved them and wanted them to be at peace. Carrying that guilt with you is something that's difficult to get through but I'm sure she would help you carry it if she could. I'm sending so much love to you and your family.
@@Wellokayig thank you so much. Sending love to you and yours ❤️
Psychological care matters too. I'm glad you were able to make a good choice for her.
Sorry to hear about your loss. Sometimes palliative care is as much helping look after ourselves as it is the person who’s passing. I’m sure she wouldn’t blame you in the slightest.
Hopefully, you learned not to try and control others. Being a narcissist is a hell of a drug. No hate, just truth. Imagine telling a grown human they can't have a drug to help them. They only lived longer than all of us and clearly knew more about their own body.
I can't hear the word 'Naloxone' without hearing Benoit Blanc in my head say, "the life-savin' antidote."
A fantastic movie
You are not alone.
the laugh-savin' Anna-dote 😎
William Smellie looks so tired of the smelly willy jokes
Poor guy. I don’t know if they had middle school back then, but middle school kids would’ve teased the heck out of him
Hopefully ethical use of placebo can help us fight the progression of antibiotic resistance via overprescription. Too many people want one "just to feel better" when they have a virus 🤦♂️😫
That said, a bigger culprit for resistance is the unethical side of agriculture industry abusing the heck out of them, which this guy goes into phenomenal detail on the history of in his antibiotics series!
From what I have heard the two countries doing best in terms of limiting antibiotic resistent bacteria are Norway and The Netherlands. However sometimes there are problems with under prescription like when a friend of mine who worked on a ship far away did not get antibiotics for his teeth even though he could not get to pharmacy later for multiple weeks if it became a big problem.
It's wild to me that it's possible to feel the placebo effect even if you KNOW what you're taking isn't real. The mind, the body, our memories, our perception... what an incredible system we are.
It's actually nutty on that note, hypnotists are better at being hypnotized!
babe wake up new pat kelly video just dropped
Placebo is the number 1 treatment prescribed for hypochondriosis 😅
Very much appreciated the Legally Blonde reference!
I love a good rom com 🫡
I wish you had gone into more detail about how placebos can still work even when you know it's a placebo.
It's simple, you believe the placebo effect is real, you take the placebo expecting the effect, you get the effect.
It can change your perception of your illness and it can reduce stress.
My parents are pharmacists. When they were first practicing it was common if a patient came back saying a drug wasn't working to send them away with some 'new' pills, which were actually the same drug just a different colour. There are also clinical studies that show that red anti depressants are more effective than blue ones.
Even now they get patients regularly telling them that their new/old pills are better when all that's happened is that either there's been a packaging change or a new brand but the same drugs.
interesting, all the antidepressants I've ever taken were blue or white. My ADHD meds are orange/pink. I wonder if there's an unconscious association with blue/white being downers and reddish pills being uppers?
@@internetfoxI've seen blue generic Adderall as well as yellow/orange generic zoloft
@@internetfoxmy anti depressant is blue n white.
@internetfox I'm surprised you have coloured pills at all, though I'm assuming they are capsules which is a bit different. In the UK where I am, there has been a move away from coloured pills to reduce accidental poisonings from children thinking they are sweets.
My SNRI is always blue, DNRI was mostly pink with one exception, across manufacturers. Just by recalling which manufacturer gave me certain results alters the effectiveness, I'm sure.
Thanks for talking about the nocebo effect!
Oh my god I love your videos so much! I didn't know medical history was so fascinating and important until I discovered your channel. Thank you for doing what you're doing 🩺💙
What a lovely comment! Thank you for the kind words about my videos - I hope they inspire you to keep learning
I am allergic to quite a few pain pills. Therefore, I don’t like to take any just in case. I found that if I mimed taking a super duper pain pill, my pain would go away. I also imagined the pill in my blood stream going to the source of the pain and dissolving it. Worked for me anyway.
Thank you so much for this, I've always wondered the history of this. I feel like people give waaaay to much credit to the placebo, the regression to the mean makes perfect sense.
As always, such an interesting video. It really makes me appreciate the scientific method and it's refinement over the years.
Omg you just uploaded and i was binging some of your vids today :'D
Good timing! Happy to help you continue the binge
Thank you as a med student i felt disconnected from what i study your videos are hyping me up again
Laughed so hard my ribs hurt from “rich people nonsense.” The mind is a powerful and at times a scary place. I have had, based on symptoms, fibromyalgia since age twelve (triggered by drowning). Until recently it was considered a disorder of hysterical women seeking attention. It left me with very mixed feelings about placebos, among other issues. Became even worse when I developed many other conditions after surviving bacterial meningitis at 50 (23 years ago). I could write a book in the positive consequences for a patient of a caring compassionate provider and the negative consequences of one who is not. It took years to find the good ones and frankly the process of getting there was incredibly stressful for someone already stressed by severe constant pain. Great presentation…learned a lot, which always makes me happy.
Your videos are really awesome, I’m super interested in both medicine & history and your work hits the spot fr. Wish I’d found your channel sooner but that I just means I have more to binge watch now :)
Legally blonde reference on point
My early 2000s movie diet was mostly rom coms. I’d put Legally Blonde up there with 10 Things I Hate About You and Miss Congeniality
@@PatKellyTeaches I have watched both of those too many times, and I'm not ashamed 🤣
Absolutely fascinating stuff. Me and a mate were discussing what the ‘worst’ thing placebo has ‘healed’ recently, while neither of us really understood how it worked. A fun chat but not very informative for either of us 😂😂😂. Great to see this pop up so I can go and school that idiot.
Its insane how much our beliefs play a role in our bodily responses to treatment. People are fully convinced something is going to work, so it does.
Or doesn't work. I had some pretty nasty nocebo being forced to take sugar pills (homeopathy) daily for multiple months because I knew they were just sugar pills [edit: and I believed it wasn't good for me to take random quality-unchecked sugar pills because how could you even trust they had the quality of plain properly manufactured sugar and weren't contaminated by anything like lack of good enough factory upkeep] and my mother wouldn't listen to me. Could also have been the alcohol tincture of mistletoe I also was forced to take though, I am not sure it was a homeopathic solution too. Of course I did have worse depression at the time, but I had depression since kindergarten (undiagnosed ADHD) so it couldn't have been that.
Medical child neglect/abuse sucks, nocebo makes it worse.
On the one hand, wtf does a placebo cost $25?! On the other, having it be expensive does lend it some legitimacy, similar to how we equate cost for quality.
Like how more unpleasant a placebo is to take the more effective it is, the most effective usually being saline injections.
Shipping, listing cost, manufacturing with sterile equipment, food grade ingredients, convincing packaging, and profits are all in the formula.
You may get something like vitamin c cheaper, but I bet the packaging is less ornate, the seller moves more in bulk for shipping, the machines to process the pills have been spread out over many more orders, and the manufacturer probably buys much higher quantities of the ingredients for a cheaper price.
studies show that if you pay more for the placebo it works better... our brain's are insane.
Ironically, the price of the placebo actually has an add placebo effect. They’ve done some studies with 150$ placebos vs 50$ placebos and studies with a 2.50$ vs a 10c with the more expensive having greater placebo effect.
This channel is a gold mine
Much appreciated. It's a lot of fun to make
This is an amazing video. Easy to listen to. A good historical and scientific documentary.
Your videos are amazing! Just recently discovered your channel and binging it
I think the placebo effect is the reason why many alternative medicine/treatments exist: They rely mostly on the patients expectations to the treatment.
However, it seems unethical to me not disclosing such things and make a profit out of it. (Eg, homeopathy, hypnosis, miracle supplements)
Thanks a lot for your videos, I love them!
Over time you've become one of my favourite channels. Keep up the good work and consistency! I love learning these things.
Messing with people's pain is so messed up... As someone who has been suffering from slipped and herniated discs for the last 15 years, without any medicine for many many of those years. Then when it was at it's worst after reinjury, being given Tylenol that messed up my liver and gave no relief. I can't imagine having surgery and then being given NOTHING. TWICE. Being given naloxone that makes the pain worse?... I've already been in so much agony for so long I was seriously considering ending it just to escape the pain.. I'd absolutely throw a fit and have heads on platters. Yeah your experiment doesn't work if they know, but giving someone something they expect to help with pain, knowing that does nothing, or with naloxone does the OPPOSITE. That's absolutely criminal. Do those tests on your own family and see how you feel about it after.
As much as I love learning about this stuff, it's really hard to watch it and take it without the real world context of knowing that marginalized groups are underrepresented in medical trials, poor people are often taken advantage of by them, and a lot of people(especially women and people with chronic illnesses) have their health issues and pain ignored by doctors and told it's all just in their head. I do feel like especially in a conversation like this, those are relevant points to bring up.
Placebo Domingo is both one of the world's greatest opera singers and one of the world's greatest medicines for curing earache.
As a physician I hate the disregard of the placebo effect. It is really the power of intention and it might be one of the stronger forces on earth. Once researchers get real about this and learn to apply it appropriately we may have a true medical breakthrough.
i have no idea how i got subscribed here, but definitely the content i like. Glad to have it on my subscription page
That’s awesome to hear, thanks dude.
just found your channel and i’m in love! thank you for all the research you did and putting it into a digestible video. great work!
That’s very nice of you to comment. Thank you!
There is another effect going on here that is not even mentioned. Just having a bit of attention, being asked about your pain and being listened to, maybe even a kind hand to the shoulder plays a major role in stress reduction and feeling better.
Hey Patrick!
I would love to see you make a video about the story of William. J Bailey, Radithor and it's most notorious victim, Eben Byers.
I feel like it's a really relevant topic to your channel!
Good video, can u do a video thst explains how overdoses work?😊
Ohh interesting topic. Are you thinking about opiate overdoses in particular?
The fact that placebos work at all, ever, throws a big wrench in our materialist theories of consciousness in my opinion.
Liquid death has the best placebo effect! It feels like I’m drinking something with special powers just because it looks cool. Normalize water being cool.
Supposedly that’s what the founder was going for with the can design. He had a good episode on the business podcast How i Built This if you’re curious
Liquid Death devotee here, and SAME, though sometimes I wonder what people who don't know it's just fun water think I'm drinking!
The founder was inspired by Red Bull Tour Water a product handed to those who are sponsored by Red Bull so they do not have to consume to much energy drink.
experimental cough may be the same thing as when the doctor asks you to cough while they have the stethoscope on your chest or back.
Criminally underrated.
21:40 perhaps "experimental" was a typo for some variation of "expectorating"?
I mean distinguishing wet and dry coughs seems a useful thing Dr Beecher might have wanted to do in his proto-meta-analysis
just a thought
Perfect match for a morning coffee (or carbonated water, I guess)
Whatever revs your engine ☕️
William SMELLIE. You can't make this up.
Really cool video, thanks a bunch for sharing this with us Big Dog!
Have they researched whether the placebo effect is different in patients with mental health conditions? These neurotransmitters are also involved in Depression and ADHD.
11:53 the legally blonde reference has me cackling 😂🙈
Well done. People with Young Onset Parkinson's Disease on average endure anywhere from 15-24 months of additional diagnostic delay in what should be their prime, watching their lives unravel while desperately seeking genuine evidence-based, biomedical diagnosis and treatment. When I encountered the claim that reduction of PD symptoms in response to a placebo is evidence of a psychogenic/functional movement disorder, I nearly lost it. I don't understand how a person can undergo 10-12 years of intense training and specialization for movement disorders, only to ignore the effect of anticipation on dopamine release. I hope you've changed that for at least a few people.
The Legally Blonde reference!
That Liquid Death part I just want to point this out: It doesn't look like an energy drink, it looks alcoholic canned drink. Which is the purpose of these drinks to look like you're drinking alcohol. It's even marketed as being canned from Austrian Alp water, it's quite literally pulling on Austria's famous wine, and Germany's famous beer reputation. It was inspired by people drinking water out of monster cans at concerts but it's biggest pull and intent is to look like an alcoholic drink similar to that of White Claw and Mikes Hard.
Pointing metal objects or any instrument at pain or wound, then approaching that spot can cause the pain to stop briefly from the anxiety or nervous fear response. The idea that a worse pain is about to happen, causes something to happen mentally or physically. I have felt it plenty of times.
Interesting video. Have you considered a video on Lyme Disease and the vaccine that is no longer available?
If I ran a pizza shop I would offer placebo pills as a topping for your pie.
It definitely works with placebo wine
I’ve wondered if side effects are sometimes coincidental in that telling someone to look for them or, if someone is hyper vigilant, they just happened to be cold, etc. and blamed it on the medication. I’ve observed this in acquaintances, family and friends. Drives me crazy…and often seems to happen when a med is working.
Was not expecting the Legally Blonde reference! 😂
I love this channel!!!
Dude, you don't have to spend that much on fancy blue and white capsules. I use saccharine tablets in propmaking and got a bottle of a thousand of them for five bucks.
As a bonus, just like many real medications, you WILL REGRET letting it touch your tongue! 😅
true, but maybe knowing they cost a lot contributes to the effect. I'd like to see a study on that.
@@internetfox Ah, true, given the nature of the experiment...
In that case, maybe they should even be charging more. XD
10:04 well this is the super over simplification of lost dog in his great experiment…
I work with kids and if they want ice or a band aid I do it even when I know it won’t do anything physically. It works every time.
As a teacher myself, I know exactly what you're talking about 😅
I think a really interesting line of placebo investigation is with GLP-1 medications, especially some of the newest ones in clinical trials, CagriSema and retatrutide. Both of them are exceedingly potent at causing weight loss and Aunt, the ladder is extremely potent at improving cardiometabolic measures such as cholesterol and triglycerides, it makes me wonder is it ethical to continue to do placebo-controlled trials when we know something works that well? And how do you keep it truly blinded when patients are losing a quarter of their body weight over the course of a year. Really makes for an interesting dilemma for trial design And brings up questions of ethicality with placebos
13:17 I just had my second wisdom tooth removed and man I would not want to be in the Naloxone group, that sounds horrific. Hopefully it was a slightly less severe dental surgery than the one I underwent.
I feel like I deal with Nocebo a lot. A lot of the medicine I take has nausea as a possible side effect but the thing about nausea is that it's obviously really easy to self induce so it's difficult for me to figure out whether I feel nauseous because of the medicine or because I expected to feel it. It's especially hard because a low level of nausea is obviously easy to ignore so when I'm busy I won't necessarily feel nauseous.
Honestly Nocebo is just really annoying, it really is the evil twin of Placebo because with both even if you're aware of them they can still happen, but with Placebo that's a good thing because that means I can exploit it but with Nocebo it's a bad thing because it leaves me unsure all the time.
I was not expecting a legally blonde reference
yes
It wasn't just painful. It was outright detrimental
0:58 that's my ~9th great grandfather!
my grandad changed our family name thankfully
Cool
Liquid death was designed to look like an alcoholic drink. Helps recovering alcoholics, especially in social situations.
Water can make you feel more alert
Question. Are those ear wax candles a placebo? I now know that the “ear wax” that is found in the candle after doing the treatment is only a chemical reaction to the heat that is created by the flame.
Someone I know says that “the Chinese have done it for centuries but I guess they’ve been wrong this whole time”
I have tried to convince them that the biggest placebo market is when it pertains to a “health cure”. Just look at snake oils. If you say something will do something, and provide “evidence” it’s more likely someone will fall for it.
Thanks
I watched legally blonde about two weeks ago and it still took me a second to realize 😂
Can you explain the lodebo and chutebo effects?
My doctor always prescribes extra-strength placebos!
What is the ethical justification for conducting placebo tests on a disorder like Parkinson's, which is known to be degenerative? Any period of "tricking" patients by not really medicating them seems cruel and unethical, allowing the degenerative effects of the disease to go unchecked/unopposed.
It is same thing when a doctor says he does not cure people with mircle drugs... Despite cures and mircle drugs being a thing IRL. Edit: It is the same I mean.
Generally in this case it would be adding the placebo along with regular treatment. See if there's a difference when the actual drug is added into the regular treatment.
They do this with non degenerative conditions as well.
i have never had a placebo effect
Ayo this dude named Smellie
I remember someone once said "medication works on the body like words do" if thats in theis video later, my bad
Why would anybody drink something called Liquid Death?
Huh. Weird, I could have sworn this was a channel on Nebula, but I guess not? Maybe I'm thinking about the guy that does documentaries about mental healthcare. Anyway, this totally belongs on there, hope you'll consider looking into that if it's possible, because the ads on RUclips are really unbearable these days.
I think he's said before that it's more a matter of someone inviting him than him just applying/signing up
@@_kalia that’s right. I admire their business model and am friends with a bunch of the Nebula creators. Maybe someday!
The fact that I said that Legally Blonde quote along with you…. 😅 and was then disappointed to come to the comment section and not seeing any mention of it
I'm glad you're starting it then!
"Happy people just don't shoot their husbands." 😂
the legally blonde reference 😂
Charlie Day thumbnail
A comment for the algorithm gods
A reply for the algorithm gods
Another reply for the algorithm gods!
The gods love engagement
What a lively and organic conversation!
Amen
In medical ethics, you have to inform the patient that its placebo - that doesn't wrap sense on me unless you said it after they received it.
Im am infertile from eating scented candles. The
Thank you for this video Patrick Kelly my middle name is Patrick and my last name is Kelley
Also I don’t think there are nearly enough books or videos to teach us about Medical History out there and your high quality videos do an amazing job of filling that gap. Anyways, thank you for everything you do to put out these videos.
to be fair, William Smellie probably did smell - as did everyone back then
The 'Placebo' Effect is the world's most profitable treatment.
The placebo effect cannot help somebody when they are dope sick
You can make your own placebo pills for cheaper, but they might not be as effective...
To me all these double-blind placebo effects studies may well be proving that methodology of these studies is wrong. Historically placebos were often sugar pills, and sugar makes some of us feel slow and lethargic. This made any medicine being tested somewhat more effective than the placebo. Another issue is that the studies have to assume all the participants are identical. Because of genetic variation we each have a slightly different metabolism. One person with an unusual metabolic response will have little effect on the outcome of the study, but they are used to prescribe treatments for everyone: including those who have the unusual response. Most people over 70 have bad experiences with medicine and little faith in doctors.
The sugar in the so called 'sugar pills' isn't only present in the placebos. It's used as a filling agent in all pills, to make a pill of a convenient size out of what is often a very very tiny amount of active ingredient. The placebos are specifically developed for each medication, and are composed of exactly the same things as the other pills are, except the active ingredient being tested.
But what happens if I take a fake placebo?
You get affected with whatever effects and side effects the substance has.
a placebo has to be expensive to work)
So that's why i like sugar pills?
You're evolutionarily wired to like sugar, it just comes with being human.
@@Call-me-Al We call placebo sugar pills in Sweden, that's the joke.
11:53 LEGALLY BLONDE MENTIONED
Discuss: homeopathy is placebo, so it works.