The Reward Circuit: How the Brain Responds to Cocaine
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- Опубликовано: 7 фев 2016
- Learn about the brain reward system and the biochemical processes that occur during cocaine use. Includes the opening Brain Reward video, "How the Brain Responds to Natural Rewards and Drugs."
This video and transcript can also be viewed at: www.nida.nih.gov/videos/rewar...
Don’t stop trying to quit and work out, run, you are young, you can make it!
God bless you man you really made my day. I am only 17 years old and just tired and sad of the life that i m living right now. Only when i have used the shit i feel good.
While i am writing i havent slept for 3 nights😩😕 this is my fourth
I hope you are ok and are able to stay clean. Keeping my fingers crossed for you.
@@isaacvandenberg3127God bless you
Nice member version. How drug/substance use changes your brain in short & long term use.
I was born in 82 in the south bronx, i had the unfortunate experience of seeing the unsavory side of the human experience during the crack era. My classmates parents were addicts n we would see them on the streets begging or carrying random items to sell. Prostitutes in horrid conditions, I used to believe crack addicts got sick when they didn’t use because of the heights & depths they would go to obtain the drugs. people from my generation aren’t immune from using crack cocaine or cocaine itself. I’ve had a history or substance abuse (age old story) surgeries had me addicted to pain meds. I hit the Jack pot. After I had weight loss surgery I was miserable I hadn’t addressed my food addiction & stabilized so the pills made me feel like I was the luckiest person on earth, all the while all my money was going to pills & I wasn’t bitter while at work I felt great & i preformed my job amazingly until my addiction went haywire & I had bad attendance at work plus repeated absences because I was either withdrawing n could begin work until I was fine or I hadn’t slept in days & I couldn’t cope. My temperament changed. I was irritable with certain personalities so I had arguments with a couple of new coworkers while on duty. I also had a bourgeois energy that some female coworkers didn’t like. The clients were very happy with me & my patience but the truth was I can appear very patient to a person I am encountering for a maximum of 45-75 minutes. Two females I worked along side on 12-16 hour tours would find it to be a long day because we were just tolerating one another which wasn’t like me at all. I wish I could apologize to them both when the time presents itself. I got so side tracked. Since I knew of the crack eta n swore against such a demonic poison I easily fell into the pill craze n I felt okay because I wasn’t on a corner getting it (at first lol) I had a prescription!!! I wasn’t like “them” lol shiiiitt I was exactly like them. I’m just venting & I hope someone struggling out there knows they aren’t alone. If u honestly wish to discuss recovery serious recovery email me & I promise to reply. Even if ur a current user but u want help I can help to get into detox that has a rehab component if ur interested. They pick u up and bring u to the place in Brooklyn. U must have health insurance. If u call them & ur ready to go you can be picked up the next morning at 6-7am or if u call the center early enough n u want to leave the same day u can also arrange that. U can be picked up, or come on ur own. the earlier in the morning the better . It’s ACI detox & rehab one of NYCS oldest rehab n detox n they allow u to smoke there u get 3 cigarette breaks per day n they provide them for u. Z brand new facility which was once a public school so it’s modern & clean. U will be set up with services before u leave whatever is best for u, even if ur homeless. u can go to long term treatment after u leave ACI (they have a website) google them. I wrote this feeeling as if someone might need it.
I've tried cocaine a few times in my late teens to early 20s. And I can say, honestly, it's the best drug I've ever had (this is by no means an endorsement). I have anxiety and depression issues and it just lineated my thoughts and I never felt so capable and alert. But despite my addictive personality, I never fell to the trap, thankfully.
It's glorified for a reason, but it's too good to be true. And we all know where that leads.
Just steer clear. I hope any addict can get the proper help instead of jail time.
Coke has nothing on MDMA
@@carlosdimas313 it does have a lot on it. Of course, everything orbiting around drugs is subjective, but ive had pure rocks of MDMA, even MDA. Very different stimulant from coke, and neither of those even touch meth.
@@digitalscale76 Coke is a waste of money and time . Do some lines and stare at a wall all night . How is that better than taking mdma . Pop one and feel bad ass lights are amazing . The Hanky Panky with the ladies is unbelievable…..
@@carlosdimas313 once again everything is very subjective, setting and surroundings. Using ecstasy is not very smart. There is often amphetamine or methamphetamine there as well as filler. Pure rocks Are the way to go. Also I'd never snort anything, I dissolve both MDMA and coke in water or a drink. For me MDMA wasn't anything amazing, i just felt calm and at peace, the close eye visuals very really funny and interesting though. I'd guess the effect would be different if I did it in a club or at a rave. Coke on the other hand is really sharp even though I don't snort it but rather digest it. Staring at a wall? Never heard of that. I have fun whatever I'm doing. For me sex is the most "potent" not with MDMA or coke or any stimulant for that matter but surprisingly with THC.
@@digitalscale76 eating coke only absorbs like 20% of it while snorting absorbs like 90%
I recently got hooked on coke and it's no joke. It will make you feel like superman but costs a lot. I currently snort about 1.5-2g a day atleast and thats not even bad. Luckily I have a good paying job so I can afford it. But remember it's addictive as hell because it makes you fell invincible but will slowly dry your life away. It's not just a 1 kind of party deal. You'll want to feel that rush again. If its for 1 night remind yourself that. It makes you crave liquor as well. I'm 19 years old snorting 2g a day and drinking 1.75ml of vodka a day. It's taking 1/2 my check atleast just for coke. Maybe do it 1 time and do it. Fuck coke. Please be safe bc the only reason i tried it is bc I want to kms.
@Dr Kelly Smith cap
Is he still alive..
Consider mushrooms. They help to break these types of patterns and will show you a new side of life . It may be a rough experience getting clean, but it'll be worth it.
Hi there, hope you've managed to kick coke. It's certainly not for everyone
@PsychicAlchemy No, instead, go to a psychiatric hospital. Shrooms are a drug and addicts won't limit their intake, will still kill you.
This is amazing
This beat is fire!!!
That clears it up😀
Dopamine does have something to do with us feeling euphoria, but that's more serotonin than dopamine. Serotonin also makes us sleepy. Probably because it takes the piss out of you. Well, dopamine takes it out of you while serotonin knocks it out of you. That's another reason why you feel tired after being very happy for a good bit of time. The neuron of dopamine is also not what gives you massive levels of energy. It gives you some energy, but it's mostly norepinephrine and epinephrine(noradrenaline and adrenaline) that gives you that. That all has to do with the NMDA receptors; N-Methyl D-Aspartate. The neurons that bind to NMDA receptors are norepinephrine, epinephrine, and glutamate. The neuron glutamate is what gives you excitement. Cocaine binds to the D1-Like receptors(D1 and D5) as well as NMDA receptors. Crank(crystal meth) and Desoxyn(methamphetamine hydrochloride) both bind to D2-Like receptors(D2, D3, and D4). Also, Adderall binds to D1 and D2 receptors, but I'm not sure which of the types and/or subtypes of amphetamine in it is responsible for it binding to both D1 and D2. Maybe it's because all of these different amphetamines are working on the CNS. Who knows! Anyways, I hope this helps some of you.
Also, anything that interacts with your serotonin is going to create the possibility of you seeing things or going into psychosis. I think Schizophrenia had more to do with serotonin than dopamine. I personally don't think dopamine has anything to do with causing Schizophrenia... at all. All it is, is that people with Schizophrenia and Schizoeffective Disorder just so happen to have higher levels of dopamine. Maybe that's the brains way of trying to make things not as bad for you as possible. I think anything with "Schizo" in it is caused by having deja vu either too many times and/or it happened for longer lengths of time than the average person. We also know living in the city also has something to do with it, too. Maybe those were the people in the city who had lots of deja vu and lived a life completely opposite of life in the country because the city, in some ways(a lot of ways), is not the natural world. It's not what nature created. A lot of them may have also been really strange people before they developed it. I'm a weird dude, but... I'm not strange. Kind of like what Waylon Jennings sang: "I've always been crazy, but it's kept me from going insane."
Good video, doesn’t explain how it damages the brain
I'm on coke while I'm watching this! It's a great time, it really is.
Why can't acetylcholinesterase digest the extra acetylcholine present in the junction??
Because "Switchman's sleeping, train hundred and two is
ON THE WRONG TRACK AND HEADED FOR YOU "
thanks brооо
Is this the same for norepinephrine??
yes for all the neurotransmitters
So if I took cocaine then thought to myself that my team had won the champions league (to get a dopamine rush) would that make cocain feel amazing since the dopamine is now blocked from returning???
You don't need to think it. If you take cocaine you'll feel AS IF your team won the champion's league. It's feel-good without anything having happened. That's why it's so dangerously addicting. Instead of working out, accomplishing things, making something good happen, and naturally releasing dopamine, your body and brain will know there's a much easier way to get that feel-good. Please don't try it.
MRI I have had a lot of these through the years cAT scans test images of the brain. A Dye is given to search for trouble areas in the brain. injuries to the head in accidents like falls
What's that got to do with anything?
Give yourself a chance to live…not just exist. ACI detox/rehab & outpatient services that include psych, vocational, medical, counseling, group therapy etc. what can u lose?
This music 🔥🔥🔥🔥
Cool! I should try cocane.
First learn how to spell it, dumb bum
im on it now
It’s fire
What an idiot
You should never try it trust me...
This doesn’t explain how it damages your brain
I have done cocaine since 11 years, Im 27 rigjt now, really I need to quit soon. I have been reading psychedelic microdose therapy, what do you think? I have been already in AA, 4 clinics, psychiatryst, etc...
Sorry for my English, I'm from Mexico
It wouldn't hurt to give it a try. If u been on cocaine for 11 years it wouldn't hurt to try. COCAINE addictions is more of a mental addiction than physical. Meaning u don't go through physical withdrawal, mental mainly. You have to make it up in your own mind to leave it alone. Its not going to be easy. But, you can do it. Stay away from anything are anyone that triggers you to wanna use. 💗 good luck 👍
@@adrianannette2143 I think he’s doing 16 years of coke abuse.
@@adrianannette2143 theres no physical addiction. This is not opiates.
@@digitalscale76 In some cases it is physical addictive though it is mostly mentally addicting. Some of the physical symptoms are fatigue, aches and pains, increased appetite, and physical cravings for cocaine but this symptom is usually only seen in people who have been abusing it for a long time and then just suddenly stops.
im tryna get some fr
Make sure you get some clean and enjoy.
Long as you don’t get hooked bro, coke is a good time once and a while but it’s one of the worst drugs to get addicted to cause of how expensive that shit is, then you start looking for cheaper alternatives like meth.
It ain’t worth it bro, trust me
JOSE LUIS RANGEL BC5537
1:50
Chi Chi get the Yayo, everybody gets a Line.
Grateful Dead on how Cocaine leads to total TRAINWRECKS
Driving that train, high on cocaine,
Casey Jones you better watch your speed
Trouble ahead, trouble behind
And you know that notion just crossed my mindThis old engine makes it on time
Leaves Central Station 'bout a quarter to nine
Hits River Junction at seventeen two
At a quarter to ten you know it's travelin' again
Driving that train, high on cocaine
Casey Jones you better, watch your speed
Trouble ahead, trouble behind
And you know that notion just crossed my mind
Trouble ahead, Lady in red
Take my advice you'd be better off DEAD
Switchman's sleeping, train hundred and two is
ON THE WRONGT RACK AND HEADED FOR YOU
Driving that train, high on cocaine
Casey Jones you better watch your speed
Trouble ahead trouble behind
And you know that notion just crossed my mind
Drive your train, whoo
Trouble with you is the trouble with me
Got two good eyes but you still don't see
Come round the bend, you know it's the end
The fireman screams and the engine just gleams
Driving that train, high on cocaine
Casey Jones you better, watch your speed
Trouble ahead, trouble behind
And you know that notion just crossed my mind
Driving that train, high on cocaine
Casey Jones you better, watch your speed
Trouble ahead, trouble behind
And you know that notion just crossed my mind
Driving that train, high on cocaine
Casey Jones you better, watch your speed
Trouble ahead, trouble behind
And you know that notion just crossed my mind
Driving that train, high on cocaine
Casey Jones you better, watch your speed
Trouble ahead, you know, trouble behind
And you know that notion just crossed my mind
And you know that notion just cross my mind
Similar to how Ritalin or Medikinet works
So is coke bad?
Kinda....its not as bad as meth. What dangerous about coke isn't the actual cocaine but what it might be cut with. So instead of using baking soda or powdered sugar as a step....dealers are starting to use fentanyl. Wich is like 5x more potent than pure heroin. However fentanyl is impossible to detect in cocaine by the naked eye...unlike baking soda . As far as going to a party and doing a couple lines....no it's not that bad. Unless your drinking the high last anywhere from 20 to 45 minutes. That also depends on the quality of the blow and weather or not your body is used to it or not. I can do a line of pure scale and go to sleep 15 minutes later. Were as most people would be talking non stop and awake. It's only bad if you abuse it. And good coke is pretty fucking expensive so it's hard to become and addict unless you have a well paying job
@@ejahtretzen9261 Or unless you're in South America
@@ejahtretzen9261 if its cut with fent youre not making it to the morning, also its a bad filler since its really expensive.
Of course it's very very BAD
it's pretty good really
The problem with cocaine is that it is medically useful, but only for an ephemeral period of time; unfortunately, it's one of those stimulates that just happens to activates the reward part of the brain.
I'm not condoning drugs because most people should not take the risk, and you have no idea what the stuff is being mixed with nowadays. The only drug I do condone-to some degree-is cannabis for both its psychological & physical aid, especially those with MS. Even with that said though, anything can be abused.
Personally, I'd say cocaine is only really necessary for dental procedures in the modern day. From what I've researched, legalising it now would be a terrible idea.
No
The first 12s of that were incredibly boring omg