I just started study medicine one week ago and already, I do nothing else. These videos are probably going to be the reason, I pass my exams properly and going to be a knowledgeable doctor. Thank you very much for all you've done and all the videos to come!
Zach you are amazing! So close to 900K subs mate! Whenever I see your videos, I am so grateful. 3 Videos in 3 Days . In Soccer you would be Hat Trick Hero. In Basketball you would be MVP
Zach I want to say from the bottom of my heart you represent the best of humanity! You are giving so much and asking for so little. You are an angel mate! (Have tears in my eyes)
I memorized a chart for this section because I didn't understand the purpose of these enzymes in lysosomes. So basically what I think I'm getting from this video is that all the sphingolipidoses are due to defects in lipid metabolism. These lipids are all derivatives of sphingosine and are part of the cell membrane whether they are sphingomylelins, ceramides, cerebrosides, or gangliosides. They are not the same as TG that undergo beta oxidation, they are broken down in lysosomes and are either released in the cytoplasm or ECM via secondary lysosomes. They are used in the liver for LDL degradation, in all cells that undergo autophagocytoses, and in the WBC for pathogen degradation. Fabry is the only XR disease the rest is AR, Fabry and Gaucher usually present in adulthood whereas the other diseases present during childhood. Only gaucher disease may present with increased risk of infection due to pancytopenia, differentiating Tay Sach from Niemann Pick via hyperreflexia vs hyptonia and no hepatosplenomegaly vs hepatosplenomegaly.
I love all of your videos, Zach! So helpful in all my courses I’ve taken thus far and I’m just 2 semesters away from graduating, then onto graduate school 😃 you’ve made learning an enjoyable experience. Do you think you could make a video series of ways that YOU study? Since you clearly have retained so much information 😃 thank you!
Even I am pre medical students preparing myself for competitive exam still I watch your videos because it's a good resource to make clear concept from them
Thank you so much You make my knowledge concrete! I have been studying biology with you. I hope you feel our happy 😊 Be safe from Covid19! Be always happy!
Please make video on some tips for studying and How to make effective notes and how to keep maintain focus.. I know there is a lot on videos on RUclips but you are deep explainer so it will be helpful.. Thanks in advance 😇
Best thing is to make notes form videos lecture or you can do another thing you can also make notes form the different books material and also from google and makes different diagram and writes in your own words as it will be easy for your revision.
Don't often see anything on LSDs like this. Thanks for raising the profile. Woild like to see something on lysosomal membrane proteins especially NPC1 (Niemann-Pick 1 protein. Amazing small writing!
I’m currently taking a paramedic class thank you for your videos. Tremendous help! For a future video topic can you do a video on med math . We were learning about IV piggybacks with dopamine drips of different Concentrations. Some of your clear explanation would really be helpful!
As an old engineer I had a brain freeze about 1:00 in. Then about 10:00 when you talk about Receptor Mediated Endocytosis a few brain cells came out of hibernation connecting stress analysis and vibrations and I nearly had a stroke. I couldn’t even relate to nonlinear optics. Holey-Moley I guess I better start with basic biology. However, after a third go of it some synapses are forming.
Really,u r awesome n your videos r also awesome n very much helpful....thank you so much zach....lots of love (India)😍😍😍....please upload videos of all the cell organelles🙏
Hi Zach, Thank you so much for the amazing explanation, I have a question to share with you regarding the NPC disease (Niemann pick type c)! Out of this explanation, what is the possible consequences of following a low carb & high fat diet and Intermittent fasting on NPC cells and how consuming different kind of fat can increase or slow down the process of the disease in the cell level?
I hope you be successful in your entire life and you worth it for all your dedication and your perseverance. I know you're work is not so easy but it worth.
Thank you so much for the video, such a clear concise explanation. However, does anyone know why Tay Sachs and Nieman Picks present so similarly besides the hepatomegaly while Gaucher and Fabry dont. Also why does gaucher seem to affect the bone (is it because the enzyme that its deficient in is only found in that bone?)? What is the reason behind Fabry causing Angiokeratomas while the others are less likely? These might all be moot points, but Im just curious to know if there is an actual answer or if its just by experience that these are the most common presentations?
If everyone in the world were like Zach, the world would be heaven! Thank you for making 3 videos in 3 days!
But... We can't have good things
I agree 🧘🏻♀️🤍
I just started study medicine one week ago and already, I do nothing else.
These videos are probably going to be the reason, I pass my exams properly and going to be a knowledgeable doctor.
Thank you very much for all you've done and all the videos to come!
This video deserves a million views. Thank you for simplifying LSD.
I would have never made it through my first year of med school without your help. Thank you for all of the great videos.
I clap after each video. Thank you so much for doing this, you're a blessing on this app! Virtual hugs
Zach you are amazing! So close to 900K subs mate! Whenever I see your videos, I am so grateful. 3 Videos in 3 Days . In Soccer you would be Hat Trick Hero. In Basketball you would be MVP
This is the first video I've seen on RUclips without a dislike! Thanks Ninja!
Making STEP 1 studying so much easier. Thank you so much!
This man is a Angel for medical students.
Thank you so much.
Keep it up.
Zach I want to say from the bottom of my heart you represent the best of humanity! You are giving so much and asking for so little. You are an angel mate! (Have tears in my eyes)
Danke!
you saved my many hours of reading
God Bless you Zach
I memorized a chart for this section because I didn't understand the purpose of these enzymes in lysosomes. So basically what I think I'm getting from this video is that all the sphingolipidoses are due to defects in lipid metabolism. These lipids are all derivatives of sphingosine and are part of the cell membrane whether they are sphingomylelins, ceramides, cerebrosides, or gangliosides. They are not the same as TG that undergo beta oxidation, they are broken down in lysosomes and are either released in the cytoplasm or ECM via secondary lysosomes. They are used in the liver for LDL degradation, in all cells that undergo autophagocytoses, and in the WBC for pathogen degradation. Fabry is the only XR disease the rest is AR, Fabry and Gaucher usually present in adulthood whereas the other diseases present during childhood. Only gaucher disease may present with increased risk of infection due to pancytopenia, differentiating Tay Sach from Niemann Pick via hyperreflexia vs hyptonia and no hepatosplenomegaly vs hepatosplenomegaly.
I love all of your videos, Zach! So helpful in all my courses I’ve taken thus far and I’m just 2 semesters away from graduating, then onto graduate school 😃 you’ve made learning an enjoyable experience. Do you think you could make a video series of ways that YOU study? Since you clearly have retained so much information 😃 thank you!
Such a simple, to the point, awesome video!!! You make learning fun. Keep going
i can't believe this man is actually real!!! a genius indeed
I will say only one sentence "you are amazing zach"❤️❤️❤️
I’m a third year phd student at Notre dame working on npc disease. Loved the video, and it was really impressive.
20 years after biology semester, recapitulation with Zach.Thank you Ninja Nerd🙏
This is wonderful. Everything I wanted to know and understand about the lysosome, I found it here. Thank you very much😊
Even I am pre medical students preparing myself for competitive exam still I watch your videos because it's a good resource to make clear concept from them
Thank you so much
You make my knowledge concrete!
I have been studying biology with you.
I hope you feel our happy 😊
Be safe from Covid19! Be always happy!
Dude, you are a hero! We all love you!
Thanks to you and your team!
Congrats zach bro you are near to 1million
Please make video on some tips for studying and How to make effective notes and how to keep maintain focus.. I know there is a lot on videos on RUclips but you are deep explainer so it will be helpful.. Thanks in advance 😇
Yessss please 🙏🙏
Best thing is to make notes form videos lecture or you can do another thing you can also make notes form the different books material and also from google and makes different diagram and writes in your own words as it will be easy for your revision.
@@drirfan72941 thanks you! 😊❤️
he already did a studying video on his channel 2-3 weeks ago
Thanks you ninja nerd for the best you have done.
U are just AMAZING Professor !
Thank you for making it easy for me to understand 🙏🏾💞
The best lecture I've ever seen! Thank you so much!
stunning!! Love all the lectures. Bless you all.
You make the lesson very easy.
OMG you are simply amazing, i enjoyed the full lecture. Thank you very much for this!
you are so awesome to watch!! Thank you for making and sharing your super personality with us!! love ur videos!!
Thank you so much for this knowledge🙂
Loves your teaching style...❤️❤️🙏🙏
Loved it! Thank you, Zach, appreciate your contribution!
Thank you so much for this wonderful video❤
You are a good teacher, thank you.
can never thank you enough for this !
Best up and coming rapper!!!
great video! I like you explained end to end process
Thank you for making this video.. you make things simplier.
can’t wait to watch this!
This helped a lot sir.... Thank you so much...
Great as usual... good job !
Thank you so much for being just the way u r
Amazing sir keep making videos on cell biology lots of love from Pakistan ❤❤
Thank you so much.
Keep it up.
Many thanks. It was really helpful.
Amazing explanation as always
Great video!! As always
Don't often see anything on LSDs like this. Thanks for raising the profile. Woild like to see something on lysosomal membrane proteins especially NPC1 (Niemann-Pick 1 protein. Amazing small writing!
Brilliant video
I’m currently taking a paramedic class thank you for your videos. Tremendous help!
For a future video topic can you do a video on med math . We were learning about IV piggybacks with dopamine drips of different Concentrations. Some of your clear explanation would really be helpful!
I love how you are repeating facts with having these little breaks, so one has a change to suggest frist
only 100k away from the million lets do this ninja nerds!
Thank you zach bro!! 😊
As an old engineer I had a brain freeze about 1:00 in. Then about 10:00 when you talk about Receptor Mediated Endocytosis a few brain cells came out of hibernation connecting stress analysis and vibrations and I nearly had a stroke. I couldn’t even relate to nonlinear optics. Holey-Moley I guess I better start with basic biology. However, after a third go of it some synapses are forming.
" couldn't see straight "
YOU ALL ROCK THANK YOU
Thank you Zach
Wow extraordinary it's makes me feel better understanding thankyou so much sir
Thank you for this amazing video
Thanks a lot for your hard work👍🙏
bro your energy while explaining is different!
Thank you sir for making amazing lactures
it was an awesome lecture but I wished that you explained other sphingolipidoses. like krabbe farber etc. still was a nice roundup video. loved it.
Thank you, Sensei
Hi fantastic lecture I can’t believe it
Sir also deliver lectures on remaining cytology such as details description on nucleus . Cell membrane. And so on👍👍👍👍👍👍👍
Kindly do a video series on how to read and interpret X-rays and other radiographs. Thanks
Excellent Lecture! Please provide me with the links for all of your biochemistry and molecular biology lectures
You are amazing...Love your videos...
Superb❤❤❤
After taking you lectures I am enable for asking any type questions to someone
I'm always waiting for your vedio guys 🌸
His liiitttlle bit deeper is very deep😌
You are a blessing
Very good explanation..
Amazing!
thanks Zach
Thanks again and again
Je parle pas anglais et j'ai quand même trouver son cours super
Wey neta que te amo, explicas super bien todo
Really,u r awesome n your videos r also awesome n very much helpful....thank you so much zach....lots of love (India)😍😍😍....please upload videos of all the cell organelles🙏
thank you so much !!
Hi ... Thanks a lot for the videos
Wow Zach you are explaining stuff that we used to think that they are non-doable in medschool and never understand 😂 lysosomal storage diseases are 💀💀
Sir pls post more videos on pathology , pharmacology and microbiology....
We r waiting....🙏🙏❤️
Hi Zach,
Thank you so much for the amazing explanation, I have a question to share with you regarding the NPC disease (Niemann pick type c)!
Out of this explanation, what is the possible consequences of following a low carb & high fat diet and Intermittent fasting on NPC cells
and how consuming different kind of fat can increase or slow down the process of the disease in the cell level?
Thank you so much
god damn i love you guys so, so, so much
Very nice content.
We want more video on organells of cell I mean on ribosome on golgi aperatus etc
Awesome 👌
Sir I am ur biggest fan sir 😌💓
I hope you be successful in your entire life and you worth it for all your dedication and your perseverance. I know you're work is not so easy but it worth.
Nice information
Excellent informative vedio
Wow❤️
Very nice
Thank you so much for the video, such a clear concise explanation. However, does anyone know why Tay Sachs and Nieman Picks present so similarly besides the hepatomegaly while Gaucher and Fabry dont. Also why does gaucher seem to affect the bone (is it because the enzyme that its deficient in is only found in that bone?)? What is the reason behind Fabry causing Angiokeratomas while the others are less likely? These might all be moot points, but Im just curious to know if there is an actual answer or if its just by experience that these are the most common presentations?