Inspiration at the wheel led to the discovery of PCR, for which he was awarded the 1993 Nobel Prize in Chemistry. Full interview at nobelprize.org/nobel_prizes/ch...
"If only he was still alive with us"... yes his death just very shortly bevor this "pandemic" is surely very convenient for some! He would smash theses tests!
He would call out the BULLSHIT that's happening because of his test. But do you think the sheep would believe him or their TV faces? Cause.... at this moment I don't have any faith in humanity at all!
He touches a very important point: he discovered this while having time to think. Most people today don't think, just consume. Especially, social media. This will have effects in the american rhythm of innovation.
We are conditioned by education entertainment/amusement and government not to be free thinkers but compliant workers consumers without questioning those in authority be they religious educational consumption hawkers (advertisers public relations) and politicians. That is “the dumbing down project” and its working !
@@laniejuanitawhitehurst1624 Yeah, that's all a real interesting idea until you become part of the real world. Questioning authority, questioning your peers? That can be a great way to prop yourself up, you especially see this in media. If the NYT publishes a completely bogus article, it is wholy in the best interests of CNN or BBC or whoever else to tear them to shreds over it. Same deal in science or education. If some research group publishes a bogus paper and I know how they could've done it better, that's my time to shine! Punching up to authority is effective and happens frequently.
I know and i love it! Would've loved to hang out with him, Talk and hear his thoughts. I gotta few thoughts i wished i had someone who could appreciate them. I know i dont have these kinda ppl around me, though.
I love how he’s talking to her like she’s gonna know how his 180 IQ brain was functioning when he discovered PCR. No she doesn’t know. Neither do we. Fun to see him relive his genius though. Got the spirit of it 😂
Well, he is engaging, but Feynman was so much more of a sharp - and humeros - wit; read some books by him; wish I had gad the pleasure to attend some of his lectures!
His test can’t isolate the current strain of coronavirus...apparently he said as much....it wasn’t designed too, these tests were also being bought by country’s all around the planet, in 2017...!!! I wonder why that was...
Some bashed him for his recreational drug use, some story about raccoons 🦝 or something, trying to discredit him. He experimented some drugs , to learn,,, R.I.P. ✨
@@carolelawmac7921 I guess you’re not familiar with irony when it is used in literature or you’ve never read anything by the author you are disparaging.
"I was looking for something else."..." PCR was the possible outcome of a solution to a hypothetical problem that didn't really exist". Listening to these words in the beginning of the interview gives me the impression that the PCR method was developed only because it could be achieved but with no application in mind for how it could be used.
@@marios.2848 Not really? PCR has been a staple in Sequencing workflows basically since it's invention. It's also been used somewhat commonly as a diagnostic ever since Quantitative PCR became a thing. Most applications of PCR so far are pre-mortum, not post.
@@marios.2848 basically they can find anything they want to if they run enough cycles, Kary himself said it shouldn't be used in that matter (not specifically about COVID) because you can manipulate the results
It’s crazy… when Mullís speaks of the control strand of RNA… They were able to adapt Mullís’s genius to their off the shelf products… plus I love this response from him
Pcr technology designed by him is absolutely wonderful technique. All the crime cases including difference between monozygotic twins can be analysed by using such technique.
Are the Rt PCR test machines moneymakers for labolatories ? How long time/ how many tests do it take to get back the invested money for them { 60k $ (?)+ running costs } to begin to make money with them?
Depends, the only real way labs make money off these tests is if they are either bought from the lab by a government or if they sell 3rd party test kits. Either of those will probably have a mark up on the price that can make them some profit. But this would be the case regardless of the testing method we use during this pandemic. Whatever method we use is gonna be sold like hot cakes, RT-PCR is just the cheapest, fastest, most effective available right now.
Invented, not discovered. Learn the definition of both and you'll see why it's a disservice to call his invention a discovery. *That's because there was nothing like it before Dr Mullis invented the PCR method.
i remember watching this and i googled him and it said he died of covid.but sure everyone did at that point now it says he died of pneumonia lol.Pretty soon we will find out what really killed our family members.
I'm not sure what you mean... When you get hit by a car, do we say you died in a car accident or that you died by having your internal organs ruptered? It's not the latter is it? Same with covid, the pneumonia and other things that kill you, they wouldn't just show up without covid absolutely ravaging your lungs and immune system.
@@GotYa *"t's not the latter is it"* Yes, it is. If I get into a car accident, bash my head on the steering wheel, and die, then the cause of death would be listed as blunt force trauma to the head, not a car accident. Covid deaths were classified completely opposite, which is immoral and wrong.
@benedictive I remember it well. And yeah, there is still no answer tho this question... One has to wonder why. In last interview I've seen Montagnier said that a healthy organism eliminates hiv in about 2-3 weeks, so the way to fight aids in Africa is the "providing clean water, increasing genital hygiene and treating diseases like malaria". I see them preparing ground to retreat from the failed hypothesis of hiv>aids causation, but still not ready for a final painful move
As for Kary Mullis interviewing scientrsts for the source article that HIV = AIDS, keep in mind that Montagnier, the co-discover of HIV, doubts that HIV causes AIDS ! Yes, there are thousands of papers "confirming," or rather, agreeing with, the prior conclusion that HIV causes AIDS, but they are not source articles, nor independent research.
You should really watch house of numbers Hiv has never been isolated the HIV drugs cause the same side effects as the so called virus does, also Robert Scott Bell Show on youtube goes into this extensively
@@shanethecolloidalsilverman718 Dude you're so full of shit. HIVs genomic sequence has been known for ages, so has it's proteome. You can't get that without isolating the virus first. Like... you could even google "HIV electron microscope" right now and find literal pictures of the virions. We have absolutely isolated HIV, unless you use the word "isolated" in a way noone else uses it.
So essentially he wanted to get rid of a technical issue so split his assay into 2 parts and from part 1 to part 2 his sample doubled and that’s how we get PCR?
Is it true that he was Trippin on LSD when he invented the PCR...? Anyone,? BTW I got this information from joe rogan's last podcast with Michael Pollan.
*Use of hallucinogens* Mullis practiced clandestine chemistry throughout his graduate studies, specializing in the synthesis of LSD; according to White, "I knew he was a good chemist because he'd been synthesizing hallucinogenic drugs at Berkeley." He detailed his experiences synthesizing and testing various psychedelic amphetamines and a difficult trip on DET in his autobiography. In a Q&A interview published in the September 1994 issue of California Monthly, Mullis said, "Back in the 1960s and early 1970s I took plenty of LSD. A lot of people were doing that in Berkeley back then. And I found it to be a mind-opening experience. It was certainly much more important than any courses I ever took." During a symposium held for centenarian Albert Hofmann, Hofmann said Mullis had told him that LSD had "helped him develop the polymerase chain reaction that helps amplify specific DNA sequences".
Wow! Troll, you sound like you're tripping or are about to do so. He is focused, easily understood (for those familiar with the topics of discussion) and able to maintain a steadfast position without flinching. I just gave you an insight on what to expect it the next few and shortly enjoyed moments of your life.... no need to thank me, I feel sorry for your destiny.
Not entirely knowledgeable in the scientific jargon here......so what does the PCR test identify? Does it identify health conditions that could potentially be in your blood?
It’s a machine that reads the glow (fluorescence) of a dye that attaches to the DNA in the nuclei in your cells and someone checks by that glow, if it’s beyond a certain threshold it’s considered you have the virus. Viruses inject their dna into the cells nucleus usually and that’s how they check. Idk how the dye tells whether it’s attached to your own normal dna or the one infused with the virus so I can’t really tell, you can’t really find a clear answer on this on the web so easily either. I think the dye just kinda glows attached to all types of dna whether it’s virus or not idk how it distinguished it from an uninfected type
It appears so, but we should be able to look at the whole person, alumni.berkeley.edu/california-magazine/winter-2019/intolerable-genius-berkeleys-most-controversial-nobel-laureate
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RIP Kary Mullis 🖤
🍏❤️🍏
I hope you knew Jesus, sounds like you might have! Your a kind man! RIP 💜
If only he was still alive with us !!!
Well, they might have sorted that one out? There are trillions of $ to be made here, remember.
Hed be disgusted. He said it should never be used to confirm the presence of a viral infection
Kinda weird he isn't though I'd you think about it.
"If only he was still alive with us"... yes his death just very shortly bevor this "pandemic"
is surely very convenient for some! He would smash theses tests!
He would call out the BULLSHIT that's happening because of his test.
But do you think the sheep would believe him or their TV faces?
Cause.... at this moment I don't have any faith in humanity at all!
He also said Fauci is dumb :)
He touches a very important point: he discovered this while having time to think. Most people today don't think, just consume. Especially, social media. This will have effects in the american rhythm of innovation.
He discovered this on LSD. Pretty awesome. We need more psychonauts in medicine - less bought and paid for pawns.
We are conditioned by education entertainment/amusement and government not to be free thinkers but compliant workers consumers without questioning those in authority be they religious educational consumption hawkers (advertisers public relations) and politicians. That is “the dumbing down project” and its working !
@@laniejuanitawhitehurst1624 Yeah, that's all a real interesting idea until you become part of the real world.
Questioning authority, questioning your peers? That can be a great way to prop yourself up, you especially see this in media. If the NYT publishes a completely bogus article, it is wholy in the best interests of CNN or BBC or whoever else to tear them to shreds over it. Same deal in science or education. If some research group publishes a bogus paper and I know how they could've done it better, that's my time to shine! Punching up to authority is effective and happens frequently.
*while on LSD
@@TheChance1991 i know several. there's more than you think, but sure, more is better!
Watching in 2024
Kary Mullis was my hero growing up. He was a very special person, so much knowledge and wisdom! RIP 🙏
Mine was Batman
ME TOO! You are a kindred spirit, Tania!
And worked in the same lab as my boss, but people are misunderstanding his comments here because his version of PCR is not used for viral detection
Interesting guy. He has that odd flare about him that denotes something of a hallmark of a genius
It’s the vacation button down 🥴😂
I know and i love it! Would've loved to hang out with him, Talk and hear his thoughts. I gotta few thoughts i wished i had someone who could appreciate them. I know i dont have these kinda ppl around me, though.
Kind of shy and socially awkward 😏
@@moodybugg-2098 Geniuses aren’t fun to “hang out” with and the thoughts they share are often disturbing.
I think what you’re referring to is a cool, calm, and collected demeanor. He exudes confidence in what he says because of this.
True scientist and a human. RIP
And there are millions more real scientists though...unsure of your point
@@TheFelltimber because he is on the video?? So whats your point under the video of him saying this?
@@TheFelltimber I'm unsure of YOUR point. What do other scientists have to do with this? He wasn't saying that he was the only scientist..
Rest in peace Kary Mullis 🙏🙏🙏
I love how he’s talking to her like she’s gonna know how his 180 IQ brain was functioning when he discovered PCR. No she doesn’t know. Neither do we. Fun to see him relive his genius though. Got the spirit of it 😂
He was on LSD while driving his car, she might know that substance too
Kary Mullis reminds me so much of another brilliant, engaging and inextinguishably interesting man, and fellow Nobel laureate: Richard Feynman
Well, he is engaging, but Feynman was so much more of a sharp - and humeros - wit; read some books by him; wish I had gad the pleasure to attend some of his lectures!
@@danihesslinger7968 Not sure why Richard was needed but
RIP Kary Mullis, a true inspiration.
His test can’t isolate the current strain of coronavirus...apparently he said as much....it wasn’t designed too, these tests were also being bought by country’s all around the planet, in 2017...!!!
I wonder why that was...
Where can I find that info please mate
@King Penda he's has nothing to do with a RT-PCR test.
I dont follow. Are you saying that RT-PCR cant detect covid because Kary Mullis said so? Some clarification would be great here lol
this dude is like totally the role model for surfer dudes. rock on duder!
If I remember correctly, he more often wore cowboy boots and hat.
He's a role model for Humanity
The Dude Abides
Rest in peace.
A real scientist, finally.
Gosh, and a real person to boot.
We in the field of biological science are thankful for Kary's work. This was a well deserved nobel!
It is not be used correctly, it is a lack of respect for him
@@brenda95gg In which area of science do you work?
@@weefeatures In which area of science do YOU work?
@@brenda95gg Used incorrectly in what sense?
Love this guy = RIP Kary
What? When?
@@JaneDoe-hl6bx last year! in August
Thank you for this clip
Chemical brilliance...and NOT an idiot savant;)...RIP brother
What is an idiot savant? Isn't that oxymoronic?
@@pocasanchez Idiot savants remember everything but can't make sense of it my friend
A true genius
Something about these genius people leave me in awe.
You can tell by watching him speak that his brain is going faster than his mouth can say words.
Love it!
Wow. I do that too. But most people just think I'm crazy and awkward. And I'm a biochem major. God bless this man.
Some bashed him for his recreational drug use, some story about raccoons 🦝 or something, trying to discredit him.
He experimented some drugs , to learn,,,
R.I.P. ✨
he has aspergers apparently
Respected sir,
Good day, thank you for sharing.
Kary Mullis is the Hunter Thompson of science. If two people could save the world today it would be that duo. Wish they were both still here
and George Carlin
Unfortunately Hunter Thompson was a psychopath.
@@carolelawmac7921 I guess you’re not familiar with irony when it is used in literature or you’ve never read anything by the author you are disparaging.
@@charlesalan62 He is just saying that Hunter Thompson is a psychopath
Don't worry; you got me!
I enjoyed his book, _Dancing Naked in the Mind Field._ It was crazy, but I like crazy.
John Malkovich should play him in the movie when all this bullshit is over
Or Val Kilmer in his iteration from The Saint, the weird professor character.
@@celtaciaclemment1229 Cool, or maybe Brad Pitt's iteration in 12 monkeys
💪💪💪
Or even better, right now, if not last year🙏
"I was looking for something else."..." PCR was the possible outcome of a solution to a hypothetical problem that didn't really exist". Listening to these words in the beginning of the interview gives me the impression that the PCR method was developed only because it could be achieved but with no application in mind for how it could be used.
Yes. Then we he realized it amplified the target x2...he had it..very cool
Applications were found after his life. E.g. detecting for SARS-COV-2 particles.
@@marios.2848 Not really?
PCR has been a staple in Sequencing workflows basically since it's invention.
It's also been used somewhat commonly as a diagnostic ever since Quantitative PCR became a thing. Most applications of PCR so far are pre-mortum, not post.
@@marios.2848 basically they can find anything they want to if they run enough cycles, Kary himself said it shouldn't be used in that matter (not specifically about COVID) because you can manipulate the results
Incorrect .... I have been doing PCR for over 15 yrs please explain
....but you won't
RIP Mullis!
R.I.P.
Google search results would have you believe that you're hallucinating watching this video.
we need to make time to think
It’s crazy… when Mullís speaks of the control strand of RNA… They were able to adapt Mullís’s genius to their off the shelf products… plus I love this response from him
So sorry he died, he was a real great clear mind !!! 💔🛐🕊🎩🇱🇷🙏🏼
On the Genetics Unzipped podcast (S3.23) they go deep into the Story Of The Polymerase Chain Reaction!
My hero
Pcr technology designed by him is absolutely wonderful technique. All the crime cases including difference between monozygotic twins can be analysed by using such technique.
Outside his cabin in 1985 is when he met the standard ET racoon. Mullis said he was not on any chemical substance when the meeting occurred.
Are the Rt PCR test machines moneymakers for labolatories ? How long time/ how many tests do it take to get back the invested money for them { 60k $ (?)+ running costs } to begin to make money with them?
Depends, the only real way labs make money off these tests is if they are either bought from the lab by a government or if they sell 3rd party test kits. Either of those will probably have a mark up on the price that can make them some profit. But this would be the case regardless of the testing method we use during this pandemic. Whatever method we use is gonna be sold like hot cakes, RT-PCR is just the cheapest, fastest, most effective available right now.
Nice guy!
What Mullis discovered was one of the most amazing discoveries in Chemistry which has gone on to change the world.
Invented, not discovered. Learn the definition of both and you'll see why it's a disservice to call his invention a discovery. *That's because there was nothing like it before Dr Mullis invented the PCR method.
Surprised Nobel Prize hasn’t taken this video down...
Why would they? Because a bunch of crackheads misinterpret his words to fit their agenda? Nah.
@MRaverz He Invented it.
i remember watching this and i googled him and it said he died of covid.but sure everyone did at that point now it says he died of pneumonia lol.Pretty soon we will find out what really killed our family members.
Covid is said to be a respiratory virus ...
He died on August 7, 2019 BEFORE Covid existed!!!
I'm not sure what you mean...
When you get hit by a car, do we say you died in a car accident or that you died by having your internal organs ruptered?
It's not the latter is it? Same with covid, the pneumonia and other things that kill you, they wouldn't just show up without covid absolutely ravaging your lungs and immune system.
@@debbysoldan4951 I mean, it kinda existed. In a bat population somewhere in China that researchers we're studying to figure out how viruses evolve.
@@GotYa
*"t's not the latter is it"*
Yes, it is.
If I get into a car accident, bash my head on the steering wheel, and die, then the cause of death would be listed as blunt force trauma to the head, not a car accident. Covid deaths were classified completely opposite, which is immoral and wrong.
After three minutes of listening to him, I estimate that my mind must have wandered fifteen times. I’m no genius.
What did Kary say about Lovely Liz and Theranos?
@benedictive I remember it well. And yeah, there is still no answer tho this question... One has to wonder why. In last interview I've seen Montagnier said that a healthy organism eliminates hiv in about 2-3 weeks, so the way to fight aids in Africa is the "providing clean water, increasing genital hygiene and treating diseases like malaria". I see them preparing ground to retreat from the failed hypothesis of hiv>aids causation, but still not ready for a final painful move
As for Kary Mullis interviewing scientrsts for the source article that HIV = AIDS, keep in mind that Montagnier, the co-discover of HIV, doubts that HIV causes AIDS ! Yes, there are thousands of papers "confirming," or rather, agreeing with, the prior conclusion that HIV causes AIDS, but they are not source articles, nor independent research.
You should really watch house of numbers Hiv has never been isolated the HIV drugs cause the same side effects as the so called virus does, also Robert Scott Bell Show on youtube goes into this extensively
@@shanethecolloidalsilverman718 Dude you're so full of shit. HIVs genomic sequence has been known for ages, so has it's proteome. You can't get that without isolating the virus first.
Like... you could even google "HIV electron microscope" right now and find literal pictures of the virions. We have absolutely isolated HIV, unless you use the word "isolated" in a way noone else uses it.
Are viruses to small to be repliacated by PCR ? Thnx
NO! They are not smaller than part of your DNA 😃
You know what I do now when I drive? Im always listening to youtube. I need to take that time to think more often.
+1
@ocuma10 pardon but.... ¿¿¿who are you????
So essentially he wanted to get rid of a technical issue so split his assay into 2 parts and from part 1 to part 2 his sample doubled and that’s how we get PCR?
❤️❤️❤️
pff, I was messin around, besides Clark doesn't have a reputation to defend, its a community college...
really? I go to Clark, lol.
So what's the point? Someone please explain?
What other diseases is PCR being used for to diagnose?
herpes simplex-virus, cytomegalovirus, Epstein-Barr-virus, hepatitvirus och HIV
If you can exclusively find primer sites for a particular barcode surrogate for a disease....then you can use PCR
It Will be probably deleted
I believe so...
Why?
can someone please explain what he's saying in English?
Look-him-up (Kary Mullis) and you could find some videos since almost all of them disappeared.
@@taniaperez3230 disappeared LOL... all of this is in text books and university lectures.
Even though he’s not from Australia he sounds like an Australian
Yeah he gives off that vibe
John Malkovich could play thus guy.
I haven’t felt so dumb in a long time
@ScientiaVeritasEtLux Really? Name one that has conclusive evidence 100% of the time.
👍
I wish i understood what he's saying :(
oh, yeah I thougt i was the only one that didn't understand hahaha
He's not a very good communicator
Transcript link under the video
@@Stardust_Truth_Seeker you're not a good listener
I don't make sense I make dollas!
This topic in all medical intrence exam 😀
It appears science is not an exact science.
Pleomorfic effect that is the só called " spike protein"
Did this guy play Doc in back to the future?
Is it true that he was Trippin on LSD when he invented the PCR...? Anyone,? BTW I got this information from joe rogan's last podcast with Michael Pollan.
*Use of hallucinogens*
Mullis practiced clandestine chemistry throughout his graduate studies, specializing in the synthesis of LSD; according to White, "I knew he was a good chemist because he'd been synthesizing hallucinogenic drugs at Berkeley." He detailed his experiences synthesizing and testing various psychedelic amphetamines and a difficult trip on DET in his autobiography. In a Q&A interview published in the September 1994 issue of California Monthly, Mullis said, "Back in the 1960s and early 1970s I took plenty of LSD. A lot of people were doing that in Berkeley back then. And I found it to be a mind-opening experience. It was certainly much more important than any courses I ever took." During a symposium held for centenarian Albert Hofmann, Hofmann said Mullis had told him that LSD had "helped him develop the polymerase chain reaction that helps amplify specific DNA sequences".
Probably yes, but many notable scientists at the time were experimenting with it. Me, 72, also took it once or twice 😃
@@rawbacon Irony, the test we use to determine Covid was discovered by an LSD drug user (and a brilliant scientist apparently)
@@rawbacon yes
Wow! Troll, you sound like you're tripping or are about to do so. He is focused, easily understood (for those familiar with the topics of discussion) and able to maintain a steadfast position without flinching. I just gave you an insight on what to expect it the next few and shortly enjoyed moments of your life.... no need to thank me, I feel sorry for your destiny.
fact check says the stament that the test doesnt detect sickness was taken out of context
He looks highly uncomfortable ...
He's always had idiopathic movements to me but I've never heard them discussed.
Translate to espanish please
Transcript link in header. You can use an online Translating site to get a rough idea.
The words of a Nobel dont mean anything without evidencie. Another Nobel
Not entirely knowledgeable in the scientific jargon here......so what does the PCR test identify? Does it identify health conditions that could potentially be in your blood?
It’s a machine that reads the glow (fluorescence) of a dye that attaches to the DNA in the nuclei in your cells and someone checks by that glow, if it’s beyond a certain threshold it’s considered you have the virus. Viruses inject their dna into the cells nucleus usually and that’s how they check. Idk how the dye tells whether it’s attached to your own normal dna or the one infused with the virus so I can’t really tell, you can’t really find a clear answer on this on the web so easily either. I think the dye just kinda glows attached to all types of dna whether it’s virus or not idk how it distinguished it from an uninfected type
In a nutshell, PCR isn't a test at all. It's a process by which viral DNA and RNA can be replicated.
my molecular biology prof absolutely hates him.. constantly talks bout how obnoxious, and how he isn't a good person.
bombchikawowow why
It appears so, but we should be able to look at the whole person, alumni.berkeley.edu/california-magazine/winter-2019/intolerable-genius-berkeleys-most-controversial-nobel-laureate