i did not read the whole title before i clicked. your comment is the first one, so as i was reading your comment my eyes slowly looked up and i cracked up laughing.
@Jerry C Ben Shapiro is also the name of a conservative talk show host who has famously said very dumb and terrible things. They are calling that Ben Shapiro evil, not the one in this video
clear, concise, interesting, very engaging talk, easy to understand, no meandering, laser focus on the topic at hand yet still casual , building a momentum and keeping it up all the way through, great stuff kind of a benchmark on how it should be done
Loved the information covered in this speech, very informative. I however want to add, it would be great if Canada would ban accelerated melting of permafrost. The sloppy mass release of methane gas from the permafrost has to be staggeringly destructive to the ozone, not to mention improperly extracting rich and well preserved world history.
Great lecture. This is the best one I've seen in a while (last one is probably the black hole firewall with Sean Carroll on this channel). I usually watch physics related talks, but this was so engaging and she did a great job of conveying the concepts in laymen's terms. Hope to see more videos of this quality :)
I like Beth, she reminds me of the professor I had for Physical Anthropology a couple of years back. Really full of life and engaging. Also, I sure was surprised to hear that horses were originally American and bison originally Asian! Seems Beringia was important in both hemispheres!
Fascinating video. The idea of de extinction is very interesting. I think Beth made a good job at explaining the science and mentioning the ethic part was mature of her. It can easily be left out as this is such an exciting project.
Was the camera at the back of the hall much cheaper to operate or something? Every time she started talking about a chart of some sort, we'd see the chart for a couple of seconds, then the view cut away to the back of the hall as she talked on about the chart.
I really enjoyed this lecture. at times she is so passionate, and thought for a moment she'd shed a tear because she is emotionally connected to some efforts in this research only to come up against more road blocks
If you are going to call the period from the Eemian interglacial period some 125.000 years ago up to the present Holocene interglacial period an "ice age' then you will have to come up with a different term for the approx. 2.75m year period in which there have been numerous cycles between icy periods and warm periods.
I just keep hearing Ian Malcolm's words in my head. This woman seems to get it though. The question should be whether or not we should more than whether or not we can.
Consider altering - if possible- the genetic for tusk production in modern day elephants. Either remove the tusk completely, or potentially alter the construction so that it has no use in so called medicinal remedies. Hell, lace it with a chemical that won't hurt the elephant but cause severe irritation to humans if ingested or applied to skin.
Elephant ivory isn't used primarily in folk medicine. It's used for artistic objects no of great value. Also, every elephant will someday die and the tusks are valuable. Ivory could be a sustainable resource.
Changing the Asian elephant or any other animal to survive in a different climate for whatever reason means changing them for good... crazy thought in my opinion....! Humans should not mess with this sort of thing in any species full stop. That includes humans..... Why not just protect the these and other amazing creatures period....!
Wood Croft What Beth Shapiro calls "tighly condensed repeat regions" are generally known as "tandem repeats". In eukaryots, these are usually located at the center of a chromosome (centromere repeats), at the ends of a chromosome (telomere repeats) but can be found elsewhere. Tandem repeats are also found in bacteria and archaea: CRISPRs (from the CRISPR/Cas9 system mentioned in the talk) are some sort of interspaced tandem repeats (CRISPR stands for clustered regularly interspaced short palindromic repeats). Tandem repeats are not the only repetitive elements found in genomes. One must mention interspersed repeats such as transposons, retrotransposons or some introns. Actually, it is said that approximately 50% of the human genome is repetitive. You might find interesting (it is free access): J. Duitatama et al (2014). Large-scale analysis of tandem repeat variability in the human genome. Nucl. Acids Res. 42(9):5728-5741. I am sorry for such a long post. Best wishes!
Beniguitar94 Why is it hard to detect it? And when they publish a "complete" genome, if it's missing the tandem repeats, why do they call it "complete"?
Wood Croft Firstly, one must understand how genomes are sequenced nowadays (check out, for example, Roché 454 sequencing). Explained briefly, extracted genomic DNA is broken into fragments (300-800 base pairs in the case of 454 sequencing). Each fragment is sequenced (there are many elegant ways of doing it) and then comes the hard work: aligning these short reads (luckily they overlap) and deducing the whole sequence. It is even harder work to deduce the sequence of a tandem repeat from fragments which can get aligned in many several ways due to the repeats. You can read more about this (writen by experts) in the following link: www.ncbi.nlm.nih.gov/books/NBK21116/ With respect to your second question, the human genome has been mapped (not sequenced), which means that we now know the sequences of all genes and their location within the genome, plus intergenic regions (in total 90% of the human genome). Nevertheless, we do not know (exactly) the sequence of centromeres or telomeres. For example, click the following link to see the sequence of the Y human chromosome:(www.ncbi.nlm.nih.gov/nuccore/568815574?report=fasta) At the beginning of the sequence, you can read letter N (nucleotide), meaning that we don't know which nucleotide it corresponds (thought, we know the number of N's). If you drag your mouse down, suddenly, you will notice that sequence starts to appear (written in As, Cs, Gs, Ts). So the real question is, should we call "complete" a genome that has been mapped? In the days when the Human Genome Project was launched, non-genic genes (non-coding regions) where considered junk DNA. In that sense, it wasn't misleading to say "we know the complete genome". In the modern world, we are starting to grasp the essential function of so called junk DNA (we know call it noncoding DNA, which is more respectful). So my amateur opinion is that it is not at all complete and that it shouldn't be called that way.
what if you can get all the dna pussels from other mammoths dna ? so if one mammoth is missing some dna but maybe another mammoth have this missing dna data can you put them together maybe ?
i mean ! lets say !"this mammoth is missing the dna for the nervsystem , but you have more than 1 mammoth so maybe another mammoth will have this missing Dna for the nervsystem" !
Changing the Asian elephant to survive in a different climate means changing the Asian elephant... crazy thought in my opinion....! Humans should not mess with this sort of thing in any species full stop. That includes humans..... Why not just protect the Asian elephant and other creatures period....!
There was no need for a land bridge between Canada and Russia to foster migration. Animals could cross quite easily over the ice bridge that existed during glacial times.
She's made it pretty clear that it's people digging for gold doing this and the scientists are just there to pick up the interesting bits that happen to wash out. Same as when fossils are found in quarries or construction sites. I'm also fairly certain the scale is so small as to be basically irrelevant.
I'm surprised she refers to Michael Mann Hockey Stick graph. That was thoroughly debunked upon it's very FIRST systematic peer review. It has been so discredited, even Gore denies ever using it, though he clearly did.
Re Jurassic Park, it needed to be frog DNA so that the plot point would work where some of the dinosaurs changed sex, allowing them to breed. A bloody stupid reason, but still a reason.
Long story short no mammoth until matrix style birthing chambers and full genetic genome building machine is invented. Or an advanced 3d printer that makes an organism instead of growing one. Instead use the technology that is available to stop extinction of all creatures in its path. Very interesting video though had me hooked till the end.
Everytime is see the lectures at the R I ,, i always tell myself , that the wrong people are ruling the world, We place trust in our politicians, and governments, but it should be the top scientists, that should rule the world!
Really, the problem with elephants is that they can't live in Siberia. If they could, we wouldn't have to protect them from habitat destruction, because there'd be more than enough habitat.
@Feiner Fug no they came about fromr humans why there is evidence from them in human now days thye broke off over a milling years ago more as a specialist in cold weather. last ice age wiped so many things out killing mammoths saber tooth tiger horses from a giant meteor. its ok if you dont know that you got plenty of company also earth is evaporating its water like mars did
i think we can do it, the tech just isnt that advanced yet. as for Ethical considerations, should we do it? that is answered by if it has a benefit to our species and life on Earth, not by how the individual Mammoths may be treated. id love to see them in the wild thriving, it wouldnt bother me if they were also in a zoo, nor would i think twice about even hunting one from a stable population. but alas, i dont htink we have wild territory for them. so it would be a pointless expenditure of money, all to see a furry elephant. No, it is not an Ethical use of time and money. Now....lets talk Neanderthals ;)
VHS Video Recorders are extinct. There is no habitat left for it and no use either. The same goes for bison, the hairy elephant and the pigeon with a suitcase on its back. Seems logical.
people need to learn to respect nature and stop trying to fix or change it ! everything that survived did so by adapting to it's surrounding, not by adapting it's surrounding to itself !
Not true, humans adapt their surroundings. We build shelter. There are numerous other species that build shelters. .... dramatic exclamation mark here --> !
Regarding Sergey Ziemov and the relocation of larger mammals to his Pleistocene Park, could those mammals have carried within their guts, flora and fauna, seeds and worms, not present in this new habitat, exposing native flora and funa, this is two way traffic, with new arrivals,the impact is solely upon this new location. How long do you isolate a large herbivore that eats of a wide variety of material I don't not cheap to contain and feed and house and provide vet services and antibiotics antimicrobials for, before your sure it's sterile and safe for release. Regards, stay well and curious.
You mean that never existed before. They do that, lookup glow in the dark cats. If you want a bigger difference, wait a few hundred years until science has caught up with fantasy.
The polar bear population has quadrupled since 1950, rising from 10,000 bears in 1950 to 39,000 bears today. Hardly being pushed to the brink of extinction.. Facts before narrative please!! Decided to watch this because of the subject of clone a mammoth!!!!
![Cody Johnson - I'm Gonna Love You (with Carrie Underwood) [Official Music Video]](http://i.ytimg.com/vi/yy9PuYMU29g/mqdefault.jpg)
I misread the title and thought I had slipped in to an alternative timeline where Ben Shapiro was an evolutionary biologist.
Evolution doesn't care about your feelings
That happened to me as well, except for the alternative timeline bit
i did not read the whole title before i clicked. your comment is the first one, so as i was reading your comment my eyes slowly looked up and i cracked up laughing.
ben shapario is her evil clone from an alternate timeline
@Jerry C Ben Shapiro is also the name of a conservative talk show host who has famously said very dumb and terrible things. They are calling that Ben Shapiro evil, not the one in this video
clear, concise, interesting, very engaging talk, easy to understand, no meandering, laser focus on the topic at hand yet still casual , building a momentum and keeping it up all the way through, great stuff kind of a benchmark on how it should be done
Loved the information covered in this speech, very informative. I however want to add, it would be great if Canada would ban accelerated melting of permafrost. The sloppy mass release of methane gas from the permafrost has to be staggeringly destructive to the ozone, not to mention improperly extracting rich and well preserved world history.
Great lecture. This is the best one I've seen in a while (last one is probably the black hole firewall with Sean Carroll on this channel). I usually watch physics related talks, but this was so engaging and she did a great job of conveying the concepts in laymen's terms. Hope to see more videos of this quality :)
as if all she says is true
I like Beth, she reminds me of the professor I had for Physical Anthropology a couple of years back. Really full of life and engaging.
Also, I sure was surprised to hear that horses were originally American and bison originally Asian! Seems Beringia was important in both hemispheres!
Great talk, brilliant presentation. I could listen to this lady all day
Prof Shapiro gives an amazing lecture! edit-just started reading her book of the same name. Well worth a read.
Fascinating video. The idea of de extinction is very interesting. I think Beth made a good job at explaining the science and mentioning the ethic part was mature of her. It can easily be left out as this is such an exciting project.
Agreed
she is the real live Felicity smock (arrow reference). a goofee genius.
Great job! Way better than a jet pack :-) you got my vote
This was great! Just downloaded both of her books. Can't wait!
This video burst my bubble of having a cloned Mammoth. Seems like we are decades away from even doing this.....if at all.
Dr. Shapiro just replaced Dr. Lipscomb as my power-crush.
Was the camera at the back of the hall much cheaper to operate or something? Every time she started talking about a chart of some sort, we'd see the chart for a couple of seconds, then the view cut away to the back of the hall as she talked on about the chart.
I really enjoyed this lecture. at times she is so passionate, and thought for a moment she'd shed a tear because she is emotionally connected to some efforts in this research only to come up against more road blocks
If you are going to call the period from the Eemian interglacial period some 125.000 years ago up to the present Holocene interglacial period an "ice age' then you will have to come up with a different term for the approx. 2.75m year period in which there have been numerous cycles between icy periods and warm periods.
I just keep hearing Ian Malcolm's words in my head. This woman seems to get it though. The question should be whether or not we should more than whether or not we can.
guess i'm not getting my own hairy elephant any time soon :(
now, now. as long as there is tindr there are hairy elephants for all!
Consider altering - if possible- the genetic for tusk production in modern day elephants. Either remove the tusk completely, or potentially alter the construction so that it has no use in so called medicinal remedies. Hell, lace it with a chemical that won't hurt the elephant but cause severe irritation to humans if ingested or applied to skin.
Don't forget rhino horn and tiger penis...well, maybe not tiger penis...
It's all based on superstition, so it wouldn't matter
@@BrianBattles lol. A good comment. U're a legend.
Elephant ivory isn't used primarily in folk medicine. It's used for artistic objects no of great value. Also, every elephant will someday die and the tusks are valuable. Ivory could be a sustainable resource.
Changing the Asian elephant or any other animal to survive in a different climate for whatever reason means changing them for good... crazy thought in my opinion....! Humans should not mess with this sort of thing in any species full stop. That includes humans..... Why not just protect the these and other amazing creatures period....!
I think we should focus on preserving elephants.
23:30 I've never heard of that. Does anyone know what she's talking about? I'd like to learn more about those "condensed repeat regions".
Wood Croft What Beth Shapiro calls "tighly condensed repeat regions" are generally known as "tandem repeats". In eukaryots, these are usually located at the center of a chromosome (centromere repeats), at the ends of a chromosome (telomere repeats) but can be found elsewhere.
Tandem repeats are also found in bacteria and archaea: CRISPRs (from the CRISPR/Cas9 system mentioned in the talk) are some sort of interspaced tandem repeats (CRISPR stands for clustered regularly interspaced short palindromic repeats).
Tandem repeats are not the only repetitive elements found in genomes. One must mention interspersed repeats such as transposons, retrotransposons or some introns. Actually, it is said that approximately 50% of the human genome is repetitive.
You might find interesting (it is free access): J. Duitatama et al (2014). Large-scale analysis of tandem repeat variability in the human genome. Nucl. Acids Res. 42(9):5728-5741.
I am sorry for such a long post. Best wishes!
Beniguitar94 Why is it hard to detect it? And when they publish a "complete" genome, if it's missing the tandem repeats, why do they call it "complete"?
Wood Croft Firstly, one must understand how genomes are sequenced nowadays (check out, for example, Roché 454 sequencing). Explained briefly, extracted genomic DNA is broken into fragments (300-800 base pairs in the case of 454 sequencing). Each fragment is sequenced (there are many elegant ways of doing it) and then comes the hard work: aligning these short reads (luckily they overlap) and deducing the whole sequence. It is even harder work to deduce the sequence of a tandem repeat from fragments which can get aligned in many several ways due to the repeats. You can read more about this (writen by experts) in the following link:
www.ncbi.nlm.nih.gov/books/NBK21116/
With respect to your second question, the human genome has been mapped (not sequenced), which means that we now know the sequences of all genes and their location within the genome, plus intergenic regions (in total 90% of the human genome). Nevertheless, we do not know (exactly) the sequence of centromeres or telomeres. For example, click the following link to see the sequence of the Y human chromosome:(www.ncbi.nlm.nih.gov/nuccore/568815574?report=fasta)
At the beginning of the sequence, you can read letter N (nucleotide), meaning that we don't know which nucleotide it corresponds (thought, we know the number of N's). If you drag your mouse down, suddenly, you will notice that sequence starts to appear (written in As, Cs, Gs, Ts).
So the real question is, should we call "complete" a genome that has been mapped? In the days when the Human Genome Project was launched, non-genic genes (non-coding regions) where considered junk DNA. In that sense, it wasn't misleading to say "we know the complete genome". In the modern world, we are starting to grasp the essential function of so called junk DNA (we know call it noncoding DNA, which is more respectful).
So my amateur opinion is that it is not at all complete and that it shouldn't be called that way.
Telomeres...
de-extinction of mammoth and then ? how do you create a self sustaining diverse gene pool for this species?
BOOORING!!! GIMME MAMMOTH NOW!!! ...jk a highly enlightening and well-delivered speech which provided the answers I clicked for.
Potentially adapt humans and other organisms for the rigorous environments of other atmospheres
It's now the end of 2022, 7 years after this talk- and I still cannot buy a ticket to Pleistocene Park. I am feeling very let down.
Why does the clip at 1:17 min give me the feeling like its straight out of a cheap horror movie.
what if you can get all the dna pussels from other mammoths dna ? so if one mammoth is missing some dna but maybe another mammoth have this missing dna data can you put them together maybe ?
i mean ! lets say !"this mammoth is missing the dna for the nervsystem , but you have more than 1 mammoth so maybe another mammoth will have this missing Dna for the nervsystem" !
Hans Henrik Büttner so and extreme jig saw puzzle???
That was fantastic and you are incredible! Thanks so much!
The graph is only representative of a minute of the deep time of Earth
Changing the Asian elephant to survive in a different climate means changing the Asian elephant... crazy thought in my opinion....! Humans should not mess with this sort of thing in any species full stop. That includes humans..... Why not just protect the Asian elephant and other creatures period....!
seent that mosquito pic, its just like that in parts of alaska. the buzzing will drive you mad.
This was brilliant
Spider goats have existed for how many decades?
As far as farm produce there is gmo everything.
Mammoths shouldn’t be that difficult.
Talks eloquently for an hour without correcting herself, restarting a sentence, even without a single "uhm..." We need more humans like this.
If you could adapt an animal for life on another planet it would be a black footed ferret, so cute. Which animal would you choose?
I LOVE this talk so much!!!
she's a good story teller!
American Chestnut trees!
There was no need for a land bridge between Canada and Russia to foster migration. Animals could cross quite easily over the ice bridge that existed during glacial times.
Clone it fast!
To add on to her Black-Footed Ferret story; Revive and Restore have cloned a Black-Footed Ferret from the Frozen Zoo!!
9 years later and no mammoth steaks in the supermarkets !
i enjoyed this beth thank you:)
35:21 Time to dope with the woolly mammoth Hb during the next winter olympics.
Fabulous!!!!
No discussion on younger dryas impact on mega fauna extinction
This lady *applies* herself, it's amazing
Brilliant in many ways, but mostly she is so hilarious that I could listen to her for hours!
So, nobody has a problem with them destroying huge patches of land by washing away the permafrost?
She's made it pretty clear that it's people digging for gold doing this and the scientists are just there to pick up the interesting bits that happen to wash out. Same as when fossils are found in quarries or construction sites. I'm also fairly certain the scale is so small as to be basically irrelevant.
they found remains of a mammoth 4 thousand year old on a island
well said
Would be so cool to have Mammoths 2.0, elephants reloaded :D
I want a sabre kitty cat.
I say get one of them hairy elephants and clone the sucker. It's bound to lead to nothing but good things.
Would it be at all important to make things easy and keep species from going extinct in the first place?
Manmoth
Is she related to Ben Shapiro?
this is like saying, we should not keep animals from going extinct because there in the way of people.
Wow 5 years old. Little did she knew that we would already clone a baby mammoth in 2020.
Fun fact: African elephant are older and bigger than mommoth
Just clone it
They need all the DNA first
I'm surprised she refers to Michael Mann Hockey Stick graph. That was thoroughly debunked upon it's very FIRST systematic peer review. It has been so discredited, even Gore denies ever using it, though he clearly did.
If we do this once, someone will make a pair of T-Rex's and we're screwed.
Why not the Dino chicken why a big furry elephant
Re Jurassic Park, it needed to be frog DNA so that the plot point would work where some of the dinosaurs changed sex, allowing them to breed. A bloody stupid reason, but still a reason.
Long story short no mammoth until matrix style birthing chambers and full genetic genome building machine is invented. Or an advanced 3d printer that makes an organism instead of growing one. Instead use the technology that is available to stop extinction of all creatures in its path. Very interesting video though had me hooked till the end.
Tasmanian Tiger?
Get on with it.
of course its a good idea , its the cost thats matters
De-extinguish
Everytime is see the lectures at the R I ,, i always tell myself , that the wrong people are ruling the world, We place trust in our politicians, and governments, but it should be the top scientists, that should rule the world!
Bet she must be fun at house parties, emegin if you could use the energy she expells to generate power, she could power the states for years to come.
Really, the problem with elephants is that they can't live in Siberia.
If they could, we wouldn't have to protect them from habitat destruction, because there'd be more than enough habitat.
maybe they could live there in summer and would gradually reevolve o mammoth-like
yes,yes.yes..........
Here's a thought...mammoths didn't live in arctic conditions.
I think no doubt they should clone a mammoth asap.
what if we create a Neanderthal and start all over agin
@Feiner Fug yes mutations will arise agin such as humans are changing, evolution is still going on ,on humans
@Feiner Fug no they came about fromr humans why there is evidence from them in human now days thye broke off over a milling years ago more as a specialist in cold weather. last ice age wiped so many things out killing mammoths saber tooth tiger horses from a giant meteor. its ok if you dont know that you got plenty of company also earth is evaporating its water like mars did
Feiner Fug A milling years are a milling years, you cannot doubt that.
FUNNY PART 16:00
Yes, we probably could. No, we definitely should not.
{:-:-:}
i think we can do it, the tech just isnt that advanced yet. as for Ethical considerations, should we do it? that is answered by if it has a benefit to our species and life on Earth, not by how the individual Mammoths may be treated. id love to see them in the wild thriving, it wouldnt bother me if they were also in a zoo, nor would i think twice about even hunting one from a stable population.
but alas, i dont htink we have wild territory for them. so it would be a pointless expenditure of money, all to see a furry elephant.
No, it is not an Ethical use of time and money. Now....lets talk Neanderthals ;)
Very important ethical questions she brings up.
VHS Video Recorders are extinct. There is no habitat left for it and no use either. The same goes for bison, the hairy elephant and the pigeon with a suitcase on its back. Seems logical.
Hey I have my father old recorder with lots of vhs. Speak for your self.
people need to learn to respect nature and stop trying to fix or change it ! everything that survived did so by adapting to it's surrounding, not by adapting it's surrounding to itself !
Not true, humans adapt their surroundings. We build shelter. There are numerous other species that build shelters. .... dramatic exclamation mark here --> !
Superglue a few mink coats to an average Asian Elephant and you're good to go. 🐘
the hockey stick theory has been totally debunked as the numbers were manufactured... bummer to see that she used it...
she is so delightfully awkward.
Regarding Sergey Ziemov and the relocation of larger mammals to his Pleistocene Park, could those mammals have carried within their guts, flora and fauna, seeds and worms, not present in this new habitat, exposing native flora and funa, this is two way traffic, with new arrivals,the impact is solely upon this new location. How long do you isolate a large herbivore that eats of a wide variety of material I don't not cheap to contain and feed and house and provide vet services and antibiotics antimicrobials for, before your sure it's sterile and safe for release. Regards, stay well and curious.
Yeah, yeah, yeah, its been "cloned" for 50 years :-)
Derrrrrrrrrrrrrr!
maybe make a species ever existed before
You mean that never existed before. They do that, lookup glow in the dark cats. If you want a bigger difference, wait a few hundred years until science has caught up with fantasy.
@@MrMichiel1983 cats are known species, something unknown
She pretty :3
Just recreate them in a computer and leave it at that.
That photo of the boat on the dry lake bed is Poyang lake in China. It wasn'r caused by climate change, it was caused by the Three Gorges dam.
Don't get in the way of a California lefty and their climate alarmism.
Can I de-divorce you?
They went extinct, leave them there.
22:15 - For all those looking for Ben Shapiro.
:D
The day of the mammoth is gone and should stay that way.
Theres 7 films demonstrating why this is a bad idea.
The polar bear population has quadrupled since 1950, rising from 10,000 bears in 1950 to 39,000 bears today. Hardly being pushed to the brink of extinction.. Facts before narrative please!! Decided to watch this because of the subject of clone a mammoth!!!!