Anti psychotic Drugs Part 2 - Classification - CNS Pharmacology

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Anti psychotic Drugs Part 2 - Classification - CNS Pharmacology
Antipsychotics are a heterogeneous group of substances used primarily to treat schizophrenia, psychosis, mania, delusions, and states of agitation. The term neuroleptics was formerly used interchangeably with antipsychotics because early antipsychotic drugs induced apathy, quiescence, and reduced psychomotor activity, but newer antipsychotic drugs no longer have these effects. The antipsychotic effect of first-generation (typical) antipsychotics (e.g., haloperidol) is based on D2 antagonism, while second-generation (atypical) antipsychotics interact with several receptors (e.g., D2, D3, D4, 5-HT). Extrapyramidal symptoms, which include acute dystonia, akathisia, and tardive dyskinesia, are the most common side effects of first-generation antipsychotics. Metabolic side effects (e.g., weight gain, insulin resistance), on the other hand, are more typical of second-generation antipsychotics. A potentially life-threatening side effect of both first-generation and second-generation antipsychotics is neuroleptic malignant syndrome, which manifests with fever, muscle rigidity, autonomic instability, and mental status changes.
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[@aamirkhan-yz2fk]

well teaching style with clear voice... but have one suggestion, there is no any word of 'shizophrenia' actually it will be schizophrenia , if u don't mind sir.....

[@chekkahemanthkumar2910]

You can spell as you want no need to suggest

[@surajkaranje3916]

Typical Antipsychotics blocks D2 receptors only , less antogonism on 5HT2
Atypical along with D2 antagonism, block 5HT2 (serotonin) with more potency than Typical therefore less EPS...
Please make correction ,
source First aid 2022 and Uworld 2022.

[@anaskpmohamed2984]

Thankyou sir

[@mayankbhargava9911]

Sir penfluridol tablet is not available in currently in india....Every brand has refused to provide this crucial tablet which my father takes...Pls help me

[@imalokhan7295]

Dr sahib ibs par aik video

[@jarnaildhindsa4531]

Sir 5htp1a receptor partial agonist bind to increase serotonin release sir answer

[@arunpandian5864]

Sir, normaly when we Dopamine is high in psychosis
Due to D2 receptor with Gi activity,
When we give D2 agoinst it activates DE receptor and results inhibitory effect
But we are giving D2 receptor blockers if then, Gi activity is blocked then dop activity increase na ??
Clear this doubt sir

[@thinkstudio1997]

Typical antipsychotic will not block Serotonin receptors

[@babayhendrayani7728]

Thats true

[@rajivdas8185]

You are really a genius.your lectures are very easy to understand

[@doctorbhanuprakash]

Glad to hear that

[@RohitSingh-gp7qx]

Thank u sir 🙏

[@sridharanabathula8126]

Excellent

[@dusktilldawn6449]

Thnk you sr

[@hamidalsaier9628]

thanks Sir im following u from sudan

[@fatimafarooq1032]

Sir which book you follow??

[@shrabaniray6968]

Sir...Please continue to teach us...

[@uzairhamdam377]

Thank you so much for

[@bediptadas7395]

Thank you ❤️

[@59shayestakhan81]

amazing lecture...thankyou sir

[@shajilak9429]

Excellent class

[@imalokhan7295]

Ibs. Par video

[@drganeshm1575]

Tq sir

[@sajjadali496]

The lecture was fantastic...

[@irshatha6235]

Good lecture thanks sir,

[@doctorbhanuprakash]

🤝🤝🤝