Thanks! Two more parts coming, one on how to compute LD by hand (not too necessary to know, but interesting) and how to compute LD in PLINK (useful to know)
@@GenomicsBootCamp Today I came across something called imputation of un-typed SNPs. Would you please expound on its significance and if possible how to do it in association studies?
Thanks for your comment! LD is usually not as much in the spotlight, compared to other topics in genomics, but I feel it is important to understand it. It is directly connected to almost all the other concepts in genomics, so I usually talk about it early on.
Tried to refresh this concept in a while. Some tips: use a numeric example, by filling the table with values. Also fix the notation, it is not a hat in the observe allele frequencies. I hope that helps.
Thank you for the great explanation. I just do not get the advantage of D prime, when you say, that if allele frequencies = similar, a high D' means the markers = good surrogates for each other. Could you or anyone maybe explain this to me? THank you
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Best explanation I've ever seen, thank you so much, very complete and comprehensive.
Great videos. Hope to see more similar contents and contents regarding GWAS
Very comprehensive, I have watched the video more than once, and I have to do so severally to actually understand this LD. Great job sir.
Thanks! Two more parts coming, one on how to compute LD by hand (not too necessary to know, but interesting) and how to compute LD in PLINK (useful to know)
@@GenomicsBootCamp Today I came across something called imputation of un-typed SNPs. Would you please expound on its significance and if possible how to do it in association studies?
@@georgewanjala4605 Both imputation and GWAS related tutorials are planned in the future, but the exact timing of these is unclear right now.
Thank you for the detailed explanations on LD! Very grateful for this
Thanks for your comment! LD is usually not as much in the spotlight, compared to other topics in genomics, but I feel it is important to understand it. It is directly connected to almost all the other concepts in genomics, so I usually talk about it early on.
Tried to refresh this concept in a while. Some tips: use a numeric example, by filling the table with values. Also fix the notation, it is not a hat in the observe allele frequencies. I hope that helps.
Great sir
Thank you for the great explanation.
I just do not get the advantage of D prime, when you say, that if allele frequencies = similar, a high D' means the markers = good surrogates for each other.
Could you or anyone maybe explain this to me?
THank you
hello, thank you for this excellent video but I couldn't understand LD decay.