I love your channel. Have accessed your helpline as well and want to publicly thank John for his feedback he gave me with regard to my particular circumstance. Thank you for providing your time and such outstanding content for this community. God bless you Alex, Dr. Scholtz and all of your staff and volunteers!
I’m just over half way through External Beam radiation, 11 down, 9 to go. Once it’s all done, it’s fingers crossed, that the cancer is cured. So far, no side effects. Getting the bladder ready, before each session is such a tricky thing to do. So, far I’ve got it right 10/11.
I know how you feel. I’m 18/24, just 10 to go. The daily drive is getting close to ending. After two months they’ll take my PSA and go from there. Good luck on your final treatments. 🙏🏽
Very timely as I was recently diagnosed with Prostate cancer w/ Mets, Gleason 8. Been on hormone therapy of Casodex and Lupron. Beginning IMRT next week after completing radiology simulation yesterday. Looking for a reliable gauge of cancer after IMRT before any chemotherapy. PSMA PET scan at UCSF looks to be a good step before advancing onto chemo. Very informative and detailed videos help in understand and discussing available treatment therapies with my doctors. Thank you!
Thank you! We hope everything goes well, and if you have any questions, feel free to get in touch with our free helpline. You can find our contact information here: pcri.org/helpline UCSF is a great institution!
My urologist is strongly recommending surgery b/c of what he calls cockroach cells - cancer that escaped the radiation. According to Dr scholz this is not an issue, but actually that the cancer had metastasized beyond the prostate. So When you have a recurrence after radiation does that mean that it's not from within the prostate itself? And why does the oncologist also recommend hormone therapy if the radiation has eliminated the cancer cells?
Hi , Please help with this question. If psa score drops to 0.15 just by AA and Firmagon within three months of starting medication and diagnosis of advance prostate cancer, in this case Chemo is still needed? If so, whats the use of chemo in this case? Please help
Hello, we have a video discussing a clinical trial out of France (search "PCRI ASCO 2021") that is looking at men with metastatic castrate-sensitive prostate cancer. Among other things, it compared treating these men with ADT (e.g. Firmagon), a 2nd generation anti-androgen (e.g. abiraterone), and then chemotherapy only after the PSA started progressing while on the two former medications versus treating them with ADT, and 2nd generation hormone therapy, and chemotherapy, all upfront, and the men who had chemotherapy upfront had longer survival than the ones who waited for their PSA to progress. The idea is that if there is any detectable PSA, there is still likely ongoing cancer activity, and chemotherapy attacks cancer by a different mechanism than ADT and second-generation anti-androgens. If there is still cancer after ADT and 2nd generation anti-androgen, then those cells are somehow resisting those treatments, and hopefully chemotherapy will be able yo eradicate them or weaken the cancer enough to delay relapse. It is not known exactly why the patients in that study had longer survival when they had the chemo upfront as opposed to waiting for the PSA to progress, but the most common theory is that it is always best to attack cancer when it is at its smallest volume, before it is able to grow, because growing cancer increases the possibility of mutations, some of which can cause resistance to treatments like ADT and chemotherapy. We also have a helpline that might be able to provide you with more information if you are interested. Our contact information is at pcri.org/helpline.
I have been made a redical ropotic prostactonomy but when I made a PSA test I found that is high but I am using presolone table because I am suffering from asthma when I do not use the presolone the PSA got down so I had made PSMA PET SCAN and there was negative so I found that the presolone table is getting high the PSA THIS THING HAPPENED TO ME TIWCE and in any once I made PSMA PET SCAN AND THE RESULTS WERE NEGATIVE
What are your thoughts on the NanoKnife? Would it be an option for salvage treatment after EBRT+ HDR Brachy treatment has failed and the PSMA scan shows no metastasis outside the gland itself. Thanks for these videos. They are very educational.
I've a question that's a little of sync, I had an Mri scan of my prostate and I was told I had a pi rads 4, I was told there was nothing outside the prostate and everything else was clear, I underwent a random plus targeted biopsy where 16 cores were taken, I got results back last week and all 16 cores returned benign, I'm a 49 year old man with a psa of 2.6 but was also told my prostate is large at 32cc, I'm just wondering can you advise me on what I should do now. thanks for your very helpful videos.
Hello, I will add this to our list of questions for future videos. Dr. Scholz has addressed similar questions before, and his suggestion was to get a repeat MRI about a year later to see if anything has changed from the original MRI, but I am not sure how that might work with your insurance, and I am also not sure if he would recommend anything else like the 4K test or anything like that, for example. So hopefully, we will have a video out soon addressing it, but in the meantime, our helpline might be able to provide you with some information. You can find our contact information at PCRI.org/helpline.
At just after 11:00 in the presentation, they begin talking about Provenge... Dr. Scholz concludes that Provenge would almost surely be effective in those with mCSPC... but the FDA has only approved it for mCRPC... so no insurance company will pay for treatment with Provenge in mCSPC!
Yeah, it's unfortunate. The FDA will typically only approve treatments for situations that have been studied in rigorous phase III trials, and since they are expensive to conduct, there have not been any done in castrate-sensitive disease yet. Strangely, there is actually an ongoing trial using Provenge in men on active surveillance (who generally aren't at risk of from prostate cancer related morbidity or mortality, even without treatment) and it is expected to be finished in 2023. (I say strangely because one might expect investigations to go to metastatic castrate-sensitive disease, the next most urgent situation behind castrate-resistant disease, rather than to men with a mostly benign condition.) However, the results of that trial could potentially open the door for its earlier use by showing that is useful earlier in the disease course, but we will have to wait and see (which may not be much comfort to those who could benefit from it now).
If PSMA shows cancer in the prostate but nothing outside, would you conclude the patient does produce PSMA, thus the negative metasteses finding likely accurate?
I will add this to our list of questions for Dr. Scholz to address in future videos. In the meantime, we have a free helpline that may be able to provide you with information based on your individual case. Our contact information can be found at pcri.org/helpline We have some other videos discussing PSMA PET scans with doctors like Eugene Kwon, MD and Thomas Hope, MD that may provide some more information for you. Based on what they have said, there is the risk that metastases could be too small to be seen on a scan. The lack of metastases on the scan would, however, lower the probability of there being anything outside the prostate. The doctor's interpretation of the scan may also depend on other features of the cancer, like the Gleason score, for example. Dr. Kwon and Dr. Hope have discussed that with higher Gleason scores, there is a higher risk of cancer becoming heterogeneous, with some cancer cells producing PSMA and others that do not. That is, however, typically a rare situation, especially outside of advanced cases, and I have not seen them discuss it in the context of the scenario that you are describing. I would think (as someone who is not a doctor) that if the cancer within the prostate was producing PSMA, at least some of the metastases (if there were any) would also be producing PSMA, but I am not totally sure, and there are always anomalies in the prostate cancer world. Hopefully, we can get Dr. Scholz to discuss your question further and we can get a video out on it in the near future. Here are some of the longer videos we have on PSMA PET and how it affects treatment decisions. Dr. Hope is a radiologist and will talk less about treatment, but Dr. Kwon is an expert in radiology and in the treatment of prostate cancer, and so he discusses both. Eugene Kwon, MD at 2021 PCRI Conference: ruclips.net/video/DhxSwN3-5jw/видео.html Eugene Kwon, MD at 2022 Mid-Year Update: ruclips.net/video/UzlPnqaAHZg/видео.html Thomas Hope, MD at 2021 Mid-Year Update: ruclips.net/video/mQzpdvLBeVM/видео.html And again, feel free to get in touch with our helpline. They are more knowledgeable than me and can hopefully help you formulate some good questions to discuss with your medical team.
I've been following this channel for over 15 months now. My PSA had spiked over a year ago. Lots of good information here. I've got your book too Dr. Schulz, "Invasion of the Prostate Snatchers". It was a great read. My personal care physician had done a PSA and it was high. I don't recall now what it was at the time but it was high enough to be concerned. He had been through a prostatectomy himself and recommended seeing a Urologist. The Urologist repeated the test and found the same. He wanted to immediately do random biopsy. That kind of freaked me out. I began researching and found this channel. I sought out a second opinion. The second Urologist was much of a mind like Dr. Schulz. He ordered some other tests. They were negative. I was asked to come back in 6 mo and my PSA was way down. Came back again after another 6 mo and PSA was 1.3. This second Urologist said his own PSA runs about 0.9 and for someone my age 72 yo 1.3 was excellent. He felt sure my elevated PSA was likely due to mild infection at the time. I was relieved. He wants me back in 12 months and says he'll continue to test me until I'm 75. Question: is this typical to stop PSA testing at 75 or is my Urologist also in a sense suggesting I likely don't have too much to worry about. He did tell me too at my previous visit to choose a different disease to be worried about. I pray he's correct. Thank you Dr. Schulz and Alex and PCRI for giving me courage and for all the help you've given me through your RUclips channel.
My father has prostate cancer gleason 9 stage4. He has completed his cycle of chemotherapy. Now he is suffering from joint pain. I wanted him to try a tbsp of chia seeds everyday. But the data on internet is confusing me. Will chia seeds be good for him?
Please please help my daddy he is in Kenya and he was diagnosed 4+4 in late march,till no treatment,please help he just turned 74,and he hasn't yet meet his new nephew,please help please
Do you have any information on this possible new treatment? Would it work on Prostate cancer? 100% of Cancer Patients in Remission After Monoclonal Antibody Trial: 'Tumors just vanished' - RUclips .
That trial was conducted on 12 patients who all had localized disease and a rare genetic mutation that prevented the cancer from repairing itself. There is actually already a drug, Keytruda, being used in prostate cancer for men with the genetic mutation microsatellite instability, but only about 1% of prostate cancer patients have this mutation. Keytruda works by a different mechanism than the one used in that trial, but it exploits a similar phenomenon in that the mutation prevents the cancer from repairing itself. Hopefully, these kinds of drugs will continue being developed and can be effectively used in more and more people.
![Digital Circus Episode 4 [TRAILER]](http://i.ytimg.com/vi/abZtsmMUbJo/mqdefault.jpg)
I love your channel. Have accessed your helpline as well and want to publicly thank John for his feedback he gave me with regard to my particular circumstance. Thank you for providing your time and such outstanding content for this community. God bless you Alex, Dr. Scholtz and all of your staff and volunteers!
I’m just over half way through External Beam radiation, 11 down, 9 to go. Once it’s all done, it’s fingers crossed, that the cancer is cured. So far, no side effects. Getting the bladder ready, before each session is such a tricky thing to do. So, far I’ve got it right 10/11.
I know how you feel. I’m 18/24, just 10 to go. The daily drive is getting close to ending. After two months they’ll take my PSA and go from there. Good luck on your final treatments. 🙏🏽
@@gr8ride411 I had my final treatment on 30 May. So glad it’s all over. Good luck to you too.
Very timely as I was recently diagnosed with Prostate cancer w/ Mets, Gleason 8. Been on hormone therapy of Casodex and Lupron. Beginning IMRT next week after completing radiology simulation yesterday. Looking for a reliable gauge of cancer after IMRT before any chemotherapy. PSMA PET scan at UCSF looks to be a good step before advancing onto chemo.
Very informative and detailed videos help in understand and discussing available treatment therapies with my doctors. Thank you!
Thank you! We hope everything goes well, and if you have any questions, feel free to get in touch with our free helpline. You can find our contact information here: pcri.org/helpline
UCSF is a great institution!
Very helpful info.
Wow , This info is long overdue.
My father psa 0.02 after chemo+hormone therapy+aberiatrone
Sir
Please talk about zoledronic acid injection for bones. My father has been advised to get injected every month.
My urologist is strongly recommending surgery b/c of what he calls cockroach cells - cancer that escaped the radiation. According to Dr scholz this is not an issue, but actually that the cancer had metastasized beyond the prostate. So When you have a recurrence after radiation does that mean that it's not from within the prostate itself? And why does the oncologist also recommend hormone therapy if the radiation has eliminated the cancer cells?
Hi , Please help with this question. If psa score drops to 0.15 just by AA and Firmagon within three months of starting medication and diagnosis of advance prostate cancer, in this case Chemo is still needed? If so, whats the use of chemo in this case? Please help
Hello, we have a video discussing a clinical trial out of France (search "PCRI ASCO 2021") that is looking at men with metastatic castrate-sensitive prostate cancer. Among other things, it compared treating these men with ADT (e.g. Firmagon), a 2nd generation anti-androgen (e.g. abiraterone), and then chemotherapy only after the PSA started progressing while on the two former medications versus treating them with ADT, and 2nd generation hormone therapy, and chemotherapy, all upfront, and the men who had chemotherapy upfront had longer survival than the ones who waited for their PSA to progress. The idea is that if there is any detectable PSA, there is still likely ongoing cancer activity, and chemotherapy attacks cancer by a different mechanism than ADT and second-generation anti-androgens. If there is still cancer after ADT and 2nd generation anti-androgen, then those cells are somehow resisting those treatments, and hopefully chemotherapy will be able yo eradicate them or weaken the cancer enough to delay relapse. It is not known exactly why the patients in that study had longer survival when they had the chemo upfront as opposed to waiting for the PSA to progress, but the most common theory is that it is always best to attack cancer when it is at its smallest volume, before it is able to grow, because growing cancer increases the possibility of mutations, some of which can cause resistance to treatments like ADT and chemotherapy.
We also have a helpline that might be able to provide you with more information if you are interested. Our contact information is at pcri.org/helpline.
I have been made a redical ropotic prostactonomy but when I made a PSA test I found that is high but I am using presolone table because I am suffering from asthma when I do not use the presolone the PSA got down so I had made PSMA PET SCAN
and there was negative so I found that the presolone table is getting high the PSA
THIS THING HAPPENED TO ME TIWCE
and in any once I made PSMA PET SCAN AND THE RESULTS WERE NEGATIVE
What are your thoughts on the NanoKnife? Would it be an option for salvage treatment after EBRT+ HDR Brachy treatment has failed and the PSMA scan shows no metastasis outside the gland itself. Thanks for these videos. They are very educational.
I've a question that's a little of sync, I had an Mri scan of my prostate and I was told I had a pi rads 4, I was told there was nothing outside the prostate and everything else was clear, I underwent a random plus targeted biopsy where 16 cores were taken, I got results back last week and all 16 cores returned benign, I'm a 49 year old man with a psa of 2.6 but was also told my prostate is large at 32cc, I'm just wondering can you advise me on what I should do now. thanks for your very helpful videos.
Hello,
I will add this to our list of questions for future videos. Dr. Scholz has addressed similar questions before, and his suggestion was to get a repeat MRI about a year later to see if anything has changed from the original MRI, but I am not sure how that might work with your insurance, and I am also not sure if he would recommend anything else like the 4K test or anything like that, for example. So hopefully, we will have a video out soon addressing it, but in the meantime, our helpline might be able to provide you with some information. You can find our contact information at PCRI.org/helpline.
At just after 11:00 in the presentation, they begin talking about Provenge... Dr. Scholz concludes that Provenge would almost surely be effective in those with mCSPC... but the FDA has only approved it for mCRPC... so no insurance company will pay for treatment with Provenge in mCSPC!
Yeah, it's unfortunate. The FDA will typically only approve treatments for situations that have been studied in rigorous phase III trials, and since they are expensive to conduct, there have not been any done in castrate-sensitive disease yet.
Strangely, there is actually an ongoing trial using Provenge in men on active surveillance (who generally aren't at risk of from prostate cancer related morbidity or mortality, even without treatment) and it is expected to be finished in 2023. (I say strangely because one might expect investigations to go to metastatic castrate-sensitive disease, the next most urgent situation behind castrate-resistant disease, rather than to men with a mostly benign condition.) However, the results of that trial could potentially open the door for its earlier use by showing that is useful earlier in the disease course, but we will have to wait and see (which may not be much comfort to those who could benefit from it now).
@@ThePCRI What is the name of the trial that you mention?
If PSMA shows cancer in the prostate but nothing outside, would you conclude the patient does produce PSMA, thus the negative metasteses finding likely accurate?
I will add this to our list of questions for Dr. Scholz to address in future videos. In the meantime, we have a free helpline that may be able to provide you with information based on your individual case. Our contact information can be found at pcri.org/helpline
We have some other videos discussing PSMA PET scans with doctors like Eugene Kwon, MD and Thomas Hope, MD that may provide some more information for you. Based on what they have said, there is the risk that metastases could be too small to be seen on a scan. The lack of metastases on the scan would, however, lower the probability of there being anything outside the prostate. The doctor's interpretation of the scan may also depend on other features of the cancer, like the Gleason score, for example. Dr. Kwon and Dr. Hope have discussed that with higher Gleason scores, there is a higher risk of cancer becoming heterogeneous, with some cancer cells producing PSMA and others that do not. That is, however, typically a rare situation, especially outside of advanced cases, and I have not seen them discuss it in the context of the scenario that you are describing. I would think (as someone who is not a doctor) that if the cancer within the prostate was producing PSMA, at least some of the metastases (if there were any) would also be producing PSMA, but I am not totally sure, and there are always anomalies in the prostate cancer world. Hopefully, we can get Dr. Scholz to discuss your question further and we can get a video out on it in the near future.
Here are some of the longer videos we have on PSMA PET and how it affects treatment decisions. Dr. Hope is a radiologist and will talk less about treatment, but Dr. Kwon is an expert in radiology and in the treatment of prostate cancer, and so he discusses both.
Eugene Kwon, MD at 2021 PCRI Conference: ruclips.net/video/DhxSwN3-5jw/видео.html
Eugene Kwon, MD at 2022 Mid-Year Update: ruclips.net/video/UzlPnqaAHZg/видео.html
Thomas Hope, MD at 2021 Mid-Year Update: ruclips.net/video/mQzpdvLBeVM/видео.html
And again, feel free to get in touch with our helpline. They are more knowledgeable than me and can hopefully help you formulate some good questions to discuss with your medical team.
@@ThePCRI Thanks. Very helpful. It would be nice if cancer was tidy and predictable.
This sounds like Brachytherapy is a good option. Very specific area with a higher dose.
I've been following this channel for over 15 months now. My PSA had spiked over a year ago. Lots of good information here. I've got your book too Dr. Schulz, "Invasion of the Prostate Snatchers". It was a great read.
My personal care physician had done a PSA and it was high. I don't recall now what it was at the time but it was high enough to be concerned. He had been through a prostatectomy himself and recommended seeing a Urologist. The Urologist repeated the test and found the same. He wanted to immediately do random biopsy. That kind of freaked me out. I began researching and found this channel. I sought out a second opinion. The second Urologist was much of a mind like Dr. Schulz. He ordered some other tests. They were negative. I was asked to come back in 6 mo and my PSA was way down. Came back again after another 6 mo and PSA was 1.3. This second Urologist said his own PSA runs about 0.9 and for someone my age 72 yo 1.3 was excellent. He felt sure my elevated PSA was likely due to mild infection at the time. I was relieved. He wants me back in 12 months and says he'll continue to test me until I'm 75.
Question: is this typical to stop PSA testing at 75 or is my Urologist also in a sense suggesting I likely don't have too much to worry about. He did tell me too at my previous visit to choose a different disease to be worried about. I pray he's correct.
Thank you Dr. Schulz and Alex and PCRI for giving me courage and for all the help you've given me through your RUclips channel.
I have 3+4=6 prostate cancer in one core out of 15 less then 5% grade1. My doctor wants to put me on casodex Is this a good idea for low grade cancer
My father has prostate cancer gleason 9 stage4.
He has completed his cycle of chemotherapy.
Now he is suffering from joint pain.
I wanted him to try a tbsp of chia seeds everyday.
But the data on internet is confusing me. Will chia seeds be good for him?
Please please help my daddy he is in Kenya and he was diagnosed 4+4 in late march,till no treatment,please help he just turned 74,and he hasn't yet meet his new nephew,please help please
Our helpline might be able to provide you with some good information. You can find our contact information at pcri.org/helpline.
Do you have any information on this possible new treatment? Would it work on Prostate cancer? 100% of Cancer Patients in Remission After Monoclonal Antibody Trial: 'Tumors just vanished' - RUclips .
That trial was conducted on 12 patients who all had localized disease and a rare genetic mutation that prevented the cancer from repairing itself. There is actually already a drug, Keytruda, being used in prostate cancer for men with the genetic mutation microsatellite instability, but only about 1% of prostate cancer patients have this mutation. Keytruda works by a different mechanism than the one used in that trial, but it exploits a similar phenomenon in that the mutation prevents the cancer from repairing itself. Hopefully, these kinds of drugs will continue being developed and can be effectively used in more and more people.
@@ThePCRI thanks for the reply.