Neurologist Explains Bruce Willis and Primary Progressive Aphasia
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- Опубликовано: 11 сен 2024
- It was announced that American actor Bruce Willis has retired from acting due to aphasia. This video explains aphasia and a rare neurodegenerative disease called primary progressive aphasia (cause, epidemiology, prognosis). All sources of this video are public, and I am not making a diagnosis in any individual.
Sources:
Bruce Willis sold nearly $65M of property as his health declined: pagesix.com/20...
Clinical trials.gov site for primary progressive aphasia: www.clinicaltr...
Vasectomy in Men With Primary Progressive Aphasia: journals.lww.c...
Typical and atypical pathology in primary progressive aphasia variants: www.ncbi.nlm.n....
Relapse in stuttering with the onset of primary progressive aphasia: pubmed.ncbi.nl...
Semantic Variant Primary Progressive Aphasia: Practical Recommendations for Treatment from 20 Years of Behavioural Research: • How Much Does Race Aff...
Primary progressive aphasia: clinicopathological correlations: www.ncbi.nlm.n....
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.
My Dad was diagnosed with PPA 8 years ago. It’s a very distressful disease. I immediately thought of it as the cause of Bruce Willis’ aphasia symptoms as it was reported to be progressive. So sad
It's very nice to hear your perspective and kind words of Bruce Willis. Of course the entire content of this video was educational for me, as I know of someone with this condition, and it's hurtful for me to witness.. I can't imagine how frustrating it is for them. Thank-You.
My mother had PPA..She started showing symptoms at the age of 58 in 1998/99, she was diagnosed in 2001, we enrolled her in a study at the Mayo Clinic for 3 years, she passed away in 2008, cause was (Aspiration) It is a heartbreaking disease!
Thank you for sharing. Hopefully we will see effective treatments soon.
Yes. My husband's Dr said ppa pts usually die from a pneumonia, due to aspiration
Fascinating information. 👏 The brain is so interesting. Really appreciate your expertise and understanding.
Thanks Joni
He suffered a head injury on set back in 2003 which caused a TBI. I can't help but think that this is a contributing factor here.
Amazing video 👏🏾👏🏾👏🏾
Thanks
Thanks for explaining this Dr. Beaber. I’d be interested in hearing your thoughts on Robin Williams and his Lewy Body Dementia.
Thanks for the video suggestion. I'll make a note of it.
Yes..celebrity suffer degenerative disease just like the public..everyone knows Lou Gehrig had ALS but so did actor Sam Shepard and David Niven..and Linda Ronstadt suffers from PsP.
This video was so informative . Thank you
Thanks
My hubby has FTD with expressive aphasia becoming primary progressive. His journey began with a horrible psychosis, delusional jealousy, that was finally (2 years) diagnosed as mixed dementia and then getting the right meds after about 6 months of trial and error. Rediagnosed to FTD a few years later. He's doing well except for loss of words now.
Sorry you went though this, but I'm glad he's doing better now.
Way before my MS diagnosis, I was begging everyone to speak more slowly. For years, I've had trouble "spitting out" sentences fluently. People ask if I'd rather speak in English than in Hebrew, and my standard reply is, "No thanks, I stammer equally well in both languages". I'm a whole lot better with writing, though. Hate to hear about progressive holes in my brain. Happy, at least, to have contradicted the previous diagnosis of "Undefined Personality Disorder". 🤭
Is there any evidence that PPA can be caused by repeated concussions? My ex husband, sadly has PPA and also had three severe head injuries playing sports in his youth. When I met him, he was 35 and he always spoke very slowly. He started developing word retrieval issues and began speaking even more slowly at around the age of 52. Very sad - I hope more funding gets channeled for research . Thank you.
I lost my sense of smell/taste at least 10 years ago. Could this possibly be related to a dementia?
My mother is suffering from PPA, probably non fluent according to your explanation. We went to several professors in neurology and neurosurgery without any actual benefit. Do you recommend any of the experimental treatments that you mentioned or any ongoing promising trials for the cure of the disease? Please answer as I am very thankful for the insight in your video and hopefully that I hear an answer from you.
EXCELLENT
Thanks
Great video.
thanks
Hello doctor,
I'm stuck with a hard decision that I can't find an answer.
I was diagnosed 7 months ago with Aggressive RRMS and I'm taking Rituximab.
Next month I'm going to travel to Germany where they have more medication for MS (I live in Iraq and we don't have a lot of MS medication)
My next infusion is after 10 days and I don't know what to do.
Should I wait until I travel so the doctors can examine me and prescribe suitable medication for my condition, or I must take my next infusion before I travel?
Knowing that I want to take the HPV vaccine.
What should I do please help me.
Sorry. I can't give you personal advice here.
Ask them if they do hsct for ms there..youtube search "60 minutes Australia hsct ms"
@@barbaradascalos4411 it's a bit early for HSCT for me my condition isn't that bad
Hsct is not to restore it is to prevent. So people get it the first day of dx. Ocrevus is same as Rituximab. So your trip may be a waste as there just isn't anything better than
Rituximab..other than hsct.
@@barbaradascalos4411 did you do HSCT?
Thanks very interesting.
Thanks.
Thank you for this information. Would you consider long term (30yrs+) low dose benzodiazepine use as a contributing factor to PPA? Thanks again.
Is there any data on this?
What are the very early symptoms ? I cannot find anyone speaking about the early symptoms ?
My beautiful mother was showing symptoms with PPA in 1998/99 and I can tell you the 1st symptoms is struggling to talk..(In my mother's case) by the year 2001 she started showing cognitive inclined..By 2004 she could not talk, read or write. This was a lady who won every spelling be in school and who sang professionally, so it was very heartbreaking.. By 2006 I couldnt even recognize my own mom as far as her personality, her character, she kind of had the mind of a 6 year old, and couldnt be alone anymore...it was the most horrific thing I've ever experienced..I miss her
@@863NightOwl LW, HOW SAD !! It brought tears to my eyes reading your experience with this most devastating disease. I am so sorry for your pain. I am really am. I hope to God I do not have this. When I am tired I say the wrong words. For example I asked my husband to get be a" cup" when I meant a "folk". If I have this horrible disease it would kill my son. He is an only child and very close to me. I suffer with depression and anxiety and brain fog so I am hoping it's that. I really think I would take my own life if I knew I had this. I lost my mother to kidney failure 3 months ago and it's really difficult to see a mother take her last breath.
Thank you, Lw for you reply. I really appreciate it.
@@kg5521 Oh my goodness , I made a typo -- I meant I would take my own life if I had this. Not my son's life. I would take my own life to save my only son the pain and torment this would cause him. To see his mother go through such a transformation from a high spirited person, full of life , laughter and love to turning into a person he doesn't know. This would devastate him. It's called laying down my life for my son !! That's how I feel. I just pray this is not the being stage of PA for me. Saying the wrong word.
Can intracranial hypertension be related to his disease?
Because I have intermittent IH and I have a lot of the same symptoms
Merhaba bm kızım da ms lütfen yorumları türkceye çevirir misiniz 🇹🇷🇹🇷🇹🇷
Sorry. I don't know how to translate or add captions.
Can SPMS patients can suffer this disease ?
Aphasia can occur in MS, but it is relatively uncommon. Other speech disorders such as dysarthria or "scanning speech" (related to cerebellar injury) are more common.
I have very obvious MS related brain atrophy (51yo male). Can you go into how brain atrophy symptoms present in MS patients? What are some classic symptoms of accelerated brain atrophy? My short and long term memory are fairly good. I have some trouble "finding the right words to say" though. My guess is that brain atrophy presents mainly as severe fatigue.
@@andrewreisinger6860 It varies quite a bit. Some people with significant brain atrophy on imaging have good cognitive function. This can be true of Alzheimer's disease in some cases too.
@@DrBrandonBeaber thanks, Dr. B! Yes, I would classify myself as having significant brain atrophy on imaging but relatively good cognitive function. Besides severe fatigue and obvious physical deficits (6.5 EDSS) the only thing I can really complain about is inability to multitask well. My reading, comprehension, and speaking ability remain good considering I was diagnosed almost 30 years ago!
This is from neurodegeneration the brain atrophy..so far hsct is only therapy that results in normal .2 atrophy. The DMT just stop lesions..they don't stop neurodegeneration.