Spent an hour trying to understand this and couldn't, then i came to RUclips and a 7-minute video explains it superbly! Thank you very much! Keep up the amazing videos!
My God I am in my final year of MBBS and am now trying to clear all my bad conceptss and trust me I never got the hang of inc. or dec. Anion gap until now!! Thank you. Thank you sm!!!!!
Thanks for filling in a 20+ year knowledge gap. I just converted everything you said into written notes - like almost every word - and now I feel like the fog has lifted. Finally. You are a star!💥
Never have I ever seen a better explanation. You helped me A LOT. Thank you so much. It makes me happy to see there are good people in the world that want to help others, like you did by sharing your knowledge. Greetings from Brazil (today I felt like all of my effort to learn English was worth it because if I hadn’t studied it I wouldn’t be able to watch your video and I’d still be struggling with this anion gap thing lol)
Learned about this in med but they never really explained what it was all about. They told me to know the equation and memorize MUDPILES and etc. This brings it all together, thank you so much!
Just to echo previous happy commenters, thank you for this excellent little video - clearly and succinctly explained with some humour thrown in as well! Much appreciated
Oh my gosh, thank you! I have been asking people to explain this to me for years and no one has ever been able to or taken the time to. I am a nurse and doctors (especially new doctors, for some reason) get so worked up about the anion gap and I am always asking them about why this is so important and they just can never tell me. So frustrating since I need to understand these decisions that drive patient care. This was such a clear and straight forward explanation. Thank you! really cool information too, the human body is amazing.
Yes, I agree with the previous correction. RTA type II is caused by impairment of the PROXIMAL tubule which cannot absorb bicarb and that gives you the acidotic state. The type I is the impairment of the distal tubule which cannot excrete H protons (acid) and that gives you the acidosis. Anyway, your video was EXTREMELY helpful and I've watched it a thousand times because I always forget this topic and your video is always the easy super nice way to remember. Thank you SO MUCH!
u latterly saved my life and my time , at first when i opened the video and heard the silly music in the back i had doubts lol , but this vedio helped beyond what i expected , THANK U
Excellent video keeping it simple as I was getting confused by the whole "renal vs GI" thing that's come up in lectures! Edit: your video provides a good base to build upon. Basically, in NAGMA, GI loss of HCO3 (diarrhea) causes kidneys to increase NH4+ excretion, resulting in decreased AG but if there is a renal loss of HCO3, then kidneys cannot respond by increasing NH4+ excretion, and you end up with HAGMA. For now, I'm happy with this as a base for my knowledge! Cheers!
😭😭😭 understood it for the first time ❤️❤️, u don't know how happy and content I m feeling ❤️, always struggled so so much to understand this topic 😭❤️ Thank you ❤️❤️
Killer video man! One small thing I noticed though. Looks like you forgot the parentheses on the equation both times you show it, 0:39 and 1:23. The equation is Anion Gap = ([Na+] + [K+]) − ([Cl−] + [HCO3−]). If you don't have the parentheses, the equation is Anion Gap = [Na+] + [K+] − [Cl−] + [HCO3−] and that would mean the subtraction wouldn't distribute to the bicarbonate as well, instead only applying to the Chloride. This would mean you'd be adding the bicarbonate. You got the math correct in your example though so I know you understand what you're talking about! Just thought I'd point that out so that it doesn't confuse anyone. Confused me for a bit haha. Thanks for the post!
Half of the practicing life is gone..........and then we realize that, these so called complex concepts were so simple and basic. Thanks..for making things simple..
I am so thankful to u doc ; u saved me from my consultant when he made round and asked me a flowwww of questions hoping he could get me . But with this video I opposed him professionally 😎😎😎😎 Lol thanks really
Had my theory exams a week ago and was quite shaky about the concept and now I have viva in a few days and thankfully I found this gem although I’m mad at myself for not finding this a bit earlier
“I like to call it anion gap because that’s what it’s called.” 😂
Eruma madu😂
Bro you not only explained anion gap but a full lecture of metabolic acidosis in 6 minutes you're a genius
Spent an hour trying to understand this and couldn't, then i came to RUclips and a 7-minute video explains it superbly!
Thank you very much! Keep up the amazing videos!
+Faisal Tahir We'll do our best! Glad you found it useful :)
My God I am in my final year of MBBS and am now trying to clear all my bad conceptss and trust me I never got the hang of inc. or dec. Anion gap until now!! Thank you. Thank you sm!!!!!
legit same, crazy how i got this far without it
Correction for 5:50
Type 1 RTA - impaired H+ secretion into urine at distal convoluted tuble
Type 2 RTA - loss of HCO3 into urine at PROXIMAL tubule
We don't all know that, actually. That's sort of why we're all here. So thanks Andy.
lol
Thanks Andy
Thanks!
Cool Breeze13: You know, residence spots are given to candidates who are nice, as well as smart. Something to keep in mind...
I literally wanna hug you lol, I’m about to graduate and only just truly understood the hypercloremia part ♥️ Thanks
Pppopppppppppppppppppppppppppppppppppppp
P
Thanks for filling in a 20+ year knowledge gap. I just converted everything you said into written notes - like almost every word - and now I feel like the fog has lifted. Finally. You are a star!💥
Never have I ever seen a better explanation. You helped me A LOT. Thank you so much. It makes me happy to see there are good people in the world that want to help others, like you did by sharing your knowledge. Greetings from Brazil (today I felt like all of my effort to learn English was worth it because if I hadn’t studied it I wouldn’t be able to watch your video and I’d still be struggling with this anion gap thing lol)
Incredibly clear and succinct - I finally understand! You have a strong future in medical education ahead of you. Cannot thank you enough bro :)
Learned about this in med but they never really explained what it was all about. They told me to know the equation and memorize MUDPILES and etc. This brings it all together, thank you so much!
0:53 was all i required to grasp the topic. Thank you so much! Lovely explanation.
Just to echo previous happy commenters, thank you for this excellent little video - clearly and succinctly explained with some humour thrown in as well! Much appreciated
Never understood this topic until i have watched the video. You are genius. Thank you
Beautifully expressed...as a surgeon...this is perhaps the best explanation..
Oh my gosh, thank you! I have been asking people to explain this to me for years and no one has ever been able to or taken the time to. I am a nurse and doctors (especially new doctors, for some reason) get so worked up about the anion gap and I am always asking them about why this is so important and they just can never tell me. So frustrating since I need to understand these decisions that drive patient care. This was such a clear and straight forward explanation. Thank you! really cool information too, the human body is amazing.
Agreed - the human body is AWESOME
Whoooooo the hell would dislike this!? Beautifully made, simple, and concise.
Haters going to hate ;)
i have never seen a video that explained anion gap as easy as this one, well done
Hello..I have a doubt..Why is chloride not lost diarrhea
thanks!, this is by far the best video on anion gap metabolic acidosis, you seriously deserve more subs!
Bless your soul!! I don’t know why it was so hard for me to grasp the why of anion gaps but this made 100% sense
Yes, I agree with the previous correction. RTA type II is caused by impairment of the PROXIMAL tubule which cannot absorb bicarb and that gives you the acidotic state. The type I is the impairment of the distal tubule which cannot excrete H protons (acid) and that gives you the acidosis. Anyway, your video was EXTREMELY helpful and I've watched it a thousand times because I always forget this topic and your video is always the easy super nice way to remember. Thank you SO MUCH!
it should be named Anion gap made easy
Seriously!
finallllllly a 4th year medical student that had finally understood that Anion gap thing
THANK YOU!!!
Here 3rd year MS haha i never understood before this 😂😂
im apracticing doctor for 10 years and I've not understood this topic until today. what a time to be alive
u latterly saved my life and my time , at first when i opened the video and heard the silly music in the back i had doubts lol , but this vedio helped beyond what i expected , THANK U
I freaking love you! Explaining medical lab science and making it hilarious! Makes me hate my life a little less as I study for my exams! LOVE!
Best explanation on anion gap. I feel like a complete nerd now. Thank you
This is a very lucid and succinct refresher on the anion gap - thank you!
Bro you just made this concept so much easier to understand.
I have an exam later today and I really appreciate this explanation. They don't explain it step by step like this in class. Thank you :)
+Evodie Versulien Hope the exam went well Evodie!
it did! all the questions that had to do with anion gap I got correctly. Thank you :)
Man saved my life simply sitting on a sofa talking to the camera for 5 min
I just signed in youtube just to give a thumb up :), it truly deserves it great job
I have an exam tomorrow and Anion Gap was the last confusing part for me .
You Saved my day :D Thanks .
+Mohamad Abdulwahed Hope it went well!
yes very well
I think this is the first time ive properly understood HAGMA vs NAGMA. well done on this and thanks!
Good to hear!
Finally understand it. Best explanation I have found online to date. Thank you so much!
Really happy you're back! Was hoping for follow ups on how your first year as a doctor has been after that first video
Excellent video keeping it simple as I was getting confused by the whole "renal vs GI" thing that's come up in lectures!
Edit: your video provides a good base to build upon. Basically, in NAGMA, GI loss of HCO3 (diarrhea) causes kidneys to increase NH4+ excretion, resulting in decreased AG but if there is a renal loss of HCO3, then kidneys cannot respond by increasing NH4+ excretion, and you end up with HAGMA. For now, I'm happy with this as a base for my knowledge! Cheers!
I rarely leave comments on YT medical videos but this was absolute class. Thanks mate
You explained such an important issue with the simplest way even better than Guyton Physiology.Thanks from Iran:)
you are a genius , thank you. no one explained it so clear like you on RUclips. you got a sub from me.
😭😭😭 understood it for the first time ❤️❤️, u don't know how happy and content I m feeling ❤️, always struggled so so much to understand this topic 😭❤️
Thank you ❤️❤️
thank you , thank you , thank you
+BOTH ABDULLAH You're welcome, you're welcome, you're welcome!
This really helped me (and other classmates) study for our pharmacotherapy exam, so thank you! Our instructor had not explained it very well...
Thanks Sarah - good luck to you and your classmates!
Excellent and much needed video. Thanks a ton. Dr Vaibhav from India !
Thanks Dr Vaibhav - glad you liked it.
I’m doing my toxicology unit and this was just the refresher I needed! Thank you
The bestest explanation ever!! Thanks a lot man. Subscribed right away.
ما قصرت يا شنب
استمر , كان شرح واضح جدا اشكرك جزيل الشكر.
One of the best explanations of this concept i've seen.
Killer video man! One small thing I noticed though. Looks like you forgot the parentheses on the equation both times you show it, 0:39 and 1:23. The equation is Anion Gap = ([Na+] + [K+]) − ([Cl−] + [HCO3−]). If you don't have the parentheses, the equation is Anion Gap = [Na+] + [K+] − [Cl−] + [HCO3−] and that would mean the subtraction wouldn't distribute to the bicarbonate as well, instead only applying to the Chloride. This would mean you'd be adding the bicarbonate. You got the math correct in your example though so I know you understand what you're talking about! Just thought I'd point that out so that it doesn't confuse anyone. Confused me for a bit haha. Thanks for the post!
If you do your proper Order of Operations, you just subtract the Cl- and HCO3- from Na+. It's super simple.
math is the reason many chose biology XD so no one notices BODMAS and stuff.
Agree
It's funny, this is the second video in a row that I noticed did that.
i think u just saved my medical career lol !! THANK THIS VID IS SOOOO HELPFULL
Beautifully simplified and visual! Thanks Mate!
Finally I have understood the concept ....thank you so much Sir
These videos are great, thanks for doing a better job than everyone else on YT in explaining this. You made it way too easy to understand...
Half of the practicing life is gone..........and then we realize that, these so called complex concepts were so simple and basic. Thanks..for making things simple..
Just amazing.🎉. Crystal clear.
Best of luck🤞
OMG YOU ARE AN ANGEL...HOW BEAUTIFULLY EXPLAINED.,....WOW IM AMAZED
THIS WAS SO INCREDIBLY HELPFUL!!! THANK YOU!!!
Thank you 🙏🏽. I just took my mother from hospital and don’t understand some things. Thank you for you info now I have an idea.
Worth watching every second. Thanks a lot👍
One of the most brilliant explanations, thanks so much!
Thanks for the compliment!
You really explained it very well, I never understood this topic so clearly as I did today by your video, thank you so much man!!
The best explanation I've ever had thank you!!
Very good video. Well explained and very articulate.
Thanks Dunc! Glad you liked it.
HippocraTV
Great video! Thank you so much! I have a physiology test coming up, and this made everything really clear!
that was the best description I ve heard.
great video man, you succeed in what my professor fails to do!
We do our best!
Thankyou so much, this really solved a major problem I was stuggling with in Biochem
Don't have enough words to thank you! Always found this topic confusing until now. Keep up the great work!
PS: Just signed in to comment this.
thanks a lot .. this is the first time I understand anion gap
I am so thankful to u doc ; u saved me from my consultant when he made round and asked me a flowwww of questions hoping he could get me . But with this video I opposed him professionally 😎😎😎😎
Lol thanks really
Wow...i finally understand acid base balance....thank you👏👏👏👏
Wow thank you very much man , this was so easy to understand , the books don't do it this way
Respect
+Ardit Alili Thank you!
That was the most articulate information alongside with fun I ever seen. Thanks
Learnt more clear than the textbook.
This was great! Thank you so much! First time watching your video and it was incredibly helpful without being too long winded!
Thank you for this! I'm convinced other people don't know what an anion gap is because they can't explain it as simply as this haha.
this was amazing not sure hwo you managed to fit in so much information in such a concise way!
thank you soo much u made it clear n easy to remember …. i watched several vedios but couldnt understand …sending u infinite blessings 😊😊😊
Oh my god, totally had a eureka moment watching this! Thanks!
Really helpful!!!My lecturers notes didnt really help that much now i fully get it :D
+XxR4GA5xX awesome! It's a tricky one. Check out our video on hyponatraemia for something similar!
Amazing video! I'm really bad when charges and chemistry comes in but this explained everything so well!
Thank you so much for such a wonderful and helpful video. You make it so easy to understand.
Had my theory exams a week ago and was quite shaky about the concept and now I have viva in a few days and thankfully I found this gem although I’m mad at myself for not finding this a bit earlier
What a helpful lecture!! I really appreciate your effort.
Wow! You are an excellent teacher, thank you!
Excellent excellent excellent!!! Thank you so much for this video!! It's short but super duper easy to understand!!
Fantastic explanation!! Thanks!
Outstanding! Please keep these videos coming!
Thank you!! You deserve so many more subs
This is an amazing video! Thank you
Thank you very much! You were the only that made me understand this tricky thing! Very clear!
You unravel my confusion. Can't thank you enough
Excellent dude. When you get a chance could you do low anion gap? I.e hypoalbuminemia? Great video
Very good the video congratulations to who made it thank you very much
Greetings from Colombia.
Thanks for your congratulations Sebastian. All the best to you in Colombia!
I would like to someday take a video of electrocardiography and reading of arterial gases.
OMG Best explanation ever....wish i ddnt waste my time on google..should have came striaght here...# new notification member
You deserve my like Sir.
And you deserve ours!
first minute of this video beat an entire semester of biology class
Omg Omg, THIS was so helpful ! Thank you so much, and greetings from Ecuador !
I was so confused .Thankyou for clearing it up .☺️
Short and precise explanation !!!! Thank yuo
Really helpful. Thank you so much! Dr. Lim from Korea
You're welcome Dr Lim! All our best to Korea.