Atrial Septal Defect (ASD) USMLE Step 1 Pathophysiology
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- Опубликовано: 18 сен 2024
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Atrial Septal Defect (ASD) - USMLE Step 1 CVS Physiology , Dr G Bhanu Prakash
Atrial Septal Defect
Overview
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Atrial Septal Defects (ASDs) arise from defective closure of the inter-atrial septum and allow for an inappropriate right-left shunt of blood following birth. ASDs are the most common subtype of congenital heart disease.
Normal Development
Overview
The right and left atria emerge from a single chamber which is septated between the fourth and sixth weeks of development. Atrial septation develops in such a way as to allow significant shunting of blood from the emerging right atrium to the emerging left atrium, a physiological priority during fetal life. However, following birth this shunt must be rapidly ablated; consequently, the inter-atrial septum develops in such a way as to provide a "flap-like" system that can be shut quickly following delivery.
Septum Primum Development (First Wall)
The first septum to divide the common atrial chamber grows, ridge-like, from the superior aspect of the atrium downward and eventually fuses with the Endocardial Cushions which defines the inferior aspect of the chamber. The hole defined by the advancing edge of the Septum Primum and the Endocardial Cushions is known as the first hole (Ostium Primum). As the Septum Primum fuses to the Endocardial Cushions (Destroying the Ostium Primum), a second hole is formed in the middle of the Septum Primum, known as the Ostium Secundum (Second Hole), which continues to allow right-to-left shunting of blood.
Septum Secundum Development (Second Wall)
A second wall, known as the Septum Secundum, begins to develop directly to the right of the maturing Septum Primum. As the Septum Secundum develops, a hole is formed in its center known as the foramen ovale which continues to allow right-to-left shunting of blood. Because the superior aspect of the Ostium Primum eventually regresses, the Ostium Primum begins to act as a flap against the foramen ovale and in doing so allows only unidirectional movement of blood from the right to the left atrium.
Delivery
During fetal life the right atrial pressure is slightly higher than the left atrial pressure, allowing blood to shunt from the right to the left atrium and thus bypass the developing fetal lung. Following delivery, the atrial pressures switch, causing the flap-like Ostium Primum to shut the foramen ovale, limit shunting of blood between the two atria, and thus promoting blood to enter the now mature fetal lungs.
#atrialseptaldefect #usmle #pathology #cardiology #physiology
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love you from left ventricle 😁
Haha nice comment thank you from hippocampus
🤣
😂😂 awesome response from cerebellum
Very Informative, EASILY understood and digested!!! Thank you, you're the BEST!!!!
Thanks for watching .. I appreciate ur words
So Nice sir in a easy way.
I need whole lecture on cyanotic and acyanotic heart diseases
Awesome
Thank you so much Sir for this awesome video & clearing my concepts🙂🙏🏻
So nice of you
WC Sir 🙂🙏🏻
How long can a person survive on a minimum basis before ASD closure and after ASD closure ? Is the person out of danger after ASD closure surgery ?
From Kenya we say ,Asante sana
Thank you sir.!
Respect from Pakistan
Thank you sir❤
Very well explained sir
Keep watching.
Great teaching. thankyou Dr.
You are welcome
you style of teaching is very good luv uhh sir 😗😗thnq i don't have words
thank u so much
Ishnoor singh qwesdfgh ghjy
Good lecture. Suddenly reminded me of Conrad Fisher.
Tysm
Thank you so much very well explained
Thank you dr
Thank you so much doctor 💛💛💛💛💛💛💛💛
very nice ,thanks
Ty 🩵
thank you so much sir
can i have your mobile no plz
Yei
Thank you sir
Welcome
Thanks sir
Nice explanation
Thanks for liking
Sir in asd case creatine increase?
Because hypertension is high.
ASD with left to right shunt
nice
Sir I want the notes of ventricular septal defects
Send me ur email id .. ill send it
cik cik
My baby have 3mm asd and 2mm vsd plz tell me what to do
great thanks Dr. i have my 7 year child with "large secundum ASD RVVO"( conclusion on report 22x17x19 mm)
Hope your child is healthy ,,, did u treatment your child
Why blood is not going from right atrium to left atrium ??
If left atrium have low pressure than right atrium it should go from right to left.
before birth the blood go from right to left because the pulmons are off and their resistance is higher.after birth when there is no more placenta for the blood to oxygenate the pulmons open and their pressure go down and now the shunt go left to right
✌✌✌✌👍
I am asd small size 9month pregnancy now...deliveryku issue varuma sir
0:07
H
Thank You Sir🙂
Most welcome