Pharmaceutical Technology | Bi-Layer Tablet Manufacturing |controlled-release formulation |02 of 02.

Bilayer tablets, sometimes called double-layer tablets, are a newer technology for the development of controlled-release formulation. They have a combination of two or more active pharmaceutical ingredients in a single dosage form.
Bilayer tablet manufacturing is a process used in pharmaceuticals to create tablets that contain two separate layers of medication in a single tablet.
Bilayer tablets are prepared with one layer of the drug for immediate release with the second layer designed to release the drug later, either as a second dose or in an extended-release form.
Nowadays, the use of bi-layered tablets is growing. Bilayer tablets are more suitable for the gradual release of a combination of two active ingredients.
Bi-layered tablet technology separates two incompatible substances in which one layer is immediate release as a loading dose, and the second layer is controlled/sustained release as a maintenance dose.
Two incompatible drugs can also be formulated into a bilayer tablet by adding an inert intermediate layer.
Bilayer tablets can also make it easier for patients because they can reduce the number of daily doses required, therefore simplifying regimens.
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