Great welcome please subscribe and share my lectures with your friends and others feel free to contact me on WhatsApp or email dushyanthreddy233@gmail.com
Thank you very much for this well articulated video. I am new to Pharmacophore Modeling and I have perfomed docking on a protein and ligand (drug), so my question is how do I know which pharmacophores are responsible for the interactions between the two?. Can I assume that the descriptors I am getting after loading the two before "submit query" is what is responsible for the interactions?. If so how do I download the table of this descriptors ? and picture of my protein-ligand complex?.
Dear viewer; please note that thorough literature to be done and find the pharmacophore and its descriptors and u may design similar descriptors and try to impose on the exiting pharmacophore this technique is called as DYLLOMS
I have an out of context question, can you demonstrate Lumo properties of a methyl side chain against an amine side chain let say in the activity of a propionic acid group which is responsible for antiinflammatory activity.
Hi Dr Dushyanth It's pleasure to write you. actualy i have a problem with Zincpharmer. could you help me to solve this problem. Error connecting to search engine. Please try again later and if the problem persists, contact the administrator. keep in contact. best regards Mahmoud
Thank you so much for your video, I would what to know after I got my hits , how do I decide which one to choose for further study? Based on SAR ? or best overlay? Thanks
Sir the hit molecules after submit query...how to do docking for best hits compunds other than the CLC GENOMIC WORKBENCH.. as this software is paid. Please can you tell some other softwares that are free. Thank you.
Please subscribe and share my lectures with your friends and others feel free to call me on WhatsApp 8919754133 surely I will make video new lectures will add up in next week thank you
It’s not a ligand based mondeling ....it can be called only once an ensemble of ligands are used to generate a common pharmacophore...here it is interactive ligand receptor based pharmacophore ...here pharmacophore is specific. To active site ...it is mostly can be termed as receptor based or interactive ligand based ...don’t confuse yourself ....please subscribe and share with your friends and others feel free to call me on WhatsApp or email at 8919754133 dushynanthreddy233@gmail.com
Please subscribe and share my lectures you need to refine the search by editing the descriptors in the pharmacophore step by step by selecting various descriptors alternatively
Please subscribe and share my lectures with your friends and others feel free to call me on my Watsaap 8919754133 or by email dushyanthreddy233@gmail.com
First of all thanks for your response. Secondly, I mentioned Zn database not Zn. Zn database is actually a database containing a large no of chemical structures, can be docked against different proteins to have potential hits.
My lectures is on zinc database obviously it will explain about database regarding moe multiple pharmacophores can’t be loaded into zinc database for virtual screening
Very good video, I learn several Softwares from a single video. More useful to researchers in the drug discovery field, Thank u.
a lot of love for ndian people with their generosity
Thank you Sir. Very useful and simple step by step explanation, useful to many researchers
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your teaching is very simple and great, I definitely learn it, thank you, Dr Malekshah from Iran
Great welcome please subscribe and share my lectures with your friends and others feel free to contact me on WhatsApp or email dushyanthreddy233@gmail.com
@@Dockingbydushyanthreddy I want to learn Qsar, how do I learn it?
I will teach you
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@@Dockingbydushyanthreddy thank you? how? in this youtub?
Super sir really nice
Keep watching enjoy and share my lectures
Sir gene related disease ka receptor kese find kre ge for drug design plz guide me
Thank you very much for this well articulated video. I am new to Pharmacophore Modeling and I have perfomed docking on a protein and ligand (drug), so my question is how do I know which pharmacophores are responsible for the interactions between the two?. Can I assume that the descriptors I am getting after loading the two before "submit query" is what is responsible for the interactions?. If so how do I download the table of this descriptors ? and picture of my protein-ligand complex?.
Dear viewer; please note that thorough literature to be done and find the pharmacophore and its descriptors and u may design similar descriptors and try to impose on the exiting pharmacophore this technique is called as DYLLOMS
Sir can we add our own designed molecules for pharmacophore mapping
yes for that you need to use technique dyloms and proprietary software
I have an out of context question, can you demonstrate Lumo properties of a methyl side chain against an amine side chain let say in the activity of a propionic acid group which is responsible for antiinflammatory activity.
dear student; homo lumo and discrete docking studies require DFT perturbations and simultaneous docking which is not performed here
Thankyou 👍
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Thank you sir for your videos.it is really very helpful for any beginners.
Waiting for your more videos.
Please add more videos on autodock
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From whre we can add filters while selecting ligands for Lipinski rule and all after getting hits after zinc software
Welcome to my channel please subscribe and share my lectures with your friends and others feel free to contact me on Watsapp 8919754133
Hi Dr Dushyanth
It's pleasure to write you. actualy i have a problem with Zincpharmer. could you help me to solve this problem. Error connecting to search engine. Please try again later and if the problem persists, contact the administrator. keep in contact.
best regards
Mahmoud
its is evident that u might be performing some errors kindly follow steps provided
Thank you so much for your video, I would what to know after I got my hits , how do I decide which one to choose for further study? Based on SAR ? or best overlay? Thanks
score of resemblence
Hello sir
Sir the hit molecules after submit query...how to do docking for best hits compunds other than the CLC GENOMIC WORKBENCH.. as this software is paid. Please can you tell some other softwares that are free.
Thank you.
autodock
Sir, can you make video on pharmacophore modelling manually as it is available in Free Discovery studio visualizer?
Please subscribe and share my lectures with your friends and others feel free to call me on WhatsApp 8919754133 surely I will make video new lectures will add up in next week thank you
@@Dockingbydushyanthreddy thanks sir
May I ask why it is called Ligand-based modelling if the protein is added on ZincPharmer? I'm confused, can you help me?
Thank youp
It’s not a ligand based mondeling ....it can be called only once an ensemble of ligands are used to generate a common pharmacophore...here it is interactive ligand receptor based pharmacophore ...here pharmacophore is specific. To active site ...it is mostly can be termed as receptor based or interactive ligand based ...don’t confuse yourself ....please subscribe and share with your friends and others feel free to call me on WhatsApp or email at 8919754133 dushynanthreddy233@gmail.com
Very nice lots of things clear. Sir! I want to read some articles. please send me some articles. How could I contact with you?
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Your videos are really very helpful. could you please make a video about Pharmacophore modeling via MOE?
I am not familiar with moe
How you did the virtual screening? Software?
Contact me on Watsapp 8919754133 and subscribe and share my lectures....
Sir, from where did you removed heteroatoms? I'm not finding my notepad file
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Respected sir... Can we do pharmacophore modelling using only the ligand molecule?
yes u can
@@Dockingbydushyanthreddy thank you sir
Hello sir, Every time I tried to submit a query in the zincpharmer gives me a server error. Could you tell me what is the problem
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I tried the whatsapp no. but I think something wrong with no. Could you tell me what is the key no of your country
Esraa Abdelmoniem +91 8919754133
Sir,while loading features,everytime it appears server error processing ligand.how can it be solved?
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@@Dockingbydushyanthreddy thank you Sir.
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@@Dockingbydushyanthreddy sure Sir.gud nt.
Sir is it possible to screen aquari results using MVD
What do u mean by Aquari
Sorry sir that is query
Yaa u can do
I got 37 thousand hits by screening pharmacophors, but I don't know weather my MVD screens this large number of compounds
Yes u can dock even with lakhs ....
Hlo sir......
Can u help me do pharmachophore model for metallobetalactamase enzyme
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sir, its showing 0 hits, then what to do
Please subscribe and share my lectures you need to refine the search by editing the descriptors in the pharmacophore step by step by selecting various descriptors alternatively
Very useful video, Thanks. Could you please upload a tutorial for the docking of Zn database using MOE?
Please subscribe and share my lectures with your friends and others feel free to call me on my Watsaap 8919754133 or by email dushyanthreddy233@gmail.com
Moe and zinc are two different things can’t be clubbed
First of all thanks for your response. Secondly, I mentioned Zn database not Zn. Zn database is actually a database containing a large no of chemical structures, can be docked against different proteins to have potential hits.
My lectures is on zinc database obviously it will explain about database regarding moe multiple pharmacophores can’t be loaded into zinc database for virtual screening
You mean we can't dock the zinc database using MOE, if I am not wrong.
This is a useful video on how to create a structure-based pharmacophore ruclips.net/video/zMeIBuMvKLU/видео.html