$1 Placebo vs $10,000 Placebo (It Matters)

Поделиться
HTML-код
  • Опубликовано: 26 мар 2024
  • Visit brilliant.org/scishow/ to get started learning STEM for free. The first 200 people will get 20% off their annual premium subscription and a 30-day free trial.
    Some placebos are far more effective than others, and they can lead to real chemical changes in the body.
    Hosted by: Stefan Chin (he/him)
    ----------
    Support SciShow by becoming a patron on Patreon: / scishow
    ----------
    Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever: Adam Brainard, Alex Hackman, Ash, Benjamin Carleski, Bryan Cloer, charles george, Chris Mackey, Chris Peters, Christoph Schwanke, Christopher R Boucher, DrakoEsper, Eric Jensen, Friso, Garrett Galloway, Harrison Mills, J. Copen, Jaap Westera, Jason A Saslow, Jeffrey Mckishen, Jeremy Mattern, Kenny Wilson, Kevin Bealer, Kevin Knupp, Lyndsay Brown, Matt Curls, Michelle Dove, Piya Shedden, Rizwan Kassim, Sam Lutfi
    ----------
    Looking for SciShow elsewhere on the internet?
    SciShow Tangents Podcast: scishow-tangents.simplecast.com/
    TikTok: / scishow
    Twitter: / scishow
    Instagram: / thescishow
    Facebook: / scishow
    #SciShow #science #education #learning #complexly
    ----------
    Sources:
    www.ncbi.nlm.nih.gov/pmc/arti...
    people.duke.edu/~dandan/webfi...
    academic.oup.com/painmedicine...
    www.ncbi.nlm.nih.gov/pmc/arti...
    www.ncbi.nlm.nih.gov/pmc/arti...
    www.jneurosci.org/content/19/...
    Image Sources:
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/ph...
    www.gettyimages.com/detail/vi...
    commons.wikimedia.org/wiki/Fi...
    www.gettyimages.com/detail/ph...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/il...
    upload.wikimedia.org/wikipedi...
    upload.wikimedia.org/wikipedi...
    upload.wikimedia.org/wikipedi...
    upload.wikimedia.org/wikipedi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    www.gettyimages.com/detail/vi...
    tinyurl.com/83x8kte4
    tinyurl.com/mw78s7cb
    tinyurl.com/2fhskvts
    tinyurl.com/4df7drmu
    tinyurl.com/ynsec76f
    tinyurl.com/mr3jt9cs
    tinyurl.com/ycx5n87z
    tinyurl.com/mv32je73

Комментарии • 568

  • @SciShow
    @SciShow  16 дней назад

    Visit brilliant.org/scishow/ to get started learning STEM for free. The first 200 people will get 20% off their annual premium subscription and a 30-day free trial.

  • @johnnydarling8021
    @johnnydarling8021 Месяц назад +792

    Me: "Brain, heal me."
    Brain: "No."
    Me: (takes placebo)
    Brain: "You son of a *****, I'm in!"

    • @TheDeadEyeSamurai
      @TheDeadEyeSamurai Месяц назад +69

      Our body is both amazing and amazingly stupid.

    • @sharifaa.8887
      @sharifaa.8887 Месяц назад +18

      ​@@TheDeadEyeSamuraiAgree. For example, autoimmune diseases.

    • @garyb8373
      @garyb8373 Месяц назад

      Me: "I'm taking a placebo"
      Brain: "You son of a b****, I'm in!"
      Stupid brain!

    • @Golden_SnowFlake
      @Golden_SnowFlake Месяц назад +3

      Best comment.

    • @kasnitch
      @kasnitch Месяц назад +3

      @@sharifaa.8887 Couldn't agree more . I'm living with 3 of them , 2 of which 'showed up' after my 50's . A real bummer having a very over active immune system . One positive so far has been I haven't had a cold or flu since 2014 .

  • @Conus426
    @Conus426 Месяц назад +648

    Its insane that the placebo effect is even real to begin with

    • @EclecticFruit
      @EclecticFruit Месяц назад +56

      I just watched Kyle Hill's "Why reality is an illusion" video and I have to say it's the perfect complement to this one, to explain a mechanism that placebo's and your mind use to work.

    • @bjdefilippo447
      @bjdefilippo447 Месяц назад +7

      Aren't minds amazing!

    • @brainwater176
      @brainwater176 Месяц назад +18

      Belief influences reality

    • @Rakaaria
      @Rakaaria Месяц назад +9

      @@EclecticFruithaha awesome! I did it in the exact order as well! Great content choice

    • @mygaffer
      @mygaffer Месяц назад +5

      We construct our realities inside our heads.

  • @JonMartinYXD
    @JonMartinYXD Месяц назад +118

    To paraphrase Jerry Seinfeld, "Give me the maximum strength placebo. Figure out how strong of a placebo will kill me, and then back it off a little bit".

    • @williamlouie569
      @williamlouie569 29 дней назад +3

      How much are you willing to pay?

    • @ME2K23
      @ME2K23 27 дней назад +1

      Im dead but, not... 😉

    • @ME2K23
      @ME2K23 27 дней назад +1

      The great Jerry beats out Confucius every time! 🤓

  • @matthewday7565
    @matthewday7565 Месяц назад +251

    There is also the nocebo effect, where being aware of potential side effects makes you more likely to feel them - even from a placebo

    • @urmomzdick
      @urmomzdick 27 дней назад

      yess I’m prone to this so I never and I mean NEVERRR research side effects of pills I take until I’m done taking them

    • @hunters4524
      @hunters4524 24 дня назад +3

      Apparently beta blockers are one of the drugs that this happens with a lot.

    • @HazeLmao
      @HazeLmao 11 дней назад

      more so you can actually make someone think they are sick or ill/injured with nocebo

  • @astralb.2647
    @astralb.2647 Месяц назад +147

    Gonna gaslight myself into believing mints will cure my chronic pain 👍
    EDIT: the mints didn't cure me. 🤨

    • @mayaenglish5424
      @mayaenglish5424 Месяц назад +20

      DO IT! 😂 That's not the stupidest Idea I've ever heard honestly. Maybe I'll give it a whirl. 😂😂😂

    • @morsumbra9692
      @morsumbra9692 Месяц назад +19

      Buy expensive ones and tell yourself its cuz theyre made with high quality health healing ingredients.

    • @tnijoo5109
      @tnijoo5109 Месяц назад +7

      Yes, when he talked about the preconditioned placebos stimulating the same neural pathways, it really made me wonder how hard it would be to condition. Are you planning on taking the mints with pain meds to start? I’m very curious about this, so please please report back what works. Thank you.

    • @joshieecs
      @joshieecs 29 дней назад +6

      now if you believed mints could cure a patient's chronic pain, you would qualify to work at the DEA

    • @deleted8594
      @deleted8594 27 дней назад

      i recommend taking opioids for chronic pain

  • @katyowens3119
    @katyowens3119 Месяц назад +278

    As an occupational therapist who specializes in pain science, I so appreciate your use of language around “pain experience.” Well done.

    • @Palmit_
      @Palmit_ Месяц назад +5

      whats your thoughts on the true pain of sponsors targeting you CNS ..even though you're already subscribed to that sponsor?

    • @ME2K23
      @ME2K23 27 дней назад +1

      Outch! 😉

  • @greenlight2k
    @greenlight2k Месяц назад +193

    00:55 "Doc, give me the strongest placebo you got!"
    Doc: "You can't handle my strongest placebo, traveller!"

    • @Hyperionl10
      @Hyperionl10 Месяц назад +29

      "Doctor, I tell you I am going into recovery and I require your STRONGEST placebo"
      "Your mind is too frail for my strongest placebo, you would think you were dying."

    • @greenlight2k
      @greenlight2k Месяц назад +5

      "An infant that hasn't passed the rouge-test yet can't handle my strongest placebo, let alone a fully conscious man!"

  • @Microtonal_Cats
    @Microtonal_Cats Месяц назад +325

    Modern snake oil sellers take advantage of this. Especially colloidal silver. "That sounds expensive, must work" (or turn you blue)

    • @Mikee512
      @Mikee512 Месяц назад +11

      IDK about colloidal silver, but if the hypothetical snake oil helps via placebo and does no harm (including but not limited to not preventing the person from seeking and accepting any available non-placebo indicated treatments), then in that specific scenario the snake oil could be a net-good for that patient.

    • @aff77141
      @aff77141 Месяц назад +15

      See the blue means that it's working

    • @GogiRegion
      @GogiRegion Месяц назад +25

      @@Mikee512Generally it's a waste of money.

    • @Palmit_
      @Palmit_ Месяц назад +3

      yes, but the real kick in the guts.. you're already subscribed to that sponsor .. yet it keeps keeps harrassing you for more more more on nearly every channel you view.... that or vpns. thats a legit sponsor. hope they dont discover snake oil.spam spam spam.. youtube adverts. spam spam spam. theres so all contents worth watching all that advertising for. worsened when already bought the product.

    • @Just_A_Dude
      @Just_A_Dude Месяц назад +3

      @@GogiRegionThe point he was making is that a placebo it ISN'T a waste of money if it successfully engages the placebo effect, because the placebo effect, ironically, provides very real benefits.

  • @FTreba
    @FTreba Месяц назад +42

    Anyone else find this so utterly bizzare?
    It's like scientifically analyzing magic tricks - except they are real.

    • @whataboutthis10
      @whataboutthis10 29 дней назад

      The ultimate _why we can't have nice things_

    • @TheSubwizzle
      @TheSubwizzle 28 дней назад

      It makes you wonder really, with the morphine. You can physically feel it kick in, especially when administered IV. Does that mean other psychoactive drugs can be simulated in the same way? Truly weird.

    • @justinwhite2725
      @justinwhite2725 18 дней назад +1

      I had having chest pain (probably acid reflux) and I had worked myself into a frenzy to the point where I wanted to self delete.
      Got taken to urgent care by ambulance and I was I so much pain I couldn't sit still and I was swearing. One of the EMTs said something to the effect 'im going to give you some morphine so you can sleep'.
      I had never had morphine and I knew how addictive it was so I was nervous.
      Her partner said 'really?' but I didn't hear her response.
      I quickly tell asleep.
      She could have just as easily given me saline despite what she said, I would never have known.

  • @elisebrown5157
    @elisebrown5157 Месяц назад +11

    I get frequent tension headaches. Once, I got out a Tylenol to take, got distracted and set it down on my nightstand. But I *thought* I had taken it. Didn't realize until later when my headache was gone and I saw the pill sitting there. I sure wish I could get that to work all the time for me! Placebo effect is amazing.

  • @YoungGandalf2325
    @YoungGandalf2325 Месяц назад +114

    1:52 "losing your lunch" is not a binary option. I have had several instances in which the said lunch was in a quantum superposition of staying down and being lost at the same time. Kinda like Schrodinger's Cat with a hair ball.

    • @lesliedonovan4975
      @lesliedonovan4975 Месяц назад +9

      This is an amazing simile.

    • @BadgerScrub
      @BadgerScrub Месяц назад +9

      During those situations, it just burns your throat. Goes straight past heartburn to throatburn

    • @signesvad
      @signesvad 28 дней назад +4

      Also it's even more of a spectrum than that, I sometimes get mild nausea where I know that I’m not actually going to throw up unless I do something to upset my stomach even further. But the felling is still there and it's not a pleasant feeling.

  • @icantthinkofaname158
    @icantthinkofaname158 29 дней назад +12

    imagine the placebos themselves were a placebo, and they both are $1

    • @JimboJuice
      @JimboJuice 27 дней назад +2

      that's called American insurance.

  • @wormspeaker
    @wormspeaker Месяц назад +104

    That explains why snake oil salesmen have been so successful over the centuries. Explains why people will pay so much money for magical copper bracelets or magnetic pendents or distilled water that as some "memory" of some substance in it. If you believe that it will work, it just might.

    • @austinfreyrikrw6651
      @austinfreyrikrw6651 Месяц назад +10

      Yup, I suspect that's how homeotherapy work too.

    • @choiswimmer
      @choiswimmer Месяц назад +9

      It's why chiropractors still have a job

    • @davidhand9721
      @davidhand9721 Месяц назад +4

      Reiki is another example.

    • @Just_A_Dude
      @Just_A_Dude Месяц назад

      ​@@davidhand9721Don't even get me started on it. "Reiki" is actually the name for a particularly terrifying type of ghost that forms when an Oni dies in such a way to leave a killing ghost. Whoever decided to name the mystic healing mumbo jumbo after those things really wasn't thinking things through.

    • @JimboJuice
      @JimboJuice 27 дней назад +1

      @@choiswimmerchiropractors have a job because they do actually provide intimidate symptomatic relief for an amount of time. It's just that unless you actually work out and strengthen the areas causing you issues you're only treating the symptoms of the underlying problem. And that is you're too lazy to actually do sit-ups to make your back not cause you agonizing pain.

  • @keith1291
    @keith1291 Месяц назад +177

    I'm a pharmacist at a hospital. I'm surprised we don't utilize this effect more. At some point you have to balance the ethics of it, which is an interesting idea in itself.

    • @thomasgauthier5691
      @thomasgauthier5691 Месяц назад +16

      Even if people know it's a placebo, it can help.

    • @bjdefilippo447
      @bjdefilippo447 Месяц назад +26

      With the cost of my prescriptions, I should be feeling perfect!

    • @thomasr6732
      @thomasr6732 Месяц назад +28

      Yea ethics… I can see companies charging 10x for a placebo after scaring them into thinking it’s better than alternatives. Profits up, your bank account down

    • @ComradeCatpurrnicus
      @ComradeCatpurrnicus Месяц назад

      ​@@thomasr6732 Yup, and corporation costs, and R&D would go down. If they can "treat" people with sugar pills while not changing their price gouging, they absolutely would in a heartbeat.

    • @jcmo5900
      @jcmo5900 Месяц назад +21

      If I went to a doctor for real help and they sent me home with pills containing no medicine, I'd have brand new blood pressure and anger management problems.

  • @birdstrum1555
    @birdstrum1555 Месяц назад +67

    Fascinating results. This is why, as long as it isn't something drastic, I try not to criticize if a placebo treatment is working for someone.

    • @EnigmaticLucas
      @EnigmaticLucas Месяц назад +3

      The placebo effect works even if you know it’s placebo, so there wouldn’t be any harm in politely telling them that it is

    • @morningfox_
      @morningfox_ Месяц назад +21

      @@EnigmaticLucasThat’s not for everyone though. You can reduce a placebos effect by explaining it away, so I’d tend not to tell people.
      It’s like when people say they feel immediately better the second they take a multivitamin. They obviously do feel better but it would be harmful or pointless for me to explain digestion times to them.

    • @neermuse
      @neermuse Месяц назад +15

      I once saw a picture of some quartz-magic believer that glued a bunch of coin-sized quartz stones to the center part of the driving wheel of her car where the airbag is, which basically turned her mostly harmless placebo into a claymore mine.

    • @lenabreijer1311
      @lenabreijer1311 Месяц назад +2

      Yes this is why I don't tell individuals that their homeopathy is just water and useless. It is a placebo and works for them.
      With enough practice and meditation and trance work you can sort of do it on yourself but for me it means I can get nothing much else done.

    • @neermuse
      @neermuse Месяц назад +5

      @@lenabreijer1311don't do that with people with dangerous crap, like cancer

  • @Deeplycloseted435
    @Deeplycloseted435 Месяц назад +47

    You can taste test two pieces of the exact same food, and put $5 on one, and $20 on the other…..and people consistently report the $20 food tastes much better. The human brain is crazy.

    • @TheSuzberry
      @TheSuzberry Месяц назад +6

      That’s how wine prices work, IMO.

    • @piggydabest
      @piggydabest 16 дней назад

      ​@@TheSuzberryi remember seeing smthn about a guy who convinced profesional wine tasters that his rly cheap wine was act rly expensive and they ranked it high up to which ones tasted the best

  • @joelle4662
    @joelle4662 Месяц назад +26

    The mind is amazing. I wish we had more funding for this type of studies on both a psychological and neurological level.

  • @kaitlynoddie9649
    @kaitlynoddie9649 Месяц назад +53

    the way placebos can still work even if you know it’s a placebo is wild. my mom takes tylenol for her nerve pain. she’s fully aware that anti-inflammatories don’t do anything for nerve pain, and yet taking tylenol makes her nerve pain go away.

    • @buggable
      @buggable Месяц назад +9

      similar to how taking a half dose of tylenol will alleviate some of my joint pain immediately, even though I know that it's way too low of a dose and it usually takes 20+ minutes.

    • @alicejenkins144
      @alicejenkins144 Месяц назад +17

      tylenol's main action isnt as an anti-inflammatory despite what earlier research believed. Modern studies have demonstrated that in truth it acts on TRPV1 receptors in the brain and spinal cord to decrease pain signalling. it makes perfect sense why it would help, though typically tylenol is too weak for most patients with nerve pain .

    • @alexrogers777
      @alexrogers777 Месяц назад

      @@alicejenkins144 maybe this is related to the TRPV1 receptors maybe not but tylenol is known to primarily act on the endo-cannabinoid system once metabolized, so it does actually have anti-inflammatory effects

    • @davidhand9721
      @davidhand9721 Месяц назад +2

      My grandma takes a Tylenol every night because she thinks it makes her sleep. I've told her that APAP is non-narcotic and doesn't even get into her CNS, and the Tylenol PM has _other drugs_ in it that make you drowsy, so just an extra strength Tylenol cannot make you drowsy, many many times. She says "oh, any pill makes me tired. I'm sensitive to drugs". I've given up trying to get her to understand. She needs the rest, after all.

    • @kaitlynoddie9649
      @kaitlynoddie9649 Месяц назад

      @@davidhand9721 i mean if it works, it works. wish that worked on my insomnia

  • @playframe6231
    @playframe6231 Месяц назад +5

    this is what ritual healing is based on.. the more impressive the ritual, the more potent the effect.

  • @ivanborsuk1110
    @ivanborsuk1110 Месяц назад +64

    so aspirin works better than acetylsalicylic acid?

    • @exosproudmamabear558
      @exosproudmamabear558 Месяц назад +16

      Depends on what person think when you say aspirin and acetylsalisilic acid. For doctors,health workers,nurses and health students later will be more effective for common people aspirin could be more effective. If the person never heard both of them before it may not have any effect difference.

    • @Kassidar
      @Kassidar Месяц назад +2

      @exosproudmamabear558 Acetylsalicylic acid is Asprin.

    • @DigiMaster236
      @DigiMaster236 Месяц назад +16

      @@Kassidar That's the point. The known brand name strengthens the placebo's effect versus using a generic "cheap" one even if they're structurally the same.

  • @gliddens24
    @gliddens24 Месяц назад +3

    Great to see we're placebo testing placebo, the placebo being now the price tag.

  • @SamanthaVimes177
    @SamanthaVimes177 Месяц назад +14

    Granny Weatherwax was a good witch because she knew it didn't matter what was in the potion. Magrat was a good physician because she thought it did.

  • @razortongue9000
    @razortongue9000 29 дней назад +1

    I'm glad you link the sources to these studies 😃

  • @PhrontDoor
    @PhrontDoor Месяц назад +8

    not sure about the hyperventilation one.. because breathing INTO a container is usually effective enough -- even a paper bag.

  • @sircrashtonii9718
    @sircrashtonii9718 29 дней назад +1

    Was really interesting to learn about actually, I've been curious about these for a while!

  • @RidinWithMyLocsOn
    @RidinWithMyLocsOn Месяц назад +3

    I can get a placebo high when I am on my way to my dealer to pick up some weed, I even feel my eyelids getting sort of heavy. But you didn't hear this from me.

  • @MemesSpaghetti
    @MemesSpaghetti Месяц назад +29

    As a general human being with no special career path, I appreciate your use of English in this video. Well done.

    • @woosh_police4018
      @woosh_police4018 Месяц назад +3

      this had me laughing for 10 minutes straight

    • @MemesSpaghetti
      @MemesSpaghetti Месяц назад +2

      @@woosh_police4018 awesome! Glad I provided you with the funnies!

    • @jp4431
      @jp4431 Месяц назад +4

      Don't sell yourself short. Everyone has to learn at some point. The fact that you're watching this channel means you've already begun to learn the language.

  • @Avendesora
    @Avendesora Месяц назад +7

    I was really sad the one time I took my mood stabilizer fully believing it was vicodin for the wisdom tooth extraction I'd just had and I didn't figure it out until I realized the pain wasn't getting any better :( I don't know if that means the placebo effect would never work on me, but it sure doesn't seem like a good sign.

  • @caspenbee
    @caspenbee Месяц назад +13

    This could really help folks with kidney or liver failure who are no longer able to take the drugs they used to. Unless the placebo causes the same kidney damage? That one seems hard to ethically study.

    • @Hi_Im_Akward
      @Hi_Im_Akward Месяц назад

      Does stress on the organs show up in people with healthy organs immediately or over time? If there is evidence of it without kidney or liver failure present, then it would be a relatively straightforward thing to test in theory.
      If the same effect happened in animals like rats, it would at least be a good starting point, but animal testing is not always accurate to human testing.

    • @davidhand9721
      @davidhand9721 Месяц назад +1

      It would really stretch the imagination if your brain could physically deteriorate your organs just out of habit...

    • @caydennormanton9682
      @caydennormanton9682 Месяц назад

      ​@@davidhand9721 That being said, a placebo is more or less just a cue or signal that your body uses to activate certain pathways, and as far as I know, the body also has pathways for killing cells (i.e. apoptosis), so is it really that far-fetched?

  • @karlrovey
    @karlrovey Месяц назад +6

    In cases where you're recovering over time, the "placebo" effect is actually just natural recovery.

    • @SeanTBarrett
      @SeanTBarrett Месяц назад

      often referred to as "regression to the mean" in the literature. weird to go this hard pro-placebo and reject anti-placebo criticism without acknowledging how often it's not a real effect in most domains

    • @mayaenglish5424
      @mayaenglish5424 Месяц назад

      Maybe they didn't mention that because it's kind of obvious? Idk but that seems like a no brainer, (I know in science we have to prove no brainers, but still lol).

  • @grkuntzmd
    @grkuntzmd 27 дней назад +1

    When I was a medical resident and we had a patient complaining of probably imaginary diseases, we use to joke with each other that we should order some "placebo-mycin".

  • @davidhand9721
    @davidhand9721 Месяц назад +2

    The fact that naloxone reversed the pain relief differentially is breaking my brain.

  • @douglasclerk2764
    @douglasclerk2764 29 дней назад +1

    I once raised a smile by asking a pharmacist if the generic placebo was as good as the real thing . . .

  • @user-xx7nh9su2k
    @user-xx7nh9su2k Месяц назад

    Very informative!

  • @jamesuthmann940
    @jamesuthmann940 28 дней назад +1

    "Doc, give me the strongest placebo you've got!" -- "Whoa, hold on, you don't want to take something too strong, you might placeb-OD."

  • @johnfausett3335
    @johnfausett3335 Месяц назад +1

    You've simply demonstrated the manipulation of expectations. The placebo effect is still just the placebo effect.

  • @drmadjdsadjadi
    @drmadjdsadjadi 15 дней назад +1

    While Aspirin is a brand name in other countries, it isn't a brand name in the USA. It is the generic term in the USA (in other countries, the generic term is ASA [acetylsalicylic acid]). Bayer lost the Aspirin brand name trademark in the United States in 1919 because too many people were using the term aspirin for the generic drug. That is why in the United States, Bayer always advertises its Aspirin as Bayer Aspirin or sometimes even just Bayer but never as just Aspirin.

  • @peronik349
    @peronik349 Месяц назад +2

    The concept of “placebo” is often misunderstood.
    firstly there are the “so-called placebo drugs”, they are specifically designed without the slightest active ingredient.
    Their objective is at a minimum not to do anything harmful, at best triggering a “placebo effect” in the patient (or according to their more explicit name “contextual effects”).
    there is also another context where the "placebo effect" works without a "placebo drug":
    If 2 equally competent doctors but
    one abrupt and not very empathetic while the other is more empathetic and listens to his patients.
    faced with the same symptoms in similar patients and if they use the same treatments, the results of the more empathetic doctor will be boosted by the contextual effects

  • @margarethargas5189
    @margarethargas5189 Месяц назад

    Thank you!

  • @AdrianAbdel
    @AdrianAbdel Месяц назад +7

    Really not surprised since this already works with any consumer goods. Anything will taste/feel better when you're told it's expensive

    • @clogs4956
      @clogs4956 Месяц назад

      Ever tried caviar? Yeurch!

    • @AdrianAbdel
      @AdrianAbdel 29 дней назад

      @@clogs4956 It's not about personal taste, which is all acquired besides sugar. Take something you enjoy, if présented with the exact same thing twice but told they are different in price and quality, the more expensive one WILL taste better.

  • @PSaiTheLegend
    @PSaiTheLegend Месяц назад

    This video was mind blowing! The brain and body are so cool

  • @Dr_V
    @Dr_V Месяц назад +1

    There's also a lesser known treatment option called pseudo-placebo. These are pharmaceuticals with mild/minimal effects but also minimal (or zero) risk of adverse reactions. They're used primarily on patients who abuse prescription drugs, when their illness/condition isn't life threatening or severely debilitating. But just like regular placebos it's mostly about presentation, you have to be convincing for such treatment to be effective.

  • @skyem5250
    @skyem5250 Месяц назад +13

    the medical version of $1 pizza vs $1000 pizza

  • @nariu7times328
    @nariu7times328 Месяц назад

    This is fascinating. I am recovering from multiple abdominal surgeries, and the brain is very powerful in processing what the body is feeling.

  • @homerodysseus4203
    @homerodysseus4203 Месяц назад +3

    I'm sadly one of those people that will know whether an opioid is real or not. I wish I wasn't, but theres a reason Ive taken Kratom instead of actual pharmaceuticals or worse for over a decade. I'd definitely volunteer for a cybernetic implant to help with opioid dependence

  • @stellaluna6421
    @stellaluna6421 Месяц назад +1

    Very curious on how these studies stack up between patients who do and don't experience chronic pain.

  • @General12th
    @General12th Месяц назад +2

    Hi Stefan!
    I think Stefan is my favorite host.

    • @avsgriffy
      @avsgriffy Месяц назад

      I'm sad he left scishow tangents, and super happy whenever I see hom in a video

  • @bbbenj
    @bbbenj Месяц назад

    Thanks.

  • @victoriaeads6126
    @victoriaeads6126 Месяц назад +1

    Imagine the implications of this for emergency situations, where medicines are limited. Placebo might be able to help some patients while more critical patients could receive the clinical treatments.

  • @rockets4kids
    @rockets4kids 29 дней назад +1

    Psychics, shamen, and similar hucksters of all types have known about this for centuries.

  • @user-ft3ed5wv7w
    @user-ft3ed5wv7w Месяц назад

    This is very intresting. I think of a way to study how you can just DECIDE to come out better, like exact the way you do while being using a placebo. There is space !

  • @robynpicknell7801
    @robynpicknell7801 29 дней назад +2

    I have a feeling that this is based on only American studies. Especially when it comes to the cheap or expensive placebo. In the UK all meds from the doctor costs the same price. Thank you NHS. The Aspirin would not work for me because Aspirin, whether placebo or not, has never helped with any pain for me.

    • @JimboJuice
      @JimboJuice 27 дней назад

      cheap vs expensive is more a way to indicate quality rather than actual value. Even if the cost is the same if you believe one to be of higher quality it would be the same effect.

    • @robynpicknell7801
      @robynpicknell7801 26 дней назад

      @@JimboJuice I understand that, but it still would not mean anything in the UK because we do not know (unless the newspapers tell us) what the various medications actually cost the government, so I do not think that the premise of cheap or expensive as a way to tell quality would work. Now the name of the company that made the medication, that might make a massive difference with better known companies possibly perceived as better quality maybe.

  • @vectoralphaAI
    @vectoralphaAI Месяц назад +1

    The human mind truly is amazing.

  • @alex0589
    @alex0589 27 дней назад

    Me: **takes two advil** (TM)
    Morpheus: He's beginning to believe

  • @helenamcginty4920
    @helenamcginty4920 Месяц назад

    Ive read that the colour is important eg. Blue/green for sleeping and calming.

  • @capt.bart.roberts4975
    @capt.bart.roberts4975 29 дней назад

    Could you do one of your excellent pieces on The Nocebo Effect?

  • @Golden_SnowFlake
    @Golden_SnowFlake Месяц назад

    That is truly impressive, though strange!

  • @Ceelvain
    @Ceelvain Месяц назад +1

    I often hear that placebo effects work even if you know you're getting a placebo, but the size of the reduction of the effect is never mentioned.
    Is it actually known?

  • @IdrilSilmarien
    @IdrilSilmarien Месяц назад +1

    1:58 For the record I am frequently have nausea 🤢 but do not vomit 🤮
    These terms are not interchangeable.

  • @dominican200
    @dominican200 Месяц назад +1

    Drugs at times tends to be the stimulus that tells your body it's time to heal. Sometimes ques, or other mediums to signal the body to repair can at times be more useful and without having as many drawbacks or side effects

  • @at330606
    @at330606 Месяц назад +10

    Is there a reverse effect? Like, if I were taking painkillers and you told me that my next dose was going to be a placebo, would the real thing be less effective?

    • @lenabreijer1311
      @lenabreijer1311 Месяц назад +2

      The reverse is telling someone "this is going to hurt and make you very sick" and then giving them just sugar. And the hurt and get sick

    • @at330606
      @at330606 Месяц назад +3

      @@lenabreijer1311 sure, that's a reversal, and I'd be curious to hear more. But I'm specifically wondering about medicine losing its effect if I believe I'm taking a sugar pill instead.

    • @phodon129
      @phodon129 Месяц назад +4

      The Closest I know of is the Nocebo effect.

    • @AeonWaves
      @AeonWaves Месяц назад

      @at330606 Short answer: yes. Longer answer: see my response to @Sethafella in this thread.

    • @at330606
      @at330606 29 дней назад

      @@phodon129 I hadn't heard of this, but I think you're right -- expecting a placebo would be a "negative expectation" that impacts the effectiveness of a real drug.

  • @sararielle
    @sararielle 14 дней назад

    the idea that "Aspirin" worked better than the generic is extra amusing bc Aspirin as been a generic ever since the Treaty of Versailles (end of WW1)

  • @robo3644
    @robo3644 Месяц назад +1

    I believe working with spirits and doing ancient magick for healing is equivalent to doing very strong placebo i wish there were more research, i think spiritual rituals can be a much stronger way of causing placebo effect

  • @rev.rachel
    @rev.rachel 20 дней назад

    The naloxone experiment is absolutely wild!

  • @betterpoliticsquetu
    @betterpoliticsquetu 29 дней назад +2

    if a placebo is working is it ethical to keep charging patients

  • @Siberius-
    @Siberius- 28 дней назад

    I imagine the more invasive it is, the more effective, too. Or if they have to wait a certain period of time to get it again, because it's too strong to take frequently. Or if they have to make sure they don't eat anything for a certain period of time beforehand.
    I just realised that the placebo must have unintentionally and unknowingly been a huge element of medicine hundreds of years ago.

  • @capt.bart.roberts4975
    @capt.bart.roberts4975 29 дней назад

    I had to be airlifted off a high mountain pass in The Himalayas, when I got altitude sickness. A penalty of living pretty much most of my life at sea level.

  • @vocalsunleashed
    @vocalsunleashed Месяц назад +1

    The placebo effect is such a strange concept to me

  • @Communism_in_Ohio
    @Communism_in_Ohio 29 дней назад +1

    I wonder if the brand name placebo effect is involved in the inflation of healthcare costs

  • @iranjohn
    @iranjohn Месяц назад

    It is possible for naloxone to relieve pain as well. It has something to do with homeostasis.

  • @lesil1000
    @lesil1000 26 дней назад

    My dad says that if you’re trying to stop smoking with hypnotherapy, you need to be paying out of pocket and it should be a lot. Being invested in the treatment makes it more likely to work. He told me about another therapist who charged a rich client more than he had been charged by previous therapists and he was able to quit smoking when he wasn’t before.

  • @johndeaux8815
    @johndeaux8815 Месяц назад

    Makes sense, some people might think that only one brand of acetaminophen works for their headaches for example, even though every brand has the same active ingredients. And to people thinking that it could be the binders/fillers, those are listed as inactive for a reason

    • @JimboJuice
      @JimboJuice 27 дней назад

      certain binders and fillers do actually change the rate of absorption, mostly relating to how far it can travel in your system before its processed. But most over the counter medicines end up having even the exact same fillers.

  • @michaellarkin8126
    @michaellarkin8126 Месяц назад +1

    I hate flying. It is one of the most anxiety inducing experiences I can think of… Even thinking of it makes me extremely uncomfortable. The only way I can get through a flight is by “chain smoking” a pencil or something. I know that it’s not a real cigarette, but it’s similar enough that I feel relaxed, just like when I used to smoke. What does that mean? Probably that nothing is real, I would guess. 😂

  • @himanshugarg6062
    @himanshugarg6062 Месяц назад +1

    "It works better for subjective symptoms better".
    Maybe this can largely be explained by the fact that for subjective symptoms, docs usually rely on patient reporting rather than actual biochem measurements of the body and if we feel like we're being cared for, we will believe we must be feeling better and thus report as such.
    "The pathways used are the same as from pre-conditioning".
    Yeah expected, because human mind is a correlation machine.
    If you gave me a piece of info say a, before you did any action b, which my body responded to with a response say c, resulting in an outcome d
    It correlates in mind the piece of info a and the body's response c together and c will happen with a even if you skip b and hence will result in the same outcome d.

  • @CheatOnlyDeath
    @CheatOnlyDeath Месяц назад +19

    They need to study the placebo effect vs a person's gullibility (their propensity to believe unproven things like lying politicians, anti-science, evidence-less beliefs, as opposed to those who read studies, gather published evidence, believe evidenced-based science and so on).
    Would someone who believes in astrology for example find more relief from placebos than someone who buys cheaper identical drugs rather than brand name drugs? Gullible people are everywhere and easy to fool about a lot of things.

    • @The_Blazement
      @The_Blazement Месяц назад

      Yes, I agree, but you missed the elephant in the room: how are you going to get anti-science people to agree to participate in a scientific study, especially one where they need to take a mystery pill given to them by scientists?

    • @leetri
      @leetri Месяц назад +5

      The thing about the placebo effect is that it works even if you know it's a placebo, even if you're skeptical.

    • @vlogbrotherdave
      @vlogbrotherdave Месяц назад +3

      It could also be closely related to belief in the medical system / doctors

    • @aftonair
      @aftonair Месяц назад

      ​​@@vlogbrotherdaveand religion. (Faith healing)

  • @ailaG
    @ailaG Месяц назад

    Re brand names, afaik the "new cola" in the 80s/90s didn't catch on because it's a replacement to a well known brand, and in blind tests people actually preferred it.

  • @dominosrcool4120
    @dominosrcool4120 Месяц назад

    My take on the placebo effect is that if you believe you are better/getting better you will. It explains why many ancient traditions that seem nonsensical to us but anecdotally were/are very effective. This could also explain many miracles that occur in patients who statistically shouldn't recover.

  • @fiveminutefridays
    @fiveminutefridays Месяц назад

    tbh I'd be really interested in hearing about long term placebo effects. Like if a medication has a negative long term effect (like addiction for opioids or stomach problems from NSAIDs), would a pre-conditioned placebo have those same negative effects since it may be using the same chemical pathways? Or would it not have those effects due to not being the substance causing the issue? Would it matter if the patient was made aware of those side effects (though i imagine thats almost impossible to study ethically lol)
    If placebos can cut down on negative side effects, would there be a potential application of "mixed placebo" treatments? Like getting a bottle of identical pills, some of which are placebos?

  • @Zippsterman
    @Zippsterman Месяц назад

    I know it's just B roll, but the guy at 2:38 only taking one of the pills and the giver just accepting it is hilarious

  • @der.Schtefan
    @der.Schtefan Месяц назад +1

    1A pharma is not a made up brand. It is quite common in Germany as a generic brand.

  • @PaulADAigle
    @PaulADAigle Месяц назад

    I'm not immune to Placebos, but generally, they don't work as much as you'd expect. I'm pretty attuned to effects on my body, but I can also make effects without anything at times, just brain power. I'm weird that way.

  • @xadahgla
    @xadahgla Месяц назад

    Piano!

  • @digiscott2181
    @digiscott2181 Месяц назад

    I've often been asked "Does Reiki really work?" and simply answer that all i can say, it's that I've had reported Many Happy Coincidences - because, although i may have Faith in Reiki - i certainly can't rule out the Placebo Effect ☯️

  • @X2Brute
    @X2Brute Месяц назад +1

    now I'm curious about what might happen if you were to say precondition for an opiate, then switch to an NSAID, would it work better because your body still does the opiate response and adds the NSAID? the same because your body uses the opiate response and ignores it? what about starting with an NSAID and switching to an opiate?

  • @HmmmmmLemmeThinkNo
    @HmmmmmLemmeThinkNo Месяц назад

    Okay but it could also be differences in the non-drug makeup of everything. The carriers/base, the saline, the coating, the capsule, the sugar itself, the dye(s). It could be anything. I'm not saying there's no placebo effect - there definitely is - but I think we lean too heavily on the theory without testing it (ie if you're doing a pain control study there should be multiple placebos with different ingredients).
    We also need to get away from the "nothing at all is just as good as medical treatment" bc it's used a fair amt as excuses about not giving pain medication, and so many chronic pain patients are desperate for pain relief.

  • @jerrybessetteDIY
    @jerrybessetteDIY Месяц назад +1

    Placebos work even if you know you are getting one. When I learned that, I told myself that cough drops would help me stop my drinking habit, and they worked. Then I said lemonade would work even better, and it did.

    • @clownloops
      @clownloops Месяц назад

      i heard a case of this woman who tried a bunch of medications to treat an illness of hers (i forget sorry)
      but she tried a placebo knowing it was one & it actually worked! she went off it & the pain came back. no clue why. she’s been on em since

  • @alancox5777
    @alancox5777 Месяц назад

    I 100% agree placebos work. I for example avoid alcohol and caffeine because I also take diazepam ( Valium). I know the non alcoholic guinesss I’m drinking has no alcohol I still get drunk. It’s crazy has hell. But the taste smell and texture or mouth feel are all identical.

  • @hair2050
    @hair2050 Месяц назад +21

    I’m feeling terrible. It’s either a sinus infection, allergies, or a cold of some sort. Can someone please recommend a placebo?

    • @blackwing1362
      @blackwing1362 Месяц назад +4

      Bananas work wonders

    • @user-qx7zc5iu3y
      @user-qx7zc5iu3y Месяц назад +3

      Yeah: homeopathic remedies.

    • @WolfieDawn
      @WolfieDawn Месяц назад +8

      A hot shower and gargle salt water.

    • @exosproudmamabear558
      @exosproudmamabear558 Месяц назад

      If you have sinus infection you need antibiotics dont just take plecebo but for all of them vit d is both in plecebo and pathologically effective. For allergic I suggest allergy vaccines they work wonders it will also decrease your sinus infections. For cold you can take high dosage vit c and zinc suplements amazing plecebo effects it also gives energy and helps immun system. You can also go for essential oils that is ptoven to be anbacterial and antiviral like mint or lavender to put in your nose so your nose can open up. Lavender also helps with relaxation(They activate relaxation receptor through smell receptors directly) so the plecebo effect will be high

    • @ZEbelgiumfreak
      @ZEbelgiumfreak Месяц назад

      I'll send you a miracle pill for 1000$

  • @ThelegalSWAG
    @ThelegalSWAG Месяц назад

    awesome thumbnail

  • @BionicMilkaholic
    @BionicMilkaholic Месяц назад

    I'm not sure how acupuncture can work. May just be a placebo, but it helped with my knee pain for a year (going weekly) until I could get surgery. And my first visit post surgery, it helped with the nausea I still had.

  • @user-ti8uo9ku5i
    @user-ti8uo9ku5i Месяц назад +1

    I love Hank Green.

  • @justinwhite2725
    @justinwhite2725 17 дней назад

    Placebos dont even have to be pills.
    My roommate was seeing a woman who used to be wheelchair bound and she said the doctors had no idea why. They concluded it was something in her brain and she needed therapy to uncondition herself out of.
    She didnt believe that.
    She went to a chiropractor. Chiropractor said 'oh i know what's going on' and massaged her neck and caused something to 'click' in her neck.
    Within a week she had mobility where she didn't before and was well enough to try to learn to walk again.
    I'm convinced the Chiropractor didnt really do anything, but gave her enough confidence in the process for her brain to start the requisite healing.
    Either way it worked and she was clearly a lot more halthy and happy than she was with the traditional doctors who didnt even attempt to leverage this phenomenon.

  • @avitalzehava5747
    @avitalzehava5747 Месяц назад

    In the study that had the opiate placebos at the different price points, I'm so curious what would have happened if they also presented the participants with another placebo that was significantly more expensive than market cost

  • @mattduncil
    @mattduncil Месяц назад

    Could the placebo effect and the preconditioning be used to help drug addiction?

  • @celestial1989
    @celestial1989 Месяц назад

    I'm gonna break my leg then tell myself that "This tape will get rid of the pain just as well as pain killers"

  • @Ingeyvlogs
    @Ingeyvlogs Месяц назад

    People who took Placebo and watching this video be like
    “ Did my body do magic”?

  • @WilliamScavengerFish
    @WilliamScavengerFish Месяц назад

    3:15 if you have never experienced an opioid painkiller (you only heard of them), would an opioid placebo still work?

  • @jaredkennedy6576
    @jaredkennedy6576 Месяц назад

    A lot of medicine is getting the body and mind to a point where they can heal themselves. It's kinda wild that you can trick that pathway into working.

  • @jnzkngs
    @jnzkngs Месяц назад

    I have permanent nerve damage and limited use of my left hand because my insurance company insisted that I try the placebos of chiropractic care and physical therapy before seeing a neurologist.