Gut Bacteria Boost Host NAD Metabolism
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- Опубликовано: 3 апр 2021
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Papers referenced in the video:
Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway:
pubmed.ncbi.nlm.nih.gov/32130...
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism:
pubmed.ncbi.nlm.nih.gov/27304...
Aerobic and resistance exercise training reverses age-dependent decline in NAD + salvage capacity in human skeletal muscle:
pubmed.ncbi.nlm.nih.gov/31207... 
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This is a great example of why your channel is so valuable. Even though I have access to most (probably all) the research you cite, this is such a multivariate question that I wouldn't even know how to begin my search, much less how to pull together the "cascade of results" into a coherent, understandable explanation.
I am sure these videos take quite a bit of time to pull together, and I can't thank you enough for the effort you put forth to help so many of us better understand the health and longevity processes that we can, at least to some extent, control.
EDITED: for spelling
Thanks Abraham Northhampton, well said!
Accordingly, "anti-aging" NAD enhancement supplements, such as NAM, NR, and NMN, should be used with caution in cancer patients with deamidated NAD synthesis tumors, as these supplements can stimulate tumor growth in the gut microflora. dependent way.
That's right, great point, and that's what the authors of the paper said!
Good stuff as usual.
What an awesome series of data. Thank you so much for sharing! I think there are some other datasets that may be related that haven't been connected quite yet - for example, resistant starch has shown to be "beneficial" for the gut microbiome - maybe we should see if the types of bacteria that thrive on the various types RS also align with ones that best help us boost NAD+ levels.
Good video, thank you!
Thank you very much
Great job! I am totally nerding out on your videos!
Thanks Jose Valle!
Great video thank you. I guess another option to increase NAD is to reduce cd38 (which you have mentioned previously). Brad Standfield's latest video discussed not using NMN or NR, and instead focusing more on CD38 reduction, but perhaps toping up with a little niacin. That last point ties in well with this video (if you don't mind supplementation).
@Pluvo2for1
It's a bit complicated because just reducing CD38 or It's effect might not be the right thing to do.
CD38 is there for a reason and we need to know more about that.
We know that scenescent cells produce CD38. So one way is to ruduce them, which is possible but hard to do.
We can reduce CD38 with Apigenin, as supplement or simply eat more Parsley (dried works too).
I wonder if keeping up the Glutathion level would help. If so, supplementing with NAC and Glycine would do it.
Another way to reduce cd38 is to consume parsley and/or chamomile tea which has a bioflavonoid called apigenin. Apigenin inhibits cd38 which allows NAD+ levels to rise.
That's right! I have a video on that, too:
ruclips.net/video/5-2YoGctcCk/видео.html
I put parsley and apigenin in all my teas now.
Gut bacteria again for the win! Great video thank you :)
Thanks Kimberly Oz!
soluble fiber I guess would improve gut microbiome and also lower the lps , 2 booster for healthy NADplus
Theoretically, would overconsumption of niacin from energy drinks and food do the trick of converting into NAD+? Also, what do you make of the Niagen brand that promises the highest quality of NAD+ supplementation?
Thank you 😍. Very interesting. OK, so we don't have studies on how to Increase NAD+ by targeting the gut microbiome, but what would you guess are DOs and DONTs in terms of diets?
I've covered that in other videos-the diet that best optimizes as many systemic biomarkers as possible, which is likely different for everyone.
5:50 "and then they look at nicotina... euh euh nicat..... euh .... NAD" :)
Excellent video! Thanks! It sounds like we might improve our NAD simply by rejuvenating our gut micro biome. Is that right?
Thanks Neil! Yes, but there aren't any studies for how to do that yet. This study is the first, and I'm betting that we'll see more studies that aim to increase systemic NAD+ by optimizing the gut microbiome.
Another very interesting video, thank you.
I've also seen a few studies that suggest that exercise modifies the gut microbiota e.g.
www.ncbi.nlm.nih.gov/pmc/articles/PMC5357536/
I wonder whether, and to what extent, this further boosts NAD+ metabolism via the mechanism you describe, as well as via NAMPT (as in the 3rd paper you reference) Unfortunately, I can't find any published evidence of which types of gut bacteria are enhanced by exercise, only of increased diversity.
Or am I off track?
Thanks Phil, you're not off track. Unfortunately, I don't think that there are studies that have looked at the impact of the exercise-microbiome-systemic NAD story. I'd bet that axis exists, though!
in your past videos about nad, you mention quercetin, apigenon, and other flavonoids but not rutin as a cd38. rutin is also very cheap and easy to get, what's your view on rutin as a cd38 inhibitor? I personally take 0,5g quercetin, 0,5g rutin, 3-5g dried parsley, 0.5g niacin, 0,5g nicotinamide
Hey Stylianos Iordanis, I'm not sure-is there published data for rutin as a CD38 inhibitor?
I'd measure NAD, as I assumed that my apigenein intake was sufficient to inhibit CD38 and potentially maximize NAD. it wasn't, though:
ruclips.net/video/-hfdUXsCeN8/видео.html
@@conqueragingordietrying1797 I suppose rutin is close enough to quercetin, so it should act as an cd38 inhibitor, as well.
Hm gram negative bacteria are not ideal
What diet is best to enhance those beneficial gut bacteria? Optimising gut microbiome to target anti aging benefits would be such an interesting study
I agree, and I have a video about that!
ruclips.net/video/L9wUIkqfFbo/видео.html
@@conqueragingordietrying1797 I'm a new subscriber so thank you for guiding me to the best video on this topic. Looking forward to being a new follower of your channel
I agree that we should treat our microbiome in a good way and keep it in shape. But why not supplementing with NA?
I didn't suggest to not supplement with NA in the video...
Would NA be a superior supplement over niacinamide?
Possibly, especially considering the problems with the amidated pathway (higher CD38, decreased NAMPT) during aging. To play devil's advocate, some tumors have an increased production of NAD+, so more NA would feed that. So if you have cancer, I wouldn't suggest any NAD-related supplement.
@@conqueragingordietrying1797 If NAD+ naturally falls with age, and cancer risk increases with age, perhaps the age related decrease in NAD is the body's way of protecting itself from cancer?
Great point, @@jackbuaer3828!
Do you take a probiotic supplement?
Nope. For those interested in that, I recommend gut microbiome testing, seeing if any bacteria of interest are deficient, and then supplementing with a probiotic if necessary. That approach has worked in animal studies, especially for increasing muscle mass in a cancer-model in mice. This approach also increased my Bifidobacteria, which were absent prior to supplementation. For ex., see this post:
michaellustgarten.com/2019/02/16/deep-sleep/
I just sent my gut microbiome for analysis last week, so updated data will be coming within the next month or so.
@@conqueragingordietrying1797 you are great. Thanks!!!
@@conqueragingordietrying1797 have you tracked your bifidobacteria level recently?
@@Avital4414 I sent my microbiome for analysis last week, so a Bifidobacteria update will also be possible.
@@conqueragingordietrying1797 I just picked up a bunch of cans of chickpeas. Best of luck with your upcoming report.
Louder next time please.
Niacin might be as good as expensive NMN
Based on the gut bacterial metabolism of niacinamide, that could be true, but also see Magdalena's comment above.
@@conqueragingordietrying1797 Can probiotics help or existing is good enough?
@@sauroman1 There aren't any published studies that have looked at that, but I'd bet those studies will be conducted sooner rather than later.
Why don't take NA directly, by supplementation?
When considering the gut bacterial pathway for NA-->NAD, that may be the best option.
Is NA = Niacin?
@@garydinmore1598 Yes
Thanks for sharing this video. I have been taking 5mg/kg dose of Niacin supplement daily for past several months. I also consume at minimum 40+ different types of plants a day to feed my microbiome. Sounds like I’m on the right track to increase my longevity!
@@conqueragingordietrying1797 can you explain why supplementing with Nam -> Na is better than just taking Na directly? Thanks
very complicated information(
Sorry to hear that-rewatching the video a few times can help! It does for me when something that I'm watching is complicated...