Really detailed and well-explained! I'm doing an APA styled college-level research paper about the evolution of prions for my 10th-grade class. Needless to say, your lecture will be cited in-text repeatedly throughout my paper. Thank you for the presentation, Mr. Ironside!
The Spanish and British smuggled sheep called Merinos which were renowned for their glossy wool and bred them with British sheep to increase the amount of meat on them which inadvertently spread Scrapie.
"Creutzfeld-Jakob" disease and "Gerstmann-Straussler-Scheinker" disease ... okay, that is really not easy for an non-native German speaker. It´s even a tongue-breaker to us.
So you are telling me you can't detect this in people other than a brain biopsy?!? that is shocking we need to improve this! What's to say we don't all have some level of prions in the brain? What are some ways the immune system can fight them?
The thing is nothing can get rid of them, nothing we know today can actually get rid of these disease prions and they are almost undetectable untill the very last years of sufferers life
1) you can detect this, it's just not so easy, fast and accurate as a biopsy is 2) we all have prions in the bran, but just the PrPc, not the PrPres/PrPsc, you can prove that just by analized how could you get them, the meet you eat and all that stuff is secure, you're covered under that, plus those are super rare "illness" (I'm not an native English speaker, so maybe illness is not the most accurate word, but you get the concept I hope) so don't commit the bias to think that you have it just bc there's no proof you don't, bc trust me, you would notice that, or at least other person would. 3) the immune system cannot do anything bc those aren't cells, those are proteins and the T-killer cannot attack something which has not a target attached to it, and in order to do so, it would need to be at least some 1000/10000 times bigger or so, a protein is just not something that could get attacked, and even if he could, as he says those are really though and resistant again proteasis, so there's nothing that our body can do to eliminate that, zero, there's no cure and those are 100% lethal 100% of the times
Is it possible that perhaps chaperones are somehow involved in both, prion diseases as well as others such as Alzheimer's, seeing as both involve misfolded proteins?
I’m a regular blood donor but I wouldn’t take blood from someone else unless it’s life or death. This is why I refused blood transfusion when I was anaemic. They wanted to give me a bag of blood after giving birth, but I opted out, my levels weren’t so bad as to it being emergency and I opted out.
@@lucianaromulus1408 I agree. But blood has a limited shelf life so to keep it around for emergencies wouldn’t really work. However, they should absolutely allow it for preplanned surgeries and such.
What are the chances of a new wave/breakout of vCJD in the future? Incubation time in some kuru cases are crazy long, arent they? The Last kuru victim died in 2005 (or 2009 some say) and they say that they stopped eating human meat in the early 1960s. So this would be a time gap of 40+ years.
He talked about this exact topic in the video, he said that those are from 6 to 50 years of incubation, but for the kuru, there's no way that a despise with less than 3 cases in the last year comes to cause an outbreak of any kind, the meat is secure and the people how did eat non safe meat are know, so it's very (like, impossible) that it will happens again, or at least not of CJD
You misinterpreted that, if you have CJD you die, like 100%, and it even takes years or decade, so probably what you mean is that had a gene that as he said in this video, helped the prion to cause death faster, but nothing more
Wym? They cause amyloid, not the other way around, and why "just", even Alzheimer's cause amyloid plaques, so I don get what you mean, it's like saying "so flue is just a form of sneeze desise"?
Really detailed and well-explained! I'm doing an APA styled college-level research paper about the evolution of prions for my 10th-grade class. Needless to say, your lecture will be cited in-text repeatedly throughout my paper. Thank you for the presentation, Mr. Ironside!
That was exceptional.
I'm doing Prions for a college course, this has been extremely useful and very informative.
Did it work out for you?
I've seen this man prof. James Ironside on so many CJD and BSE videos and documentaries. Legend.
The Spanish and British smuggled sheep called Merinos which were renowned for their glossy wool and bred them with British sheep to increase the amount of meat on them which inadvertently spread Scrapie.
"Creutzfeld-Jakob" disease and "Gerstmann-Straussler-Scheinker" disease ... okay, that is really not easy for an non-native German speaker. It´s even a tongue-breaker to us.
I'm an English speaking American. German is closely related to English, not that hard. Try pronouncing Russian or Chinese titled diseases 😅
Was in the 5th Dundee BB Company with James (Jimmy, as he was known then). Always a mature and highly intelligent boy. Nice guy.
when they make a biography on this homie, you KNOW they're casting John Malkovich
terrific lecture. really horrifying stuff.
My sister has been diagnosed with CJD. 4/2021. We are heartbroken.
So sad
How’s she now?
When was she jabbed?
How was she diagnosed?
Is she still alive?
Very informative and interesting.
Hopefully those beefburgers I ate in the nineties haven't left any prions behind.
So you are telling me you can't detect this in people other than a brain biopsy?!? that is shocking we need to improve this! What's to say we don't all have some level of prions in the brain? What are some ways the immune system can fight them?
The thing is nothing can get rid of them, nothing we know today can actually get rid of these disease prions and they are almost undetectable untill the very last years of sufferers life
1) you can detect this, it's just not so easy, fast and accurate as a biopsy is
2) we all have prions in the bran, but just the PrPc, not the PrPres/PrPsc, you can prove that just by analized how could you get them, the meet you eat and all that stuff is secure, you're covered under that, plus those are super rare "illness" (I'm not an native English speaker, so maybe illness is not the most accurate word, but you get the concept I hope) so don't commit the bias to think that you have it just bc there's no proof you don't, bc trust me, you would notice that, or at least other person would.
3) the immune system cannot do anything bc those aren't cells, those are proteins and the T-killer cannot attack something which has not a target attached to it, and in order to do so, it would need to be at least some 1000/10000 times bigger or so, a protein is just not something that could get attacked, and even if he could, as he says those are really though and resistant again proteasis, so there's nothing that our body can do to eliminate that, zero, there's no cure and those are 100% lethal 100% of the times
Is it possible that perhaps chaperones are somehow involved in both, prion diseases as well as others such as Alzheimer's, seeing as both involve misfolded proteins?
See lectures of Stanley Prusiner.
I’m a regular blood donor but I wouldn’t take blood from someone else unless it’s life or death. This is why I refused blood transfusion when I was anaemic. They wanted to give me a bag of blood after giving birth, but I opted out, my levels weren’t so bad as to it being emergency and I opted out.
We should be allowed to donate for ourselves, like we all have personal blood banks. Its a crime we arent allowed to
@@lucianaromulus1408 I agree. But blood has a limited shelf life so to keep it around for emergencies wouldn’t really work. However, they should absolutely allow it for preplanned surgeries and such.
@MsJustice4ever why couldn't we just routinely donate though ?
awesome upload The University of Edinburgh. I killed that thumbs up on your video. Maintain up the excellent work.
Prof. Ironside deserves better questions from an informed audience.
Thank you for this Video
Very pertinent given covid and inoculation risk of same
@@sbraypaynt the mRNA experimental gene therapy aka "vaccine"
dandelion root
Thanks , hopefully I can talk about this in my Cambridge interview
Did you??
What are the chances of a new wave/breakout of vCJD in the future?
Incubation time in some kuru cases are crazy long, arent they? The Last kuru victim died in 2005 (or 2009 some say) and they say that they stopped eating human meat in the early 1960s. So this would be a time gap of 40+ years.
He talked about this exact topic in the video, he said that those are from 6 to 50 years of incubation, but for the kuru, there's no way that a despise with less than 3 cases in the last year comes to cause an outbreak of any kind, the meat is secure and the people how did eat non safe meat are know, so it's very (like, impossible) that it will happens again, or at least not of CJD
This prof is true asmr:))
exceptional!
Please turn on the subtitles while watching this.
Very good thank's!
I know people who owned a steak house and their children died of CJD somehow the parents were carriers How is that?
You misinterpreted that, if you have CJD you die, like 100%, and it even takes years or decade, so probably what you mean is that had a gene that as he said in this video, helped the prion to cause death faster, but nothing more
Is this just a form of amyloid disease?
Wym? They cause amyloid, not the other way around, and why "just", even Alzheimer's cause amyloid plaques, so I don get what you mean, it's like saying "so flue is just a form of sneeze desise"?
Please find a cure
dandelion root
@@mdimarco87 As a cure?
Definitely Michael Ironside's long lost brother! Or half-brother..
Nanobots programmed on the 43% betasheet of the prions :D
This could save our planet if a human version evened out our population a bit
Boring.
Interesting!
No one asked
Yes you are!!