Thank you! I try to produce content that is understandable (to some degree) by anyone, but also provides something interesting for those working in science.
@@jnewmark41 wow, interesting. So it sounds like the hardest part would be getting over the initial fear and getting myself to actually do it. Would you agree? Also, it’s been a while since your initial post. Would you recommend doing it? And are you still better from it today?
Thanks for video. I will be trying spravato this week if insurance approves. I have Major depression. If insurance doesn’t approve I might have to look into infusions
I realize this is a year later, but i take ketamine at home orally and thru suppositories (for major depression). I'm happy to share more info with you if you'd like!
I stumbled upon your channel because I was genuinely curious about what ‘Kratom’ was and why it’s so attractive to the people who choose to take it. While I didn’t exactly find the anecdotal ‘user’ perspective I was originally seeking, I came to find that your pharmacological and neuro-based explanations have immense educational value for any ‘casually curious’ individuals like me! I appreciate the work you do and you’ve certainly earned my subscription. Thank you and keep up the good work! :)
I just asked my ketamine doctor this and was relieved to find out he did. Its so hard to know if I'm dissacociating and hard to explain to my doctor what my response has been. I feel like its been helping but i cant explain how or why.
In off-label clinical use of ketamine, a bolus, all at once IV dose of ketamine seems particularly effective for very resistant depression. It produces a very strong dissociate effect, scary, a near-death experience perhaps, where consciousness is maintained but reality disappears. Not a first-line use, or for the faint-hearted. There is very limited trial work on bolus IV but the published research indicates it is effective. I would agree there is little research on whether dissociation is desirable, but a high serum concentration seems important. In clinical use of oral ketamine, the responses were highly variable but when it did act quickly and produced dissociation, the effect was better. Oral ketamine, while convenient, is too variable. Intranasal seems much better.
Indeed. I think oral does seem the weakest choice, could also be related to the relatively heavy metabolism (and who knows if i.e. norketamine counteracts some of the effects). The rapid rise in ketamine concentration could be important in pushing neural homeostasis to an extreme. But obviously there's not enough evidence to make any clear conclusions, other than that IV and intranasal seem to be superior to oral ketamine.
@@Neuropharmacistues, i had issue with oral ketamine - i tried rapid release sublingual tablets and troches, so i switched to suppositories which helped tremendously. I dont know if its just my body and how it absorbs or what but it seemed much more consistent. Im looking into spravato as well.
Do you know how dissociation occurs without the use of drugs? E.g. during a panic attack. Is there any research into whether ketamine induced dissociation would be unhelpful in those who already experience dissociation due to mental illness? Great videos btw, thanks
The study "Deep posteromedial cortical rhythm in dissociation" suggests that both the dissociation produced by drugs like ketamine and that observed in certain patients with epilepsy may share features of certain rhythms of neuronal activity in spesific cortical areas, but it remains unclear whether the emergence of dissociation in a wider context can be pinpointed to such a spesific mechanism. There is also no real evidence to support the notion that ketamine induced (subjective experience of) dissociation is a major driving force for therapeutic outcomes. Since dissociation can occur in the context of many psychiatric disorders, at this stage, it is difficult to speculate on what how pre-existing dissociation responds to dissociative anesthetics like ketamine. This is also not really my area of knowledge, perhaps a psychiatrist working with dissociative disorders would know more.
Your videos are fantastic. And thank you for including references!
Thank you! I try to produce content that is understandable (to some degree) by anyone, but also provides something interesting for those working in science.
Ketamine completely wiped out my horrible anxiety
was the experience scary at all? i've been wanting to do it but i'm scared of the what it might be like because of my anxiety
@@mach7rs Only in my mind.....once it takes effect, your Default Mode Network goes "offline." Fear stops existing.
@@jnewmark41 wow, interesting. So it sounds like the hardest part would be getting over the initial fear and getting myself to actually do it. Would you agree? Also, it’s been a while since your initial post. Would you recommend doing it? And are you still better from it today?
@@mach7rs Yes! I go occasionally for booster, ESPECIALLY b/c of Trump and all that stress. next on the list is psilocybin....
Amazing thank you
Thanks for watching!
Thanks for video. I will be trying spravato this week if insurance approves. I have Major depression. If insurance doesn’t approve I might have to look into infusions
I realize this is a year later, but i take ketamine at home orally and thru suppositories (for major depression). I'm happy to share more info with you if you'd like!
I stumbled upon your channel because I was genuinely curious about what ‘Kratom’ was and why it’s so attractive to the people who choose to take it. While I didn’t exactly find the anecdotal ‘user’ perspective I was originally seeking, I came to find that your pharmacological and neuro-based explanations have immense educational value for any ‘casually curious’ individuals like me!
I appreciate the work you do and you’ve certainly earned my subscription. Thank you and keep up the good work! :)
Thank you for your very kind comment! Welcome aboard :)
Way to hard to find this, and many people want it. Keep it up, this willl explode soon.
Have you ever used K yourself?
I just asked my ketamine doctor this and was relieved to find out he did. Its so hard to know if I'm dissacociating and hard to explain to my doctor what my response has been. I feel like its been helping but i cant explain how or why.
No answer is also an answer...
In off-label clinical use of ketamine, a bolus, all at once IV dose of ketamine seems particularly effective for very resistant depression. It produces a very strong dissociate effect, scary, a near-death experience perhaps, where consciousness is maintained but reality disappears. Not a first-line use, or for the faint-hearted. There is very limited trial work on bolus IV but the published research indicates it is effective.
I would agree there is little research on whether dissociation is desirable, but a high serum concentration seems important. In clinical use of oral ketamine, the responses were highly variable but when it did act quickly and produced dissociation, the effect was better. Oral ketamine, while convenient, is too variable. Intranasal seems much better.
Indeed. I think oral does seem the weakest choice, could also be related to the relatively heavy metabolism (and who knows if i.e. norketamine counteracts some of the effects). The rapid rise in ketamine concentration could be important in pushing neural homeostasis to an extreme.
But obviously there's not enough evidence to make any clear conclusions, other than that IV and intranasal seem to be superior to oral ketamine.
@@Neuropharmacistues, i had issue with oral ketamine - i tried rapid release sublingual tablets and troches, so i switched to suppositories which helped tremendously. I dont know if its just my body and how it absorbs or what but it seemed much more consistent. Im looking into spravato as well.
Do you know how dissociation occurs without the use of drugs? E.g. during a panic attack. Is there any research into whether ketamine induced dissociation would be unhelpful in those who already experience dissociation due to mental illness?
Great videos btw, thanks
The study "Deep posteromedial cortical rhythm in dissociation" suggests that both the dissociation produced by drugs like ketamine and that observed in certain patients with epilepsy may share features of certain rhythms of neuronal activity in spesific cortical areas, but it remains unclear whether the emergence of dissociation in a wider context can be pinpointed to such a spesific mechanism.
There is also no real evidence to support the notion that ketamine induced (subjective experience of) dissociation is a major driving force for therapeutic outcomes. Since dissociation can occur in the context of many psychiatric disorders, at this stage, it is difficult to speculate on what how pre-existing dissociation responds to dissociative anesthetics like ketamine. This is also not really my area of knowledge, perhaps a psychiatrist working with dissociative disorders would know more.