Alex Marson, UCSF/Gladstone. "Decoding & Reprogramming Immune Cell Circuits with CRISPR"

The goal of the Marson lab is to understand genetic circuits that control human immune cell function in health and disease. We have begun to identify autoimmunity risk variants that disrupt immune cell circuits, and how pathogenic circuits may be targeted with novel therapeutics. Our lab has developed new tools for CRISPR genome engineering in primary human T cells. We are now pursuing a comprehensive strategy to test how coding and non-coding genetic variation controls functional programs in the immune system. Genome engineered human T cells hold great potential for the next generation of cell-based therapies for cancer, autoimmunity, and infectious diseases.

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