_RUclips timestamps by Les_ 04:32 Please help science edutainment *Announcements* 05:12 Flu virus Meeting Sept 29 - Oct 2 @Brisbane, Australia
www.immunisationcoalition.org.au/events/options-xii-for-the-control-of-influenza/ 06:26 *Biology News (courtesy of Dr Amy Rosenfeld)* Measle cases in NYC and DC Global childhood immunization stalls (WHO) Licensed H5N1 vaccines protect against circulating strains (Nat Med) Viruses moving without passports (European CDC) 15:15 OC42-SARS-CoV-2 replacement spike virus (PNAS) 39:05 Deep mutational scanning of Lassa virus glycoprotein (Immunity) 1:10:41 *Your correspondence answered by scientists* see microbe.tv/twiv/twiv-1133-letters/ 1:10:52 Fernando 1:19:51 Suzanne 1:25:58 Peter 1:36:39 *Picks of the Week* 1:36:44 Dixon 1:38:29 Kathy 1:41:26 Rich 1:47:43 Alan 1:53:45 Vincent 1:57:36 If you this please donate _Audio podcast timestamps by Jolene_
@@tonaruch8623 I produce these timestamps before Dr Jolene Ramsey independently gets a chance to listen and compile hers. There are members around the world that listen right away and I want something to be available for them.
I agree. Could you from now on skip emails with politics in them? It only riles you, the author and the listeners and usually leads to nothing but people becoming polarized more and more. In the end it might really lead to listeners leaving. C'mon, we came here for the science, not for the politics.
Love to listen ...even to you all addressing the political mess during Covid. I lived in Mexico during the swine flu. Everything shut down immediately. Living in Tucson years ago that Hanta talk sparked my memories.
I'd feel a bit reasured if they had on hand the PPE necessary to manage an outbreak radius of the expected virulence(?) of the soup they are cooking. I have in my rural area an ammunition factory. They actually located the place with some thought to safety and put their own convenience second.
Kathy’s pick to listen to the Edwin Lennette Lectures at ASV, specifically Gail Wertz ‘s , was so uplifting and inspiring. Definitely worth listening to . Thanks Kathy.
In your country (USA) I think the best you can hope for in the current political environment is to communicate the evidence as clearly as possible. Let informed people make their choice. Not saying it's the best way forward in theory, but in practice it's the best you can do. Let the unvaccinated suffer the consequences. Just keep on disseminating the truth as best as it can be divined. To achieve anything any better requires a political solution which won't come because the science of mass manipulation goes unchallenged. Indeed it is an almost invisible science, a tool used exclusively by those with a lust for money and power.
Hi all, ....Love the program- love the learning -thank you all....! ..My 3 kids are fully vaccinated....I always avoided taking them to malls, airports etc when they were newborns.......But 35 m. kids not vacinated..W-O-W that's TERRIFYING>>
But if furin site is exiced,, then is not Sars Cov 2 Spike. Or is it? If lost Furin site is a los a function. Then there is no S1 subunit leak... Pathogenesis mechanism change. What about the UTRs are from OC virus... have to look for the article
Unless you formally studied the subject material in grad school your have better odds of rebuilding a Pratt & Whitney commercial jet engine from top to bottom _with no experience_ than you do understanding complex biological phenomena. No being facetious here, either.
Thank you all for your devotion to science education. I have a question. How do scientists dispose of used virus particles or recombinant viruses safely?
Consider that the traffic term "VISION ZERO" was embraced by Europe and NYC. Riduculous 😂 Professionals use their own language. Yup. Yup. Love calling them little micro rats "fit."
@@Sceince007 not only is it illegal they went around back channels to find that research in Wuhan. It’s dirty. If you can’t tell the truth than it’s dirty.
Respectfully....A virologist cannot determine the safety of a lab. Human behavior makes the danger, not the organism. It is a sociological, tactical and political issue. A brief lapse in security or procedure over time.... How about a war? Civil unrest? A coup? natural disaster? Any of those can crack a lab wide open. Lets say a doomsday cult shows up, fully armed; Are all your colleagues likely to sacrifice their lives? Would the weakest link cower and give them access? You make a biological agent ..... You create a potential for it's escape. I'm all ears, but you may want to turn to an expert in human nature and society. They would not have your confidence..... It will take some years to improve public faith and trust... not that it's your fault; TWIV is excellent ... but the media rhetoric, insults, the governments hypocrisy, irresponsible handling of information... and frankly.... the apparent greed and lack of transparency in the roll outs. That is a burden you inherit.
We have input from experts on human behavior. In the aircraft industry, after WWII, aircraft designers, at Boeing and elsewhere, had to make flying safe enough to be acceptable to the general public, and they did lots of research into the behavioral aspects of aircraft accidents. Every significant accident was investigated by a panel of experts, who usually found the cause -- sometimes equipment design, sometimes pilot operation. For example, some accidents were caused by a pilot using the wrong control (moving the landing gear up rather than down, for example). A frequent cause was that controls were not standardized, and moving a landing gear up in one aircraft would move it down in another aircraft. The solution was to standardize controls. The saying is that every change in the operating manual was made with blood. This led to the specialty of safety engineering, which was used in the medical industry for example in designing complex equipment like lasers. (One guy who wrote about this was Robert Wachter, MD.) With biological labs, we now have a significant experience handling pathogens. They're not perfectly safe -- nothing can be -- but they're safe enough to argue that the benefits far outweigh the risks. I would argue that exaggerated speculations over security risks prevented us from cooperating with Chinese doctors and scientists, and cost us a significant fraction of those 1.1 million COVID-19 deaths.
@@norman_5623 A single accident with aircraft and lasers are a danger to those present at that time. A single accidental release of a GOF virus means a global catastrophe for all of humanity in perpetuity. Beyond comparison. You say yourself "They're not perfectly safe -- nothing can be". You'll need better than an argument of "risk/benefit", if you are making pathogens more infectious, virulent and lethal in a lab. ONE MISTAKE... and millions.. BILLIONS could die. The risk is absolute and existential. Without absolute, infallible, perfect containment, the risk is unacceptable. You have fully convinced me, no hands are safe to perform GOF. It a gamble with mass death and permanent disability, without consent. Knowing first hand the death, disability, illness and misery STILL caused by Covid-19... The failures of containment.. the impossibility of eradication.... To be making worse... Accepting that it COULD escape... There is no greater threat. There is no benefit to match it!
@@norman_5623I don't think Boeing was a great example. Or rather, they are an excellent example of how accidents happen despite good intentions and regulatory oversight.
1:19:51 please clip out the mail bag questions and answers this week as its own short for ease of sharing because there are some very important discussions happening in this section, especially in regards to natural spillover and alternative conspiracy hypotheses for the origin of SARs-COV2. You all beautifully addressed some common laypersons misunderstandings about viral evolution and why none of the other suggestions are remotely logical when the science is more fully understood. I see the same misconceptions that these writers bring up all over any video that tries to have this conversation and it needs to be better refuted, thank you so much for addressing these questions 🦠 🙏 🧪
_RUclips timestamps by Les_
04:32 Please help science edutainment
*Announcements*
05:12 Flu virus Meeting Sept 29 - Oct 2 @Brisbane, Australia
www.immunisationcoalition.org.au/events/options-xii-for-the-control-of-influenza/
06:26 *Biology News (courtesy of Dr Amy Rosenfeld)*
Measle cases in NYC and DC
Global childhood immunization stalls (WHO)
Licensed H5N1 vaccines protect against circulating strains (Nat Med)
Viruses moving without passports (European CDC)
15:15 OC42-SARS-CoV-2 replacement spike virus (PNAS)
39:05 Deep mutational scanning of Lassa virus glycoprotein (Immunity)
1:10:41 *Your correspondence answered by scientists*
see microbe.tv/twiv/twiv-1133-letters/
1:10:52 Fernando
1:19:51 Suzanne
1:25:58 Peter
1:36:39 *Picks of the Week*
1:36:44 Dixon
1:38:29 Kathy
1:41:26 Rich
1:47:43 Alan
1:53:45 Vincent
1:57:36 If you this please donate
_Audio podcast timestamps by Jolene_
ty homie
Thanks Jolene!😊
@@tonaruch8623 I produce these timestamps before Dr Jolene Ramsey independently gets a chance to listen and compile hers. There are members around the world that listen right away and I want something to be available for them.
@@lesfaby8997thanks Les! I appreciate the time stamps
@@tonaruch8623 me too. Thanks Les
Politics is driving me crazy. Science keeps me sane. Thank you
I agree. Could you from now on skip emails with politics in them? It only riles you, the author and the listeners and usually leads to nothing but people becoming polarized more and more. In the end it might really lead to listeners leaving. C'mon, we came here for the science, not for the politics.
What a great discussion re spillovers! So many people need to listen to this. Thank you!
That’s excellent. Thank you very much. Keep up the great work
Always great to listen to you all!!!
Thank you Vincent. ❤❤❤
Another great episode
Glad to see almost the whole gang!
The apex predators aren't people. Some will never figure it out.
Nice to see the friends together though I missed dr barker
Love to listen ...even to you all addressing the political mess during Covid. I lived in Mexico during the swine flu. Everything shut down immediately.
Living in Tucson years ago that Hanta talk sparked my memories.
I'd feel a bit reasured if they had on hand the PPE necessary to manage an outbreak radius of the expected virulence(?) of the soup they are cooking. I have in my rural area an ammunition factory. They actually located the place with some thought to safety and put their own convenience second.
Questions about biosecurity of WIV seem to be linked to 2 cables sent by US officials who visited the lab in 2018.
Kathy’s pick to listen to the Edwin Lennette Lectures at ASV, specifically
Gail Wertz ‘s , was so uplifting and inspiring. Definitely worth listening to . Thanks Kathy.
In your country (USA) I think the best you can hope for in the current political environment is to communicate the evidence as clearly as possible.
Let informed people make their choice.
Not saying it's the best way forward in theory, but in practice it's the best you can do.
Let the unvaccinated suffer the consequences.
Just keep on disseminating the truth as best as it can be divined.
To achieve anything any better requires a political solution which won't come because the science of mass manipulation goes unchallenged.
Indeed it is an almost invisible science, a tool used exclusively by those with a lust for money and power.
Hi all, ....Love the program- love the learning -thank you all....! ..My 3 kids are fully vaccinated....I always avoided taking them to malls, airports etc when they were newborns.......But 35 m. kids not vacinated..W-O-W that's TERRIFYING>>
But if furin site is exiced,, then is not Sars Cov 2 Spike. Or is it? If lost Furin site is a los a function. Then there is no S1 subunit leak... Pathogenesis mechanism change. What about the UTRs are from OC virus... have to look for the article
Unless you formally studied the subject material in grad school your have better odds of rebuilding a Pratt & Whitney commercial jet engine from top to bottom _with no experience_ than you do understanding complex biological phenomena.
No being facetious here, either.
My reaction to the title before listening is "Yikes".
It should still be yikes.
We need more Gain of Function to save the planet.
Is Fenners and White virology a good book for virology exams?? Asking as a Medicine student
Thank you all for your devotion to science education. I have a question. How do scientists dispose of used virus particles or recombinant viruses safely?
Depends on the context but chemically with a disinfectant or via autoclaving.
good stuff
Thanks
You can’t use the phrase “gain of function” it will never be accepted by the general public or government officials.
Consider that the traffic term "VISION ZERO" was embraced by Europe and NYC.
Riduculous 😂
Professionals use their own language. Yup. Yup. Love calling them little micro rats "fit."
@@rbdesigner725 should general public not be educated on the subject so can start accepting ?
@@Sceince007 there’s no reason to accept and in fact “Gain of function” was made illegal by the US government.
@@Sceince007 not only is it illegal they went around back channels to find that research in Wuhan. It’s dirty. If you can’t tell the truth than it’s dirty.
Respectfully....A virologist cannot determine the safety of a lab. Human behavior makes the danger, not the organism. It is a sociological, tactical and political issue. A brief lapse in security or procedure over time.... How about a war? Civil unrest? A coup? natural disaster? Any of those can crack a lab wide open. Lets say a doomsday cult shows up, fully armed; Are all your colleagues likely to sacrifice their lives? Would the weakest link cower and give them access?
You make a biological agent ..... You create a potential for it's escape. I'm all ears, but you may want to turn to an expert in human nature and society. They would not have your confidence..... It will take some years to improve public faith and trust... not that it's your fault; TWIV is excellent ... but the media rhetoric, insults, the governments hypocrisy, irresponsible handling of information... and frankly.... the apparent greed and lack of transparency in the roll outs. That is a burden you inherit.
Hmm something to think about for sure 🤔
Who is qualified to "determine the safety of a lab"?
We have input from experts on human behavior. In the aircraft industry, after WWII, aircraft designers, at Boeing and elsewhere, had to make flying safe enough to be acceptable to the general public, and they did lots of research into the behavioral aspects of aircraft accidents. Every significant accident was investigated by a panel of experts, who usually found the cause -- sometimes equipment design, sometimes pilot operation. For example, some accidents were caused by a pilot using the wrong control (moving the landing gear up rather than down, for example). A frequent cause was that controls were not standardized, and moving a landing gear up in one aircraft would move it down in another aircraft. The solution was to standardize controls. The saying is that every change in the operating manual was made with blood. This led to the specialty of safety engineering, which was used in the medical industry for example in designing complex equipment like lasers. (One guy who wrote about this was Robert Wachter, MD.) With biological labs, we now have a significant experience handling pathogens. They're not perfectly safe -- nothing can be -- but they're safe enough to argue that the benefits far outweigh the risks. I would argue that exaggerated speculations over security risks prevented us from cooperating with Chinese doctors and scientists, and cost us a significant fraction of those 1.1 million COVID-19 deaths.
@@norman_5623 A single accident with aircraft and lasers are a danger to those present at that time. A single accidental release of a GOF virus means a global catastrophe for all of humanity in perpetuity. Beyond comparison.
You say yourself "They're not perfectly safe -- nothing can be". You'll need better than an argument of "risk/benefit", if you are making pathogens more infectious, virulent and lethal in a lab. ONE MISTAKE... and millions.. BILLIONS could die. The risk is absolute and existential. Without absolute, infallible, perfect containment, the risk is unacceptable.
You have fully convinced me, no hands are safe to perform GOF. It a gamble with mass death and permanent disability, without consent.
Knowing first hand the death, disability, illness and misery STILL caused by Covid-19... The failures of containment.. the impossibility of eradication.... To be making worse... Accepting that it COULD escape... There is no greater threat. There is no benefit to match it!
@@norman_5623I don't think Boeing was a great example. Or rather, they are an excellent example of how accidents happen despite good intentions and regulatory oversight.
Wellcome back, to "The Dude!!!"
Anyone knows how does vaccine work?
Yeah, I looked up that alpha-dystroglycan too. Nice to know I'm asking the right questions.
So does open air nuclear weapon testing according to the experts
Vincent is a joke
1:19:51 please clip out the mail bag questions and answers this week as its own short for ease of sharing because there are some very important discussions happening in this section, especially in regards to natural spillover and alternative conspiracy hypotheses for the origin of SARs-COV2. You all beautifully addressed some common laypersons misunderstandings about viral evolution and why none of the other suggestions are remotely logical when the science is more fully understood. I see the same misconceptions that these writers bring up all over any video that tries to have this conversation and it needs to be better refuted, thank you so much for addressing these questions 🦠 🙏 🧪