I like the train of thought: turning on genes → how to color bacteria in cool ways → natural clock → drug delivery → curing tuberculosis → how flowers blossom → why snakes are so long → how to make a snake-mouse Can't wait for “Home-grown snake people” and “DIY sand worm from Dune”
Man, I love these streams. I always miss them, and I never have time to watch the full streams. I wish we had shorter form (f.e. half the time) videos. Nothing wrong with these videos, they offer educational content to the world, which is awesome
In theory, it should be possible but the immune system is just very complex and hard to trick. The big difficulty would be to modify the donor organs to be accepted by the patient without destroying them. That seems much more complex and dangerous than just growing them in a Lab. (Growing them in a Lab is also very very difficult)
Sounds extremely ineffective though. Wouldnt just decellurized organs that are implanted with your stem cells to then divide and inhabit the shell of the organ work better?
Theoretically you could but just practically it doesnt seem feasible. One of the biggest predictors of transplant success is how quickly you go from donor to recipient, adding in tons of genetic engineering is almost certainly going to have a significant negative impact on viability. You would also need to know in advance what modifications would need to be made well in advance which isn't realistic for many transplant scenarios either.
As someone who is a pretty decent programmer. This would be fun to model in software so we can write human readable code for this. That way you could in " concept " program a cell in the same format as programming languages. The same amount of abstraction is used in modern computing where a lower level language is actually what powers a higher level language 🙃 That way in the future, we could legit just have a computer program the cells via a machine without human intervention.
Can we make a Timer DNA circuit so that if we genetically modify a species by fitting this ckt , say 3rd generation do not have reproduction capabilities.
Gen Engineering is the way of the future. Grow what you need, make what you want. The future is now, depending on the place you call home. If this seems wrong, is because it's true.
I commented several questions and don't know where they went, about what would it take to create custom organelles, why can't you use plasmids with mammals, and what kind of unit cell would you use to grow a brain if you could like a crystal. None of those comments appear here, wonder where they went?
Mammals tend to have linear DNA while plasmids are circular also the whole nucleus surrounded by the nuclear envelope with my favorite structure in the nuclear pore
Any recommendations on papers/online courses diving further into genetic circuit design? Coming at this as a 3rd year Molec Bio/CS undergrad, and I'm trying to build a tree of prerequisite knowledge I'd need for all this.
I know that oscillation requires repression with significant delay to prevent the system from reaching an equilibrium. Is this not a problem when working with genetic switches due to the relatively long amount of time it takes from transcription to translation when compared to the time it takes for repressors to bind to and repress genes?
What’s the difference between the gene programming of the video (I think it’s called gene therapy in healthcare context) and the CRISPR gene editing technique?
Gene editing is a generic term for all sorts of techniques to change the protein production of cells, gene therapy refers to any use of these techniques specifically for medical reasons, CRISPR/CAS is one small set of these techniques, based on a type of bacterial immune system. There are many other ways to get the same results, which one will work best heavily depends on the specific situation. @TheThoughtEmporium has gone over a lot of this with *much* more detail in previous streams.
What is going on there is an abundance of positive ions apparently not being diffused or something like that potassium maybe scan doesn't taste like salt what exactly is going on and what do I need to do to start diffusing positive potassium ions
We've come a long way since I got my Biology degree 20 years ago, too bad I never got to use it. I think AI is going to revolutionize the possibilities.
How can we be 100% sure that changing one expression of a gene does not affect another gene's function/expression elsewhere in the organism? I mean we think we know everything but our understanding of the complex mechanisms within biology/organisms are being updated constantly, or am i wrong?
Becouse one gene only doses for one specific protein it has no infkuence on the coding of another gene you can be very pericise in how to target the dna
Of course, the real manbat 9000 is switching on the latent ‘human’ echo location gene 🧬 by inserting it into the human Genome from actual bats with CRISPR!
A full adder is like your first real digital circuit that isn't a hello world, computers have other parts that look a lot different like memory and decoders
Fair enough but a lot of his ideas are usually projects of decades in a university and lots of funding and people working on it. Not saying he shouldn't focus on one thing and accomplish something. But it can be pretty insane just getting the correct materials and equipment to try to push the technology bar.
As a Bioengineering major, you guys are my idols :) thanks once again for sharing such knowledge
Same here
I like the train of thought: turning on genes → how to color bacteria in cool ways → natural clock → drug delivery → curing tuberculosis → how flowers blossom → why snakes are so long → how to make a snake-mouse
Can't wait for “Home-grown snake people” and “DIY sand worm from Dune”
His content in 2037 : Budget friendly DIY LEGAL homemade Godzilla (Accurate scale to scale specimen)
I hope to be able to do similar stuff with my channel too
starts at 2:25
my dumbass was staring at stream starting soon not realizing its already done lol
Pin this
Or you just check the description for the transcript...
Content creators are OUT, creature creators are IN 👏👏
Man, I love these streams. I always miss them, and I never have time to watch the full streams. I wish we had shorter form (f.e. half the time) videos. Nothing wrong with these videos, they offer educational content to the world, which is awesome
@@adairjanney7109 But but but but my procastination
I love the advice about reading A LOT. It's important. Showing this to mah students.
Bro you are my favorite youber ever I wish there were more of you
Exzellente Lektion
Didaktisch hervorragend gestaltet
Spannend erzählt
Danke
Never expected that you’d be able to make gates with proteins
just wait
for wut?@@Afkmuds
Would it be possible to modify cells of a donor organ so the host body would not reject it?
maybe by a virus but a virus doesn't have that large memory
In theory, it should be possible but the immune system is just very complex and hard to trick. The big difficulty would be to modify the donor organs to be accepted by the patient without destroying them. That seems much more complex and dangerous than just growing them in a Lab. (Growing them in a Lab is also very very difficult)
You’d probably need to modify every single cell of the organ and make sure that every cell is really modified…
Sounds extremely ineffective though. Wouldnt just decellurized organs that are implanted with your stem cells to then divide and inhabit the shell of the organ work better?
Theoretically you could but just practically it doesnt seem feasible. One of the biggest predictors of transplant success is how quickly you go from donor to recipient, adding in tons of genetic engineering is almost certainly going to have a significant negative impact on viability. You would also need to know in advance what modifications would need to be made well in advance which isn't realistic for many transplant scenarios either.
I have no clue what I'm watching, but I hope u get rich
As someone who is a pretty decent programmer. This would be fun to model in software so we can write human readable code for this.
That way you could in " concept " program a cell in the same format as programming languages.
The same amount of abstraction is used in modern computing where a lower level language is actually what powers a higher level language 🙃
That way in the future, we could legit just have a computer program the cells via a machine without human intervention.
Once i hearded that the repressilator is a solution waiting for a problem, and honestly, i love that
I do not understand a word but I feel like it’s very well presented :)
Can we make a Timer DNA circuit so that if we genetically modify a species by fitting this ckt , say 3rd generation do not have reproduction capabilities.
Playing with molecules of life has a lot of fun 👍👨🔬
Aw, I missed this stream; I’ll have to check it out later.
Gen Engineering is the way of the future. Grow what you need, make what you want. The future is now, depending on the place you call home. If this seems wrong, is because it's true.
Word
I commented several questions and don't know where they went, about what would it take to create custom organelles, why can't you use plasmids with mammals, and what kind of unit cell would you use to grow a brain if you could like a crystal.
None of those comments appear here, wonder where they went?
Plasmids have been enginerrd for use in mammalian cells. These have been modified to be more compatible to mammalian cellular machinery
Mammals tend to have linear DNA while plasmids are circular also the whole nucleus surrounded by the nuclear envelope with my favorite structure in the nuclear pore
Any recommendations on papers/online courses diving further into genetic circuit design? Coming at this as a 3rd year Molec Bio/CS undergrad, and I'm trying to build a tree of prerequisite knowledge I'd need for all this.
I know that oscillation requires repression with significant delay to prevent the system from reaching an equilibrium. Is this not a problem when working with genetic switches due to the relatively long amount of time it takes from transcription to translation when compared to the time it takes for repressors to bind to and repress genes?
When is part4 coming out? :D
By far the best scientific name for anything is the “rectoanal inhibitory reflex”…..
I remember reading recently about controlling the organism internal clock, yeah imagine the possibilities of controlling embryo development speed?=0
Not something in practicality you really want though most tumor necrosis factor genes and senescence genes keep you from getting cancer.
Neat, what software you use to model/program DNA?
I use a Cytoscape plugin to gain an understanding of the behaviour of complex gene regulatory networks. Idk what he uses tho haha
How would a bacteria be species dependent? so. like for that drug delivery bacteria, only do something if i'm inside a human?
this solves the antibiotic problem
"You will have a snake-mouse"
I mean that exists, its called a ferret /s
Have you read the book Blood Music? This reminds me of that…
What’s the difference between the gene programming of the video (I think it’s called gene therapy in healthcare context) and the CRISPR gene editing technique?
Gene editing is a generic term for all sorts of techniques to change the protein production of cells, gene therapy refers to any use of these techniques specifically for medical reasons, CRISPR/CAS is one small set of these techniques, based on a type of bacterial immune system. There are many other ways to get the same results, which one will work best heavily depends on the specific situation. @TheThoughtEmporium has gone over a lot of this with *much* more detail in previous streams.
Do promoters and inverters always work on the genes right next to them?
Now I want to see a snakemouse.
What is going on there is an abundance of positive ions apparently not being diffused or something like that potassium maybe scan doesn't taste like salt what exactly is going on and what do I need to do to start diffusing positive potassium ions
The only thing i pictured while watching this was just the fluffy ponnies bio toy concept
We've come a long way since I got my Biology degree 20 years ago, too bad I never got to use it. I think AI is going to revolutionize the possibilities.
That's sad to hear
It already is they have fully automated biolabs in Australia that are run by AI. All people do is add reagents to fill tanks and collect the data.
Wait no cre lox system??
How can we be 100% sure that changing one expression of a gene does not affect another gene's function/expression elsewhere in the organism?
I mean we think we know everything but our understanding of the complex mechanisms within biology/organisms are being updated constantly, or am i wrong?
Becouse one gene only doses for one specific protein it has no infkuence on the coding of another gene you can be very pericise in how to target the dna
@@definitlynotbenlente7671
Not true gene produced proteins most certainly affect other gene expressions otherwise gene pathways wouldn't exist.
You're not wrong that's exactly what it is and the deeper you go the more complex it becomes.
Great video.
Of course, the real manbat 9000 is switching on the latent ‘human’ echo location gene 🧬 by inserting it into the human Genome from actual bats with CRISPR!
I am new to your channel and I am curious if it is possible to diy scale CRSIPR or gene modification on animals e.g in dog breeding Thanks
NAND to Tetris: Genetic engineering edition when?
Can you think about ethics
we want to do a project on genetic circuits for iGEM this year, any ideas or tips anybody?
Next DOOM episode is coming out somewhere next month, he's talking about this at 1h28m
I wish he would look more at the camera when answering questions... Instead of just flailing his gaze wildly like a flagellum.
Díky!
great I hope they send us home the nuclear teleport and the consciousness transferring monitor to the host
A full adder is like your first real digital circuit that isn't a hello world, computers have other parts that look a lot different like memory and decoders
Where can get degree in Genetic engineering?
episode 4 PLSSSSSSSSSSSSSSSSSS make a series!!!
Can you make something that will make my hair grow again? Going bald and want to get it back
... I can't wait until we can science up a way for doggo to play call of duty.
Where are part 1 and 2?
it's in the "live" section of the channel www.youtube.com/@thethoughtemporium/streams
ruclips.net/video/E_TAHxPBqKY/видео.html
ruclips.net/video/1ThNnuSuZC0/видео.html
Do you have a kick starter?
Wo ein Wille ist, ist auch ein Weg.
Lesgooo part 3
Will it run Doom. Callback to your last project.
Am waiting for someone to program doom into genetics.
Someday someone's mouse snake will run doom
Isn‘t that basically your immune system?
When the next 1 droppin
Catgirls, I sleep.
Lamia, real shit?!
1:30:56 what a great thing to say to trigger interest in science!
I subbed asap
So cool
If only we can create DNA RAM
Respectful
Please make another parr
مراقبة الاشخاص الايرانيين عم تتم عن طريق
ال الحمض النووي الالكتروني ..
Snake people, let's go
Don't we have enough politicians 😅
Do you ever actually make anything useful ?
Fair enough but a lot of his ideas are usually projects of decades in a university and lots of funding and people working on it. Not saying he shouldn't focus on one thing and accomplish something. But it can be pretty insane just getting the correct materials and equipment to try to push the technology bar.
Manufacturing Spider silk in bulk is his real project
Definitely I need friends like you 😮😱🤌🏽🤌🏽 New sub here !