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Does Dr. Longo: (1) Define what the control rat chow is composed of? (Seed oils? Plant or animal protein? Refined grains? Corn or soy? Vegetable carbs?) and: (2) Also test with an animal-based FMD? (3) Test against higher quality RF rather then refeed with the standard diet? ANY diet that goes from highly-processed food (the control rat chow?) to low-processed (whether plant- or animal-based) would likely result in the improvement parameters Longo reports. Less processed food over time can only be better. A reduction in neoplasms & dermatitis in the test group is a move in the right direction, but still disturbingly present. Perhaps if different FMD & RF diets are tested for various health markers, we'd have a much better basis for recommending the composition of the FMD and the RF diets.
This was amazing, Nic! pls do interject comments from ur exercise physiology knowledge 😀A few questions: 1. What do you think about this: They did FMD for mice every 2 weeks. and measurements happened around 1, 2 &3 days of RF. If we loosely translate that to humans, then we can do FMD every 18 months (or once/yr) measured FMD mice after RF, when the RF is 2 days, that would be like 80 days, right? And 3 days of RF would be around 120 days for us.... And if we do FMD every 3-4 months we might see roughly similar results? 2. if the sizes of the organs increases (including the muscle tissues), then shouldn’t the lean body mass also increase? 😀
1. I think Longo mentions that the maximum time between cycles is 3 months, so that seems to follow your train of thought, Moj. I think the Insider version of the other study (the series based on study 68) looked at 3 months, if I remember correctly. 2. Excellent point - although, I don't think the increase in weight of the heart, liver, and kidneys would be substantial enough to lead to noticeable increases in lean mass. However, if muscle mass had also increased, that might be enough. So, taking that, I think you bring up a great point that it likely eliminates muscle mass as a major factor since lean mass wasn't different.
Brother. My Weight is 83 KGS. Male. Age is 33 and height is 5'9 inch. My body looks lean but I have a big belly as I lived my past lifes in lots of junk snacks, sweets, restaurant non veg foods (only chicken and goat). I have never visited any gym in life but I used to do freehand at home and spot running. Question is: How do I reduce my belly fat to the minimum? I am a muslim, so I am planning to do rigorous fasting, like no water or food after sunrise and break the fast at sunset with dates and fruits. And I will live my life on dates and fruits and coconut water only for next 3 months. Please advice will that help? Thank you
Fascinating! But, I I’ll need to listen to it a couple of times to absorb all the information. What I would like to see done is a comparison of the fasting mimicking diet, done as Valter Longo recommends, (I think every three months?) with straight up fasting done for 72 hours once a month, in HUMANS for one year, with no other interventions by the researchers. The information we are looking for is how these two programs effect the human body in the ordinary human (all ages) not for some strict arbitrarily imposed restrictions by the researchers. After one year all the important biological markers, including cognition, strength etc, including biological age, could be measured. It would be super informative. (I don’t think it should matter about lifestyle differences because humans have different lifestyles, and we want to know, given those varied lifestyles, does fasting and FMD have positive health effects.)
Thank you, I think is is such a valuable video - I couldn't make head nor tail of any of that data - but you broke it down so clearly. I think those 14% longevity mouses in each camp were the 110 year olds the news sometimes gets a hold of, the ones who drank like a fish their entire lives, and ate fried bacon for every meal, and smoked cigars since they were 13. I bet those mouses could have eaten and done whatever they liked and it wouldn't have made a lick of difference to their longevity. The rest of us need to look at our family - I only have one grandparent who didn't go out before their time - while the other three were taken by nasty more modern diseases of Alzheimer's, diabetes, and cancer.
I wonder why the FMD has such a high percentage of carbs. Is this because they are catering to people who haven't become fat adapted yet by first following a low carb diet, the carbs making the transition easier? Can you reduce the carbs to give yourself a little wiggle room with the fat? I understand that the low protein might help stimulate the autophagy, but I was just wondering about why the carbs are so high. The level of calories is fine. I was thinking of having the carbs less than fifty grams which is easy to do even with the low protein. The Prolong diet just seems like a simple solution, something easy. I really did like the video and was so convinced that I adapted the diet with a lower carb version with good results. You were on target with the muscle retention and the loss of visceral fat. I wish I had your lab though. Would a straight fast be as good on the refeed?
Assuming that this **does** translate to humans (and nobody is sure; humans are very different from mice) do you, Nic, plan on doing FMD every three months? And if you do, will you attempt to re-create the Prolon kit? If you could, it would be useful to many people. I think that many more people would do it if it was more affordable.
Why, Bruce? If you're consuming a standard 2000 kcalorie diet to maintain your weight and you're consuming even 50% of that in this diet (so, 1000 kcalories), and you are consuming 10% protein, that leads to 25 grams of protein a day. You consider 25 grams or protein to be anything other than low? That's considering the highest values offered ^. If it were the 37% of kcalories, we're talking just shy of 19 grams of protein a day. Either of those values aren't enough to subsist life long term, so what do you consider 'low', then?
@@Physionic It's very nice that people who learned nutrition through Google have the audacity to teach and explain to professors and scientists what is relevant and up-to-date and what is not...Where do you teach Bruce? I'm interested in signing up!
I don't mind Bruce disagreeing - everyone should feel comfortable to have discussion, and I'm not infallible, but I do need reasoning, as anyone who is scientifically minded should (which is the point of Physionic).
@@yaronmosheezer4580 an understandable misunderstanding, it is common mistakes that people frame 10% of protein as "low". But here it is not 10% of maintenance.
![Does Intermittent Fasting, WITHOUT WEIGHT LOSS, improve your Health? [Study Breakdown]](http://i.ytimg.com/vi/1t0HUSlFNiQ/mqdefault.jpg)
![Does Intermittent Fasting, WITHOUT WEIGHT LOSS, improve your Health? [Study Breakdown]](/img/tr.png)
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Hi, I signed up for the additional content but I dont see an extended video on this topic on the website.
Just want to say Thank You for doing this. Amazing information. 👍
This is amazing! Thank you for allowing us to understand this process!Priceless info for an old gal like me!😊
Heading over to the insider link to see if and how it translates to me! 😄
Thank you so much for amazing science 🙌
keep up the astonishing work sir
Thank you.
Another solid video. Your content is great…keep it up
Thanks, A.
Does Dr. Longo:
(1) Define what the control rat chow is composed of? (Seed oils? Plant or animal protein? Refined grains? Corn or soy? Vegetable carbs?) and:
(2) Also test with an animal-based FMD?
(3) Test against higher quality RF rather then refeed with the standard diet?
ANY diet that goes from highly-processed food (the control rat chow?) to low-processed (whether plant- or animal-based) would likely result in the improvement parameters Longo reports. Less processed food over time can only be better.
A reduction in neoplasms & dermatitis in the test group is a move in the right direction, but still disturbingly present. Perhaps if different FMD & RF diets are tested for various health markers, we'd have a much better basis for recommending the composition of the FMD and the RF diets.
This was amazing, Nic! pls do interject comments from ur exercise physiology knowledge 😀A few questions:
1. What do you think about this: They did FMD for mice every 2 weeks. and measurements happened around 1, 2 &3 days of RF. If we loosely translate that to humans, then we can do FMD every 18 months (or once/yr) measured FMD mice after RF, when the RF is 2 days, that would be like 80 days, right? And 3 days of RF would be around 120 days for us.... And if we do FMD every 3-4 months we might see roughly similar results?
2. if the sizes of the organs increases (including the muscle tissues), then shouldn’t the lean body mass also increase?
😀
1. I think Longo mentions that the maximum time between cycles is 3 months, so that seems to follow your train of thought, Moj. I think the Insider version of the other study (the series based on study 68) looked at 3 months, if I remember correctly.
2. Excellent point - although, I don't think the increase in weight of the heart, liver, and kidneys would be substantial enough to lead to noticeable increases in lean mass. However, if muscle mass had also increased, that might be enough. So, taking that, I think you bring up a great point that it likely eliminates muscle mass as a major factor since lean mass wasn't different.
It's not a long video, but a very interesting video.
Curious to learn about correlation between FMD & Type 2 Diabetes regression
Brother. My Weight is 83 KGS. Male. Age is 33 and height is 5'9 inch. My body looks lean but I have a big belly as I lived my past lifes in lots of junk snacks, sweets, restaurant non veg foods (only chicken and goat). I have never visited any gym in life but I used to do freehand at home and spot running.
Question is: How do I reduce my belly fat to the minimum?
I am a muslim, so I am planning to do rigorous fasting, like no water or food after sunrise and break the fast at sunset with dates and fruits. And I will live my life on dates and fruits and coconut water only for next 3 months.
Please advice will that help?
Thank you
Short Version: ruclips.net/video/8OoH6IgKvSw/видео.html
I wonder if you really need to do low protein for these healthspan benefits or could you just reduce methionine and leucine while increasing glycine
Interesting. You could very well be right. Great point.
That's an interesting idea.
Indeed
Fascinating! But, I I’ll need to listen to it a couple of times to absorb all the information. What I would like to see done is a comparison of the fasting mimicking diet, done as Valter Longo recommends, (I think every three months?) with straight up fasting done for 72 hours once a month, in HUMANS for one year, with no other interventions by the researchers. The information we are looking for is how these two programs effect the human body in the ordinary human (all ages) not for some strict arbitrarily imposed restrictions by the researchers. After one year all the important biological markers, including cognition, strength etc, including biological age, could be measured. It would be super informative. (I don’t think it should matter about lifestyle differences because humans have different lifestyles, and we want to know, given those varied lifestyles, does fasting and FMD have positive health effects.)
I couldn’t agree more. I’d love to see an experiment like that, Jenny.
Thank you, I think is is such a valuable video - I couldn't make head nor tail of any of that data - but you broke it down so clearly.
I think those 14% longevity mouses in each camp were the 110 year olds the news sometimes gets a hold of, the ones who drank like a fish their entire lives, and ate fried bacon for every meal, and smoked cigars since they were 13. I bet those mouses could have eaten and done whatever they liked and it wouldn't have made a lick of difference to their longevity. The rest of us need to look at our family - I only have one grandparent who didn't go out before their time - while the other three were taken by nasty more modern diseases of Alzheimer's, diabetes, and cancer.
I wonder why the FMD has such a high percentage of carbs. Is this because they are catering to people who haven't become fat adapted yet by first following a low carb diet, the carbs making the transition easier? Can you reduce the carbs to give yourself a little wiggle room with the fat? I understand that the low protein might help stimulate the autophagy, but I was just wondering about why the carbs are so high. The level of calories is fine. I was thinking of having the carbs less than fifty grams which is easy to do even with the low protein. The Prolong diet just seems like a simple solution, something easy. I really did like the video and was so convinced that I adapted the diet with a lower carb version with good results. You were on target with the muscle retention and the loss of visceral fat. I wish I had your lab though. Would a straight fast be as good on the refeed?
Assuming that this **does** translate to humans (and nobody is sure; humans are very different from mice) do you, Nic, plan on doing FMD every three months? And if you do, will you attempt to re-create the Prolon kit? If you could, it would be useful to many people. I think that many more people would do it if it was more affordable.
About reaction to new opbject, HOW do they determine that it's simple curiosity.. and NOT 'I'm starving, is that edible ?"
Well done. Even lay men can understand...
I'm really glad to hear it, Sham - thank you.
I'd sure wish he would stop saying 10% for protein is "extremely low".
Studies with preconceptions are not true science.
Why, Bruce?
If you're consuming a standard 2000 kcalorie diet to maintain your weight and you're consuming even 50% of that in this diet (so, 1000 kcalories), and you are consuming 10% protein, that leads to 25 grams of protein a day. You consider 25 grams or protein to be anything other than low?
That's considering the highest values offered ^. If it were the 37% of kcalories, we're talking just shy of 19 grams of protein a day.
Either of those values aren't enough to subsist life long term, so what do you consider 'low', then?
@@Physionic
It's very nice that people who learned nutrition through Google have the audacity to teach and explain to professors and scientists what is relevant and up-to-date and what is not...Where do you teach Bruce? I'm interested in signing up!
I don't mind Bruce disagreeing - everyone should feel comfortable to have discussion, and I'm not infallible, but I do need reasoning, as anyone who is scientifically minded should (which is the point of Physionic).
@@Physionic
"Without data you're just another person with an opinion"
(W.Edwards deming
data scientist)
@@yaronmosheezer4580 an understandable misunderstanding, it is common mistakes that people frame 10% of protein as "low". But here it is not 10% of maintenance.