Renin Angiotensin Aldosterone Sysytem - Renin Pathway easy Explanation
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- Опубликовано: 28 авг 2024
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When the plasma sodium concentration is lower than normal or the renal blood flow is reduced, the juxtaglomerular cells in the kidneys convert prorenin (an intracellular protein) into renin, which is then secreted directly into the circulation. Plasma renin then cuts a short, 10 amino acid long, peptide off a plasma protein known as angiotensinogen. The short peptide is known as angiotensin I.[2] Angiotensin I is then converted, by the removal of 2 amino acids, to form an octapeptide known as angiotensin II, by the enzyme angiotensin-converting enzyme (ACE) found in the lung capillaries. Angiotensin II is a potent vaso-active peptide that causes arterioles to constrict, resulting in increased arterial blood pressure.[3] Angiotensin II also stimulates the secretion of the hormone aldosterone from the adrenal cortex.[3] Aldosterone causes the tubular epithelial cells of the kidneys to increase the reabsorption of sodium ions from the tubular fluid back into the blood, while at the same time causing them to excrete potassium ions into the tubular fluid which will become urine.
RELATED TOPICS
renin
catalysis
protein
chemical compound
organic compound
endocrine system
polymer
blood pressure
angiotensin
enzyme
Renin-angiotensin system, physiological system that regulates blood pressure
Renin is an enzyme secreted into the blood from specialized cells that encircle the arterioles at the entrance to the glomeruli of the kidneys (the renal capillary networks that are the filtration units of the kidney). The renin-secreting cells, which compose the juxtaglomerular apparatus, are sensitive to changes in blood flow and blood pressure. The primary stimulus for increased renin secretion is decreased blood flow to the kidneys, which may be caused by loss of sodium and water (as a result of diarrhea, persistent vomiting, or excessive perspiration) or by narrowing of a renal artery. Renin catalyzes the conversion of a plasma protein called angiotensinogen into a decapeptide (consisting of 10 amino acids) called angiotensin I. An enzyme in the serum called angiotensin-converting enzyme (ACE) then converts angiotensin I into an octapeptide (consisting of eight amino acids) called angiotensin II. Angiotensin II acts via receptors in the adrenal glands to stimulate the secretion of aldosterone, which stimulates salt and water reabsorption by the kidneys, and the constriction of small arteries (arterioles), which causes an increase in blood pressure. Angiotensin II further constricts blood vessels through its inhibitory actions on the reuptake into nerve terminals of the hormone norepinephrine.
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You have one of the clearest, yet well developed videos regarding this topic. I appreciate your good work
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Best factor about this video: no unnecessary information _ VERY CONCISE AND TO THE POINT! So many other videos are more full of BS!
This Helped me sooooo much. I loved how clear everything was layed out. Very east to follow and I understood everything that was presented. Thank you for taking the time to make this video.
I am grateful for this video. ONE MINOR CORRECTION though. Angiotensin II (MAINLY acts of the EFFERENT arterioles) although angiotensin II constrict both, AAAfferent and EEEfferent, it preferentially constrict Efferent arterioles. One way I remember the mechanism of action of ACE inhibitors, is by remembering "A"-->Angiotensin II "C"--> constrict "E"--> Efferent. Other than that, Thank you very much for this easy to grasp explanation. Have a lovely day! :)
Well you have also a good concept
Thank you for correcting
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Thank You! It's so hard to find content that's clear and to the point. THANK YOU THANK YOU
Sir thank you so much for helping me ! Your explanation is 1000000X better than my Endocrine subject lecturer. May god bless you.
Taking pharmacology at the moment and with this video and a few others I watched on ANS I just realized RUclips will be my best friend these days lmao very well explained, short and to the point, I absolutely loved this video and I am so happy to come across it. I'd give it a million likes if it wasn't because I can only give 1 😂 . Mad respect and admiration to all the people who make educational vids for ease of understanding.
Wow thank u so much for that elaborate, yet easy explanation. I was curious to know about renin aldosterone pathway, since I learnt very briefly about it in school, this lesson made it all very clear for me. Thanks again:))
U are totally underrated !!!
U deserve a lot more
Excellent work by the way.
Thank you, this was such a short and sweet video which contained everything I needed to know about the R.A.A.S. system. Cheers !
Hey !
I’ve been trying to understand this system for forever. Thank you!
Best explained till date.
One of the best videos I’ve seen on the RAAS thank you
This is the best explanation taken from Guyton that i've seen so far.
Clear cut explanation...❤️❤️❤️
One of the best videos on RAAS Mechanism
ive been trying to understand this for months.... and it finally makes sense!!
The most clear lecture on raas mechanism
Thank you....i like the step by step process
best explanation. so easy. thx
+Freny Vaghela Thank you Freny
Excellent... most simplified yet detailed explanation
THANK YOU. That was way easier to follow than other descriptions I read.
Thank you for clarify the concept
The simplest and best explanation. Thank you so much
Thank you! The best so far
Very simply explained...thank you so much
You guys are amazing!! Thanks for making RAAS much easier!!
Explanation is simple and it is easily understood
I am glad it helped
Very well done MEDSimplified ! Great stuff. Looking forward to more.
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thank you sir ,in a short time spain you teach us very more.keep it up good job
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Very Well Done boy!
Clear, Relevant and Simple 👍
This helped me so much...Thank you so much
In a simplified way ,very well understood
We want more videos from your channel according to the physiology.some topics in physiology are very difficult to understand..
And thank you for your teaching :-)
Amazing explanation.....
I am preparing for my interview for MR job.
This details helped me alot
Thank you for the easy explanation, it really helped me! Good luck!
Thank you sir for this it is really helpful for us
Doesn't angiotensin II constrict the Efferent (not afferent) arteriole and increase (not decrease) GFR though
Crystal clear concept.....👍
very well explained. thank you! what software do you use to animate your videos?
Ang 2 constricts Efferent Arterioles, not afferent. Which increases the Pgc hydrostatic pressure resulting in more squeezing of the sponge (glomerulus) increasing GFR.
Very good explanation
Very nice video and well done explanation
Very well explained 🙏
Thanks... simple and clear presentation. Loved it
Smooth as butter man
😊 glad u liked it Anup
Awesome lecture!
Best explanation .. Thank u
I am very glad you liked the content. Thank you for Appreciating.🙂🙂
Well clear explanation💚🌟👏
Videos having best animation nd explanation always...
mansi khanpara
do you prepare for neet and aiims
Thanks for the short and easy to understand video. There were a few typographical errors in the video which if corrected, would make it perfect.
Nice video..it's very helpful
I am very glad you liked the content. Thank you for Appreciating.🙂🙂
Best explanation 👌
Superb explanation 👌👌👏👏
Thanks alot mate keep up the good work !
Thank you. The best explanation so far
+erdisa gjyshka you are most welcome 😊
Excellent explanation about raas mechanism
Nice expansion
The video is straight to point and clear!! Thumbs up for that, yet it has so many typos 🤔 maybe something to work on? 👍
This is so helpful. Thank you so much for posting this!
In the book it's written angiotensin ii increases the GFR since pressure is increased.
A good articulation of Guyton chapter 19
thank you👍👍
Excellent video never found it on youtube
may you flourish forever
#Bio2U Classes
Best i use this as presentation nd ppl impressed
You are the best
Thank you for all your videos
Beautifully explained. Thank you so much :)
Awesome sir! I understood everything clearly. Thank you soo much sir.
Thank you so much. The explanation was amazing but the only thing is that some words are not spelled right. Maybe just keep that in mind when making future videos.
Very well explained video. Thank you for posting this.
love this! We need more videos like this!
Thank you so much . You make it easy for me .
Too helpful. Thank you 😊
Thank you for making this so clear. So appreciate you making this video! :-)
That was so helpful!!! Thank you so much
THANK YOU !!! This was so helpful and easy to follow!
Thanks a million
Very good break down. THANKS!
Very easy to understand. Thanks
very helpful! Thanks
Thanks much for this video
great channel
Superb explanation
Nyss explaination
Very helpful vedio
Well explained and engaging video 👍 would have liked mention of vasopressin and natriuretic peptides too. Potassium? May be some feedback loops.
really simplified and to the point. however, for future videos put an audio voice over the animations as your accent is hard to follow
Pls make videos on nerve conduction
Very helpful
Really helpful thank you
wow it's so amazing and simplified 😍😍😍😍
Thanks so much 🙏
liked b4 watching
+harsh v singh thank you harsh
Tq so much sir for making this topic so easy... can you plz make a video on Cardiac Output as soon as possible
Thanks Thanks Thanks !! Great piece of work... Helped me
Super thanks
that was perfect!!!!!