Renin Angiotensin Aldosterone Sysytem - Renin Pathway easy Explanation

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When the plasma sodium concentration is lower than normal or the renal blood flow is reduced, the juxtaglomerular cells in the kidneys convert prorenin (an intracellular protein) into renin, which is then secreted directly into the circulation. Plasma renin then cuts a short, 10 amino acid long, peptide off a plasma protein known as angiotensinogen. The short peptide is known as angiotensin I.[2] Angiotensin I is then converted, by the removal of 2 amino acids, to form an octapeptide known as angiotensin II, by the enzyme angiotensin-converting enzyme (ACE) found in the lung capillaries. Angiotensin II is a potent vaso-active peptide that causes arterioles to constrict, resulting in increased arterial blood pressure.[3] Angiotensin II also stimulates the secretion of the hormone aldosterone from the adrenal cortex.[3] Aldosterone causes the tubular epithelial cells of the kidneys to increase the reabsorption of sodium ions from the tubular fluid back into the blood, while at the same time causing them to excrete potassium ions into the tubular fluid which will become urine.
RELATED TOPICS
renin
catalysis
protein
chemical compound
organic compound
endocrine system
polymer
blood pressure
angiotensin
enzyme
Renin-angiotensin system, physiological system that regulates blood pressure
Renin is an enzyme secreted into the blood from specialized cells that encircle the arterioles at the entrance to the glomeruli of the kidneys (the renal capillary networks that are the filtration units of the kidney). The renin-secreting cells, which compose the juxtaglomerular apparatus, are sensitive to changes in blood flow and blood pressure. The primary stimulus for increased renin secretion is decreased blood flow to the kidneys, which may be caused by loss of sodium and water (as a result of diarrhea, persistent vomiting, or excessive perspiration) or by narrowing of a renal artery. Renin catalyzes the conversion of a plasma protein called angiotensinogen into a decapeptide (consisting of 10 amino acids) called angiotensin I. An enzyme in the serum called angiotensin-converting enzyme (ACE) then converts angiotensin I into an octapeptide (consisting of eight amino acids) called angiotensin II. Angiotensin II acts via receptors in the adrenal glands to stimulate the secretion of aldosterone, which stimulates salt and water reabsorption by the kidneys, and the constriction of small arteries (arterioles), which causes an increase in blood pressure. Angiotensin II further constricts blood vessels through its inhibitory actions on the reuptake into nerve terminals of the hormone norepinephrine.
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Best factor about this video: no unnecessary information _ VERY CONCISE AND TO THE POINT! So many other videos are more full of BS!

[@Jmont.]

This Helped me sooooo much. I loved how clear everything was layed out. Very east to follow and I understood everything that was presented. Thank you for taking the time to make this video.

[@B3bita1215]

I am grateful for this video. ONE MINOR CORRECTION though. Angiotensin II (MAINLY acts of the EFFERENT arterioles) although angiotensin II constrict both, AAAfferent and EEEfferent, it preferentially constrict Efferent arterioles. One way I remember the mechanism of action of ACE inhibitors, is by remembering "A"-->Angiotensin II "C"--> constrict "E"--> Efferent. Other than that, Thank you very much for this easy to grasp explanation. Have a lovely day! :)

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[@isabellearrowood210]

Wow thank u so much for that elaborate, yet easy explanation. I was curious to know about renin aldosterone pathway, since I learnt very briefly about it in school, this lesson made it all very clear for me. Thanks again:))

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U deserve a lot more
Excellent work by the way.

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Thank you, this was such a short and sweet video which contained everything I needed to know about the R.A.A.S. system. Cheers !

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Hey !

[@aneekaak]

I’ve been trying to understand this system for forever. Thank you!

[@keshavvatsa1960]

Best explained till date.

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One of the best videos I’ve seen on the RAAS thank you

[@DrKevynOliveira]

This is the best explanation taken from Guyton that i've seen so far.

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[@MEDSimplified]

+Freny Vaghela Thank you Freny

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Thank you for clarify the concept

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Explanation is simple and it is easily understood

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Thank you sir for this it is really helpful for us

[@leighfountain1800]

Doesn't angiotensin II constrict the Efferent (not afferent) arteriole and increase (not decrease) GFR though

[@yuktajoshi382]

Crystal clear concept.....👍

[@vikrampinto]

very well explained. thank you! what software do you use to animate your videos?

[@otto9875]

Ang 2 constricts Efferent Arterioles, not afferent. Which increases the Pgc hydrostatic pressure resulting in more squeezing of the sponge (glomerulus) increasing GFR.

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Very good explanation

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I am very glad you liked the content. Thank you for Appreciating.🙂🙂

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Videos having best animation nd explanation always...

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mansi khanpara
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[@swethapadaala2750]

Thanks for the short and easy to understand video. There were a few typographical errors in the video which if corrected, would make it perfect.

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Nice video..it's very helpful

[@MEDSimplified]

I am very glad you liked the content. Thank you for Appreciating.🙂🙂

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Best explanation 👌

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Nice expansion

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The video is straight to point and clear!! Thumbs up for that, yet it has so many typos 🤔 maybe something to work on? 👍

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This is so helpful. Thank you so much for posting this!

[@omprakashbiswas3254]

In the book it's written angiotensin ii increases the GFR since pressure is increased.

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A good articulation of Guyton chapter 19

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Nyss explaination

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[@nelc9824]

Well explained and engaging video 👍 would have liked mention of vasopressin and natriuretic peptides too. Potassium? May be some feedback loops.

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really simplified and to the point. however, for future videos put an audio voice over the animations as your accent is hard to follow

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Pls make videos on nerve conduction

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