Non Steroidal Anti-inflammatory Drugs|| Pharmacology Chapter 2 part 9 (

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  • Опубликовано: 28 окт 2024
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    In this video we study about
    #Non_Steroidal_Anti_Inflammatory_Drugs
    ( #NSAIDs)
    The drugs are used to treat Inflammation , and mild to moderate Pain and fever are
    called Non steroidal anti Inflammatory drugs .
    Inflammation : It is a condition in which part of the body becomes reddened , swollen ,
    hot, and painful , especially as a reaction to injury or infection .
    #Classification_of_Non_Steroidal_Anti_Inflammatory_Drugs (NSIADs)
    1) Non -Selective COX inhibitors
    a) Salicylates : Aspirin
    b) pyrazolone Derivatives : Phenylbutazone
    c) Indole Derivatives : Indomethacin
    d) Propionic Acid Derivatives : Ibuprofen
    e) Aril Acetic Acid Derivatives : Diclofenac
    f) oxycame Derivatives : Piroxicam
    #Indications_Non_Steroidal_Anti_Inflammatory_Drugs
    1) #Analgesia : NSIADs are used to eliminate or treat mild to moderate pain like :
    a) headache
    b) toothaches
    c) muscle aches
    d) arthritis
    e) migraine
    f) Dysmenorrhea
    2) #Antipyresis : NSIADs are used to treat fever / to normalize body temperature .
    3) Anti Inflammation : NSIADs are used to stop inflammation and pain like :
    a) Rheumatoids
    b) osteoarthritis
    c) Ankylosing spondylitis
    d) bursitis
    #Adverse_Effects_Non_Steroidal_Anti_Inflammatory_Drugs
    1) In Stomach : NSIADs block the biosynthesis of PG ( prostaglandins ) , which inhibit the
    acid secretion and promote the secretion of cytoprotective mucus in the GIT . If these
    PGs are inhibited there are more chances to damage the inner layer of stomach , and
    may cause the gastric ulcer .
    2) In Platelets : The function of platelets are disturbed because NSIADs prevent the
    formation of TXA2 ( thromboxane A2 ) , which helps in blood clotting .
    3) In Uterus : prostaglandins help to open the cervix because of contraction , but in the
    case of inhibition of PGs cause difficulty in labor .(child birth )
    4) In Kidneys : NSIADs decrease the renal blood flow and the glomerular filtration rate .
    #Contraindication_Of_Non_Steroidal_Anti_Inflammatory_Drugs
    1) with NSIADs hypersensitivity ( an exaggerated response by immune to a drug ) .
    2) In peptic Ulcer ,
    3) In children suffering from chicken pox or influenza .
    4) In chronic liver disease
    5) In during pregnancy .
    6) in breastfeeding mother .
    Detail study of some drugs
    1) Aspirin :
    It is a non selective anti- inflammatory drug .
    #Non_Steroidal_Anti_Inflammatory_Drugs_by_srpharmacy
    #srpharmacy
    ‪@srpharmacy‬

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